EE03921B1 - N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine - Google Patents

N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine

Info

Publication number: EE03921B1
Authority: EE; Estonia
Prior art keywords: benzofuranyl; preparation; urea derivatives; urea; derivatives
Prior art date: 1995-03-06

Application number

EE9600030A

Other languages

English (en)

Estonian (et)

Other versions

EE9600030A (et

Inventor

Br�unlich Gabriele

Fischer Rdiger

Es-Sayed Mazen

Henning Rolf

Sperzel Michael

Schlemmer Karl-Heinz

Nielsch Ulrich

Tudhope Stephen

Sturton Graham

S. Abram Trevor

F. Fitzgerald Mary

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-06

Filing date

1996-03-05

Publication date

2002-12-16

1996-03-05 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

1996-10-15 Publication of EE9600030A publication Critical patent/EE9600030A/xx

2002-12-16 Publication of EE03921B1 publication Critical patent/EE03921B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
AIDS & HIV (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Cosmetics (AREA)

EE9600030A 1995-03-06 1996-03-05 N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine EE03921B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9504460.8A GB9504460D0 (en)	1995-03-06	1995-03-06	N-(3-Benzofuranyl)urea-derivatives

Publications (2)

Publication Number	Publication Date
EE9600030A EE9600030A (et)	1996-10-15
EE03921B1 true EE03921B1 (et)	2002-12-16

Family

ID=10770709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600030A EE03921B1 (et)	1995-03-06	1996-03-05	N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine

Country Status (41)

Country	Link
US (2)	US6399657B1 (xx)
EP (1)	EP0731099B1 (xx)
JP (1)	JP3204901B2 (xx)
KR (2)	KR100405579B1 (xx)
CN (2)	CN1134419A (xx)
AR (1)	AR002710A1 (xx)
AT (1)	ATE193704T1 (xx)
BG (2)	BG100396A (xx)
BR (1)	BR9600930A (xx)
CA (1)	CA2170824A1 (xx)
CO (1)	CO4370145A1 (xx)
CZ (1)	CZ66796A3 (xx)
DE (1)	DE69608721T2 (xx)
DK (1)	DK0731099T3 (xx)
DZ (1)	DZ1998A1 (xx)
EE (1)	EE03921B1 (xx)
ES (1)	ES2147320T3 (xx)
FI (1)	FI960998L (xx)
GB (1)	GB9504460D0 (xx)
GR (1)	GR3034240T3 (xx)
HR (1)	HRP960071B1 (xx)
HU (1)	HU222282B1 (xx)
IL (1)	IL117349A (xx)
MA (1)	MA23815A1 (xx)
MY (1)	MY117526A (xx)
NO (1)	NO313672B1 (xx)
NZ (1)	NZ286107A (xx)
PE (1)	PE43597A1 (xx)
PL (1)	PL189206B1 (xx)
PT (1)	PT731099E (xx)
RO (1)	RO116622B1 (xx)
RU (1)	RU2162845C2 (xx)
SI (1)	SI0731099T1 (xx)
SK (1)	SK281817B6 (xx)
SV (1)	SV1996000015A (xx)
TN (1)	TNSN96035A1 (xx)
TR (1)	TR199600177A2 (xx)
TW (1)	TW336934B (xx)
UA (1)	UA46714C2 (xx)
YU (1)	YU49359B (xx)
ZA (1)	ZA961774B (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9312853D0 (en)	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5591776A (en)	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
GB9504460D0 (en) *	1995-03-06	1995-04-26	Bayer Ag	N-(3-Benzofuranyl)urea-derivatives
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
GB9525262D0 (en) *	1995-12-11	1996-02-07	Bayer Ag	Heterocyclylcarbonyl substituted benzofuranyl-ureas
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
GB9614718D0 (en)	1996-07-12	1996-09-04	Bayer Ag	3-ureido-pyridofurans and -pyridothiophenes
JPH10168095A (ja) *	1996-12-10	1998-06-23	Cci Corp	炎症性腸疾患予防および治療剤
WO2000027802A1 (en) *	1998-11-12	2000-05-18	Ariad Pharmaceuticals, Inc.	Bicyclic signal transduction inhibitors, compositions containing them & uses thereof
GB2350110A (en) *	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active benzofurans
GB2350111A (en) *	1999-05-17	2000-11-22	Bayer Ag	Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350112A (en) *	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active cycloalkyl ketones
GB2350109A (en) *	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active benzofuranyl sulfonates
BR0307905A (pt) *	2002-02-22	2006-04-04	Bayer Pharmaceuticals Corp	derivados de benzotiofeno e benzofurano úteis no tratamento de distúrbios hiperproliferativos
US7144885B2 (en)	2002-02-22	2006-12-05	Bayer Pharmaceuticals Corporation	Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
MXPA05005379A (es) *	2002-11-19	2006-02-17	Achillion Pharmaceuticals Inc	Tioureas de arilo sustituidas y compuestos relacionados; inhibidores de duplicacion viral.
AU2003303678A1 (en)	2003-01-03	2004-08-10	Genzyme Corporation	Urea derivatives and their use as anti-inflammatory agents
TW200528459A (en) *	2004-01-06	2005-09-01	Achillion Pharmaceuticals Inc	Azabenzofuran substituted thioureas; inhibitors of viral replication
TW200600492A (en) *	2004-05-18	2006-01-01	Achillion Pharmaceuticals Inc	Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JPWO2006137350A1 (ja) *	2005-06-22	2009-01-15	キッセイ薬品工業株式会社	新規なフロピリジン誘導体、それを含有する医薬組成物およびそれらの用途
RS53084B (sr)	2006-07-05	2014-06-30	Takeda Gmbh	Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4, kao što je roflumilast, roflumilast-n-oksid za lečenje inflamatornih plućnih obolenja
WO2012123353A1 (en)	2011-03-17	2012-09-20	Algiax Pharmaceuticals Gmbh	Novel use of benzofuranylsulfonates
WO2013156232A1 (en) *	2012-04-16	2013-10-24	Algiax Pharmaceuticals Gmbh	Use of benzofuranylsulfonates in neuropathic pain
AU2015233686B2 (en)	2014-03-18	2019-07-11	Algiax Pharmaceuticals Gmbh	2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
EP3165224A1 (en)	2015-11-09	2017-05-10	Albert-Ludwigs-Universität Freiburg	Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
JP6788966B2 (ja) *	2015-12-24	2020-11-25	丸善製薬株式会社	化粧料
EP4020024A1 (en)	2020-12-22	2022-06-29	Paul Scherrer Institut	Method for producing high aspect ratio fan-shaped optics

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1382742A (en) *	1972-09-19	1975-02-05	Labaz	Benzofuran derivatives and process for preparing the same
GB1464242A (en) *	1974-04-18	1977-02-09	Smithkline Corp	Benzoyl benzofurans and compositions comprising them
AU559687B2 (en) *	1981-07-01	1987-03-19	Upjohn Company, The	Pyridinyl-and imidazolyl-benzofurane and benzothiophenes
EP0146243A1 (en) *	1983-10-31	1985-06-26	Merck Frosst Canada Inc.	Lipoxygenase inhibitors
US4663347A (en)	1983-10-31	1987-05-05	Merck Frosst Canada, Inc.	Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) *	1983-10-31	1989-04-18	Merck Frosst Canada, Inc.	Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) *	1983-10-31	1990-06-12	Merck Frosst Canada, Inc.	Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US5087638A (en) *	1984-06-20	1992-02-11	Merck Frosst Canada, Inc.	Benzofuran derivatives
US4703053A (en) *	1985-10-28	1987-10-27	Warner-Lambert Company	Benzothiophenes and benzofurans and antiallergic use thereof
GB9200623D0 (en) *	1992-01-13	1992-03-11	Bayer Ag	Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
GB9309324D0 (en) *	1993-05-06	1993-06-16	Bayer Ag	Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
GB9504460D0 (en) *	1995-03-06	1995-04-26	Bayer Ag	N-(3-Benzofuranyl)urea-derivatives

