EE04354B1 - Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid - Google Patents

Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid

Info

Publication number: EE04354B1
Authority: EE; Estonia
Prior art keywords: medicaments; indolyl; manufacture; acid derivatives; glyoxylic acid
Prior art date: 1998-04-02

Application number

EEP200000581A

Other languages

English (en)

Estonian (et)

Inventor

Nickel Bernd

Szelenyi Istvan

Schmidt Jrgen

Emig Peter

Reichert Dietmar

G�Nther Eckhard

Brune Kay

Original Assignee

Asta Medica Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-02

Filing date

1999-03-22

Publication date

2004-10-15

1999-03-22 Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft

2002-02-15 Publication of EE200000581A publication Critical patent/EE200000581A/xx

2004-10-15 Publication of EE04354B1 publication Critical patent/EE04354B1/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

EEP200000581A 1998-04-02 1999-03-22 Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid EE04354B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19814838A DE19814838C2 (de)	1998-04-02	1998-04-02	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP1999/001918 WO1999051224A1 (de)	1998-04-02	1999-03-22	Indolyl-3-glyoxylsäure-derivate mit antitumorwirkung

Publications (2)

Publication Number	Publication Date
EE200000581A EE200000581A (et)	2002-02-15
EE04354B1 true EE04354B1 (et)	2004-10-15

Family

ID=7863398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000581A EE04354B1 (et)	1998-04-02	1999-03-22	Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid

Country Status (32)

Country	Link
US (4)	US6232327B1 (xx)
EP (1)	EP1071420B1 (xx)
JP (2)	JP5253696B2 (xx)
KR (1)	KR100583545B1 (xx)
CN (1)	CN1148183C (xx)
AR (1)	AR018175A1 (xx)
AT (1)	ATE304352T1 (xx)
AU (1)	AU768510B2 (xx)
BG (1)	BG64838B1 (xx)
BR (1)	BR9909902A (xx)
CA (1)	CA2326833C (xx)
DE (2)	DE19814838C2 (xx)
DK (1)	DK1071420T3 (xx)
EE (1)	EE04354B1 (xx)
ES (1)	ES2249884T3 (xx)
GE (1)	GEP20032967B (xx)
HR (1)	HRP20000643A2 (xx)
HU (1)	HUP0101530A3 (xx)
ID (1)	ID26504A (xx)
IL (2)	IL138737A0 (xx)
IS (1)	IS2307B (xx)
NO (1)	NO327721B1 (xx)
NZ (1)	NZ507084A (xx)
PL (1)	PL192779B1 (xx)
RS (1)	RS49866B (xx)
RU (1)	RU2262339C2 (xx)
SK (1)	SK286393B6 (xx)
TR (1)	TR200002853T2 (xx)
TW (1)	TWI230608B (xx)
UA (1)	UA70942C2 (xx)
WO (1)	WO1999051224A1 (xx)
ZA (1)	ZA200006150B (xx)

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1998
- 1998-04-02 DE DE19814838A patent/DE19814838C2/de not_active Expired - Fee Related
1999
- 1999-03-22 IL IL13873799A patent/IL138737A0/xx active IP Right Grant
- 1999-03-22 CN CNB998059234A patent/CN1148183C/zh not_active Expired - Fee Related
- 1999-03-22 RS YUP-593/00A patent/RS49866B/sr unknown
- 1999-03-22 SK SK1430-2000A patent/SK286393B6/sk not_active IP Right Cessation
- 1999-03-22 DK DK99910372T patent/DK1071420T3/da active
- 1999-03-22 NZ NZ507084A patent/NZ507084A/en not_active IP Right Cessation
- 1999-03-22 GE GEAP19995611A patent/GEP20032967B/en unknown
- 1999-03-22 JP JP2000541995A patent/JP5253696B2/ja not_active Expired - Fee Related
- 1999-03-22 ID IDW20001988A patent/ID26504A/id unknown
- 1999-03-22 EE EEP200000581A patent/EE04354B1/xx not_active IP Right Cessation
- 1999-03-22 TR TR2000/02853T patent/TR200002853T2/xx unknown
- 1999-03-22 EP EP99910372A patent/EP1071420B1/de not_active Expired - Lifetime
- 1999-03-22 HR HR20000643A patent/HRP20000643A2/hr not_active Application Discontinuation
- 1999-03-22 KR KR1020007010934A patent/KR100583545B1/ko not_active Expired - Fee Related
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- 1999-03-22 HU HU0101530A patent/HUP0101530A3/hu unknown
- 1999-03-22 AT AT99910372T patent/ATE304352T1/de active
- 1999-03-22 BR BR9909902-0A patent/BR9909902A/pt not_active IP Right Cessation
- 1999-03-22 WO PCT/EP1999/001918 patent/WO1999051224A1/de not_active Ceased
- 1999-03-22 PL PL343525A patent/PL192779B1/pl unknown
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- 1999-03-22 CA CA002326833A patent/CA2326833C/en not_active Expired - Fee Related
- 1999-03-22 ES ES99910372T patent/ES2249884T3/es not_active Expired - Lifetime
- 1999-03-22 AU AU29349/99A patent/AU768510B2/en not_active Ceased
- 1999-03-22 UA UA2000116192A patent/UA70942C2/uk unknown
- 1999-03-23 TW TW088104599A patent/TWI230608B/zh not_active IP Right Cessation
- 1999-03-31 AR ARP990101501A patent/AR018175A1/es unknown
- 1999-04-02 US US09/285,058 patent/US6232327B1/en not_active Expired - Lifetime
2000
- 2000-09-22 IS IS5635A patent/IS2307B/is unknown
- 2000-09-27 IL IL138737A patent/IL138737A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004916A patent/NO327721B1/no not_active IP Right Cessation
- 2000-10-12 BG BG104849A patent/BG64838B1/bg unknown
- 2000-10-31 ZA ZA200006150A patent/ZA200006150B/en unknown
2001
- 2001-03-19 US US09/810,604 patent/US20030023093A1/en not_active Abandoned
2002
- 2002-12-04 US US10/309,204 patent/US7579365B2/en not_active Expired - Fee Related
2007
- 2007-08-20 US US11/894,591 patent/US20080027110A1/en not_active Abandoned
2011
- 2011-03-10 JP JP2011053448A patent/JP2011148809A/ja active Pending

