EE200100370A - Teraapias kasutatavad spirofuropüridiinide uued aralküülamiinid - Google Patents

Teraapias kasutatavad spirofuropüridiinide uued aralküülamiinid

Info

Publication number: EE200100370A
Authority: EE; Estonia
Prior art keywords: spirofuropyridines; aralkylamines; therapy; novel; spirofuropyridines used
Prior art date: 1999-01-15

Application number

EEP200100370A

Other languages

English (en)

Inventor

Loch James Iii

Mullen George

Phillips Eifion

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-15

Filing date

1999-12-23

Publication date

2002-10-15

1999-12-23 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-10-15 Publication of EE200100370A publication Critical patent/EE200100370A/et

2005-08-15 Publication of EE04528B1 publication Critical patent/EE04528B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Psychiatry (AREA)
Addiction (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

EEP200100370A 1999-01-15 1999-12-23 Teraapias kasutatavad spirofuropridiinide aralklamiinid EE04528B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9900100A SE9900100D0 (sv)	1999-01-15	1999-01-15	New compounds
PCT/SE1999/002478 WO2000042044A1 (en)	1999-01-15	1999-12-23	Novel aralkyl amines of spirofuropyridines useful in therapy

Publications (2)

Publication Number	Publication Date
EE200100370A true EE200100370A (et)	2002-10-15
EE04528B1 EE04528B1 (et)	2005-08-15

Family

ID=20414101

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100370A EE04528B1 (et)	1999-01-15	1999-12-23	Teraapias kasutatavad spirofuropridiinide aralklamiinid

Country Status (34)

Country	Link
US (2)	US6995167B2 (et)
EP (1)	EP1147114B1 (et)
JP (1)	JP2002534525A (et)
KR (1)	KR100660496B1 (et)
CN (1)	CN1132837C (et)
AR (1)	AR022283A1 (et)
AT (1)	ATE240960T1 (et)
AU (1)	AU775433B2 (et)
BR (1)	BR9916906A (et)
CA (1)	CA2359990A1 (et)
CZ (1)	CZ20012554A3 (et)
DE (1)	DE69908185T2 (et)
DK (1)	DK1147114T3 (et)
EE (1)	EE04528B1 (et)
ES (1)	ES2200590T3 (et)
HK (1)	HK1040517B (et)
HU (1)	HUP0200513A3 (et)
ID (1)	ID30034A (et)
IL (1)	IL144266A0 (et)
IS (1)	IS6000A (et)
MY (1)	MY118109A (et)
NO (1)	NO20013478L (et)
NZ (1)	NZ512733A (et)
PT (1)	PT1147114E (et)
RU (1)	RU2233282C2 (et)
SA (1)	SA00200987B1 (et)
SE (1)	SE9900100D0 (et)
SI (1)	SI1147114T1 (et)
SK (1)	SK9932001A3 (et)
TR (1)	TR200102042T2 (et)
TW (2)	TWI227237B (et)
UA (1)	UA71598C2 (et)
WO (1)	WO2000042044A1 (et)
ZA (1)	ZA200105527B (et)

Families Citing this family (56)

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SE9900100D0 (sv)	1999-01-15	1999-01-15	Astra Ab	New compounds
FR2790474B1 (fr) *	1999-03-05	2001-04-06	Synthelabo	Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
US6569865B2 (en)	2001-06-01	2003-05-27	Astrazeneca Ab	Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine
PT1397366E (pt) *	2001-06-01	2007-04-30	Astrazeneca Ab	Novo ligando para os receptores nicotínicos da acetilcolina úteis em terapia
EP1432707B1 (en) *	2001-10-02	2012-03-28	Pharmacia & Upjohn Company LLC	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
NZ561993A (en) *	2002-04-18	2008-09-26	Astrazeneca Ab	Spiroazabicyclic heterocyclic amines as potent ligands for nicotinic acetylcholine receptors
JP4511196B2 (ja) *	2002-04-18	2010-07-28	アストラゼネカ・アクチエボラーグ	チエニル化合物
CN1325500C (zh) *	2002-04-18	2007-07-11	阿斯特拉曾尼卡有限公司	呋喃基化合物
EP1531820A1 (en)	2002-08-30	2005-05-25	Memory Pharmaceuticals Corporation	Anabaseine derivatives useful in the treatment of neurodegenerative diseases
SE0202598D0 (sv) *	2002-09-02	2002-09-02	Astrazeneca Ab	Alpha-7 Nicotinic receptor agonists and statins in combination
GB0220581D0 (en)	2002-09-04	2002-10-09	Novartis Ag	Organic Compound
AU2003276919B2 (en)	2002-09-25	2013-05-16	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
CN102657651A (zh) *	2002-12-06	2012-09-12	范因斯坦医学研究院	用α 7受体结合胆碱能激动剂抑制炎症
US7238715B2 (en) *	2002-12-06	2007-07-03	The Feinstein Institute For Medical Research	Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
WO2004063201A1 (ja) *	2003-01-08	2004-07-29	Mitsubishi Pharma Corporation	統合失調症治療剤
US20050129610A1 (en) *	2003-06-24	2005-06-16	Johns Hopkins University	Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor
BRPI0415546A (pt) *	2003-10-21	2006-12-26	Astrazeneca Ab	composto, composição farmacêutica, uso de um composto, e, métodos de tratamento ou profilaxia de doenças ou condições humanas, e de distúrbios
US7045530B2 (en)	2003-12-22	2006-05-16	Abbott Laboratories	Spirocyclic quinuclidinic ether derivatives
US20050234095A1 (en)	2004-03-25	2005-10-20	Wenge Xie	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
PE20060437A1 (es)	2004-06-18	2006-06-08	Novartis Ag	COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en)	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
AR053710A1 (es) *	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
GB0521508D0 (en)	2005-10-21	2005-11-30	Novartis Ag	Organic compounds
US8316104B2 (en)	2005-11-15	2012-11-20	California Institute Of Technology	Method and apparatus for collaborative system
GB0525673D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
GB0525672D0 (en)	2005-12-16	2006-01-25	Novartis Ag	Organic compounds
RU2448111C2 (ru) *	2006-08-21	2012-04-20	Дженентек, Инк.	Соединения азабензофуранила и способ их применения
CL2008000119A1 (es)	2007-01-16	2008-05-16	Wyeth Corp	Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
SA08290475B1 (ar)	2007-08-02	2013-06-22	Targacept Inc	(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
EP2307389B1 (en)	2008-06-20	2013-01-23	AstraZeneca AB	Dibenzothiazepine derivative and use thereof
CN103664973B (zh)	2008-10-17	2017-04-19	泽农医药公司	螺羟吲哚化合物及其作为治疗剂的用途
AU2009316557B2 (en)	2008-11-19	2015-08-27	Envivo Pharmaceuticals, Inc.	Treatment of cognitive disorders with (R)-7-chloro-N-(quinuclidin-3-yl) benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
BRPI1014793A2 (pt) *	2009-05-11	2016-04-05	Envivo Pharmaceuticals Inc	tratamento de distúrbios de cognição com determinados receptores de ácido alfa-7-nicotínico em combinação com inibidores de acetil-colinesterase
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US8445696B2 (en)	2009-10-14	2013-05-21	Xenon Pharmaceuticals Inc.	Synthetic methods for spiro-oxindole compounds
BR112012021086A2 (pt)	2010-02-26	2016-05-17	Xenon Pharmaceuticals Inc	composições farmacêuticas de composto espiro-oxindole para administração tópica e seu uso como agentes terapêuticos
CA2799744C (en)	2010-05-17	2020-01-28	Envivo Pharmaceuticals, Inc.	A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
GB201111704D0 (en)	2011-07-07	2011-08-24	Takeda Pharmaceutical	Novel compounds
GB201111705D0 (en)	2011-07-07	2011-08-24	Takeda Pharmaceutical	Compounds and their use
JO3115B1 (ar)	2011-08-22	2017-09-20	Takeda Pharmaceuticals Co	مركبات بيريدازينون واستخدامها كمثبطات daao
WO2013154712A1 (en)	2012-04-12	2013-10-17	Xenon Pharmaceuticals Inc.	Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
US9585877B2 (en)	2012-05-08	2017-03-07	Forum Pharmaceuticals, Inc.	Methods of maintaining, treating or improving cognitive function
GB201209587D0 (en)	2012-05-30	2012-07-11	Takeda Pharmaceutical	Therapeutic compounds
JP6478923B2 (ja)	2013-02-07	2019-03-06	ヘプタレスセラピューティクスリミテッドＨｅｐｔａｒｅｓＴｈｅｒａｐｅｕｔｉｃｓＬｉｍｉｔｅｄ	ムスカリンｍ４受容体アゴニストとしてのピペリジン−１−イル及びアゼピン−１−イルカルボキシレート
EA029430B1 (ru)	2013-06-21	2018-03-30	Такеда Фармасьютикл Компани Лимитед	Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина
GB201314286D0 (en)	2013-08-08	2013-09-25	Takeda Pharmaceutical	Therapeutic Compounds
GB201318222D0 (en)	2013-10-15	2013-11-27	Takeda Pharmaceutical	Novel compounds
GB201320905D0 (en)	2013-11-27	2014-01-08	Takeda Pharmaceutical	Therapeutic compounds
TW201613864A (en)	2014-02-20	2016-04-16	Takeda Pharmaceutical	Novel compounds
WO2016127068A1 (en)	2015-02-05	2016-08-11	Teva Pharmaceuticals International Gmbh	Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
WO2017218920A1 (en)	2016-06-16	2017-12-21	Teva Pharmaceuticals International Gmbh	Asymmetric synthesis of funapide
GB201616839D0 (en)	2016-10-04	2016-11-16	Takeda Pharmaceutical Company Limited	Therapeutic compounds
GB201619514D0 (en)	2016-11-18	2017-01-04	Takeda Pharmaceuticals Co	Novel compounds
JP2021138648A (ja)	2020-03-04	2021-09-16	武田薬品工業株式会社	経口固形製剤

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SE9900100D0 (sv)	1999-01-15	1999-01-15	Astra Ab	New compounds

1999
- 1999-01-15 SE SE9900100A patent/SE9900100D0/xx unknown
- 1999-12-23 HU HU0200513A patent/HUP0200513A3/hu unknown
- 1999-12-23 ID IDW00200101529A patent/ID30034A/id unknown
- 1999-12-23 DK DK99967044T patent/DK1147114T3/da active
- 1999-12-23 CA CA002359990A patent/CA2359990A1/en not_active Abandoned
- 1999-12-23 KR KR1020017008939A patent/KR100660496B1/ko not_active Expired - Fee Related
- 1999-12-23 SI SI9930375T patent/SI1147114T1/xx unknown
- 1999-12-23 CN CN998164224A patent/CN1132837C/zh not_active Expired - Fee Related
- 1999-12-23 SK SK993-2001A patent/SK9932001A3/sk unknown
- 1999-12-23 WO PCT/SE1999/002478 patent/WO2000042044A1/en not_active Ceased
- 1999-12-23 CZ CZ20012554A patent/CZ20012554A3/cs unknown
- 1999-12-23 AU AU23343/00A patent/AU775433B2/en not_active Ceased
- 1999-12-23 PT PT99967044T patent/PT1147114E/pt unknown
- 1999-12-23 NZ NZ512733A patent/NZ512733A/en unknown
- 1999-12-23 ES ES99967044T patent/ES2200590T3/es not_active Expired - Lifetime
- 1999-12-23 US US09/529,654 patent/US6995167B2/en not_active Expired - Fee Related
- 1999-12-23 BR BR9916906-1A patent/BR9916906A/pt not_active Application Discontinuation
- 1999-12-23 AT AT99967044T patent/ATE240960T1/de not_active IP Right Cessation
- 1999-12-23 IL IL14426699A patent/IL144266A0/xx unknown
- 1999-12-23 HK HK02102161.7A patent/HK1040517B/en not_active IP Right Cessation
- 1999-12-23 TR TR2001/02042T patent/TR200102042T2/xx unknown
- 1999-12-23 DE DE69908185T patent/DE69908185T2/de not_active Expired - Fee Related
- 1999-12-23 EP EP99967044A patent/EP1147114B1/en not_active Expired - Lifetime
- 1999-12-23 UA UA2001085777A patent/UA71598C2/uk unknown
- 1999-12-23 JP JP2000593611A patent/JP2002534525A/ja active Pending
- 1999-12-23 RU RU2001122812/04A patent/RU2233282C2/ru not_active IP Right Cessation
- 1999-12-23 EE EEP200100370A patent/EE04528B1/et not_active IP Right Cessation
2000
- 2000-01-13 AR ARP000100156A patent/AR022283A1/es not_active Application Discontinuation
- 2000-01-13 MY MYPI20000100A patent/MY118109A/en unknown
- 2000-01-21 TW TW089100989A patent/TWI227237B/zh not_active IP Right Cessation
- 2000-01-21 TW TW093106537A patent/TW200413387A/zh unknown
- 2000-02-21 SA SA00200987A patent/SA00200987B1/ar unknown
2001
- 2001-07-04 ZA ZA200105527A patent/ZA200105527B/en unknown
- 2001-07-12 IS IS6000A patent/IS6000A/is unknown
- 2001-07-13 NO NO20013478A patent/NO20013478L/no not_active Application Discontinuation
2005
- 2005-07-14 US US11/181,098 patent/US7196096B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT1147114E (pt)	2003-10-31
ATE240960T1 (de)	2003-06-15
IS6000A (is)	2001-07-12
MY118109A (en)	2004-08-30
HK1040517B (en)	2003-09-05
UA71598C2 (en)	2004-12-15
TW200413387A (en)	2004-08-01
HUP0200513A2 (en)	2002-06-29
SI1147114T1 (en)	2003-12-31
TWI227237B (en)	2005-02-01
CA2359990A1 (en)	2000-07-20
EP1147114B1 (en)	2003-05-21
EP1147114A1 (en)	2001-10-24
US6995167B2 (en)	2006-02-07
TR200102042T2 (tr)	2002-05-21
IL144266A0 (en)	2002-05-23
CZ20012554A3 (cs)	2002-01-16
NZ512733A (en)	2003-08-29
JP2002534525A (ja)	2002-10-15
SE9900100D0 (sv)	1999-01-15
NO20013478D0 (no)	2001-07-13
ID30034A (id)	2001-11-01
EE04528B1 (et)	2005-08-15
HUP0200513A3 (en)	2004-07-28
NO20013478L (no)	2001-09-14
KR100660496B1 (ko)	2006-12-22
ZA200105527B (en)	2002-10-04
SA00200987B1 (ar)	2006-11-07
US20050250802A1 (en)	2005-11-10
US7196096B2 (en)	2007-03-27
AR022283A1 (es)	2002-09-04
DE69908185T2 (de)	2004-06-03
CN1132837C (zh)	2003-12-31
CN1337964A (zh)	2002-02-27
ES2200590T3 (es)	2004-03-01
US20030149065A1 (en)	2003-08-07
DK1147114T3 (da)	2003-09-15
HK1040517A1 (en)	2002-06-14
SK9932001A3 (en)	2002-04-04
AU775433B2 (en)	2004-07-29
WO2000042044A1 (en)	2000-07-20
DE69908185D1 (de)	2003-06-26
RU2233282C2 (ru)	2004-07-27
BR9916906A (pt)	2001-10-30
KR20010086167A (ko)	2001-09-08
AU2334300A (en)	2000-08-01

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EE200100370A (et)	2002-10-15	Teraapias kasutatavad spirofuropüridiinide uued aralküülamiinid
DK1637127T3 (da)	2014-08-04	Terapeutisk mikroskum
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DE60020617D1 (de)	2005-07-14	Zementierkopf
ID27841A (id)	2001-04-26	Turunan-turunan biaril terapeutik
DE69924365D1 (de)	2005-04-28	Massagegerät
DE60011853D1 (de)	2004-08-05	Injektionsspritze
NO20014490D0 (no)	2001-09-14	Medisinske blandinger
NO20014560D0 (no)	2001-09-19	Quinasoliner og terapautisk anvendelse derav
FI20000863A0 (fi)	2000-04-11	Uusi hoitomenetelmä
PT1235558E (pt)	2006-09-29	Agentes terapeuticos
ID18679A (id)	1998-04-30	Penggunaan terapi lanjutan
ID25571A (id)	2000-10-19	Popok sekali pakai
ID24782A (id)	2000-08-10	Popok sekali pakai
EE200100623A (et)	2003-02-17	Melatoniini terapeutiline kasutamine
PT1178981E (pt)	2003-11-28	3-piridil-4-arilpirrois substituidos e metodos terapeuticos e profilacticos
IS5996A (is)	2001-07-10	Notkun á kólesteról lækkandi miðli
NO20016301D0 (no)	2001-12-21	Terapeutiske midler
ID30381A (id)	2001-11-29	Penggunaan arilalkanoilpiridazina
NO20023003D0 (no)	2002-06-21	Benzofenon-glykopyranosider, samt fremstilling og terapeutisk anvendelse
SE9802023D0 (sv)	1998-06-08	New therapeutic use
NO20014850L (no)	2001-12-07	CML-terapi
EE200200053A (et)	2003-04-15	Isoretinoiini valmistamise protsess

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