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EA200600050A1 - Способы получения инсулина в растениях - Google Patents

Способы получения инсулина в растениях

Info

Publication number
EA200600050A1
EA200600050A1 EA200600050A EA200600050A EA200600050A1 EA 200600050 A1 EA200600050 A1 EA 200600050A1 EA 200600050 A EA200600050 A EA 200600050A EA 200600050 A EA200600050 A EA 200600050A EA 200600050 A1 EA200600050 A1 EA 200600050A1
Authority
EA
Eurasian Patent Office
Prior art keywords
insulin
nucleic acid
plants
getting
methods
Prior art date
Application number
EA200600050A
Other languages
English (en)
Other versions
EA014887B1 (ru
Inventor
Морис М. Молони
Джозеф Бут
Ричард Кеон
Кори Найкифорук
Гейс Ван Роэйен
Original Assignee
Сембайосиз Джинетикс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сембайосиз Джинетикс Инк. filed Critical Сембайосиз Джинетикс Инк.
Publication of EA200600050A1 publication Critical patent/EA200600050A1/ru
Publication of EA014887B1 publication Critical patent/EA014887B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Описаны способы получения инсулина в растениях. В одном варианте данное изобретение относится к способу экспрессии инсулина в растениях, включающему: (а) получение конструкции химерной нуклеиновой кислоты, содержащейся в 5'-3' направлении транскрипции в виде функционально связанных компонентов: (i) последовательности нуклеиновой кислоты, способной контролировать экспрессию в клетках семян растений; и (ii) последовательности нуклеиновой кислоты, кодирующей полипептид инсулина; (b) введение конструкции химерной нуклеиновой кислоты в клетку растения; и (с) выращивание клетки растений в зрелом растении, способном давать семена, где семена экспрессируют инсулин.
EA200600050A 2003-06-17 2004-06-17 Способ экспрессии инсулина в семенах растения, способ получения семян растений, содержащих инсулин, и растения, способные производить семена, содержащие инсулин EA014887B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47881803P 2003-06-17 2003-06-17
US54953904P 2004-03-04 2004-03-04
PCT/CA2004/000896 WO2004111244A2 (en) 2003-06-17 2004-06-17 Methods for the production of insulin in plants

Publications (2)

Publication Number Publication Date
EA200600050A1 true EA200600050A1 (ru) 2006-06-30
EA014887B1 EA014887B1 (ru) 2011-02-28

Family

ID=33555509

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600050A EA014887B1 (ru) 2003-06-17 2004-06-17 Способ экспрессии инсулина в семенах растения, способ получения семян растений, содержащих инсулин, и растения, способные производить семена, содержащие инсулин

Country Status (23)

Country Link
US (2) US7547821B2 (ru)
EP (2) EP1633876B1 (ru)
JP (2) JP4864701B2 (ru)
KR (1) KR101216762B1 (ru)
CN (1) CN1836047B (ru)
AR (1) AR044803A1 (ru)
AT (1) ATE405660T1 (ru)
AU (1) AU2004247762B2 (ru)
BR (1) BRPI0411479A (ru)
CA (1) CA2528741A1 (ru)
CY (1) CY1108477T1 (ru)
DE (1) DE602004015980D1 (ru)
DK (1) DK1633876T3 (ru)
EA (1) EA014887B1 (ru)
ES (1) ES2313018T3 (ru)
IL (1) IL172469A (ru)
MX (1) MXPA05013723A (ru)
NO (1) NO20055885L (ru)
NZ (1) NZ544522A (ru)
PL (1) PL1633876T3 (ru)
PT (1) PT1633876E (ru)
TW (1) TWI345587B (ru)
WO (1) WO2004111244A2 (ru)

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Also Published As

Publication number Publication date
TWI345587B (en) 2011-07-21
CY1108477T1 (el) 2014-04-09
AU2004247762A1 (en) 2004-12-23
WO2004111244A2 (en) 2004-12-23
DE602004015980D1 (de) 2008-10-02
DK1633876T3 (da) 2008-12-08
JP2011200251A (ja) 2011-10-13
JP2007523611A (ja) 2007-08-23
MXPA05013723A (es) 2006-03-13
NO20055885L (no) 2006-01-17
IL172469A0 (en) 2006-04-10
EP1959017A1 (en) 2008-08-20
AR044803A1 (es) 2005-10-05
EP1633876A2 (en) 2006-03-15
EA014887B1 (ru) 2011-02-28
CN1836047A (zh) 2006-09-20
NZ544522A (en) 2008-03-28
BRPI0411479A (pt) 2006-07-25
TW200510529A (en) 2005-03-16
US7547821B2 (en) 2009-06-16
ES2313018T3 (es) 2009-03-01
HK1088037A1 (en) 2006-10-27
PT1633876E (pt) 2008-11-03
WO2004111244A3 (en) 2005-02-03
AU2004247762B2 (en) 2010-05-27
CN1836047B (zh) 2010-12-22
US20050039235A1 (en) 2005-02-17
KR101216762B1 (ko) 2013-01-02
KR20060052705A (ko) 2006-05-19
JP4864701B2 (ja) 2012-02-01
IL172469A (en) 2011-08-31
EP1633876B1 (en) 2008-08-20
US20090282583A1 (en) 2009-11-12
CA2528741A1 (en) 2004-12-23
ATE405660T1 (de) 2008-09-15
PL1633876T3 (pl) 2009-01-30

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