Also Published As

Publication number	Publication date
SK286393B6 (sk)	2008-09-05
CN1299280A (zh)	2001-06-13
ATE304352T1 (de)	2005-09-15
BG64838B1 (bg)	2006-06-30
NO20004916D0 (no)	2000-09-29
PL192779B1 (pl)	2006-12-29
NO327721B1 (no)	2009-09-14
IS2307B (is)	2007-10-15
ZA200006150B (en)	2001-01-11
RU2262339C2 (ru)	2005-10-20
PL343525A1 (en)	2001-08-27
BG104849A (en)	2001-05-31
AR018175A1 (es)	2001-10-31
RS49866B (sr)	2008-08-07
JP2011148809A (ja)	2011-08-04
CN1148183C (zh)	2004-05-05
UA70942C2 (uk)	2004-11-15
JP2002510622A (ja)	2002-04-09
EP1071420B1 (de)	2005-09-14
NO20004916L (no)	2000-12-01
DE19814838A1 (de)	1999-10-14
TWI230608B (en)	2005-04-11
HK1036408A1 (en)	2002-01-04
HUP0101530A3 (en)	2002-12-28
IL138737A (en)	2007-02-11
IS5635A (is)	2000-09-22
YU59300A (sh)	2002-11-15
KR20010042368A (ko)	2001-05-25
JP5253696B2 (ja)	2013-07-31
AU768510B2 (en)	2003-12-18
EE200000581A (et)	2002-02-15
IL138737A0 (en)	2001-10-31
US20030023093A1 (en)	2003-01-30
WO1999051224A1 (de)	1999-10-14
AU2934999A (en)	1999-10-25
CA2326833C (en)	2009-06-23
NZ507084A (en)	2003-10-31
US20080027110A1 (en)	2008-01-31
HRP20000643A2 (en)	2001-04-30
US7579365B2 (en)	2009-08-25
DK1071420T3 (da)	2006-01-16
US6232327B1 (en)	2001-05-15
DE59912562D1 (en)	2005-10-20
EP1071420A1 (de)	2001-01-31
SK14302000A3 (sk)	2001-11-06
KR100583545B1 (ko)	2006-05-26
HUP0101530A2 (hu)	2001-11-28
GEP20032967B (en)	2003-05-27
US20030195360A1 (en)	2003-10-16
DE19814838C2 (de)	2001-01-18
ID26504A (id)	2001-01-11
CA2326833A1 (en)	1999-10-14
BR9909902A (pt)	2000-12-26
ES2249884T3 (es)	2006-04-01
TR200002853T2 (tr)	2001-02-21

Publication	Publication Date	Title
EE04354B1 (et)	2004-10-15	Indolüül-3-glüoksüülhappe derivaadid, nende kasutamine ravimite valmistamiseks ja neid sisaldavad kasvajavastase toimega ravimid
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EE200400059A (et)	2004-04-15	Diarüültsükloalküülderivaadid, nende kasutamine ravimite valmistamiseks ning neid sisaldav ravim
EE200000168A (et)	2001-04-16	Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE9700153A (et)	1998-02-16	Heterotsükliga kondenseerunud püridiinid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
EE9800028A (et)	1998-08-17	Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
EE9700060A (et)	1997-10-15	2-arüül-asendatud püridiinid,nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
NO20011216L (no)	2001-05-09	Azetidinderivater, deres fremstilling og medikamenter inneholdende forbindelsene
EE04399B1 (et)	2004-12-15	Spiroasabitsüklilised heterotsüklilised ühendid, nende valmistamise protsess, neid sisaldavad ravimkoostised ja nende kasutamine ravis
EE9700145A (et)	1998-02-16	Tsükloalkaanpüridiinid, nende valmistamismeetod, kasutamine ravimite tootmiseks ja nimetatud ühendeid sisaldavad ravimid
EE200000037A (et)	2000-10-16	Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
HUP0104497A3 (en)	2002-07-29	Benzamide derivatives, their preparation, medicaments containing them and their use
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EE04463B1 (et)	2005-04-15	3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis
EE200200138A (et)	2003-06-16	Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
EE9700044A (et)	1997-08-15	Heteroarüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid.
EE200100009A (et)	2002-06-17	Bensimidasoolid, nende valmistamine ja kasutamineravimitena
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DE59905572D1 (de)	2003-06-18	Substituierte 4-amino-2-aryl-pyrimidine, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate

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