DE69939538D1 - Mit einer kohlenhydratgruppe chemisch modifizierte proteine - Google Patents
Mit einer kohlenhydratgruppe chemisch modifizierte proteineInfo
- Publication number
- DE69939538D1 DE69939538D1 DE69939538T DE69939538T DE69939538D1 DE 69939538 D1 DE69939538 D1 DE 69939538D1 DE 69939538 T DE69939538 T DE 69939538T DE 69939538 T DE69939538 T DE 69939538T DE 69939538 D1 DE69939538 D1 DE 69939538D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- chemically modified
- present
- relates
- cysteine residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001720 carbohydrates Chemical group 0.000 title 1
- 102000035118 modified proteins Human genes 0.000 title 1
- 108091005573 modified proteins Proteins 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000008300 Mutant Proteins Human genes 0.000 abstract 3
- 108010021466 Mutant Proteins Proteins 0.000 abstract 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 3
- FHBSGPWHCCIQPG-UHFFFAOYSA-N hydroxy-methyl-oxo-sulfanylidene-$l^{6}-sulfane Chemical class CS(S)(=O)=O FHBSGPWHCCIQPG-UHFFFAOYSA-N 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- GWIKYPMLNBTJHR-UHFFFAOYSA-M thiosulfonate group Chemical group S(=S)(=O)[O-] GWIKYPMLNBTJHR-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9168798P | 1998-07-02 | 1998-07-02 | |
| US13144699P | 1999-04-28 | 1999-04-28 | |
| PCT/US1999/015138 WO2000001712A2 (en) | 1998-07-02 | 1999-07-02 | Chemically modified proteins with a carbohydrate moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69939538D1 true DE69939538D1 (de) | 2008-10-23 |
Family
ID=26784230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69939538T Expired - Fee Related DE69939538D1 (de) | 1998-07-02 | 1999-07-02 | Mit einer kohlenhydratgruppe chemisch modifizierte proteine |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6512098B2 (de) |
| EP (1) | EP1093459B1 (de) |
| JP (1) | JP2002519050A (de) |
| AT (1) | ATE407941T1 (de) |
| AU (1) | AU749383B2 (de) |
| CA (1) | CA2331783C (de) |
| DE (1) | DE69939538D1 (de) |
| WO (1) | WO2000001712A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU749383B2 (en) | 1998-07-02 | 2002-06-27 | Genencor International, Inc. | Chemically modified proteins with a carbohydrate moiety |
| AU772427B2 (en) * | 1998-11-10 | 2004-04-29 | Genencor International, Inc. | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity |
| MXPA01010896A (es) * | 1999-04-28 | 2003-06-24 | Genencor Int | Antagonistas cataliticos especificamente dirigidos al objetivo y usos de los mismos. |
| US6627744B2 (en) * | 1999-07-02 | 2003-09-30 | Genencor International, Inc. | Synthesis of glycodendrimer reagents |
| EP3594334A3 (de) * | 2000-03-08 | 2020-03-18 | Novozymes A/S | Varianten mit veränderten eigenschaften |
| US20040097720A1 (en) * | 2001-04-02 | 2004-05-20 | Bott Richard R. | Use of glycodendrimer reagents for inhibiting adhesion by microorganisms |
| US7312301B2 (en) | 2002-12-31 | 2007-12-25 | Nektar Therapeutics Al, Corporation | Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof |
| US20040180852A1 (en) * | 2003-03-10 | 2004-09-16 | Cara-Lynne Schengrund | Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus |
| DE602004032345D1 (de) * | 2003-06-24 | 2011-06-01 | Isis Innovation | Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen |
| GB0507123D0 (en) * | 2005-04-08 | 2005-05-11 | Isis Innovation | Method |
| BRPI0706400A2 (pt) * | 2006-01-17 | 2011-03-29 | Organon Nv | processos para a hidrólise enzimática seletiva de terc-butil ésteres c-terminais de substratos de peptìdeo, para a sìntese convergente de um peptìdeo de dois ou mais fragmentos de peptìdeo, para a sìntese enzimática por etapas de um peptìdeo na direção do terminal c, e para a sìntese de peptìdeo |
| US20080221027A1 (en) * | 2007-03-09 | 2008-09-11 | The Regents Of The University Of California | Composition and Methods for the Treatment of Duchene Muscular Dystrophy |
| GB0801966D0 (en) * | 2008-02-04 | 2008-03-12 | Isis Innovation | Process |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244791A (en) | 1984-05-29 | 1993-09-14 | Genecor International, Inc. | Methods of ester hydrolysis |
| US5155033A (en) | 1989-01-06 | 1992-10-13 | Genencor, Inc. | Subtilisins modified at position 225 resulting in a shift in catalytic activity |
| US5972682A (en) | 1984-05-29 | 1999-10-26 | Genencor International, Inc. | Enzymatically active modified subtilisins |
| CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
| DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
| EP0542931B1 (de) | 1990-08-09 | 1999-12-08 | Genentech, Inc. | Serinproteasevarianten mit peptidligase aktivität |
| US5629173A (en) | 1990-08-09 | 1997-05-13 | Genentech, Inc. | Methods of use of serine protease variants having peptide ligase activity |
| US5340735A (en) | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
| US5316935A (en) | 1992-04-06 | 1994-05-31 | California Institute Of Technology | Subtilisin variants suitable for hydrolysis and synthesis in organic media |
| US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| US5837516A (en) | 1995-03-03 | 1998-11-17 | Genentech, Inc. | Subtilisin variants capable of cleaving substrates containing basic residues |
| US6946280B1 (en) | 1996-03-29 | 2005-09-20 | Genencor International, Inc. | Enzyme multimer and process of producing same |
| CA2763810C (en) | 1996-11-26 | 2013-04-02 | The Governing Council Of The University Of Toronto | Chemically modified subtilisin mutants |
| MA24811A1 (fr) | 1997-10-23 | 1999-12-31 | Procter & Gamble | Compositions de lavage contenant des variantes de proteases multisubstituees |
| US6395532B1 (en) | 1998-01-23 | 2002-05-28 | Genencor International, Inc. | Modified enzymes and their use for peptide synthesis |
| DE69942910D1 (de) | 1998-01-23 | 2010-12-16 | Univ Toronto | Chemisch modifizierte enzyme und methoden zu ihrer herstellung und zum screeningder enzyme |
| AU749383B2 (en) | 1998-07-02 | 2002-06-27 | Genencor International, Inc. | Chemically modified proteins with a carbohydrate moiety |
-
1999
- 1999-07-02 AU AU52081/99A patent/AU749383B2/en not_active Ceased
- 1999-07-02 US US09/347,029 patent/US6512098B2/en not_active Expired - Lifetime
- 1999-07-02 AT AT99937203T patent/ATE407941T1/de not_active IP Right Cessation
- 1999-07-02 WO PCT/US1999/015138 patent/WO2000001712A2/en not_active Ceased
- 1999-07-02 CA CA002331783A patent/CA2331783C/en not_active Expired - Fee Related
- 1999-07-02 JP JP2000558113A patent/JP2002519050A/ja active Pending
- 1999-07-02 DE DE69939538T patent/DE69939538D1/de not_active Expired - Fee Related
- 1999-07-02 EP EP99937203A patent/EP1093459B1/de not_active Expired - Lifetime
-
2002
- 2002-02-01 US US10/062,970 patent/US6930180B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000001712A9 (en) | 2000-06-22 |
| US6512098B2 (en) | 2003-01-28 |
| AU5208199A (en) | 2000-01-24 |
| US20010018200A1 (en) | 2001-08-30 |
| EP1093459A2 (de) | 2001-04-25 |
| CA2331783A1 (en) | 2000-01-13 |
| JP2002519050A (ja) | 2002-07-02 |
| EP1093459B1 (de) | 2008-09-10 |
| WO2000001712A3 (en) | 2000-05-11 |
| US20020146803A1 (en) | 2002-10-10 |
| WO2000001712A2 (en) | 2000-01-13 |
| AU749383B2 (en) | 2002-06-27 |
| EP1093459A4 (de) | 2002-02-06 |
| US6930180B2 (en) | 2005-08-16 |
| ATE407941T1 (de) | 2008-09-15 |
| CA2331783C (en) | 2009-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |