EP0575373A1 - Topical soap-gel preparation - Google Patents
Topical soap-gel preparationInfo
- Publication number
- EP0575373A1 EP0575373A1 EP92905575A EP92905575A EP0575373A1 EP 0575373 A1 EP0575373 A1 EP 0575373A1 EP 92905575 A EP92905575 A EP 92905575A EP 92905575 A EP92905575 A EP 92905575A EP 0575373 A1 EP0575373 A1 EP 0575373A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- weight
- fatty acids
- soap
- gel preparation
- polyols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0229—Sticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/262—Organic compounds, e.g. vitamins containing oxygen containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/265—Organic compounds, e.g. vitamins containing oxygen containing glycerol
Definitions
- the invention relates to a shaped preparation for the use of cosmetic and pharmaceutical active ingredients, in particular in stick form, based on a soap gel which, because of its composition at normal temperature, has very good dimensional stability and good abrasion properties and is largely free of lower alcohols .
- Soap gels have long been known as carriers for topical cosmetic and pharmaceutical active ingredients.
- Sodium stearate gels in aqueous lower alcohols and glycols are usually used as be ⁇ fen.
- such gels have the disadvantage that they are usually too stiff and, when used on the skin, give off very little product to the skin.
- US Pat. No. 2,900,306 it had already been proposed according to US Pat. No. 2,900,306 to add a water-soluble myristic acid soap to the preparation.
- the addition of fatty acid esters and ethylene oxide and propylene oxide condensation products had already been recommended to improve the gel time, reduce syneresis and stickiness (US Pat. No. 4,617,185).
- Such additives are sometimes disadvantageous in terms of transparency.
- the object was therefore to find a shaped soap gel preparation which has both good transparency, good dimensional stability and a satisfactory release upon contact with the skin.
- this object was achieved by a soap gel preparation for the topical application of cosmetic and pharmaceutical active ingredients based on a gel containing alkali soaps 3 - 10 wt .-% of a mixture of fatty acids with 16 - 22 carbon atoms in the form of their alkali soaps
- the proportion of soaps of branched-chain fatty acids according to the invention ensures that the preparations retain good strength in the temperature range below 35 ° C., but melt immediately on contact with the skin and become slippery, so that a thin film of the preparation easily forms spread on the skin.
- Suitable linear saturated fatty acids are palmitic acid, stearic acid, arachinic acid and behenic acid or technical mixtures which predominantly consist of such fatty acids, e.g. B. hardened palm oil fatty acid or hardened tallow fatty acid. Stearic acid is preferably used.
- branched saturated fatty acids examples include 2-hexyl-decanoic acid, 2-0ctyl-dodecanoic acid or other branched fatty acids with 16-22 carbon atoms.
- isostearic acid is preferably suitable.
- Isostearic acid is primarily understood to be a mixture of liquid, branched chain isomers of stearic acid which is accessible by hydrogenation of the isomeric, liquid monomeric fatty acids which are obtained as a by-product in the diraerization of unsaturated fatty acids.
- This isostearic acid and further branched fatty acids are described in J.Am.Oil Chem. Soc. November 1979 (Vol 56), pages 823A-827A. So it is a mixture whose main components are methyl branched isomers.
- Isostearic acid is a commercial product and is offered, for example, under the name E ersol 875 (Henkel Corp.).
- the mixture of linear and branched fatty acids is present entirely or predominantly as an alkali salt (alkali soap), preferably as a sodium soap.
- alkali soap preferably as a sodium soap.
- the quantitative ratio of linear to branched fatty acids in the fatty acid mixture to be used according to the invention influences the strength of the soap gel preparation and the abrasion behavior. With increasing proportion of isostearic acid, the firmness decreases and the release to the skin increases. But these parameters are also influenced by the total content of fatty acids in the gel.
- the fatty acid mixture is preferably used in an amount of 5-8% by weight.
- the fatty acid mixture preferably consists of 80-95% by weight of stearic acid and 5-20% by weight of branched saturated fatty acids.
