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EA200000862A1 - Фармацевтическая композиция, содержащая трамадол-лекарственное средство для лечения мигрени - Google Patents

Фармацевтическая композиция, содержащая трамадол-лекарственное средство для лечения мигрени

Info

Publication number
EA200000862A1
EA200000862A1 EA200000862A EA200000862A EA200000862A1 EA 200000862 A1 EA200000862 A1 EA 200000862A1 EA 200000862 A EA200000862 A EA 200000862A EA 200000862 A EA200000862 A EA 200000862A EA 200000862 A1 EA200000862 A1 EA 200000862A1
Authority
EA
Eurasian Patent Office
Prior art keywords
migraine
treatment
medicine
pharmaceutical composition
composition containing
Prior art date
Application number
EA200000862A
Other languages
English (en)
Other versions
EA002166B1 (ru
Inventor
Хельмут Момбергер
Марк Рабер
Original Assignee
Аста Медика Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аста Медика Аг filed Critical Аста Медика Аг
Publication of EA200000862A1 publication Critical patent/EA200000862A1/ru
Publication of EA002166B1 publication Critical patent/EA002166B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к применению фармацевтических композиций, содержащих в качестве активного соединения трамадол или его энантиомер или фармацевтически приемлемую соль и метоклопрамид, домперидон или другие противорвотные соединения прокинетического действия или их фармацевтически приемлемую соль, для лечения мигрени и головных болей типа мигрени, а также для лечения болевых симптомов, сопровождающихся тошнотой и/или рвотой (например, при химиотерапии) и/или затяжным опорожнением желудка (например, в послеоперационный период, при диабетическом гастропарезе).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000862A 1998-02-21 1999-02-17 Фармацевтическая композиция, содержащая трамадол - лекарственное средство для лечения мигрени EA002166B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19807535A DE19807535A1 (de) 1998-02-21 1998-02-21 Pharmazeutische Kombinationen mit Tramadol
PCT/DE1999/000428 WO1999042095A1 (de) 1998-02-21 1999-02-17 Pharmazeutische kombinationen mit tramadol

Publications (2)

Publication Number Publication Date
EA200000862A1 true EA200000862A1 (ru) 2001-02-26
EA002166B1 EA002166B1 (ru) 2001-12-24

Family

ID=7858642

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000862A EA002166B1 (ru) 1998-02-21 1999-02-17 Фармацевтическая композиция, содержащая трамадол - лекарственное средство для лечения мигрени

Country Status (25)

Country Link
EP (1) EP1056448B1 (ru)
JP (1) JP2002503689A (ru)
KR (1) KR100567154B1 (ru)
CN (1) CN1141937C (ru)
AR (1) AR018102A1 (ru)
AT (1) ATE257700T1 (ru)
AU (1) AU748993B2 (ru)
BG (1) BG64888B1 (ru)
BR (1) BR9909211A (ru)
CZ (1) CZ291941B6 (ru)
DE (2) DE19807535A1 (ru)
DK (1) DK1056448T3 (ru)
EA (1) EA002166B1 (ru)
ES (1) ES2212549T3 (ru)
HU (1) HU225656B1 (ru)
IL (1) IL137505A (ru)
NO (1) NO327860B1 (ru)
NZ (1) NZ506020A (ru)
PL (1) PL204075B1 (ru)
PT (1) PT1056448E (ru)
SK (1) SK284937B6 (ru)
TR (1) TR200002411T2 (ru)
TW (1) TWI228040B (ru)
WO (1) WO1999042095A1 (ru)
ZA (1) ZA991212B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002531431A (ja) * 1998-12-02 2002-09-24 ダーウィン・ディスカバリー・リミテッド 治療用製品およびその使用
DE19940944B4 (de) * 1999-08-31 2006-10-12 Grünenthal GmbH Retardierte, orale, pharmazeutische Darreichungsformen
AU3582101A (en) * 2000-03-01 2001-09-12 Euro-Celtique S.A. The treatment of functional gastrointestinal disorders
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US7553858B2 (en) * 2003-12-17 2009-06-30 Meda Pharma Gmbh & Co. Kg Combination of flupirtine and tramadol
PL2124556T3 (pl) 2006-10-09 2015-02-27 Charleston Laboratories Inc Kompozycje farmaceutyczne
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
ES2527448T3 (es) 2008-04-28 2015-01-23 Zogenix, Inc. Nuevas formulaciones para el tratamiento de la migraña
US20130213393A1 (en) 2009-12-22 2013-08-22 Evoke Pharma, Inc. Nasal formulations of metoclopramide
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
GB2541571A (en) * 2014-04-10 2017-02-22 Charleston Laboratories Inc Pharmaceutical compositions
CA3055170A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
US11517545B2 (en) 2016-12-15 2022-12-06 Evoke Pharma, Inc. Treatment of moderate and severe gastroparesis
US20220257542A1 (en) * 2019-07-30 2022-08-18 Frontbio Inc. Pharmaceutical composition comprising trimethobenzamide or pharmaceutically acceptable salt thereof as active ingredient for preventing or treating neuropathic pain
JP7195660B1 (ja) 2021-09-09 2022-12-26 壽製薬株式会社 口腔内崩壊錠

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU528098B2 (en) * 1978-11-16 1983-04-14 Beecham Group Plc Analgesic tablet
AU528310B2 (en) * 1978-11-16 1983-04-21 Beecham Group Plc Composition of paracetamol and metoclopramide
CA2020018A1 (en) * 1990-06-27 1991-12-28 Don L. Simmons Method and composition for treating the migraine complex
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
FR2712809B1 (fr) * 1993-11-26 1996-04-12 Union Pharma Scient Appl Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide.
FR2720936B1 (fr) * 1994-06-08 1997-04-30 Synthelabo Poudres à base de métoclopramide et de paracétamol ou de dérivés d'acide acétylsalicylique.
GB9523566D0 (en) * 1995-11-17 1996-01-17 Euro Celtique Sa Pharmaceutical formulation
FR2741532B1 (fr) * 1995-11-28 1998-08-21 Bouchara Sa Nouvelles compositions pharmaceutiques a action antimigraineuse et leur mode de preparation
GB2313309B (en) * 1996-05-24 2000-01-26 Ninh Thuy On Pharmaceutical compositions comprising a nonsteroidal anti-inflammatory drug and domperidone in the treatment of migraine

Also Published As

Publication number Publication date
TR200002411T2 (tr) 2000-12-21
DE19807535A1 (de) 1999-08-26
CN1141937C (zh) 2004-03-17
NO20004143D0 (no) 2000-08-18
HUP0100964A3 (en) 2003-09-29
PL204075B1 (pl) 2009-12-31
ATE257700T1 (de) 2004-01-15
EP1056448A1 (de) 2000-12-06
IL137505A (en) 2005-07-25
SK284937B6 (sk) 2006-02-02
WO1999042095A1 (de) 1999-08-26
BR9909211A (pt) 2000-11-14
TWI228040B (en) 2005-02-21
ZA991212B (en) 1999-08-03
ES2212549T3 (es) 2004-07-16
JP2002503689A (ja) 2002-02-05
EA002166B1 (ru) 2001-12-24
KR20010041110A (ko) 2001-05-15
DE59908305D1 (de) 2004-02-19
DK1056448T3 (da) 2004-05-17
PT1056448E (pt) 2004-05-31
AU748993B2 (en) 2002-06-13
AU3514899A (en) 1999-09-06
NO20004143L (no) 2000-09-27
NO327860B1 (no) 2009-10-05
NZ506020A (en) 2002-05-31
BG64888B1 (bg) 2006-08-31
KR100567154B1 (ko) 2006-04-04
AR018102A1 (es) 2001-10-31
BG104758A (en) 2001-04-30
HU225656B1 (en) 2007-05-29
PL342546A1 (en) 2001-06-18
CN1291092A (zh) 2001-04-11
HUP0100964A2 (hu) 2001-08-28
HK1035143A1 (en) 2001-11-16
EP1056448B1 (de) 2004-01-14
SK12172000A3 (sk) 2001-04-09
CZ20002939A3 (cs) 2000-12-13
CZ291941B6 (cs) 2003-06-18
IL137505A0 (en) 2001-07-24

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): BY KZ RU

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU