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NO20073436L - Nye heterosykliske forbindelser nyttige for behandling av inflammatoriske og allergiske forstyrrelser - Google Patents

Nye heterosykliske forbindelser nyttige for behandling av inflammatoriske og allergiske forstyrrelser

Info

Publication number
NO20073436L
NO20073436L NO20073436A NO20073436A NO20073436L NO 20073436 L NO20073436 L NO 20073436L NO 20073436 A NO20073436 A NO 20073436A NO 20073436 A NO20073436 A NO 20073436A NO 20073436 L NO20073436 L NO 20073436L
Authority
NO
Norway
Prior art keywords
treatment
allergic
inflammatory
pharmaceutically acceptable
heterocyclic compounds
Prior art date
Application number
NO20073436A
Other languages
English (en)
Inventor
Laxmikant Atmaram Gharat
Balasubramanian Gopalan
Neelima Khairatkar-Joshi
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2005/003798 external-priority patent/WO2006064355A2/en
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of NO20073436L publication Critical patent/NO20073436L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det beskrives nye fosfodiesterase type 4 (PDE4)-inhibitorer med formel (I) samt analoger, tautomerer, enantiomerer, diastereomerer, regioisomerer, stereoisomerer, polymorfer, farmasøytisk akseptable salter, egnede N-oksider, farmasøytisk akseptable solvater derav. Videre beskrives farmasøytiske preparater inneholdende disse forbindelser og som er nyttige for behandling av allergiske og inflammatoriske sykdommer inkludert astma, kronisk bronkitt, atopisk dermatitt, urticaria, allergisk rinitt, allergisk konjunktivitt, vernal konjunktivitt, eosinofilisk granulom, psoriasis, reumatoid artritt, septisk sjokk, ulcerøs kolitt, Crohns sykdom, reperfusjonsskade i myokardium og reperfusjonsskade i hjernen, kronisk glomerulonefritt, endotoksisk sjokk og adult respiratorisk disstress-syndrom.
NO20073436A 2004-12-17 2007-07-03 Nye heterosykliske forbindelser nyttige for behandling av inflammatoriske og allergiske forstyrrelser NO20073436L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1352MU2004 2004-12-17
PCT/IB2005/003798 WO2006064355A2 (en) 2004-12-17 2005-12-15 Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders

Publications (1)

Publication Number Publication Date
NO20073436L true NO20073436L (no) 2007-09-05

Family

ID=38658137

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073436A NO20073436L (no) 2004-12-17 2007-07-03 Nye heterosykliske forbindelser nyttige for behandling av inflammatoriske og allergiske forstyrrelser

Country Status (9)

Country Link
US (1) US7943634B2 (no)
CN (1) CN101124229B (no)
DK (1) DK1831227T3 (no)
ES (1) ES2417491T3 (no)
NO (1) NO20073436L (no)
PT (1) PT1831227E (no)
SI (1) SI1831227T1 (no)
UA (1) UA88795C2 (no)
ZA (1) ZA200706097B (no)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
DE602004020332D1 (de) * 2003-04-11 2009-05-14 Glenmark Pharmaceuticals Sa Neue heterozyklische verbindungen, die sich für die behandlung von entzündlichen und allergischen erkrankungen eignen: verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
US8524905B2 (en) * 2007-05-22 2013-09-03 Glenmark Pharmaceuticals S.A. Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
CN103864779B (zh) * 2012-12-07 2016-06-22 天津科技大学 一种1-(苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用
CN103864781A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新型1，9-二取代四氢咔啉类衍生物的制备及其抗肿瘤药物中的应用
CN104961742B (zh) * 2015-03-17 2017-04-12 丁新生 具有防治阿尔茨海默病作用的化合物及其应用
CN106883270B (zh) 2015-11-26 2019-03-26 财团法人工业技术研究院 有机金属化合物、包含其的有机发光装置
CN113754675B (zh) * 2020-06-04 2022-09-02 首都医科大学 二甲基二氧六环-四氢-β-咔啉-3-羧酸的合成,生物活性和应用
CN116514824A (zh) * 2022-01-29 2023-08-01 上海科技大学 三并环类化合物、其制备方法和用途
CN116041258A (zh) * 2022-11-21 2023-05-02 安徽工业大学 一种硝基香兰素杂环衍生物、制备方法及其应用

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Also Published As

Publication number Publication date
US20090306082A1 (en) 2009-12-10
DK1831227T3 (da) 2013-08-19
CN101124229B (zh) 2012-07-18
SI1831227T1 (sl) 2013-09-30
CN101124229A (zh) 2008-02-13
ES2417491T3 (es) 2013-08-08
ZA200706097B (en) 2008-07-30
UA88795C2 (ru) 2009-11-25
PT1831227E (pt) 2013-08-23
US7943634B2 (en) 2011-05-17

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