- polyols with 3-6 carbon atoms and 2-6 hydroxyl groups e.g. Ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, glycerin, erythritol, pentaerythritol, trimethylolpropane, sorbitol, anhydrosorbitol, cyclohexanetriol, inositol ⁇ be set.
- Propylene glycols and glycerol alone or mixtures of these polyols with sorbitol and / or butylene glycol are preferred.
- polyols are preferably contained in a total amount of 70-90% by weight of the soap gel preparation. Particularly favorable application properties are obtained if mixtures of 10-80% by weight glycerol, 10-80% by weight propylene glycol and 5-20% by weight sorbitol and / or 1,4-butylene glycol are contained as polyols .
- a particularly stable, transparent soap gel preparation with good release properties to the skin contains:
- the soap gel preparations according to the invention serve the topical application of cosmetic and pharmaceutical active ingredients.
- active ingredients are incorporated into the soap gel preparation depending on the dosage required for the particular application.
- cosmetic active ingredients e.g. antimicrobial, deodorant, skin moisturizing, antiperspirant, depilating, coloring and fragrant substances as well as cosmetic oils.
- pharmaceutical active ingredients e.g. To understand antibiotics, corticosteroids, local anesthetics, and other active substances that are used against skin diseases.
- the amount of cosmetic or pharmaceutical active ingredients will generally be in the order of 0.1-5% by weight of the preparation, preferably in a range of 0.1-1% by weight of the preparation.
- a particularly preferred area of application for the soap gel preparations according to the invention is that of deodorant sticks.
- such products contain deodorising substances as cosmetic active ingredients.
- Suitable deodorant active ingredients are, for example, antimicrobial substances such as, for example, 2 f 4,4 * trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorohexidine digluco ⁇ at or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase-curing substances such as triethyl citrate or Triacetin, astringent substances such as As sodium aluminum chlorohydroxyl and other known body deodorants or antiperspirant.
- antimicrobial substances such as, for example, 2 f 4,4 * trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorohexidine digluco ⁇ at or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase-curing substances
- the invention may preparations contain further auxiliaries, which are conducive to improving the off ⁇ unawares and storage stability.
- auxiliaries are, for example complexing agents, Antioxida ⁇ tien, preservatives, fragrances, coloring ⁇ agents, opacifiers, pearlescent or finely divided fumed Kie ⁇ selklare. It has also been shown that turbidity and crystallization phenomena during storage can be prevented by adding a water-soluble salt, preferably sodium chloride, as a further auxiliary. in an amount of approximately 0.1 to 0.3% by weight, based on the preparation of soap gel. Overall, the amount of these auxiliaries should not make up more than 5% by weight of the soap gel preparation; such auxiliaries are preferably present in a total amount of about 1-3% by weight in the preparation.
- the soap gel preparations according to the invention are preferably free of lower alcohols. However, it is optionally possible to use up to 10% by weight of lower alcohols, such as. B. incorporate ethanol or isopropanol into the preparations.
- the soap gel preparations according to the invention are expediently carried out by mixing polyols, water and fatty acid mixtures in a container with heating to about 50-90 ° C., this mixture the alkali metal hydroxide in the form of a concentrated aqueous solution adds and moves the mass until the saponification of the fatty acids with formation of a clear solution is complete. Then the active ingredients and auxiliaries can be mixed in one after the other while cooling. Finally, the mass is converted into a mold, e.g. poured into a pencil sleeve and allowed to cool there to a temperature at which the mass solidifies to form a stable gel.
- a mold e.g. poured into a pencil sleeve and allowed to cool there to a temperature at which the mass solidifies to form a stable gel.
- Soap gel preparations of the composition given in Table I were prepared in the following way:
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Abstract
Une préparation de gel de savon pour l'application topique de substances actives cosmétiques et pharmaceutiques, en particulier sous la forme d'un bâton, à une base d'un gel de savon composé de 3-10 % en poids de savons alcalins d'un mélange d'acides gras C16-C22, 30-90 % en poids de polyols et 1-30 % en poids d'eau, présente une transparence et stabilité de forme particulièrement bonnes, ainsi que des propriétés de dégagement satisfaisantes lors du contact avec la peau si le mélange d'acides gras contient de 60 à 95 % en poids d'acides gras linéaires saturés, ainsi que de 5 à 40 % en poids d'acides gras ramifiés saturés.A soap gel preparation for the topical application of cosmetic and pharmaceutical active substances, in particular in the form of a stick, based on a soap gel consisting of 3-10% by weight of alkaline soaps of a mixture of C16-C22 fatty acids, 30-90% by weight of polyols and 1-30% by weight of water, exhibits particularly good transparency and shape stability, as well as satisfactory release properties upon contact with the skin if the fatty acid mixture contains 60-95% by weight of saturated linear fatty acids, as well as 5-40% by weight of saturated branched fatty acids.
Description
"Topische Seifenoel-Zubereituno" "Topical soap oil preparation"
Die Erfindung betrifft eine geformte Zubereitung zur Anwendung kosmeti¬ scher und pharmazeutischer Wirkstoffe, insbesondere in Stift-Form, auf der Basis eines Seifengels, das aufgrund seiner Zusammensetzung bei Normal¬ temperatur eine sehr gute Formbeständigkeit und gute Abriebeigenschaften aufweist und von niederen Alkoholen weitgehend frei ist.The invention relates to a shaped preparation for the use of cosmetic and pharmaceutical active ingredients, in particular in stick form, based on a soap gel which, because of its composition at normal temperature, has very good dimensional stability and good abrasion properties and is largely free of lower alcohols .
Seifengele sind als Träger für topisch anzuwendende kosmetische und phar¬ mazeutische Wirkstoffe seit langem bekannt. Üblicherweise werden als Sei¬ fen Natriumstearat-Gele in wäßrigen niederen Alkoholen und Glycolen einge¬ setzt. Solche Gele haben jedoch den Nachteil, daß sie meistens zu steif sind und bei der Anwendung auf der Haut nur sehr wenig Produkt an die Haut abgeben. Zur Verbesserung der Abgabeeigenschaften solcher Seifengelzube¬ reitungen war nach US 2,900,306 bereits vorgeschlagen worden, der Zuberei¬ tung eine wasserlösliche Myristinsäureseife beizumischen. In anderen Druckschriften war zur Verbesserung der Gelierzeit, der Verringerung der Synärese und der Klebrigkeit bereits der Zusatz von Fettsäureestern und Ethylenoxid- und Propylenoxid-Kondensationsprodukte empfohlen worden (US 4,617,185). Solche Zusätze sind teilweise nachteilig im Hinblick auf die Transparenz.Soap gels have long been known as carriers for topical cosmetic and pharmaceutical active ingredients. Sodium stearate gels in aqueous lower alcohols and glycols are usually used as be¬ fen. However, such gels have the disadvantage that they are usually too stiff and, when used on the skin, give off very little product to the skin. To improve the dispensing properties of such soap gel preparations, it had already been proposed according to US Pat. No. 2,900,306 to add a water-soluble myristic acid soap to the preparation. In other publications, the addition of fatty acid esters and ethylene oxide and propylene oxide condensation products had already been recommended to improve the gel time, reduce syneresis and stickiness (US Pat. No. 4,617,185). Such additives are sometimes disadvantageous in terms of transparency.
Es bestand daher die Aufgabe, eine geformte Seifengel-Zubereitung zu fin¬ den, die sowohl eine gute Transparenz, gute Formstabilität und eine be¬ friedigende Abgabe beim Kontakt mit der Haut aufweist.The object was therefore to find a shaped soap gel preparation which has both good transparency, good dimensional stability and a satisfactory release upon contact with the skin.
