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EA200701268A1 - Новые гетероциклические соединения, применяемые для лечения воспалительных и аллергических нарушений - Google Patents

Новые гетероциклические соединения, применяемые для лечения воспалительных и аллергических нарушений

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Publication number
EA200701268A1
EA200701268A1 EA200701268A EA200701268A EA200701268A1 EA 200701268 A1 EA200701268 A1 EA 200701268A1 EA 200701268 A EA200701268 A EA 200701268A EA 200701268 A EA200701268 A EA 200701268A EA 200701268 A1 EA200701268 A1 EA 200701268A1
Authority
EA
Eurasian Patent Office
Prior art keywords
allergic
treatment
pharmaceutically acceptable
well
inflammatory
Prior art date
Application number
EA200701268A
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English (en)
Other versions
EA014956B1 (ru
Inventor
Лаксмикант Атмарам Гарат
Баласубраманиан Гопалан
Неелима Каираткар-Джоши
Original Assignee
ГЛЕНМАРК ФАРМАСЬЮТИКАЛС Эс.Эй
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Application filed by ГЛЕНМАРК ФАРМАСЬЮТИКАЛС Эс.Эй filed Critical ГЛЕНМАРК ФАРМАСЬЮТИКАЛС Эс.Эй
Publication of EA200701268A1 publication Critical patent/EA200701268A1/ru
Publication of EA014956B1 publication Critical patent/EA014956B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61P27/14—Decongestants or antiallergics
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D495/04—Ortho-condensed systems

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Abstract

Настоящее изобретение относится к новым ингибиторам фосфодиэстеразы 4 типа (PDE-4) формулы (1)а также их аналогам, таутомерам, энантиомерам, диастереомерам, региоизомерам, стереоизомерам, полиморфным модификациям, фармацевтически приемлемым солям, соответствующим N-оксидам и фармацевтически приемлемым сольватам указанных веществ, а также к фармацевтическим композициям, содержащим указанные соединения, которые применимы для лечения аллергических и воспалительных состояний, включающих астму, хронический бронхит, атопический дерматит, крапивницу, аллергический ринит, аллергический конъюнктивит, весенний конъюнктивит, эозинофильную гранулему, псориаз, ревматоидный артрит, септический шок, язвенный колит, болезнь Крона, реперфузионное поражение миокарда и реперфузионное поражение мозга, хронический гломерулонефрит, эндотоксический шок и респираторный дистресс-синдром у взрослых.
EA200701268A 2004-12-17 2005-12-15 Гетероциклические соединения, применяемые для лечения воспалительных и аллергических нарушений EA014956B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63723204P 2004-12-17 2004-12-17
IN1352MU2004 2004-12-17
PCT/IB2005/003798 WO2006064355A2 (en) 2004-12-17 2005-12-15 Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders

Publications (2)

Publication Number Publication Date
EA200701268A1 true EA200701268A1 (ru) 2007-12-28
EA014956B1 EA014956B1 (ru) 2011-04-29

Family

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EA200701268A EA014956B1 (ru) 2004-12-17 2005-12-15 Гетероциклические соединения, применяемые для лечения воспалительных и аллергических нарушений

Country Status (18)

Country Link
US (1) US8129401B2 (ru)
EP (1) EP1831227B1 (ru)
JP (1) JP5122974B2 (ru)
KR (1) KR101317119B1 (ru)
AP (1) AP2334A (ru)
AR (1) AR066386A1 (ru)
AU (1) AU2005315319B2 (ru)
BR (1) BRPI0517211B8 (ru)
CA (1) CA2591438C (ru)
EA (1) EA014956B1 (ru)
IL (1) IL183827A (ru)
MA (1) MA29231B1 (ru)
MX (1) MX2007007345A (ru)
MY (1) MY143483A (ru)
NZ (1) NZ555809A (ru)
PL (1) PL1831227T3 (ru)
TW (1) TWI359814B (ru)
WO (1) WO2006064355A2 (ru)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2663178C (en) * 2006-09-11 2016-01-12 Matrix Laboratories Ltd. Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
RU2334514C1 (ru) * 2006-12-01 2008-09-27 Институт физиологически активных веществ Российской Академии наук СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
WO2008081282A2 (en) * 2006-12-20 2008-07-10 Glenmark Pharmaceuticals S.A. Process for the synthesis of n9-(3,5-dichloro-4-pyridyl)-6- difluoromethoxybenzo(4,5)furo(3,2-c)pyridine-9-carboxamide and salts thereof
WO2008093221A2 (en) * 2007-02-01 2008-08-07 Glenmark Pharmaceuticals, S.A. Pharmaceutical compositions containing pde4 inhibitor for the treatment of inflammatory and allergic disorders
US8524905B2 (en) 2007-05-22 2013-09-03 Glenmark Pharmaceuticals S.A. Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
ES2552733T3 (es) 2007-11-16 2015-12-01 Rigel Pharmaceuticals, Inc. Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
US8129390B2 (en) 2007-12-12 2012-03-06 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds and methods for using the same
EP2070913A1 (en) 2007-12-14 2009-06-17 CHIESI FARMACEUTICI S.p.A. Ester derivatives as phosphodiesterase inhibitors
KR101614723B1 (ko) 2008-01-11 2016-04-22 알바니 몰레큘라 리써치, 인크. Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌
BRPI0911681B8 (pt) 2008-04-23 2021-05-25 Rigel Pharmaceuticals Inc composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro
MX2011010582A (es) 2009-04-09 2011-10-19 Boehringer Ingelheim Int Inhibidores de la replicacion del vih.
JP5827943B2 (ja) 2009-04-29 2015-12-02 メディベイション テクノロジーズ， インコーポレイテッド ピリド［４，３−ｂ］インドールおよびその使用方法
US9255094B2 (en) 2009-04-29 2016-02-09 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
JP2012532144A (ja) 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
WO2011132051A2 (en) * 2010-04-19 2011-10-27 Glenmark Pharmaceuticals S.A. Tricycle compounds as phosphodiesterase-10 inhibitors
RU2417081C1 (ru) * 2010-05-07 2011-04-27 Ольга Филипповна Сибирева Способ лечения больных хроническим гломерулонефритом в сочетании с хроническим описторхозом
NZ603895A (en) * 2010-06-24 2014-10-31 Leo Pharma As Novel phosphodiesterase inhibitors
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
WO2012098495A1 (en) 2011-01-19 2012-07-26 Glenmark Pharmaceuticals Sa Pharmaceutical composition that includes revamilast and a beta-2 agonist
AU2012207335A1 (en) 2011-01-19 2013-07-25 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
WO2012110946A1 (en) 2011-02-17 2012-08-23 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate
AU2012219251B2 (en) 2011-02-18 2016-05-12 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
WO2012168907A1 (en) 2011-06-10 2012-12-13 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising revamilast and montelukast or zafirlukast
WO2013084182A1 (en) 2011-12-08 2013-06-13 Glenmark Pharmaceuticals S.A. Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent
EP2968323A4 (en) 2013-03-13 2016-12-14 Flatley Discovery Lab PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
AR096721A1 (es) 2013-06-25 2016-01-27 Bristol Myers Squibb Co Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos
BR112015031432A2 (pt) 2013-06-25 2017-07-25 Bristol Myers Squibb Co compostos de carbazol carboxamida úteis como inibidores de cinase
CN110511209B (zh) 2014-10-24 2022-07-05 百时美施贵宝公司 可用作激酶抑制剂的吲哚甲酰胺化合物
HRP20192197T2 (hr) 2014-10-24 2020-11-13 Bristol-Myers Squibb Company Derivati karbazola
SG10201903621SA (en) 2014-10-24 2019-05-30 Bristol Myers Squibb Co Tricyclic atropisomer compounds
CN106496322A (zh) * 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 人胰岛素或其类似物的酰化衍生物的制备方法
JP6472428B2 (ja) * 2015-12-09 2019-02-20 財團法人食品工業發展研究所 キサンチンオキシダーゼ活性の阻害におけるβ−カルボリンアルカロイドの使用
CN112979667B (zh) * 2019-12-02 2022-04-22 首都医科大学 二氧六环修饰的四氢咔啉-3-甲酰-The,其合成,活性和应用
