DK54390A - Okularcyklosporinpraeparat - Google Patents

Okularcyklosporinpraeparat Download PDF

Info

Publication number: DK54390A
Authority: DK; Denmark
Prior art keywords: cyclosporine; enhance; corn oil; ocular; agents
Prior art date: 1987-09-03

Application number

DK054390A

Other languages

English (en)

Other versions

DK54390D0 (da

Inventor

Renee Kaswan

Original Assignee

Univ Georgia Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-03

Filing date

1990-03-01

Publication date

1990-05-03

1987-09-03 Priority claimed from US07/092,466 external-priority patent/US4839342A/en

1990-03-01 Application filed by Univ Georgia Res Found filed Critical Univ Georgia Res Found

1990-03-01 Publication of DK54390D0 publication Critical patent/DK54390D0/da

1990-05-03 Publication of DK54390A publication Critical patent/DK54390A/da

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229960001265 ciclosporin Drugs 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
239000000203 mixture Substances 0.000 abstract 3
239000002285 corn oil Substances 0.000 abstract 2
235000005687 corn oil Nutrition 0.000 abstract 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
-1 antifungals Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229940121357 antivirals Drugs 0.000 abstract 1
OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 abstract 1
229960003870 bromhexine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003246 corticosteroid Substances 0.000 abstract 1
229960001334 corticosteroids Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003172 expectorant agent Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
229960002216 methylparaben Drugs 0.000 abstract 1
229940066491 mucolytics Drugs 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
230000004489 tear production Effects 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
239000005526 vasoconstrictor agent Substances 0.000 abstract 1
239000000080 wetting agent Substances 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK054390A 1987-09-03 1990-03-01 Okularcyklosporinpraeparat DK54390A (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US07/092,466 US4839342A (en)	1987-09-03	1987-09-03	Method of increasing tear production by topical administration of cyclosporin
US11721887A	1987-11-04	1987-11-04
US18782388A	1988-04-29	1988-04-29
PCT/US1988/003039 WO1989001772A1 (en)	1987-09-03	1988-08-31	Ocular cyclosporin composition

Publications (2)

Publication Number	Publication Date
DK54390D0 DK54390D0 (da)	1990-03-01
DK54390A true DK54390A (da)	1990-05-03

Family

ID=27377210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK054390A DK54390A (da)	1987-09-03	1990-03-01	Okularcyklosporinpraeparat

Country Status (12)

Country	Link
US (1)	US5411952A (da)
EP (1)	EP0391909B1 (da)
JP (1)	JPH0667850B2 (da)
KR (1)	KR920003601B1 (da)
AT (1)	ATE109970T1 (da)
DE (1)	DE3851152T2 (da)
DK (1)	DK54390A (da)
ES (1)	ES2012116A6 (da)
GR (1)	GR1000558B (da)
IE (1)	IE65582B1 (da)
PH (1)	PH24814A (da)
WO (1)	WO1989001772A1 (da)

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US4384996A (en) *	1981-01-09	1983-05-24	Sandoz Ltd.	Novel cyclosporins
JPS58501675A (ja) *	1981-10-09	1983-10-06	フエ−リング・ア−ベ−	物質ｐ「きつ」抗質からなる薬材
EP0145714A1 (en) *	1983-05-25	1985-06-26	Alcon Laboratories, Inc.	Ophthalmic gel
US4708861A (en) *	1984-02-15	1987-11-24	The Liposome Company, Inc.	Liposome-gel compositions
CH667274A5 (de) *	1984-03-23	1988-09-30	Sandoz Ag	Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) *	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
EP0170623B1 (en) *	1984-08-02	1990-11-28	Sandoz Ag	Novel pharmaceutical use of (nva)2-cyclosporine
GB8422253D0 (en) *	1984-09-04	1984-10-10	Sandoz Ltd	Organic compounds
EP0194972B1 (en) *	1985-03-11	1992-07-29	Sandoz Ag	Novel cyclosporins
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) *	1985-04-26	1986-11-07	Yutaka Mizushima	点眼剤
US4745100A (en) *	1985-05-14	1988-05-17	Eye Research Institute Of Retina Foundation	Stimulation of tear secretion
US4861580A (en) *	1985-10-15	1989-08-29	The Liposome Company, Inc.	Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) *	1985-11-13	1985-12-18	Ici Plc	Ocular treatment
US4923699A (en) *	1988-06-03	1990-05-08	Kaufman Herbert E	Eye treatment suspension

