EE200200553A - Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis - Google Patents

Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis

Info

Publication number: EE200200553A
Authority: EE; Estonia
Prior art keywords: synthesis; carboxybutyl; perindopril; application; novel process
Prior art date: 2000-03-31

Application number

EEP200200553A

Other languages

English (en)

Inventor

Souvie Jean-Claude

Original Assignee

Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-03-30

Publication date

2004-04-15

2001-03-30 Application filed by Laboratoires Servier filed Critical Laboratoires Servier

2004-04-15 Publication of EE200200553A publication Critical patent/EE200200553A/et

2008-10-15 Publication of EE05079B1 publication Critical patent/EE05079B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EEP200200553A 2000-03-31 2001-03-30 Meetod N-[(S)-1-karboksbutl]-(S)-alaniini estrite snteesimiseks ning nende rakendamine perindopriili snteesis EE05079B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0004112A FR2807037B1 (fr)	2000-03-31	2000-03-31	NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr)	2000-03-31	2001-03-30	Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (2)

Publication Number	Publication Date
EE200200553A true EE200200553A (et)	2004-04-15
EE05079B1 EE05079B1 (et)	2008-10-15

Family

ID=8848711

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200553A EE05079B1 (et)	2000-03-31	2001-03-30	Meetod N-[(S)-1-karboksbutl]-(S)-alaniini estrite snteesimiseks ning nende rakendamine perindopriili snteesis

Country Status (35)

Country	Link
US (1)	US6818788B2 (et)
EP (1)	EP1268398B1 (et)
JP (1)	JP3930322B2 (et)
KR (1)	KR100498869B1 (et)
CN (1)	CN1171855C (et)
AP (1)	AP1483A (et)
AR (1)	AR027754A1 (et)
AT (1)	ATE297377T1 (et)
AU (2)	AU4843301A (et)
BG (1)	BG65832B1 (et)
BR (1)	BRPI0109609B1 (et)
CA (1)	CA2404700C (et)
CZ (1)	CZ302840B6 (et)
DE (1)	DE60111364T2 (et)
DK (1)	DK1268398T3 (et)
EA (1)	EA004314B1 (et)
EE (1)	EE05079B1 (et)
ES (1)	ES2242743T3 (et)
FR (1)	FR2807037B1 (et)
GE (1)	GEP20063796B (et)
HR (1)	HRP20020860B1 (et)
HU (1)	HU229188B1 (et)
ME (1)	ME00437B (et)
MX (1)	MXPA02009378A (et)
NO (1)	NO328064B1 (et)
NZ (1)	NZ521324A (et)
OA (1)	OA12324A (et)
PL (1)	PL199714B1 (et)
PT (1)	PT1268398E (et)
RS (1)	RS50239B (et)
SI (1)	SI1268398T1 (et)
SK (1)	SK286851B6 (et)
UA (1)	UA73562C2 (et)
WO (1)	WO2001056353A2 (et)
ZA (1)	ZA200207150B (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827860B1 (fr) *	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
US7521566B2 (en)	2003-02-28	2009-04-21	Les Laboratoires Servier	Process for preparation of perindopril and salts thereof
EP1362845B1 (fr) *	2003-09-01	2009-10-14	Les Laboratoires Servier	Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril
ES2256693T3 (es) *	2003-09-30	2006-07-16	Les Laboratoires Servier	Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
EP1403278B1 (fr) *	2003-09-30	2005-06-08	Les Laboratoires Servier	Procédé de synthèse de la N-((S)-1-carbéthoxybutyl)-(S)-alanine et application à la synthèse du perindopril
ES2603856T3 (es) *	2004-03-29	2017-03-01	Les Laboratoires Servier	Procedimiento para preparar una composición farmacéutica sólida
GB2413128A (en)	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
WO2006006183A2 (en) *	2004-07-12	2006-01-19	Matrix Laboratories Ltd	An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) *	2005-12-01	2007-06-06	KRKA, tovarna zdravil, d.d., Novo mesto	Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4247716A (en) *	1977-09-02	1981-01-27	Mitsui Toatsu Chemicals, Inc.	Process for producing pyruvic acid
FR2620699B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) *	2000-04-11	2002-05-17	Adir	Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

2000
- 2000-03-31 FR FR0004112A patent/FR2807037B1/fr not_active Expired - Fee Related
2001
- 2001-03-20 PL PL346554A patent/PL199714B1/pl unknown
- 2001-03-30 ME MEP-2008-664A patent/ME00437B/me unknown
- 2001-03-30 DK DK01921440T patent/DK1268398T3/da active
- 2001-03-30 CA CA 2404700 patent/CA2404700C/fr not_active Expired - Fee Related
- 2001-03-30 PT PT01921440T patent/PT1268398E/pt unknown
- 2001-03-30 WO PCT/FR2001/000959 patent/WO2001056353A2/fr not_active Ceased
- 2001-03-30 AR ARP010101537 patent/AR027754A1/es not_active Application Discontinuation
- 2001-03-30 AU AU4843301A patent/AU4843301A/xx active Pending
- 2001-03-30 HR HR20020860A patent/HRP20020860B1/xx not_active IP Right Cessation
- 2001-03-30 AU AU2001248433A patent/AU2001248433B2/en not_active Ceased
- 2001-03-30 HU HU0101335A patent/HU229188B1/hu not_active IP Right Cessation
- 2001-03-30 MX MXPA02009378A patent/MXPA02009378A/es active IP Right Grant
- 2001-03-30 SI SI200130380T patent/SI1268398T1/xx unknown
- 2001-03-30 EP EP20010921440 patent/EP1268398B1/fr not_active Expired - Lifetime
- 2001-03-30 EE EEP200200553A patent/EE05079B1/et unknown
- 2001-03-30 CZ CZ20023235A patent/CZ302840B6/cs not_active IP Right Cessation
- 2001-03-30 US US10/221,973 patent/US6818788B2/en not_active Expired - Lifetime
- 2001-03-30 SK SK1405-2002A patent/SK286851B6/sk not_active IP Right Cessation
- 2001-03-30 DE DE2001611364 patent/DE60111364T2/de not_active Expired - Lifetime
- 2001-03-30 NZ NZ521324A patent/NZ521324A/en not_active IP Right Cessation
- 2001-03-30 AT AT01921440T patent/ATE297377T1/de active
- 2001-03-30 JP JP2001556065A patent/JP3930322B2/ja not_active Expired - Fee Related
- 2001-03-30 GE GEAP20016674A patent/GEP20063796B/en unknown
- 2001-03-30 AP APAP/P/2002/002628A patent/AP1483A/en active
- 2001-03-30 KR KR10-2002-7012810A patent/KR100498869B1/ko not_active Expired - Fee Related
- 2001-03-30 ES ES01921440T patent/ES2242743T3/es not_active Expired - Lifetime
- 2001-03-30 BR BRPI0109609-5A patent/BRPI0109609B1/pt not_active IP Right Cessation
- 2001-03-30 EA EA200201027A patent/EA004314B1/ru not_active IP Right Cessation
- 2001-03-30 RS YUP73202 patent/RS50239B/sr unknown
- 2001-03-30 OA OA1200200303A patent/OA12324A/en unknown
- 2001-03-30 CN CNB018074936A patent/CN1171855C/zh not_active Expired - Fee Related
- 2001-03-30 UA UA2002108639A patent/UA73562C2/uk unknown
2002
- 2002-09-05 ZA ZA200207150A patent/ZA200207150B/en unknown
- 2002-09-26 NO NO20024616A patent/NO328064B1/no not_active IP Right Cessation
- 2002-10-30 BG BG107234A patent/BG65832B1/bg unknown

