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EA200600358A1 - Фенил- или пиридиламидные соединения в качестве антагонистов простагландина е2 - Google Patents

Фенил- или пиридиламидные соединения в качестве антагонистов простагландина е2

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Publication number
EA200600358A1
EA200600358A1 EA200600358A EA200600358A EA200600358A1 EA 200600358 A1 EA200600358 A1 EA 200600358A1 EA 200600358 A EA200600358 A EA 200600358A EA 200600358 A EA200600358 A EA 200600358A EA 200600358 A1 EA200600358 A1 EA 200600358A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenyl
group
antagonists
compounds
prostaglandine
Prior art date
Application number
EA200600358A
Other languages
English (en)
Other versions
EA009201B1 (ru
Inventor
Тацуя Ямагиси
Йосиюки Окумура
Сейдзи Нукуи
Казунари Накао
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200600358A1 publication Critical patent/EA200600358A1/ru
Publication of EA009201B1 publication Critical patent/EA009201B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract

Настоящее изобретение относится к соединению формулы (I), в котором А представляет фенильную группу и т.п.; В представляет собой арильную группу и т.п.; Е представляет собой 1,4-фениленовую группу; Rи Rнезависимо представляют собой атом водорода и т.п.; Rи Rнезависимо представляют собой атом водорода и т.п.; Rпредставляет собой -COH и т.п.; Rпредставляет собой алкильную группу, имеющую от 1 до 6 атомов углерода и т.п.; Х представляет собой метиленовую группу и т.п. Данные соединения могут быть использованы для лечения опосредуемых простагландином патологических состояний, таких как боль или т.п., у млекопитающего. Указанные соединения действуют как антагонисты рецептора простагландина Е2. Настоящее изобретение также относится к фармацевтической композиции, содержащей описанное выше соединение.
EA200600358A 2003-09-03 2004-08-23 Фенил - или пиридиламидные соединения в качестве антагонистов простагландина e2 EA009201B1 (ru)

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