Diese Aufgabe wurde erfiπduπgsgemäß gelöst durch eine Seifengel-Zuberei¬ tung für die topische Anwendung kosmetischer und pharmazeutischer Wirk¬ stoffe auf der Grundlage eines Gels von Alkaliseifen, enthaltend 3 - 10 Gew.-% eines Gemisches von Fettsäuren mit 16 - 22 C-Atomen in Form ihrer AlkaliseifenAccording to the invention, this object was achieved by a soap gel preparation for the topical application of cosmetic and pharmaceutical active ingredients based on a gel containing alkali soaps 3 - 10 wt .-% of a mixture of fatty acids with 16 - 22 carbon atoms in the form of their alkali soaps
30 - 90 Gew.-% Polyole mit 3 - 6 C-Atomen und 2 - 6 Hydroxylgruppen30 - 90 wt .-% polyols with 3 - 6 carbon atoms and 2 - 6 hydroxyl groups
1 - 30 Gew.-% Wasser,1 - 30% by weight water,
sowie kosmetische oder pharmazeutische Wirkstoffe, und gegebenenfalls wei¬ ter übliche Hilfsmittel, worin das Fettsäuregemischas well as cosmetic or pharmaceutical active ingredients, and optionally further conventional auxiliaries, in which the fatty acid mixture
60 - 95 Gew.-% lineare gesättigte Fettsäuren und 5 - 40 Gew.-% verzweigte gesättigte Fettsäuren enthält.Contains 60-95% by weight of linear saturated fatty acids and 5-40% by weight of branched saturated fatty acids.
Durch den erfiπdungsgemäßen Anteil an Seifen von verzweigtkettigen Fett¬ säuren wird erreicht, daß die Zubereitungen im Temperaturbereich unterhalb 35°C zwar eine gute Festigkeit behalten, beim Kontakt mit der Haut aber sofort anschmelzen und gleitfähig werden, so daß sich leicht ein dünner Film der Zubereitung auf der Haut verteilen läßt.The proportion of soaps of branched-chain fatty acids according to the invention ensures that the preparations retain good strength in the temperature range below 35 ° C., but melt immediately on contact with the skin and become slippery, so that a thin film of the preparation easily forms spread on the skin.
Als lineare gesättigte Fettsäuren kommen Palmitinsäure, Stearinsäure, Ara- chinsäure und Behensäure oder technische Gemische in Frage, die überwie¬ gend aus solchen Fettsäuren bestehen, z. B. gehärtete Palmölfettsäure oder gehärtete Taigfettsäure. Bevorzugt wird Stearinsäure eingesetzt.Suitable linear saturated fatty acids are palmitic acid, stearic acid, arachinic acid and behenic acid or technical mixtures which predominantly consist of such fatty acids, e.g. B. hardened palm oil fatty acid or hardened tallow fatty acid. Stearic acid is preferably used.
Als verzweigte gesättigte Fettsäuren kommen beispielsweise die 2-Hexyl- decansäure, die 2-0ctyl-dodecansäure oder andere verzweigte Fettsäuren mit 16 - 22 C-Atomen in Frage.Examples of suitable branched saturated fatty acids are 2-hexyl-decanoic acid, 2-0ctyl-dodecanoic acid or other branched fatty acids with 16-22 carbon atoms.
Bevorzugt geeignet ist jedoch die Isostearinsäure. Unter Isostearinsäure wird in erster Linie ein Gemisch aus flüssigen, verzweigtkettigen Isomeren der Stearinsäure verstanden, das durch Hydrierung der bei der Diraerisie- rung ungesättigter Fettsäuren als Nebenprodukt anfallenden isomeren, flüs¬ sigen Monomerfettsäuren zugänglich ist. Diese Isostearinsäure sowie wei¬ tere verzweigte Fettsäuren werden in J.Am.Oil Chem. Soc. November 1979 (Vol 56), Seiten 823A - 827A, näher beschrieben. Demnach handelt es sich um ein Gemisch, dessen Hauptbestandteile methylverzweigte Isomere sind. Isostearinsäure ist ein Handelsprodukt und wird z.B. unter der Bezeichnung E ersol 875 (Henkel Corp.) angeboten.However, isostearic acid is preferably suitable. Isostearic acid is primarily understood to be a mixture of liquid, branched chain isomers of stearic acid which is accessible by hydrogenation of the isomeric, liquid monomeric fatty acids which are obtained as a by-product in the diraerization of unsaturated fatty acids. This isostearic acid and further branched fatty acids are described in J.Am.Oil Chem. Soc. November 1979 (Vol 56), pages 823A-827A. So it is a mixture whose main components are methyl branched isomers. Isostearic acid is a commercial product and is offered, for example, under the name E ersol 875 (Henkel Corp.).
