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ECSP14013164A - Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide - Google Patents

Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide

Info

Publication number
ECSP14013164A
ECSP14013164A ECSP14013164A ECSP14013164A EC SP14013164 A ECSP14013164 A EC SP14013164A EC SP14013164 A ECSP14013164 A EC SP14013164A EC SP14013164 A ECSP14013164 A EC SP14013164A
Authority
EC
Ecuador
Prior art keywords
hiteroaromatic
pirazol
vanilloid
carboxamide
replaced
Prior art date
Application number
Other languages
English (en)
Inventor
Gregor Bahrenberg
Bernhard Lesch
Jeewoo Lee
Robert Frank-Foltyn
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46640622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP14013164(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ECSP14013164A publication Critical patent/ECSP14013164A/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)

Abstract

DERIVADOS DE CARBOXAMIDA Y UREA QUE CONTIENEN PIRAZOL HETEROAROMATICO SUSTITUIDO COMO LIGANDOS DEL RECEPTOR DE VANILLOIDE
ECSP14013164 2011-07-26 2014-01-22 Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide ECSP14013164A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11006114 2011-07-26

Publications (1)

Publication Number Publication Date
ECSP14013164A true ECSP14013164A (es) 2014-11-28

Family

ID=46640622

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP14013164 ECSP14013164A (es) 2011-07-26 2014-01-22 Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide

Country Status (17)

Country Link
US (1) US20130029962A1 (es)
EP (1) EP2736900A1 (es)
JP (1) JP2014521616A (es)
KR (1) KR20140049026A (es)
CN (1) CN103842357A (es)
AR (1) AR087301A1 (es)
BR (1) BR112014001880A2 (es)
CA (1) CA2842916A1 (es)
CL (1) CL2013003816A1 (es)
CO (1) CO6940410A2 (es)
EA (1) EA201400161A1 (es)
EC (1) ECSP14013164A (es)
HK (1) HK1198697A1 (es)
MX (1) MX2014000779A (es)
PE (1) PE20140836A1 (es)
WO (1) WO2013013815A1 (es)
ZA (1) ZA201400085B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120125267A (ko) 2010-01-29 2012-11-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 나프티리딘 및 ｓｙｋ 키나제 억제제로서의 이의 용도
US20130029961A1 (en) * 2011-07-26 2013-01-31 Gruenenthal Gmbh Substituted Heterocyclic Aza Compounds
KR101986484B1 (ko) 2011-07-26 2019-06-10 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴놀린 및 이의 약제로서의 용도
US9695350B2 (en) 2013-05-31 2017-07-04 Halliburton Energy Services, Inc. Ampholyte polymeric compounds in subterranean applications
AU2014365740A1 (en) 2013-12-19 2016-05-26 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides iv
CA2934327A1 (en) 2013-12-19 2015-06-25 Grunenthal Gmbh Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers
EP3083597B1 (en) * 2013-12-19 2017-11-22 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers
MX383114B (es) * 2014-06-11 2025-03-13 Bayer Cropscience Ag Proceso para la preparación de 3,5-bis(haloalquil)pirazoles por medio de la acilación de cetiminas.
MX373603B (es) * 2014-10-24 2020-05-26 Ono Pharmaceutical Co Activador de canales de kcnq2-5.
CN107108593B (zh) * 2014-11-24 2020-03-24 美迪福伦Dbt有限公司 作为类香草素受体配体ii的基于取代的恶唑和噻唑的羧酰胺和脲衍生物
CN104478911A (zh) * 2014-12-19 2015-04-01 成都安斯利生物医药有限公司 一种制备3-三氟甲基吡咯硼酸的方法
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
RS62639B1 (sr) 2015-07-06 2021-12-31 Alkermes Inc Hetero-halo inhibitori histonskih deacetilaza
CN105523995A (zh) * 2015-12-17 2016-04-27 浙江汇能生物股份有限公司 一种咯萘啶中间体2-甲氧基-5-氨基吡啶的制备方法
CN105753783B (zh) * 2016-04-08 2017-12-15 李文淏 一种合成塞来昔布的方法
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
EP3241830A1 (de) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
US20190367457A1 (en) 2016-12-30 2019-12-05 Mitobridge, Inc. Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (acmsd) inhibitors
MD3570834T2 (ro) 2017-01-11 2022-04-30 Alkermes Inc Inhibitori biciclici ai histon deacetilazei
JP7152471B2 (ja) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド ヒストン脱アセチル化酵素の二環阻害剤
WO2022030589A1 (ja) * 2020-08-05 2022-02-10 国立大学法人北海道大学 単座配位尿素化合物を含む配位子とそれを含むホウ素化触媒
TW202317520A (zh) * 2021-06-15 2023-05-01 德商歌林達有限公司 經取代之吡唑醯胺
CN116675685A (zh) * 2022-02-25 2023-09-01 东北农业大学 含吡啶联噁唑烷酮类化合物及其合成方法和应用
EP4568667A2 (en) * 2022-08-10 2025-06-18 Vettore, LLC Salts of heterocyclic inhibitors of monocarboxylate transporter 4 for the treatment of disease
PL247051B1 (pl) * 2022-11-29 2025-05-05 Univ Medyczny W Lublinie N-podstawione pochodne 1-(1-fenylo-3-arylo)-1H-pirazol-4-ylo) metanaminy, sposób ich wytwarzania i ich zastosowanie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008023159A1 (en) * 2006-08-24 2008-02-28 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
JP2010083763A (ja) * 2008-09-29 2010-04-15 Mitsui Chemicals Inc ピラゾール誘導体およびその製造方法、ならびに殺菌剤
MX2011011797A (es) 2009-05-07 2011-11-29 Gruenenthal Gmbh Fenilureas y fenilamidas sustituidas como ligandos del receptor de vanilloides.
PL2427436T3 (pl) 2009-05-07 2013-06-28 Gruenenthal Gmbh Podstawione aromatyczne pochodne karboksamidu i mocznika jako ligandy receptora waniloidowego

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WO2013013815A1 (en) 2013-01-31
BR112014001880A2 (pt) 2017-02-21
CA2842916A1 (en) 2013-01-31
US20130029962A1 (en) 2013-01-31
ZA201400085B (en) 2015-07-29
MX2014000779A (es) 2014-03-27
CN103842357A (zh) 2014-06-04
JP2014521616A (ja) 2014-08-28
KR20140049026A (ko) 2014-04-24
HK1198697A1 (en) 2015-05-29
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AR087301A1 (es) 2014-03-12
WO2013013815A8 (en) 2014-01-09

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