Also Published As

Publication number	Publication date
PT1268398E (pt)	2005-09-30
CN1171855C (zh)	2004-10-20
BR0109609A (pt)	2004-01-13
ATE297377T1 (de)	2005-06-15
HRP20020860B1 (hr)	2011-02-28
NZ521324A (en)	2004-03-26
FR2807037A1 (fr)	2001-10-05
JP3930322B2 (ja)	2007-06-13
OA12324A (en)	2006-05-12
JP2003534241A (ja)	2003-11-18
EA004314B1 (ru)	2004-02-26
MXPA02009378A (es)	2003-02-12
ES2242743T3 (es)	2005-11-16
SK286851B6 (sk)	2009-06-05
EE05079B1 (et)	2008-10-15
HK1053301A1 (en)	2003-10-17
YU73202A (sh)	2006-03-03
NO328064B1 (no)	2009-11-16
AP2002002628A0 (en)	2002-09-30
FR2807037B1 (fr)	2002-05-10
US6818788B2 (en)	2004-11-16
RS50239B (sr)	2009-07-15
PL199714B1 (pl)	2008-10-31
EP1268398A2 (fr)	2003-01-02
CA2404700C (fr)	2007-02-20
HU0101335D0 (en)	2001-06-28
NO20024616D0 (no)	2002-09-26
CA2404700A1 (fr)	2001-08-09
BRPI0109609B1 (pt)	2015-04-14
EA200201027A1 (ru)	2003-02-27
CN1420862A (zh)	2003-05-28
WO2001056353A2 (fr)	2001-08-09
WO2001056353A3 (fr)	2002-04-18
NO20024616L (no)	2002-09-26
HU229188B1 (hu)	2013-09-30
DK1268398T3 (da)	2005-10-03
AP1483A (en)	2005-10-31
BG65832B1 (bg)	2010-02-26
HUP0101335A3 (en)	2002-11-28
BG107234A (bg)	2003-07-31
DE60111364T2 (de)	2006-03-16
KR20030017484A (ko)	2003-03-03
UA73562C2 (uk)	2005-08-15
PL346554A1 (en)	2001-09-10
GEP20063796B (en)	2006-04-25
KR100498869B1 (ko)	2005-07-04
AU4843301A (en)	2001-08-14
HRP20020860A2 (en)	2004-02-29
ZA200207150B (en)	2003-09-05
ME00437B (me)	2011-10-10
AR027754A1 (es)	2003-04-09
US20030045744A1 (en)	2003-03-06
SI1268398T1 (en)	2005-10-31
HUP0101335A2 (hu)	2001-11-28
CZ302840B6 (cs)	2011-12-07
AU2001248433B2 (en)	2004-10-28
EP1268398B1 (fr)	2005-06-08
SK14052002A3 (sk)	2003-02-04
DE60111364D1 (de)	2005-07-14

Publication	Publication Date	Title
EP1636250A4 (en)	2010-11-03	SELF-ORGANIZING PEPTIDES CONTAINING MODIFICATIONS AND METHOD FOR THEIR USE
ATE369338T1 (de)	2007-08-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salze
EE200200553A (et)	2004-04-15	Uudne protsess N-[(S)-1-karboksübutüül]-(S)-alaniini estrite sünteesimiseks ning nende rakendamine perindopriili sünteesis
NO20024811D0 (no)	2002-10-04	Fremgangsmåte ved syntese av N-[(S)-1-karboksybutyl]-(S)- alaninestere og anvendelse i syntesen av perindopril
EE200400107A (et)	2004-10-15	Protsess kõrgpuhta perindopriili ning sünteesis kasulike vaheühendite valmistamiseks
AU2001250467A1 (en)	2001-10-25	Method for synthesis of N-[(S)-1-carboxybutyl]-(S)-alanine esters and use in synthesis of perindopril
AU2001248433A1 (en)	2001-10-25	Novel method for synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and use in synthesis of perindopril
EG24152A (en)	2008-08-19	Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
SI1362845T1 (sl)	2010-01-29	Nov postopek za pripravo estrov n((s)-1-karboksibutil)-(s)-alanina in uporaba za sintezo perindoprila
DK1400531T3 (da)	2006-05-15	Fremgangsmåde til fremstilling af N-[(S)-1-ethoxycarbonyl-butyl]-(S)-alanin og anvendelse heraf ved syntese af perindopril
SI1272454T1 (sl)	2007-10-31	Postopek za sintezo estrov n-((s)-karboksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
DK1403278T3 (da)	2005-10-03	Syntesefremgangsmåde for N-[(S)-1-ethoxycarbonylbutyl]-(S)-alanin og anvendelse heraf ved syntesen af perindopril
ATE394364T1 (de)	2008-05-15	Reinigungsverfahren von n-(1(s)-ethoxycarbonyl-3- phenylpropyl)-l-alanin

Legal Events

Date	Code	Title	Description
2008-04-15	HK1A	Erratum in gazette
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231