Das Gemisch aus linearen und verzweigten Fettsäuren liegt ganz oder über¬ wiegend als Alkalisalz (Alkaliseife) vor, bevorzugt als Natriumseife. Ein gewisser Anteil an freier, unverseifter Fettsäure, etwa in einer Menge von 0,01 - 0,5 Gew.-% der Zubereitung ist jedoch nicht von Nachteil.The mixture of linear and branched fatty acids is present entirely or predominantly as an alkali salt (alkali soap), preferably as a sodium soap. A certain proportion of free, unsaponified fatty acid, for example in an amount of 0.01-0.5% by weight of the preparation, is not disadvantageous.
Das Mengenverhältnis von linearen zu verzweigten Fettsäuren in dem erfin¬ dungsgemäß zu verwendenden Fettsäuregemisch hat Einfluß auf die Festigkeit der Seifengel-Zubereitung und auf das Abriebverhalten. Mit steigendem An¬ teil an Isostearinsäure nimmt die Festigkeit ab und die Abgabe an die Haut nimmt zu. Aber auch mit dem Gesamtgehalt an Fettsäuren im Gel werden diese Parameter beeinflußt. Bevorzugt wird das Fettsäuregemisch in einer Menge von 5 - 8 Gew.-% eingesetzt. Das Fettsäuregemisch besteht bevorzugt aus 80 - 95 Gew.-% Stearinsäure und 5 - 20 Gew.-% verzweigten gesättigten Fett¬ säuren.The quantitative ratio of linear to branched fatty acids in the fatty acid mixture to be used according to the invention influences the strength of the soap gel preparation and the abrasion behavior. With increasing proportion of isostearic acid, the firmness decreases and the release to the skin increases. But these parameters are also influenced by the total content of fatty acids in the gel. The fatty acid mixture is preferably used in an amount of 5-8% by weight. The fatty acid mixture preferably consists of 80-95% by weight of stearic acid and 5-20% by weight of branched saturated fatty acids.
Als Polyole mit 3 - 6 C-Atomen und 2 - 6 Hydroxylgruppen können z.B. Ethy- lenglycol, 1,2-Propylenglycol, 1,3-Propylenglycol, 1,2-Butylenglycol, 1,3-Butylenglycol, 1,4-Butylenglycol, Glycerin, Erythrit, Pentaerythrit, Trimethylolpropan, Sorbit, Anhydrosorbit, Cyclohexantriol, Inosit einge¬ setzt werden. Bevorzugt eignen sich Propylenglycole und Glycerin allein oder Gemische dieser Polyole mit Sorbit und/oder Butylenglycol. Diese Po¬ lyole sind bevorzugt in einer Gesamtmenge von 70 - 90 Gew.-% der Seifen¬ gel-Zubereitung enthalten. Besonders günstige Anwendungseigenschaften wer¬ den erhalten, wenn als Polyole Gemische aus 10 - 80 Gew.-% Glycerin, 10 - 80 Gew.-% Propylenglycol und 5 - 20 Gew.-% Sorbit und/oder 1,4 Butylen¬ glycol enthalten sind.As polyols with 3-6 carbon atoms and 2-6 hydroxyl groups, e.g. Ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, glycerin, erythritol, pentaerythritol, trimethylolpropane, sorbitol, anhydrosorbitol, cyclohexanetriol, inositol ¬ be set. Propylene glycols and glycerol alone or mixtures of these polyols with sorbitol and / or butylene glycol are preferred. These polyols are preferably contained in a total amount of 70-90% by weight of the soap gel preparation. Particularly favorable application properties are obtained if mixtures of 10-80% by weight glycerol, 10-80% by weight propylene glycol and 5-20% by weight sorbitol and / or 1,4-butylene glycol are contained as polyols .