CN112898376B (zh) * 2019-12-02 2022-06-24 首都医科大学 二氧六环修饰的四氢咔啉-3-甲酰-The-HGK,其制备,抗肿瘤活性和应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1041861A (en) 1962-03-14 1966-09-07 Organon Labor Ltd Pyrrolidone derivatives and pharmaceutical preparations containing them
US3759948A (en) * 1969-06-25 1973-09-18 Merck & Co Inc Non-steroid anti-inflammatory compounds
NL7008628A (ru) 1969-06-25 1970-12-29
US3846553A (en) * 1969-12-03 1974-11-05 Merck & Co Inc 3-substituted-2-pyridones in the treatment of pain, fever or inflammation
NL7016899A (ru) 1969-12-03 1971-06-07
US4222944A (en) * 1978-07-31 1980-09-16 Hoffmann-La Roche Inc. Halo-3-dibenzofuran alkanonitriles
JPS62158253A (ja) 1985-12-28 1987-07-14 Kirin Brewery Co Ltd ４−アミノピリジンアミド誘導体
JPH0812430B2 (ja) 1986-07-07 1996-02-07 キヤノン株式会社 電子写真感光体
EP0257956B2 (en) * 1986-08-19 2000-11-22 Genentech, Inc. Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion
JPS63250378A (ja) * 1987-04-07 1988-10-18 Mitsubishi Kasei Corp インド−ル誘導体
US5202344A (en) 1990-12-11 1993-04-13 G. D. Searle & Co. N-substituted lactams useful as cholecystokinin antagonists
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
AU3738293A (en) 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
EP0652868B1 (en) 1992-07-28 2004-11-10 Aventis Pharma Limited INHIBITORS OF c-AMP PHOSPHODIESTERASE
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
GB9304920D0 (en) 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
SI0706513T1 (en) 1993-07-02 2002-10-31 Altana Pharma Ag Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors
GB9315595D0 (en) 1993-07-28 1993-09-08 Res Inst Medicine Chem New compounds
WO1995009837A1 (en) 1993-10-01 1995-04-13 Smithkline Beecham Corporation Cyano compounds
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
GB9404706D0 (en) 1994-03-11 1994-04-27 Smithkline Beecham Corp Compounds
CN1166169A (zh) 1994-07-27 1997-11-26 三共株式会社 用作毒蕈碱性受体别构效应物的杂环化合物
DE69637257T2 (de) * 1995-04-14 2008-06-12 Smithkline Beecham Corp. Verfahren zur Herstellung eines Dosierinhalators
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
DE19616573C2 (de) * 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
EP0931045A1 (en) 1996-09-04 1999-07-28 Warner-Lambert Company Matrix metalloproteinase inhibitors and their therapeutic uses
US6177440B1 (en) * 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
JP3530004B2 (ja) * 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
BRPI9909660B8 (pt) 1998-03-19 2021-05-25 Vertex Pharma compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos
CN1308627A (zh) 1998-05-12 2001-08-15 美国家用产品公司 可用于治疗胰岛素抗性和高血糖的11－芳基－苯并[b]萘并[2,3－d]呋喃和11－芳基－苯并[b]萘并[2,3－d]噻吩
US6110962A (en) * 1998-05-12 2000-08-29 American Home Products Corporation 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
JP2003528072A (ja) 2000-03-17 2003-09-24 ブリストル−マイヤーズ スクイブ ファーマ カンパニー マトリックスメタロプロテアーゼおよびＴＮＦ−αの阻害剤としての環状β−アミノ酸誘導体
US6924292B2 (en) 2000-03-23 2005-08-02 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
WO2002060867A2 (en) 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Carbazole derivatives and their uses as heparanase inhibitors
US20020128920A1 (en) * 2001-03-06 2002-09-12 Dilip Chopra System and method for providing lowest costs purchasing
AU2002306687A1 (en) 2001-03-13 2002-09-24 Glenmark Pharmaceuticals Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
AU2003253130A1 (en) 2002-08-19 2004-03-03 Glenmark Pharmaceuticals Limited Condensed heterocyclic compounds as pde-iv inhibitors for the treatment of inflammatory and allergic disorders
WO2004022536A1 (en) 2002-09-04 2004-03-18 Glenmark Pharmaceuticals Limited New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
DE60317918T2 (de) * 2002-10-23 2009-01-29 Glenmark Pharmaceuticals Ltd. Tricyclische verbindungen zur behandlung von entzündlichen und allergischen erkrankungen verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
WO2004069831A1 (en) * 2003-02-10 2004-08-19 Glenmark Pharmaceuticals Ltd. Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation
NZ542882A (en) * 2003-04-11 2007-10-26 Glenmark Pharmaceuticals Sa Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them

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