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ECSP16005630A - Derivados de dehidroleucodina y usos de estos - Google Patents

Derivados de dehidroleucodina y usos de estos

Info

Publication number
ECSP16005630A
ECSP16005630A ECIEPI20165630A ECPI201605630A ECSP16005630A EC SP16005630 A ECSP16005630 A EC SP16005630A EC IEPI20165630 A ECIEPI20165630 A EC IEPI20165630A EC PI201605630 A ECPI201605630 A EC PI201605630A EC SP16005630 A ECSP16005630 A EC SP16005630A
Authority
EC
Ecuador
Prior art keywords
dehydroleucodine
derivatives
present
provides
amine derivatives
Prior art date
Application number
ECIEPI20165630A
Other languages
English (en)
Inventor
Darin E Jones
Cesar M Compadre
Paola E Ordoñez
Peter Crooks
Omar Malagon
Monica L Guzman
Giovanni Vidari
Original Assignee
Univ Arkansas
Univ Tecnica Particular De Loja
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arkansas, Univ Tecnica Particular De Loja, Univ Cornell filed Critical Univ Arkansas
Publication of ECSP16005630A publication Critical patent/ECSP16005630A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención proporciona derivados de dehidroleucodina. En particular, la presente invención proporciona derivados de amina de dehidroleucodina y métodos para utilizar la dehidroleucodina y los derivados de amina de dehidroleucodina para inhibir el crecimiento de las células de cáncer.
ECIEPI20165630A 2013-07-11 2016-02-11 Derivados de dehidroleucodina y usos de estos ECSP16005630A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361845214P 2013-07-11 2013-07-11

Publications (1)

Publication Number Publication Date
ECSP16005630A true ECSP16005630A (es) 2017-02-24

Family

ID=52280644

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI20165630A ECSP16005630A (es) 2013-07-11 2016-02-11 Derivados de dehidroleucodina y usos de estos

Country Status (5)

Country Link
US (2) US20160176839A1 (es)
EP (1) EP3019165A4 (es)
CA (1) CA2917343A1 (es)
EC (1) ECSP16005630A (es)
WO (1) WO2015006715A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3019165A4 (en) 2013-07-11 2017-01-25 The Board of Trustees of the University of Arkansas Dehydroleucodine derivatives and uses thereof
CN119330943B (zh) * 2024-10-18 2025-09-19 江苏省中国科学院植物研究所 一种氨基酸倍半萜内酯化合物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693127B1 (en) * 1997-07-03 2004-02-17 Paracure, Inc. Pharmaceutical compositions of arglabin and arglabin derivatives
US6908630B2 (en) * 2000-08-01 2005-06-21 Metaproteomics, Llc Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2
US20100196889A1 (en) * 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
WO2011131103A1 (zh) * 2010-04-23 2011-10-27 天津尚德药缘科技有限公司 含笑内酯衍生物，其药物组合物及其制备方法和用途
US8884027B2 (en) * 2010-10-22 2014-11-11 University Of Rochester Melampomagnolide B derivatives as antileukemic and cytotoxic agents
WO2012145678A1 (en) * 2011-04-20 2012-10-26 Regents Of The University Of Minnesota Anti-cancer and anti-inflammatory parthenolide compounds
EP3019165A4 (en) 2013-07-11 2017-01-25 The Board of Trustees of the University of Arkansas Dehydroleucodine derivatives and uses thereof
US10463644B2 (en) * 2013-07-15 2019-11-05 Accendatech Uses of sesquiterpene lactone compounds and their derivatives in drugs preparation

Also Published As

Publication number Publication date
EP3019165A1 (en) 2016-05-18
US11059800B2 (en) 2021-07-13
EP3019165A4 (en) 2017-01-25
WO2015006715A1 (en) 2015-01-15
CA2917343A1 (en) 2015-01-15
US20160176839A1 (en) 2016-06-23
US20190185442A1 (en) 2019-06-20

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