Eine besonders formstabile, transparente Seifengel-Zubereitung mit guten Abgabeeigenschaften an die Haut enthält:A particularly stable, transparent soap gel preparation with good release properties to the skin contains:
5 - 8 Gew.-% des Fettsäuregemisches in Form der Natrium-Seifen, 70 - 90 Gew.-* aus der Gruppe Glycerin, 1,2-Propylenglycol, 1,3-Propylenglycol oder deren Gemische mit Sorbit und/oder 1,4 Butylenglycol sowie 5 - 25 Gew.-% Wasser.5 - 8% by weight of the fatty acid mixture in the form of sodium soaps, 70 - 90% by weight * from the group glycerol, 1,2-propylene glycol, 1,3-propylene glycol or mixtures thereof with sorbitol and / or 1,4 butylene glycol and 5-25% by weight water.
Die erfindungsgemäßen Seifengel-Zubereitungen dienen der topischen Anwen¬ dung kosmetischer und pharmazeutischer Wirkstoffe. Solche Wirkstoffe wer¬ den, je nach der für die speziellen Anwendung erforderlichen Dosierung in die Seifengel-Zubereitung eingearbeitet. Als kosmetische Wirkstoffe sind z.B. antimikrobielle, deodorierende, hautfeuchthaltende, schweißhemmende, depilierende, färbende und duftende Stoffe sowie kosmetische Öle anzuse¬ hen. Als phar akologische Wirkstoffe sind z.B. Antibiotika, Corticosteroi- de, Lokalanästhetika, sowie sonstige Wirkstoffe zu verstehen, die gegen Hautkrankheiten angewendet werden. Die Menge der kosmetischen oder pharma¬ zeutischen Wirkstoffe wird in der Regel in einer Größenordnung von 0,1 - 5 Gew.-% der Zubereitung, bevorzugt in einem Bereich von 0,1 - 1 Gew.-* der Zubereitung liegen.The soap gel preparations according to the invention serve the topical application of cosmetic and pharmaceutical active ingredients. Such active ingredients are incorporated into the soap gel preparation depending on the dosage required for the particular application. As cosmetic active ingredients e.g. antimicrobial, deodorant, skin moisturizing, antiperspirant, depilating, coloring and fragrant substances as well as cosmetic oils. As pharmaceutical active ingredients e.g. To understand antibiotics, corticosteroids, local anesthetics, and other active substances that are used against skin diseases. The amount of cosmetic or pharmaceutical active ingredients will generally be in the order of 0.1-5% by weight of the preparation, preferably in a range of 0.1-1% by weight of the preparation.
Ein besonders bevorzugtes Anwendungsgebiet für die erfindungsgemäßen Sei- feπgel-Zubereitungen ist das der Deodorant-Stifte. In solchen Produkten sind erfindungsgemäß als kosmetische Wirkstoffe deodorierende Substanzen enthalten. Geeignete Deodorant-Wirkstoffe sind z.B. antimikrobielle Stoffe wie z.B. 2f4,4*-Trichlor-2'-hydroxydiphenylether (Irgasan DP300), Chlor- hexidin-diglucoπat oder Phenoxyethanol, deodorierende, antimikrobielle ätherische Öle, Farnesol, lipaseheramende Stoffe wie z.B. Triethylcitrat oder Triacetin, adstringierende Substanzen wie z. B. Natrium-Aluminium- chlorhydroxylactat und andere bekannte Körperdeodorantien oder Anti- transpiraπtieπ.A particularly preferred area of application for the soap gel preparations according to the invention is that of deodorant sticks. According to the invention, such products contain deodorising substances as cosmetic active ingredients. Suitable deodorant active ingredients are, for example, antimicrobial substances such as, for example, 2 f 4,4 * trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorohexidine diglucoπat or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase-curing substances such as triethyl citrate or Triacetin, astringent substances such as As sodium aluminum chlorohydroxyl and other known body deodorants or antiperspirant.
Neben den genannten Wirkstoffen können die erfindungsgemäßen Seifengel-Zu¬ bereitungen weitere Hilfsmittel enthalten, die zur Verbesserung des Aus¬ sehens und der Lagerstabilität dienlich sind. Solche Hilfsmittel sind z.B. Komplexbildner, Antioxidaπtien, Konservierungsmittel, Duftstoffe, Färbe¬ mittel, Trübungsmittel, Perlglanzpigmente oder feinteilige, pyrogene Kie¬ selsäure. Es hat sich auch gezeigt, daß Trübungen und Kristallisationser¬ scheinungen bei Lagerung dadurch verhindert werden können, daß man als weiteres Hilfsmittel ein wasserlösliches Salz, bevorzugt Natriumchlorid, in einer Menge von ca. 0,1 bis 0,3 Gew.-%, bezogen auf die Seifengel-Zube¬ reitung, zugibt. Insgesamt sollte die Menge dieser Hilfsmittel nicht mehr als 5 Gew.-% der Seifengel-Zubereitung ausmachen, bevorzugt sind solche Hilfsmittel in einer Menge von insgesamt etwa 1 - 3 Gew.% in der Zuberei¬ tung enthalten.In addition to the active substances soap gel Zu¬ the invention may preparations contain further auxiliaries, which are conducive to improving the off ¬ unawares and storage stability. Such auxiliaries are, for example complexing agents, Antioxidaπtien, preservatives, fragrances, coloring ¬ agents, opacifiers, pearlescent or finely divided fumed Kie ¬ selsäure. It has also been shown that turbidity and crystallization phenomena during storage can be prevented by adding a water-soluble salt, preferably sodium chloride, as a further auxiliary. in an amount of approximately 0.1 to 0.3% by weight, based on the preparation of soap gel. Overall, the amount of these auxiliaries should not make up more than 5% by weight of the soap gel preparation; such auxiliaries are preferably present in a total amount of about 1-3% by weight in the preparation.
Die erfindungsgemäßen Seifengel-Zubereitungen sind vorzugsweise fre von niederen Alkoholen. Es ist jedoch gegebenenfalls möglich, bis zu 10 Gew.-% niederer Alkohole wie z. B. Ethanol oder Isopropanol in die Zubereitungen einzuarbeiten.The soap gel preparations according to the invention are preferably free of lower alcohols. However, it is optionally possible to use up to 10% by weight of lower alcohols, such as. B. incorporate ethanol or isopropanol into the preparations.
Die Herstellung der erfindungsgemäßen Seifengel-Zubereitungen wird zweck¬ mäßig in der Weise durchgeführt, daß man Polyole, Wasser und Fettsäurege¬ mische in einem Behälter unter Erwärmen auf ca. 50 - 90 °C mischt, dieser Mischung das Alkalihydroxid in Form einer konzentrierten wäßrigen Lösung zusetzt und die Masse bewegt, bis die Verseifung der Fettsäuren unter Bil¬ dung einer klaren Lösung abgeschlossen ist. Dann können die Wirkstoffe und Hilfsmittel während der Abkühlung nacheinander untergemischt werden. Schließlich wird die Masse bei einer Temperatur oberhalb der Gelbildungs¬ temperatur in eine Form, z.B. in eine Stifthülse, gegossen und dort auf eine Temperatur abkühlen gelassen, bei der die Masse zum formstabilen Gel erstarrt.The soap gel preparations according to the invention are expediently carried out by mixing polyols, water and fatty acid mixtures in a container with heating to about 50-90 ° C., this mixture the alkali metal hydroxide in the form of a concentrated aqueous solution adds and moves the mass until the saponification of the fatty acids with formation of a clear solution is complete. Then the active ingredients and auxiliaries can be mixed in one after the other while cooling. Finally, the mass is converted into a mold, e.g. poured into a pencil sleeve and allowed to cool there to a temperature at which the mass solidifies to form a stable gel.
Die folgenden Beispiele sollen den Erfindungsgegenstand näher erläutern: The following examples are intended to explain the subject of the invention in more detail:
B e s p i e l eB e s p i e l e
Es wurden Seifengel-Zubereitungen der in der Tabelle I angegebenen Zusam¬ mensetzung auf folgende Weise hergestellt:Soap gel preparations of the composition given in Table I were prepared in the following way:
Polyole, Wasser und Fettsäuren wurden in einem Behälter gemischt und auf 70°C erwärmt. Zu dieser Mischung wurde die Natronlauge portionsweise zuge¬ geben, wobei die Masse unter Verseifung klar und homogen wurde. Nach Zu¬ gabe der übrigen Zusätze und des Parfümöls wurde die Masse in Stifthülsen gegossen und auf +20°C abkühlen gelassen.Polyols, water and fatty acids were mixed in a container and heated to 70 ° C. The sodium hydroxide solution was added in portions to this mixture, the mass becoming clear and homogeneous with hydrolysis. After the addition of the other additives and the perfume oil, the mass was poured into pencil sleeves and allowed to cool to + 20 ° C.
Es wurden formstabile Seifengel-Stifte mit guter Formstabilität und sehr guten Abgabeeigenschaften erhalten. Dimensionally stable soap gel sticks with good dimensional stability and very good dispensing properties were obtained.
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4107712A DE4107712A1 (en) | 1991-03-09 | 1991-03-09 | TOPICAL SOAP ANGEL PREPARATION |
| DE4107712 | 1991-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0575373A1 true EP0575373A1 (en) | 1993-12-29 |
Family
ID=6426954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP92905575A Withdrawn EP0575373A1 (en) | 1991-03-09 | 1992-03-02 | Topical soap-gel preparation |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0575373A1 (en) |
| JP (1) | JPH06505245A (en) |
| CA (1) | CA2105873A1 (en) |
| DE (1) | DE4107712A1 (en) |
| FI (1) | FI933892A7 (en) |
| HU (1) | HUT65716A (en) |
| WO (1) | WO1992015280A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402225D0 (en) * | 1994-02-05 | 1994-03-30 | Solid Ltd | Hair dye composition |
| US5879414A (en) * | 1994-09-19 | 1999-03-09 | Solid Products Limited | Hydrous hair dyeing stick compositions |
| DE19624162C2 (en) * | 1996-06-18 | 1998-07-09 | Dalli Werke Waesche & Koerperp | Transparent soap composition and soap bars made from it |
| DE19642874C1 (en) * | 1996-10-17 | 1998-05-07 | Henkel Kgaa | Deodorising preparations |
| DE10355712A1 (en) * | 2003-11-26 | 2005-06-16 | Beiersdorf Ag | Cosmetic formulations based on fatty acids |
| WO2007031793A2 (en) * | 2005-09-16 | 2007-03-22 | Reckitt Benckiser (Uk) Limited | Improvements in or relatimg to cosmetic compositions |
| WO2021239360A1 (en) * | 2020-05-25 | 2021-12-02 | Beiersdorf Ag | Peg-free soap gel preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069666D1 (en) * | 1979-08-15 | 1985-01-03 | Procter & Gamble | Cosmetic gel stick composition |
| US4759924A (en) * | 1982-09-29 | 1988-07-26 | The Procter & Gamble Company | Cosmetic sticks |
| DE3889575T2 (en) * | 1987-03-04 | 1995-01-12 | Procter & Gamble | Gelled pens based on soap. |
-
1991
- 1991-03-09 DE DE4107712A patent/DE4107712A1/en not_active Withdrawn
-
1992
- 1992-03-02 EP EP92905575A patent/EP0575373A1/en not_active Withdrawn
- 1992-03-02 JP JP4504963A patent/JPH06505245A/en active Pending
- 1992-03-02 WO PCT/EP1992/000456 patent/WO1992015280A1/en not_active Ceased
- 1992-03-02 CA CA002105873A patent/CA2105873A1/en not_active Abandoned
- 1992-03-02 FI FI933892A patent/FI933892A7/en not_active Application Discontinuation
- 1992-03-02 HU HU9302548A patent/HUT65716A/en unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9215280A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| HU9302548D0 (en) | 1993-12-28 |
| FI933892L (en) | 1993-09-06 |
| WO1992015280A1 (en) | 1992-09-17 |
| DE4107712A1 (en) | 1992-09-10 |
| FI933892A0 (en) | 1993-09-06 |
| CA2105873A1 (en) | 1992-09-17 |
| HUT65716A (en) | 1994-07-28 |
| JPH06505245A (en) | 1994-06-16 |
| FI933892A7 (en) | 1993-09-06 |
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