DK3626257T3 - Fremgangsmåder og sammensætninger til levering af arylsulfatase a i centralnervesystemet - Google Patents

Fremgangsmåder og sammensætninger til levering af arylsulfatase a i centralnervesystemet Download PDF

Info

Publication number: DK3626257T3
Authority: DK; Denmark
Prior art keywords: delivering; compositions; methods; nervous system; central nervous
Prior art date: 2010-06-25

Application number

DK19192508.0T

Other languages

English (en)

Inventor

Nazila Salamat-Miller

Katherine Taylor

Paul Campolieto

Zahra Shahrokh

Jing Pan

Lawrence Charnas

Teresa Leah Wright

Pericles Calias

Original Assignee

Shire Human Genetic Therapies

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-25

Filing date

2011-06-25

Publication date

2021-11-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45352777&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3626257(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-06-25 Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies

2011-06-25 Priority claimed from EP11799037.4A external-priority patent/EP2585104B1/en

2021-11-08 Application granted granted Critical

2021-11-08 Publication of DK3626257T3 publication Critical patent/DK3626257T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06008—Cerebroside-sulfatase (3.1.6.8)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01046—Galactosylceramidase (3.2.1.46)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
- C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
- C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Diabetes (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Hematology (AREA)
Mycology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Biotechnology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Oil, Petroleum & Natural Gas (AREA)

DK19192508.0T 2010-06-25 2011-06-25 Fremgangsmåder og sammensætninger til levering af arylsulfatase a i centralnervesystemet DK3626257T3 (da)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US35885710P	2010-06-25	2010-06-25
US36078610P	2010-07-01	2010-07-01
US38786210P	2010-09-29	2010-09-29
US201161435710P	2011-01-24	2011-01-24
US201161442115P	2011-02-11	2011-02-11
US201161476210P	2011-04-15	2011-04-15
US201161495268P	2011-06-09	2011-06-09
EP11799037.4A EP2585104B1 (en)	2010-06-25	2011-06-25	Methods and compositions for cns delivery of arylsulfatase a

Publications (1)

Publication Number	Publication Date
DK3626257T3 true DK3626257T3 (da)	2021-11-08

Family

ID=45352777

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK19192679.9T DK3626258T3 (da)	2010-06-25	2011-06-25	Fremgangsmåder og sammensætninger til cns-levering af iduronat-2-sulfatase
DK19192508.0T DK3626257T3 (da)	2010-06-25	2011-06-25	Fremgangsmåder og sammensætninger til levering af arylsulfatase a i centralnervesystemet
DK16179150.4T DK3103469T3 (en)	2010-06-25	2011-06-25	Indgivelse af terapeutiske midler til centralnervesystemet

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK19192679.9T DK3626258T3 (da)	2010-06-25	2011-06-25	Fremgangsmåder og sammensætninger til cns-levering af iduronat-2-sulfatase

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK16179150.4T DK3103469T3 (en)	2010-06-25	2011-06-25	Indgivelse af terapeutiske midler til centralnervesystemet

Country Status (24)

