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EA200600042A1 - Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах - Google Patents

Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах

Info

Publication number
EA200600042A1
EA200600042A1 EA200600042A EA200600042A EA200600042A1 EA 200600042 A1 EA200600042 A1 EA 200600042A1 EA 200600042 A EA200600042 A EA 200600042A EA 200600042 A EA200600042 A EA 200600042A EA 200600042 A1 EA200600042 A1 EA 200600042A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
proteins
formation
glycosylation
disulfidic
Prior art date
Application number
EA200600042A
Other languages
English (en)
Other versions
EA011299B1 (ru
Inventor
Бенджамин Ги Дэвис
Дэвид Филип Гэмблин
Энтони Джон Фэйрбэнкс
Филипп Гарньер
Original Assignee
Айсис Инновейшен Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314743A external-priority patent/GB0314743D0/en
Priority claimed from GB0328884A external-priority patent/GB0328884D0/en
Application filed by Айсис Инновейшен Лимитед filed Critical Айсис Инновейшен Лимитед
Publication of EA200600042A1 publication Critical patent/EA200600042A1/ru
Publication of EA011299B1 publication Critical patent/EA011299B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Раскрыты способы для образования дисульфидных связей, особенно в белках, пептидах и аминокислотах и реагенты, применяемые в этих способах. Способы и реагенты являются особенно полезными для контролируемого гликозилирования белков, пептидов и аминокислот. В этих способах в качестве реагентов или промежуточных соединений используют тиосульфонатные или селененилсульфидные соединения. Некоторые белки и пептиды, содержащие селененилсульфидные группы, также составляют часть данного изобретения.
EA200600042A 2003-06-24 2004-06-24 Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах EA011299B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314743A GB0314743D0 (en) 2003-06-24 2003-06-24 Reagents and methods
GB0328884A GB0328884D0 (en) 2003-12-12 2003-12-12 Methods
PCT/GB2004/002706 WO2005000862A2 (en) 2003-06-24 2004-06-24 Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins

Publications (2)

Publication Number Publication Date
EA200600042A1 true EA200600042A1 (ru) 2006-08-25
EA011299B1 EA011299B1 (ru) 2009-02-27

Family

ID=33554162

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600042A EA011299B1 (ru) 2003-06-24 2004-06-24 Способы образования дисульфидных связей и гликозилирования белков и реагенты, применяемые в этих способах

Country Status (13)

Country Link
US (1) US8637578B2 (ru)
EP (1) EP1644390B1 (ru)
JP (1) JP4787155B2 (ru)
KR (1) KR20060019611A (ru)
AT (1) ATE506370T1 (ru)
AU (1) AU2004251105B2 (ru)
BR (1) BRPI0411766A (ru)
CA (1) CA2529341A1 (ru)
DE (1) DE602004032345D1 (ru)
EA (1) EA011299B1 (ru)
IL (1) IL172729A0 (ru)
NZ (1) NZ544654A (ru)
WO (1) WO2005000862A2 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507123D0 (en) * 2005-04-08 2005-05-11 Isis Innovation Method
CN1299603C (zh) * 2005-07-01 2007-02-14 浙江大学 糖基化谷类蛋白质－硒元素复合物制备方法
GB0602352D0 (en) * 2006-02-06 2006-03-15 Glycoform Ltd Glycoconjugation
AU2009236256B9 (en) * 2008-04-14 2015-09-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of the pleckstrin homology domain and methods for using same
US20140308699A1 (en) 2010-07-30 2014-10-16 Glycode Yeast artificial chromosome carrying the mammalian glycosylation pathway
JP2014509864A (ja) 2011-03-23 2014-04-24 グリコド Ｇｄｐ−フコースを産生可能な酵母組換え細胞
MX393754B (es) 2012-12-14 2025-03-24 Phusis Therapeutics Inc Metodos y composiciones para inhibir cnksr1
EP3240411A4 (en) 2014-11-12 2019-02-20 Tumorend LLC COMPOSITIONS, METHODS AND TREATMENTS FOR INHIBITING CELL ADHESION AND VIRUS BINDING AND PENETRATION
US10227356B2 (en) 2015-04-20 2019-03-12 Phusis Therapeutics, Inc. Compounds, compositions and methods for inhibiting CNKSR1
US11931428B2 (en) * 2019-08-23 2024-03-19 Wake Forest University Health Sciences Selective hydrogen sulfide probe and uses thereof
CN112979509B (zh) * 2021-03-10 2022-04-22 江西师范大学 一种三氟甲磺酰基炔酰胺类化合物及其制备方法和用途
WO2024050809A1 (zh) * 2022-09-09 2024-03-14 四川大学 一种蛋白和/或多肽糖基化修饰的方法
EP4346356A1 (en) 2022-09-29 2024-04-03 Novaled GmbH Semiconducting material, process for preparing a layer of the semiconducting material, organic semiconducting device comprising the semiconducting material and compound
EP4391765A1 (en) 2022-12-23 2024-06-26 Novaled GmbH Organic light emitting diode, display device comprising the same and compound
EP4472384B1 (en) 2023-05-30 2025-11-19 Novaled GmbH Compound, organic light emitting diode, and display device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61205249A (ja) 1985-03-08 1986-09-11 Wako Pure Chem Ind Ltd 有機スルフイン酸塩の新規製法
DE3766567D1 (de) 1986-08-13 1991-01-17 Seitetsu Kagaku Co Ltd Verfahren zur herstellung von alkalimetallbenzolsulfinaten.
CA2106301C (en) * 1991-03-18 1999-04-06 Chi-Huey Wong Oligosaccharide enzyme substrates and inhibitors: method and compositions
CA2072763C (en) 1992-06-29 1994-05-17 Omar Chaudhry Process for the preparation of disulfides from thiols
IL123771A (en) * 1995-09-28 2002-11-10 Redox Pharma Corp Metal complexes as cysteine protease inhibitors
DE69939538D1 (de) * 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
MXPA01010896A (es) 1999-04-28 2003-06-24 Genencor Int Antagonistas cataliticos especificamente dirigidos al objetivo y usos de los mismos.
US6627744B2 (en) * 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents

Also Published As

Publication number Publication date
EA011299B1 (ru) 2009-02-27
ATE506370T1 (de) 2011-05-15
JP2007527376A (ja) 2007-09-27
EP1644390B1 (en) 2011-04-20
WO2005000862A2 (en) 2005-01-06
NZ544654A (en) 2009-05-31
AU2004251105A1 (en) 2005-01-06
BRPI0411766A (pt) 2006-08-08
JP4787155B2 (ja) 2011-10-05
AU2004251105B2 (en) 2010-04-01
EP1644390A2 (en) 2006-04-12
KR20060019611A (ko) 2006-03-03
US20070213506A1 (en) 2007-09-13
CA2529341A1 (en) 2005-01-06
DE602004032345D1 (de) 2011-06-01
IL172729A0 (en) 2006-04-10
US8637578B2 (en) 2014-01-28
WO2005000862A3 (en) 2005-08-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU