[go: up one dir, main page]

EA199800768A1 - Новые производные эритромицина, способ их получения и их применение в качестве медикаментов - Google Patents

Новые производные эритромицина, способ их получения и их применение в качестве медикаментов

Info

Publication number
EA199800768A1
EA199800768A1 EA199800768A EA199800768A EA199800768A1 EA 199800768 A1 EA199800768 A1 EA 199800768A1 EA 199800768 A EA199800768 A EA 199800768A EA 199800768 A EA199800768 A EA 199800768A EA 199800768 A1 EA199800768 A1 EA 199800768A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
production
medical documents
erythromycin derivatives
new erythromycin
Prior art date
Application number
EA199800768A
Other languages
English (en)
Other versions
EA001376B1 (ru
Inventor
Константэн Агуридас
Жан-Франсуа Шанто
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA199800768A1 publication Critical patent/EA199800768A1/ru
Publication of EA001376B1 publication Critical patent/EA001376B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретение относится к соединениям формулы (I), в которых:Х представляет собой радикал СНили SO, или атом кислорода, Y представляет собой радикал (CH)- (СН = СН)(СН), где m + n + о ≤ 8, n = 0 или 1, Ar представляет собой арил, W представляет собой атом водорода или остаток карбаматной функции. Соединения формулы (I) обладают интересными антибиотическими свойствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800768A 1996-02-28 1997-02-27 Новые производные эритромицина, способ их получения и их применение в качестве медикаментов EA001376B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602472A FR2745290B1 (fr) 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
PCT/FR1997/000351 WO1997031929A1 (fr) 1996-02-28 1997-02-27 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
EA199800768A1 true EA199800768A1 (ru) 1999-02-25
EA001376B1 EA001376B1 (ru) 2001-02-26

Family

ID=9489659

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800768A EA001376B1 (ru) 1996-02-28 1997-02-27 Новые производные эритромицина, способ их получения и их применение в качестве медикаментов

Country Status (31)

Country Link
US (1) US6096714A (ru)
EP (1) EP0885234B1 (ru)
JP (1) JP4102440B2 (ru)
KR (1) KR100486053B1 (ru)
CN (1) CN1168734C (ru)
AP (1) AP952A (ru)
AR (1) AR005999A1 (ru)
AT (1) ATE217633T1 (ru)
AU (1) AU716204B2 (ru)
BG (1) BG63207B1 (ru)
BR (1) BR9707709B1 (ru)
CZ (1) CZ293893B6 (ru)
DE (1) DE69712610T2 (ru)
DK (1) DK0885234T3 (ru)
EA (1) EA001376B1 (ru)
EE (1) EE9800265A (ru)
ES (1) ES2176698T3 (ru)
FR (1) FR2745290B1 (ru)
HU (1) HU227567B1 (ru)
IL (1) IL125622A (ru)
NO (1) NO983955D0 (ru)
NZ (1) NZ331600A (ru)
OA (1) OA10845A (ru)
PL (1) PL191736B1 (ru)
PT (1) PT885234E (ru)
SK (1) SK118498A3 (ru)
TR (1) TR199801713T2 (ru)
UA (1) UA58504C2 (ru)
WO (1) WO1997031929A1 (ru)
YU (1) YU37098A (ru)
ZA (1) ZA971659B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9649598A (en) * 1997-10-29 1999-05-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a, 11,12-carbamate derivatives
WO1999021870A1 (en) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
KR20020002380A (ko) 1999-01-27 2002-01-09 실버스타인 아써 에이. 케톨라이드 항생물질
HK1045523A1 (zh) * 1999-05-24 2002-11-29 辉瑞产品公司 13-甲基红霉素衍生物
AU6183700A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6316400A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6183800A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
ITMI20021726A1 (it) 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
US20050014706A1 (en) * 2003-07-14 2005-01-20 Kanakeshwari Falzari Method of treating tuberculosis
WO2007069264A2 (en) * 2005-12-15 2007-06-21 Alembic Limited Reference standards for determining the purity of telithromycin and processes therefor
US9453042B2 (en) * 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
JP5711352B2 (ja) 2010-03-22 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライドの結晶形、およびその使用
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
IN2014DN08939A (ru) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487411A (en) * 1892-12-06 Island
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5444031A (en) * 1993-01-21 1995-08-22 Calgon Carbon Corporation Process for making catalytic carbon
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
FR2745290A1 (fr) 1997-08-29
CN1168734C (zh) 2004-09-29
AP9801318A0 (en) 1998-09-30
NO983955L (no) 1998-08-27
AU1929897A (en) 1997-09-16
BG63207B1 (bg) 2001-06-29
PL328608A1 (en) 1999-02-01
FR2745290B1 (fr) 1998-04-03
NZ331600A (en) 1999-08-30
CN1212700A (zh) 1999-03-31
AR005999A1 (es) 1999-07-21
JP4102440B2 (ja) 2008-06-18
DK0885234T3 (da) 2002-08-26
WO1997031929A1 (fr) 1997-09-04
UA58504C2 (ru) 2003-08-15
CZ258798A3 (cs) 1998-12-16
BG102691A (en) 1999-06-30
NO983955D0 (no) 1998-08-27
DE69712610D1 (de) 2002-06-20
EA001376B1 (ru) 2001-02-26
ES2176698T3 (es) 2002-12-01
BR9707709B1 (pt) 2014-10-14
AP952A (en) 2001-03-29
JP2000505469A (ja) 2000-05-09
US6096714A (en) 2000-08-01
TR199801713T2 (xx) 1998-12-21
ZA971659B (en) 1998-02-26
PL191736B1 (pl) 2006-06-30
KR100486053B1 (ko) 2005-06-16
ATE217633T1 (de) 2002-06-15
KR19990087324A (ko) 1999-12-27
AU716204B2 (en) 2000-02-24
HUP9902576A3 (en) 2001-03-28
EP0885234A1 (fr) 1998-12-23
EE9800265A (et) 1999-02-15
DE69712610T2 (de) 2002-11-28
IL125622A0 (en) 1999-04-11
IL125622A (en) 2003-10-31
YU37098A (sh) 1999-07-28
CZ293893B6 (cs) 2004-08-18
PT885234E (pt) 2002-10-31
BR9707709A (pt) 1999-04-06
SK118498A3 (en) 1999-07-12
HU227567B1 (en) 2011-08-29
EP0885234B1 (fr) 2002-05-15
OA10845A (fr) 2003-02-05
HUP9902576A1 (hu) 1999-12-28

Similar Documents

Publication Publication Date Title
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
BG100951A (en) Novel erythromycin derivatives, method for their preparation and their use as drugs
NO970495D0 (no) Aryltioforbindelser som anti-bakterielle og antivirale midler
DE69301897D1 (de) Erythromycinderivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimitteln
NL990025I1 (nl) Sulfamaatderivaten met anticonvulsieve werking.
AU4523797A (en) Atherosclerosis treatment
TR199802160T2 (xx) Ateroskleroz tedavisi i�in azetidinon t�revleri.
DE69226815D1 (de) 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
EP0429681A4 (en) Intermediate for 2-alkynyladenosine synthesis, production of said intermediate, production of 2-alkynyladenosine from said intermediate, and stable 2-alkynyladenosine derivative
EA199800109A1 (ru) Производные азетидинона для лечения атеросклероза
AT380471B (de) Verfahren zur herstellung von neuen 2-oxoazetidin-derivate
BR9610905A (pt) Derivados de sulfamato processo de fabricação de derivados de sulfamato e composições farmacêuticas
AU2321688A (en) Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes
EA199900156A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
EA199900528A1 (ru) Новые производные эритромицина, способ их получения и применения в качетве медикаментов
MA24197A1 (fr) Nouvelles fungarrestines
EA200200665A1 (ru) Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие
EA200100163A1 (ru) Новые производные 6-деоксиэритромицина, способ их получения и их применение в качестве лекарственных средств
EA199800767A1 (ru) Производные 1(2h)хинолинкарбоновой кислоты, способ их получения и их применение в синтезе веществ, обладающих антибиотическими свойствами

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MK4A Patent expired

Designated state(s): RU