DE4107712A1 - TOPICAL SOAP ANGEL PREPARATION - Google Patents

Abstract

Disclosed is a soap-gel preparation for the topical application of cosmetic and pharmaceutical substances, in particular a preparation in the form of a stick, the preparation being based on a soap gel consisting of 3-10 % by wt. of alkali soaps of a C16-C22 fatty-acid mixture, 30-90 % by wt. of polyols and 1-30 % by wt. of water. Preparations of this kind are particularly transparent, are dimensionally stable and have satisfactory release characteristics on contact with the skin when the fatty-acid mixture contains 60-95 % by wt. of saturated straight-chain fatty acids and 5-40 % by wt. of saturated branched-chain fatty acids.

Description

The invention relates to a shaped preparation for use cosmetics shear and pharmaceutical active ingredients, especially in stick form, on the Basis of a soap gel, which due to its composition is normal temperature a very good dimensional stability and good abrasion properties has and is largely free of lower alcohols.

Soap gels are used as carriers for topical cosmetic and pharmaceutical products active pharmaceutical ingredients have been known for a long time. Usually as being fen sodium stearate gels in aqueous lower alcohols and glycols puts. However, such gels have the disadvantage that they are usually too stiff and when used on the skin only very little product on the skin submit. To improve the dispensing properties of such soap gel accessories riding was already proposed according to US 29 00 306, the preparation a water-soluble myristic acid soap. In other Publications was to improve gel time, reduce the Syneresis and stickiness already the addition of fatty acid esters and Ethylene oxide and propylene oxide condensation products have been recommended (US 46 17 185). Such additives are sometimes disadvantageous with regard to the transparency.

The task was therefore to find a shaped soap gel preparation the one that has both good transparency, good dimensional stability and a be has peaceful release on contact with the skin.

This object was achieved according to the invention by a soap gel preparation tion for the topical application of cosmetic and pharmaceutical effects Containing substances based on a gel of alkali soaps

3-10 wt .-% of a mixture of fatty acids with 16-22 carbon atoms in the form of their alkali soaps
30-90 wt .-% polyols with 3-6 carbon atoms and 2-6 hydroxyl groups
1-30% by weight water,

as well as cosmetic or pharmaceutical active ingredients, and optionally further usual auxiliaries, wherein the fatty acid mixture

60-95% by weight of linear saturated fatty acids and
Contains 5-40 wt .-% branched saturated fatty acids.

Due to the proportion of branched-chain fat soaps according to the invention Acids is achieved that the preparations in the temperature range below Keep a good firmness at 35 ° C, but on contact with the skin melt immediately and become slippery, so that it is easy to thin Spread the film of the preparation on the skin.

Palmitic acid, stearic acid and macaw come as linear saturated fatty acids quinic acid and behenic acid or technical mixtures in question consist of such fatty acids, for. B. hardened palm oil fatty acid or hardened tallow fatty acid. Stearic acid is preferably used.

Examples of branched saturated fatty acids are 2-hexyl decanoic acid, 2-octyl-dodecanoic acid or other branched fatty acids 16-22 carbon atoms in question.

However, isostearic acid is preferably suitable. Taking isostearic acid is primarily a mixture of liquid, branched chain isomers understood the stearic acid by hydrogenating the dimerisie tion of unsaturated fatty acids as a by-product of isomeric fluids sigen monomer fatty acids is accessible. This isostearic acid and white tere branched fatty acids are described in J.Am.Oil Chem. Soc. November 1979 (Vol 56), pages 823A-827A. So it is  a mixture whose main components are methyl branched isomers. Isostearic acid is a commercial product and is e.g. B. under the name Emersol 875 (Henkel Corp.).

The mixture of linear and branched fatty acids is completely or above predominantly as an alkali salt (alkali soap), preferably as a sodium soap. A certain amount of free, unsaponified fatty acid, approximately in an amount of However, 0.01-0.5% by weight of the preparation is not a disadvantage.

The ratio of linear to branched fatty acids in the inventions The fatty acid mixture to be used according to the invention has an influence on the strength the soap gel preparation and the abrasion behavior. With increasing on Part of isostearic acid decreases the firmness and the release to the skin increases. But also with the total content of fatty acids in the gel Parameters affected. The fatty acid mixture is preferred in an amount of 5-8 wt .-% used. The fatty acid mixture preferably consists of 80-95% by weight stearic acid and 5-20% by weight branched saturated fat acids.

As polyols with 3-6 C atoms and 2-6 hydroxyl groups such. B. Ethy lenglycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, glycerin, erythritol, pentaerythritol, Trimethylolpropane, sorbitol, anhydrosorbitol, cyclohexanetriol, inositol are used will. Propylene glycols and glycerol alone are preferred or mixtures of these polyols with sorbitol and / or butylene glycol. This butt lyols are preferred in a total amount of 70-90% by weight of the soaps gel preparation included. Particularly favorable application properties obtained when, as polyols, mixtures of 10-80% by weight glycerol, 10-80% by weight propylene glycol and 5-20% by weight sorbitol and / or 1.4 butylene glycol are included.

A particularly stable, transparent soap gel preparation with good Delivery properties to the skin include:

5-8% by weight of the fatty acid mixture in the form of the sodium soaps,
70-90% by weight from the group glycerol, 1,2-propylene glycol, 1,3-propylene glycol or their mixtures with sorbitol and / or 1,4-butylene glycol and
5-25 wt% water.

The soap gel preparations according to the invention are used for topical use application of cosmetic and pharmaceutical agents. Such agents who depending on the dosage required for the specific application the soap gel preparation incorporated. As cosmetic active ingredients are e.g. B. antimicrobial, deodorant, skin moisturizing, antiperspirant, depilating, coloring and scented substances as well as cosmetic oils hen. As pharmacological agents such. B. antibiotics, corticosteroi de, local anesthetics, as well as other active substances to be understood against Skin diseases can be applied. The amount of cosmetic or pharmaceutical active ingredients are usually in the order of 0.1-5 % By weight of the preparation, preferably in a range of 0.1-1% by weight of the Preparation.

A particularly preferred field of application for the invention fengel preparations are those of the deodorant sticks. In such products are deodorising substances according to the invention as cosmetic active ingredients contain. Suitable deodorant active ingredients are e.g. B. antimicrobial substances such as B. 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorine hexidine digluconate or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase inhibiting substances such as B. triethyl citrate or triacetin, astringent substances such as e.g. B. sodium aluminum chlorohydroxyctate and other known body deodorants or anti perspirants.

In addition to the active ingredients mentioned, the soap gel additives according to the invention Preparations contain other tools to improve the off see and are conducive to storage stability. Such tools are e.g. B. Complexing agents, antioxidants, preservatives, fragrances, colors medium, opacifiers, pearlescent pigments or finely divided, pyrogenic grains silica. In total, the amount of these aids should not exceed 5 Make up wt .-% of the soap gel preparation, such auxiliary are preferred  medium in a total amount of about 1-3% by weight in the preparation contain.

The soap gel preparations according to the invention are preferably free of lower alcohols. However, it may be possible to add up to 10% by weight. lower alcohols such as B. ethanol or isopropanol in the preparations to incorporate.

The preparation of the soap gel preparations according to the invention is useful carried out moderately in such a way that polyols, water and fatty acids mix in a container while heating to approx. 50-90 ° C, mix this Mix the alkali hydroxide in the form of a concentrated aqueous solution adds and moves the mass until the saponification of the fatty acids under Bil a clear solution has been completed. Then the active ingredients and Aids are mixed in one after the other during cooling. Eventually the mass becomes at a temperature above the gelation temperature in a mold, e.g. B. poured into a pencil sleeve and on there allowed to cool to a temperature at which the mass becomes a dimensionally stable gel stiffens.

The following examples are intended to explain the subject of the invention in more detail:  

Examples

Soap gel preparations of the composition given in Table I were prepared in the following manner:
Polyols, water and fatty acids were mixed in a container and heated to 70 ° C. The sodium hydroxide solution was added in portions to this mixture, the mass becoming clear and homogeneous with hydrolysis. After addition of the other additives and the perfume oil, the mass was poured into pencil sleeves and allowed to cool to + 20 ° C.

There were stable soap gel pens with good dimensional stability and very maintain good dispensing properties.  

Table 1

Claims (5)

1. Soap gel preparation for the topical application of cosmetic and pharmaceutical active ingredients, in particular in stick form, on the basis of a gel of alkali soaps containing 3-10% by weight of a mixture of fatty acids with 16-22 carbon atoms in the form of them Alkaline soaps
30-90 wt .-% polyols with 3-6 carbon atoms and 2-6 hydroxyl groups
1-30% by weight of water, as well as cosmetic or pharmaceutical active ingredients and optionally other customary auxiliaries, characterized in that the fat contains 60-95% by weight of linear, saturated fatty acids and 5-40% by weight of branched saturated fatty acids in an acidic mixture. 2. soap gel preparation according to claim 1, characterized in that the linear saturated fatty acid stearic acid and the branched saturated te fatty acid is isostearic acid. 3. soap gel preparation according to claim 1 or 2, characterized in that as polyols glycerol and / or propylene glycol or mixtures of these Substances with sorbitol and / or 1,4-butylene glycol in a total amount of 70-90 wt .-% of the preparation are included. 4. soap gel preparation according to claims 1 to 3, characterized records that as polyols mixtures of 10-80 wt .-% glycerol, 10- 80% by weight propylene glycol and 5-20% by weight sorbitol and / or 1,4-buty lenglycol is included. 5. soap gel preparation according to claims 1 to 4, characterized in that it contains 5-8 wt .-% of the fatty acid mixture in the form of sodium soaps
70-90% by weight polyols
5-25 wt% water