1988
- 1988-08-31 DE DE3851152T patent/DE3851152T2/de not_active Expired - Lifetime
- 1988-08-31 WO PCT/US1988/003039 patent/WO1989001772A1/en not_active Ceased
- 1988-08-31 AT AT88908033T patent/ATE109970T1/de not_active IP Right Cessation
- 1988-08-31 JP JP63507463A patent/JPH0667850B2/ja not_active Expired - Lifetime
- 1988-08-31 KR KR1019890700680A patent/KR920003601B1/ko not_active Expired
- 1988-08-31 EP EP88908033A patent/EP0391909B1/en not_active Expired - Lifetime
- 1988-09-02 IE IE266388A patent/IE65582B1/en not_active IP Right Cessation
- 1988-09-02 ES ES8802718A patent/ES2012116A6/es not_active Expired - Lifetime
- 1988-09-02 PH PH37495A patent/PH24814A/en unknown
- 1988-09-05 GR GR880100578A patent/GR1000558B/el not_active IP Right Cessation
1990
- 1990-02-06 US US07/474,683 patent/US5411952A/en not_active Expired - Lifetime
- 1990-03-01 DK DK054390A patent/DK54390A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
GR1000558B (el)	1992-08-26
KR890701084A (ko)	1989-12-19
IE882663L (en)	1989-03-03
JPH0667850B2 (ja)	1994-08-31
JPH03503159A (ja)	1991-07-18
ATE109970T1 (de)	1994-09-15
EP0391909A1 (en)	1990-10-17
PH24814A (en)	1990-10-30
ES2012116A6 (es)	1990-03-01
EP0391909B1 (en)	1994-08-17
KR920003601B1 (ko)	1992-05-04
DE3851152D1 (de)	1994-09-22
DK54390D0 (da)	1990-03-01
IE65582B1 (en)	1995-11-01
DE3851152T2 (de)	1995-01-26
US5411952A (en)	1995-05-02
GR880100578A (en)	1989-06-22
WO1989001772A1 (en)	1989-03-09

Publication	Publication Date	Title
DK54390D0 (da)	1990-03-01	Okularcyklosporinpraeparat
CA1303503C (en)	1992-06-16	Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
MX9702349A (es)	1997-06-28	Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma.
AU690377B2 (en)	1998-04-23	Application of superoxide dismutase in liposomes
CA2059403A1 (en)	1992-07-16	Use of Carrageenans in Topical Ophthalmic Compositions
EP1225168A3 (en)	2003-03-26	Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ATE165237T1 (de)	1998-05-15	Starkschaumende orale zusammensetzung
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
IE811654L (en)	1982-02-01	Ophthalmic composition
DE3172298D1 (en)	1985-10-24	Pharmaceutical compositions
US4269835A (en)	1981-05-26	Nasal composition for relieving nasal distress
ATE223200T1 (de)	2002-09-15	Einen carboanhydrase-hemmer und xanthangummi enthaltendes augenarzneimittel
DE3167210D1 (en)	1984-12-20	Pharmaceutical composition
KR880007068A (ko)	1988-08-26	13-시스 레티노산의 용도
KR950000138A (ko)	1995-01-03	안(眼)국소용 조성물
KR950702422A (ko)	1995-07-29	(에스)-티몰롤 헤미하이드레이트를 함유하는 안약 국소 조성물(ophthalmic topical composition containing (s)-timolol hemihydrate)
RU95106983A (ru)	1997-11-27	Офтальмологический состав, способ его получения и средство для офтальмологического состава
CA2015427A1 (en)	1990-10-26	Pharmaceutical composition for topical ophthalmic use having improved local tolerability
IT1241928B (it)	1994-02-01	Composizione oftalmica per l'uso nel mantenimento della midriasi oculare
KeeS	1996	Johnson Syndrome are two disorders usually described as mucin deficiency dry eye syndromes. A classic example of mucin deficiency caused by degeneration or loss of goblet cells is hypo-vitaminosis A. This can be induced experimentally in laboratory animals and is found endemically in developing countries. It appears that Vitamin A is necessary for maturation of goblet cells, and that it
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
IT1257884B (it)	1996-02-16	Formulazioni farmaceutiche per il trattamento di malattie periferiche vascolari a base di vincamina o di un suo sale farmaceuticamente accettabile.

Legal Events

Date	Code	Title	Description
2000-04-10	AHB	Application shelved due to non-payment