1995
- 1995-03-06 GB GBGB9504460.8A patent/GB9504460D0/en active Pending
1996
- 1996-02-13 HR HR960071A patent/HRP960071B1/xx not_active IP Right Cessation
- 1996-02-22 ES ES96102650T patent/ES2147320T3/es not_active Expired - Lifetime
- 1996-02-22 SI SI9630186T patent/SI0731099T1/xx unknown
- 1996-02-22 AT AT96102650T patent/ATE193704T1/de not_active IP Right Cessation
- 1996-02-22 DE DE69608721T patent/DE69608721T2/de not_active Expired - Fee Related
- 1996-02-22 PT PT96102650T patent/PT731099E/pt unknown
- 1996-02-22 DK DK96102650T patent/DK0731099T3/da active
- 1996-02-22 EP EP96102650A patent/EP0731099B1/en not_active Expired - Lifetime
- 1996-02-28 AR ARP960101567A patent/AR002710A1/es unknown
- 1996-02-29 RO RO96-00425A patent/RO116622B1/ro unknown
- 1996-03-01 NZ NZ286107A patent/NZ286107A/en unknown
- 1996-03-01 MA MA24172A patent/MA23815A1/fr unknown
- 1996-03-01 CA CA002170824A patent/CA2170824A1/en not_active Abandoned
- 1996-03-04 TN TNTNSN96035A patent/TNSN96035A1/fr unknown
- 1996-03-04 IL IL11734996A patent/IL117349A/en not_active IP Right Cessation
- 1996-03-04 FI FI960998A patent/FI960998L/fi not_active IP Right Cessation
- 1996-03-04 PL PL96313070A patent/PL189206B1/pl not_active IP Right Cessation
- 1996-03-04 BG BG100396A patent/BG100396A/bg unknown
- 1996-03-04 BG BG100396A patent/BG62732B1/bg unknown
- 1996-03-05 UA UA96030864A patent/UA46714C2/uk unknown
- 1996-03-05 ZA ZA961774A patent/ZA961774B/xx unknown
- 1996-03-05 NO NO19960884A patent/NO313672B1/no unknown
- 1996-03-05 TW TW085102648A patent/TW336934B/zh active
- 1996-03-05 RU RU96104360/04A patent/RU2162845C2/ru not_active IP Right Cessation
- 1996-03-05 YU YU13396A patent/YU49359B/sh unknown
- 1996-03-05 TR TR96/00177A patent/TR199600177A2/xx unknown
- 1996-03-05 HU HU9600549A patent/HU222282B1/hu not_active IP Right Cessation
- 1996-03-05 JP JP07308496A patent/JP3204901B2/ja not_active Expired - Fee Related
- 1996-03-05 SK SK297-96A patent/SK281817B6/sk unknown
- 1996-03-05 EE EE9600030A patent/EE03921B1/xx not_active IP Right Cessation
- 1996-03-05 DZ DZ960039A patent/DZ1998A1/fr active
- 1996-03-05 KR KR1019960005676A patent/KR100405579B1/ko not_active Expired - Fee Related
- 1996-03-05 MY MYPI96000815A patent/MY117526A/en unknown
- 1996-03-05 CZ CZ96667A patent/CZ66796A3/cs unknown
- 1996-03-06 CN CN96103073A patent/CN1134419A/zh active Pending
- 1996-03-06 SV SV1996000015A patent/SV1996000015A/es unknown
- 1996-03-06 CO CO96010870A patent/CO4370145A1/es unknown
- 1996-03-06 CN CNB011033924A patent/CN1176651C/zh not_active Expired - Fee Related
- 1996-03-06 PE PE1996000153A patent/PE43597A1/es not_active Application Discontinuation
- 1996-03-06 BR BR9600930A patent/BR9600930A/pt not_active Application Discontinuation
1999
- 1999-05-21 US US09/316,536 patent/US6399657B1/en not_active Expired - Fee Related
2000
- 2000-08-23 GR GR20000401927T patent/GR3034240T3/el not_active IP Right Cessation
2002
- 2002-05-24 US US10/154,743 patent/US6677372B2/en not_active Expired - Fee Related
2003
- 2003-06-24 KR KR1020030040949A patent/KR100438633B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0731099T3 (da)	2000-09-25
YU49359B (sh)	2005-09-19
HU9600549D0 (en)	1996-04-29
IL117349A (en)	2002-09-12
ES2147320T3 (es)	2000-09-01
HUP9600549A2 (en)	1997-07-28
AR002710A1 (es)	1998-04-29
DZ1998A1 (fr)	2002-07-20
FI960998A7 (fi)	1996-09-07
TNSN96035A1 (fr)	2005-03-15
CN1313284A (zh)	2001-09-19
CN1176651C (zh)	2004-11-24
KR100405579B1 (ko)	2004-03-19
JP3204901B2 (ja)	2001-09-04
HRP960071B1 (en)	2001-04-30
SI0731099T1 (en)	2000-08-31
NO960884D0 (no)	1996-03-05
ATE193704T1 (de)	2000-06-15
DE69608721D1 (de)	2000-07-13
FI960998L (fi)	1996-09-07
EP0731099B1 (en)	2000-06-07
HK1013285A1 (en)	1999-08-20
GR3034240T3 (en)	2000-12-29
NO313672B1 (no)	2002-11-11
NO960884L (no)	1996-09-09
US6399657B1 (en)	2002-06-04
RU2162845C2 (ru)	2001-02-10
PL313070A1 (en)	1996-09-16
ZA961774B (en)	1996-09-17
SV1996000015A (es)	1997-02-17
KR960034194A (ko)	1996-10-22
NZ286107A (en)	1998-08-26
PE43597A1 (es)	1997-12-26
HUP9600549A3 (en)	1998-04-28
DE69608721T2 (de)	2000-10-05
IL117349A0 (en)	1996-07-23
JPH08253466A (ja)	1996-10-01
BR9600930A (pt)	1997-12-30
GB9504460D0 (en)	1995-04-26
PT731099E (pt)	2000-11-30
EP0731099A1 (en)	1996-09-11
TR199600177A2 (tr)	1996-10-21
US6677372B2 (en)	2004-01-13
AU705667B2 (en)	1999-05-27
TW336934B (en)	1998-07-21
FI960998A0 (fi)	1996-03-04
BG62732B1 (bg)	2000-06-30
HRP960071A2 (en)	1997-12-31
US20030109578A1 (en)	2003-06-12
UA46714C2 (uk)	2002-06-17
CA2170824A1 (en)	1996-09-07
CZ66796A3 (en)	1996-09-11
EE9600030A (et)	1996-10-15
MA23815A1 (fr)	1996-10-01
SK29796A3 (en)	1996-10-02
RO116622B1 (ro)	2001-04-30
BG100396A (bg)	1996-12-31
CN1134419A (zh)	1996-10-30
MY117526A (en)	2004-07-31
AU4582896A (en)	1996-09-19
CO4370145A1 (es)	1996-10-07
HU222282B1 (hu)	2003-05-28
KR100438633B1 (ko)	2004-07-02
YU13396A (sh)	1999-06-15
SK281817B6 (sk)	2001-08-06
PL189206B1 (pl)	2005-07-29

Publication	Publication Date	Title
EE03921B1 (et)	2002-12-16	N-(3-bensofuranüül)karbamiidderivaadid, nende valmistamismeetod ja kasutamine
EE03482B1 (et)	2001-08-15	Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine
EE03568B1 (et)	2001-12-17	Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine
FI962927A7 (fi)	1996-07-19	Tetrasykliinijohdannaisia, valmistusmenetelmä ja käyttö
CY2013003I1 (el)	2014-07-02	Φωσφονοκεφεμικα παραγωγα, διαδικασια για την παρασκευη τους, και χρηση αυτων
FI964395L (fi)	1996-10-31	Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
DK0826673T3 (da)	2003-03-24	Acetamidderivater, fremgangsmåde til fremstilling deraf og medicinske præparater
FI955235L (fi)	1996-05-03	Oksatsolidiinionijohdannaiset, niiden valmistus ja käyttö
FI955913A7 (fi)	1995-12-08	Uudet erytromysiinijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI953898A0 (fi)	1995-08-18	Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita
FI962917A7 (fi)	1996-07-19	Mikrokapselit, menetelmä niiden valmistamiseksi, ja niiden käyttö
FI951468A7 (fi)	1995-10-01	Lipopeptidijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
EE03825B1 (et)	2002-08-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE9800145A (et)	1998-10-15	Fenüülamidiini derivaadid, meetodid nende valmistamiseks ja nende kasutamine arstimitena
FI931232L (fi)	1994-09-20	Makeutusaine, menetelmä sen valmistamiseksi ja sen käyttö
FI951631L (fi)	1995-04-05	Substituoituja kynureniinejä, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI972988A0 (fi)	1997-07-14	Menetelmiä ja farmaseuttisia koostumuksia, joissa käytetään desmetyyliselegiliiniä
FI933544A7 (fi)	1993-08-11	Tiadiatsiinikarboksamidijohdannaiset, menetelmät niiden valmistamiseks i ja lääkkeet
FI961977A7 (fi)	1996-05-09	N-substituoidut atsabisykloalkaanijohdannaiset, niiden valmistus ja kä yttö
EE04117B1 (et)	2003-08-15	Karboksüasendatud tsüklilised karboksamiidi derivaadid, nende valmistamise meetod ja kasutamine
DK0728741T3 (da)	2000-12-18	Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til fremstilling deraf, anvendelse deraf til fre
FI963785L (fi)	1996-09-23	Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia
FI953290A7 (fi)	1995-08-25	Uusia syklopropyylijohdannaisia, menetelmä niiden valmistamiseksi ja n iiden käyttö

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-12-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20070305