Country	Link
US (17)	US9814764B2 (da)
JP (22)	JP6250616B2 (da)
CN (4)	CN104857504A (da)
AR (6)	AR082025A1 (da)
BR (1)	BR112012033214B1 (da)
CA (1)	CA3171308A1 (da)
CL (7)	CL2012003655A1 (da)
DK (3)	DK3626258T3 (da)
ES (3)	ES2896060T3 (da)
HK (1)	HK1214149A1 (da)
HR (3)	HRP20211660T1 (da)
HU (6)	HUE055963T2 (da)
LT (3)	LT3626257T (da)
MX (1)	MX354776B (da)
NZ (2)	NZ702800A (da)
PE (8)	PE20130648A1 (da)
PL (1)	PL2588130T3 (da)
PT (6)	PT2588130T (da)
RS (3)	RS61683B1 (da)
RU (1)	RU2761342C2 (da)
SI (3)	SI3626258T1 (da)
SM (1)	SMT201600385B (da)
TW (9)	TWI609694B (da)
UA (3)	UA125743C2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8497246B2 (en)	2006-08-18	2013-07-30	Armagen Technologies, Inc.	Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
EP2997976A1 (en)	2007-07-27	2016-03-23	Armagen Technologies, Inc.	Methods and compositions for increasing alpha-l-iduronidase activity in the cns
JP2013507131A (ja)	2009-10-09	2013-03-04	アーメイゲン・テクノロジーズ・インコーポレイテッド	Ｃｎｓにおけるイズロン酸２−スルファターゼ活性を増加させるための方法および組成物
SMT201600385T1 (it)	2010-06-25	2017-03-08	Shire Human Genetic Therapies	Trasporto di agenti terapeutici all’snc
BR112012033197A2 (pt)	2010-06-25	2017-06-06	Shire Human Genetic Therapies	métodos e composições para liberação de cns de n-sulfatase de heparano.
PT2588130T (pt)	2010-06-25	2016-11-25	Shire Human Genetic Therapies	Entrega de agentes terapêuticos no cns
KR102720061B1 (ko)	2010-06-25	2024-10-22	다케다 파머수티컬 컴패니 리미티드	아릴설파타제 a의 cns 전달을 위한 방법들 및 조성물들
US20220133863A1 (en) *	2010-06-25	2022-05-05	Shire Human Genetic Therapies, Inc.	Treatment of sanfilippo syndrome type b
US8486399B2 (en)	2011-12-02	2013-07-16	Armagen Technologies, Inc.	Methods and compositions for increasing arylsulfatase A activity in the CNS
CA2859988A1 (en) *	2011-12-23	2013-06-27	Shire Human Genetic Therapies, Inc.	Treatment of cognitive impairment of hunter syndrome by intrathecal delivery of iduronate-2-sulfatase
EP2793922B1 (en)	2011-12-23	2019-10-30	Shire Human Genetic Therapies, Inc.	Stable formulations for cns delivery of arylsulfatase a
HK1222093A1 (zh) *	2013-05-15	2017-06-23	明尼苏达大学董事会	腺相关病毒介导的基因向中枢神经系统转移
US10538589B2 (en) *	2015-01-14	2020-01-21	Armagen Inc.	Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
EP3292206B8 (en)	2015-05-07	2022-02-09	Takeda Pharmaceutical Company Limited	Glucocerebrosidase gene therapy for parkinson's disease
PT3397270T (pt)	2015-12-30	2024-05-09	Green Cross Corp	Composições para utilização no tratamento da síndrome de hunter
RU2751235C2 (ru)	2016-02-24	2021-07-12	Байомарин Фармасьютикал Инк.	Терапевтические слитые белки направленного действия на основе лизосомных ферментов, соответствующие составы и их применения
SG11201808176TA (en)	2016-04-15	2018-10-30	The Trustees Of The Univ Of Pennsyvania	Gene therapy for treating mucopolysaccharidosis type ii
CA3076036A1 (en)	2017-09-22	2019-03-28	The Trustees Of The University Of Pennsylvania	Gene therapy for treating mucopolysaccharidosis type ii
BR112020016673A2 (pt)	2018-02-28	2020-12-15	Seikagaku Corporation	Embalagem, método para produzir uma embalagem, e, composição farmacêutica.
CN108534695A (zh) *	2018-05-04	2018-09-14	无锡恩特卫自动化检测设备有限公司	一种基于机器视觉系统的瓶塞漏酒检测方法及装置
KR102671857B1 (ko) *	2018-05-30	2024-06-04	주식회사 녹십자	대뇌 측뇌실 투여에 의해 헌터증후군을 치료하기 위한 방법 및 조성물
JP2020002130A (ja)	2018-06-25	2020-01-09	Ｊｃｒファーマ株式会社	蛋白質含有水性液剤
JP7253771B2 (ja) *	2019-01-18	2023-04-07	株式会社大一商会	遊技機
JP7253770B2 (ja) *	2019-01-18	2023-04-07	株式会社大一商会	遊技機
CR20230178A (es)	2020-10-14	2023-07-26	Denali Therapeutics Inc	Proteínas de fusión que comprenden enzimas sulfoglucosamina sulfohidrolasa y métodos de estas
CN113283465B (zh) *	2021-04-02	2022-04-29	电子科技大学	一种弥散张量成像数据分析方法及装置
CA3223707A1 (en)	2021-06-21	2022-12-29	Hanadie Yousef	Regenerative polypeptides and uses thereof
CN115116623A (zh) *	2022-06-28	2022-09-27	深圳市儿童医院	一种基于icd疾病编码的抗菌药物使用指标评价方法、终端
WO2025054521A1 (en) *	2023-09-07	2025-03-13	Juvena Therapeutics, Inc.	Igf2 fusion protein formulations and therapeutic uses thereof
WO2025075929A1 (en) *	2023-10-02	2025-04-10	Neurona Therapeutics Inc.	Methods of treating seizure activity

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3133001A (en) *	1959-11-26	1964-05-12	Muset Pedro Puig	Stabilization of enzymes
US4743265A (en)	1986-04-23	1988-05-10	Dij Catheter Corp	Articulated catheter placement device
US5222982A (en)	1991-02-11	1993-06-29	Ommaya Ayub K	Spinal fluid driven artificial organ
ES2164098T3 (es) *	1993-02-02	2002-02-16	Xoma Technology Ltd	Composiciones farmaceuticas que contienen una proteina bactericida aumentadora de la permeabilidad y un tensioactivo.
US5863782A (en)	1995-04-19	1999-01-26	Women's And Children's Hospital	Synthetic mammalian sulphamidase and genetic sequences encoding same
US6118045A (en)	1995-08-02	2000-09-12	Pharming B.V.	Lysosomal proteins produced in the milk of transgenic animals
AUPN674895A0 (en)	1995-11-23	1995-12-14	Women's And Children's Hospital	Synthetic mammalian alpha-N-acetylglucosaminidase and genetic sequences encoding same
DE69808402T2 (de)	1997-08-22	2003-07-03	Seikagaku Corp., Tokio/Tokyo	Arzneimittel zur Behandlung von durch Hernie gestörter intervertebraler Bandscheibe
AU3113700A (en)	1998-12-07	2000-06-26	Genzyme Corporation	Treatment of pompe's disease
US6217552B1 (en)	1999-03-01	2001-04-17	Coaxia, Inc.	Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma
US7412285B2 (en)	1999-04-09	2008-08-12	Oncostim, Inc.	Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US6368315B1 (en)	1999-06-23	2002-04-09	Durect Corporation	Composite drug delivery catheter
US20020052311A1 (en)	1999-09-03	2002-05-02	Beka Solomon	Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
US6534300B1 (en)	1999-09-14	2003-03-18	Genzyme Glycobiology Research Institute, Inc.	Methods for producing highly phosphorylated lysosomal hydrolases
US20020099025A1 (en) *	1999-12-30	2002-07-25	Heywood James A.	Treatment of neurological disorders
US6866844B2 (en) *	2002-11-07	2005-03-15	Biomarin Pharmaceutical Inc.	Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
US7560424B2 (en)	2001-04-30	2009-07-14	Zystor Therapeutics, Inc.	Targeted therapeutic proteins
US7629309B2 (en)	2002-05-29	2009-12-08	Zystor Therapeutics, Inc.	Targeted therapeutic proteins
US20040005309A1 (en)	2002-05-29	2004-01-08	Symbiontics, Inc.	Targeted therapeutic proteins
ES2300439T3 (es)	2001-04-30	2008-06-16	Zystor Therapeutics , Inc.	Reconocimiento subcelular de proteinas terapeuticas.
US20030040479A1 (en)	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
US20030072761A1 (en)	2001-10-16	2003-04-17	Lebowitz Jonathan	Methods and compositions for targeting proteins across the blood brain barrier
CA2463473A1 (en)	2001-10-16	2003-04-24	Symbiontics Inc.	Targeted therapeutic proteins
WO2003068159A2 (en)	2002-02-11	2003-08-21	Wake Forest University	Compositions and methods for treating pain using cyclooxygenase-1 inhibitors
ES2367257T3 (es)	2002-04-25	2011-10-31	Shire Human Genetic Therapies, Inc.	Tratamiento de deficit de alfa-galactosidasa a.
EP1514106A4 (en)	2002-05-29	2007-05-09	Zystor Therapeutics Inc	TARGETED THERAPEUTIC PROTEINS
EP1426069A1 (en)	2002-12-02	2004-06-09	Diana Evelyn Miller	Drug delivery system
WO2004064750A2 (en)	2003-01-22	2004-08-05	Duke University	Improved constructs for expressing lysosomal polypeptides
WO2004069190A2 (en)	2003-01-31	2004-08-19	Mount Sinai School Of Medicine Of New York University	Combination therapy for treating protein deficiency disorders
CN1788017B (zh) *	2003-02-10	2013-04-24	to-BBB控股股份有限公司	炎症状态下在血脑屏障中差异表达的核酸
EP1592709A2 (en)	2003-02-10	2005-11-09	TO-BBB Holding B.V.	Differentially expressed nucleic acids in the blood-brain barrier under inflammatory conditions
EP1638605B1 (en)	2003-06-20	2014-01-08	Raptor Pharmaceutical, Inc.	Delivery of therapeutic compounds to the brain and other tissues
US20050026823A1 (en)	2003-06-20	2005-02-03	Biomarin Pharmaceutical Inc.	Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
US7442372B2 (en) *	2003-08-29	2008-10-28	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
EP2532742B1 (en) *	2004-01-30	2018-08-08	Shire Pharmaceuticals Ireland Limited	Recombinant arylsulfatase A for reducing galatosyl sulphatide levels in a subject
US20060029656A1 (en)	2004-02-03	2006-02-09	Biodelivery Sciences International, Inc.	Replacement enzyme cochleates
CA2556245A1 (en)	2004-02-06	2005-08-25	Biomarin Pharmaceutical Inc.	Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
CN1922313B (zh)	2004-02-10	2011-10-26	生物马林医药公司	酸性α-糖苷酶及其片段
US20050208090A1 (en) *	2004-03-18	2005-09-22	Medtronic, Inc.	Methods and systems for treatment of neurological diseases of the central nervous system
UA11577U (en)	2004-04-21	2006-01-16	Academician A P Romodanov Inst	Device for intrathecal drug administration into spinal canal
RU2006144851A (ru)	2004-06-15	2008-06-20	Бакстер Интернэшнл Инк. (Us)	Применение терапевтических средств ex-vivo в виде твердых микрочастиц
WO2006015961A2 (en) *	2004-08-11	2006-02-16	Ciba Specialty Chemicals Holding Inc.	Enzyme-based time temperature indicator
IL165334A0 (en) *	2004-11-22	2006-01-15	Mediwound Ltd	Debriding composition from bromelain and methods of producing same
EP1889628B1 (en) *	2005-05-11	2013-12-11	JCR PHARMACEUTICALS Co., LTD.	Lipid liposome composition
MX2007015602A (es)	2005-06-08	2008-02-21	Amicus Therapeutics Inc	Tratamiento de trastornos del sistema nervioso central asociados con mutaciones en genes que codifican las enzimas lisosomicas.
AR059089A1 (es)	2006-01-20	2008-03-12	Genzyme Corp	Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
DK1988823T3 (da)	2006-02-09	2018-12-03	Genzyme Corp	Langsom intraventrikulær administration
CN101410408A (zh) *	2006-04-04	2009-04-15	希尔制药爱尔兰有限责任公司	用于浓缩多肽的方法
ES2744499T3 (es)	2006-04-04	2020-02-25	Chiesi Farm Spa	Un proceso para la concentración de un polipéptido
GB0611463D0 (en)	2006-06-09	2006-07-19	Novartis Ag	Organic compounds
US20080076120A1 (en)	2006-09-14	2008-03-27	Millennium Pharmaceuticals, Inc.	Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US8419710B2 (en) *	2006-12-06	2013-04-16	Medtronic, Inc.	Methods for infusing fluids via an implantable infusion system
US20090041741A1 (en)	2007-03-06	2009-02-12	Saint Louis University	Modified enzyme and treatment method
EP2174661B1 (en)	2007-06-29	2012-12-19	National University Corporation Nagoya University	Agent for improving neuropathic pain
WO2009017005A1 (ja)	2007-07-27	2009-02-05	Sharp Kabushiki Kaisha	移動局装置、基地局装置、通信システム及びプログラム
BRPI0815416A2 (pt)	2007-08-15	2014-10-21	Amunix Inc	Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
WO2009062348A1 (en) *	2007-11-14	2009-05-22	Institute Of Microbiology, Chinese Academy Of Sciences	Methods for inhibiting influenza virus infection and their drugs
TWI543768B (zh)	2007-11-30	2016-08-01	艾伯維生物技術有限責任公司	蛋白質調配物及製造其之方法
US7722865B2 (en) *	2008-01-18	2010-05-25	Biomarin Pharmaceutical Inc.	Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
HUE032074T2 (en)	2008-01-18	2017-08-28	Biomarin Pharm Inc	Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
TW200936156A (en) *	2008-01-28	2009-09-01	Novartis Ag	Methods and compositions using Klotho-FGF fusion polypeptides
WO2009131698A2 (en)	2008-04-23	2009-10-29	Iowa State University Research Foundation, Inc.	PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOF
HRP20170698T1 (hr)	2008-05-07	2017-09-22	Biomarin Pharmaceutical Inc.	Lizosomski usmjereni peptidi i njihove uporabe
US8436489B2 (en)	2009-06-29	2013-05-07	Lightsail Energy, Inc.	Compressed air energy storage system utilizing two-phase flow to facilitate heat exchange
SMT201600385T1 (it)	2010-06-25	2017-03-08	Shire Human Genetic Therapies	Trasporto di agenti terapeutici all’snc
UA115649C2 (uk)	2010-06-25	2017-12-11	Шае Хюмен Дженетік Терапіс, Інк.	Способи та композиції для доставки до цнс ідуронат-2-сульфатази
KR102720061B1 (ko)	2010-06-25	2024-10-22	다케다 파머수티컬 컴패니 리미티드	아릴설파타제 a의 cns 전달을 위한 방법들 및 조성물들
BR112012033197A2 (pt)	2010-06-25	2017-06-06	Shire Human Genetic Therapies	métodos e composições para liberação de cns de n-sulfatase de heparano.
WO2011163651A2 (en)	2010-06-25	2011-12-29	Shire Human Genetic Therapies, Inc.	METHODS AND COMPOSITIONS FOR CNS DELIVERY OF β-GALACTOCEREBROSIDASE
MX2013000324A (es)	2010-06-25	2013-02-01	Shire Human Genetic Therapies	Tratamiento del sindrome de sanfilippo tipo b.
PT2588130T (pt)	2010-06-25	2016-11-25	Shire Human Genetic Therapies	Entrega de agentes terapêuticos no cns
JP2012062312A (ja)	2010-08-19	2012-03-29	Yoshikatsu Eto	ハンター症候群の治療剤
US8580922B2 (en) *	2011-03-04	2013-11-12	Shire Human Genetic Therapies, Inc.	Peptide linkers for polypeptide compositions and methods for using same
EP2793922B1 (en)	2011-12-23	2019-10-30	Shire Human Genetic Therapies, Inc.	Stable formulations for cns delivery of arylsulfatase a
JP6623213B2 (ja)	2014-08-11	2019-12-18	シャイアーヒューマンジェネティックセラピーズインコーポレイテッド	リソソーム酵素に融合したマンノース−６−リン酸含有ペプチド
US10603364B2 (en)	2014-08-11	2020-03-31	Shire Human Genetic Therapies, Inc.	Lysosomal targeting and uses thereof
US10556015B2 (en)	2014-10-24	2020-02-11	Criteo S.A.	Lysosomal targeting of enzymes, and uses thereof
US9673835B1 (en)	2015-12-04	2017-06-06	Taiwan Semiconductor Manufacturing Co., Ltd.	Pipelined SAR with TDC converter

2011
- 2011-06-25 PT PT117990358T patent/PT2588130T/pt unknown
- 2011-06-25 MX MX2013000321A patent/MX354776B/es active IP Right Grant
- 2011-06-25 CN CN201510172262.0A patent/CN104857504A/zh active Pending
- 2011-06-25 HU HUE19192679A patent/HUE055963T2/hu unknown
- 2011-06-25 PE PE2012002498A patent/PE20130648A1/es not_active Application Discontinuation
- 2011-06-25 ES ES19192508T patent/ES2896060T3/es active Active
- 2011-06-25 HU HUE11799035A patent/HUE031036T2/en unknown
- 2011-06-25 RS RS20210291A patent/RS61683B1/sr unknown
- 2011-06-25 ES ES16179150T patent/ES2858726T3/es active Active
- 2011-06-25 NZ NZ702800A patent/NZ702800A/en not_active IP Right Cessation
- 2011-06-25 CN CN201610086722.2A patent/CN105664142A/zh active Pending
- 2011-06-25 PE PE2017000503A patent/PE20170938A1/es unknown
- 2011-06-25 HU HUE16179150A patent/HUE052944T2/hu unknown
- 2011-06-25 LT LTEP19192508.0T patent/LT3626257T/lt unknown
- 2011-06-25 PE PE2012002476A patent/PE20130589A1/es not_active Application Discontinuation
- 2011-06-25 PT PT117990374T patent/PT2585104T/pt unknown
- 2011-06-25 HR HRP20211660TT patent/HRP20211660T1/hr unknown
- 2011-06-25 DK DK19192679.9T patent/DK3626258T3/da active
- 2011-06-25 UA UAA201507529A patent/UA125743C2/uk unknown
- 2011-06-25 ES ES19192679T patent/ES2895655T3/es active Active
- 2011-06-25 RS RS20211359A patent/RS62620B1/sr unknown
- 2011-06-25 UA UAA201507721A patent/UA129740C2/uk unknown
- 2011-06-25 PE PE2012002475A patent/PE20130579A1/es active IP Right Grant
- 2011-06-25 HR HRP20211520TT patent/HRP20211520T1/hr unknown
- 2011-06-25 PE PE2017001612A patent/PE20180130A1/es unknown
- 2011-06-25 CA CA3171308A patent/CA3171308A1/en active Pending
- 2011-06-25 SI SI201132007T patent/SI3626258T1/sl unknown
- 2011-06-25 CN CN201510512218.XA patent/CN105233277B/zh active Active
- 2011-06-25 SI SI201131959T patent/SI3103469T1/sl unknown
- 2011-06-25 PT PT117990366T patent/PT2593131T/pt unknown
- 2011-06-25 NZ NZ702803A patent/NZ702803A/en unknown
- 2011-06-25 CN CN201610569581.XA patent/CN106139133B/zh active Active
- 2011-06-25 DK DK19192508.0T patent/DK3626257T3/da active
- 2011-06-25 PT PT191925080T patent/PT3626257T/pt unknown
- 2011-06-25 LT LTEP16179150.4T patent/LT3103469T/lt unknown
- 2011-06-25 DK DK16179150.4T patent/DK3103469T3/da active
- 2011-06-25 PT PT161791504T patent/PT3103469T/pt unknown
- 2011-06-25 PE PE2012002479A patent/PE20130637A1/es not_active Application Discontinuation
- 2011-06-25 RS RS20211191A patent/RS62520B1/sr unknown
- 2011-06-25 HU HUE19192508A patent/HUE056884T2/hu unknown
- 2011-06-25 RU RU2017125281A patent/RU2761342C2/ru active
- 2011-06-25 PT PT191926799T patent/PT3626258T/pt unknown
- 2011-06-25 PE PE2018000183A patent/PE20180801A1/es unknown
- 2011-06-25 PL PL11799035T patent/PL2588130T3/pl unknown
- 2011-06-25 BR BR112012033214-7A patent/BR112012033214B1/pt active IP Right Grant
- 2011-06-25 UA UAA201507719A patent/UA125060C2/uk unknown
- 2011-06-25 PE PE2012002474A patent/PE20130578A1/es not_active Application Discontinuation
- 2011-06-25 SI SI201132014T patent/SI3626257T1/sl unknown
- 2011-06-25 HU HUE11799037A patent/HUE046409T2/hu unknown
- 2011-06-25 LT LTEP19192679.9T patent/LT3626258T/lt unknown
- 2011-06-25 HU HUE11799036A patent/HUE046856T2/hu unknown
- 2011-06-27 TW TW106108970A patent/TWI609694B/zh active
- 2011-06-27 AR ARP110102246A patent/AR082025A1/es not_active Application Discontinuation
- 2011-06-27 AR ARP110102241A patent/AR081677A1/es not_active Application Discontinuation
- 2011-06-27 AR ARP110102245A patent/AR081681A1/es unknown
- 2011-06-27 TW TW106135183A patent/TWI669128B/zh active
- 2011-06-27 TW TW109118555A patent/TWI790444B/zh active
- 2011-06-27 TW TW113122692A patent/TW202506172A/zh unknown
- 2011-06-27 TW TW100122534A patent/TWI602573B/zh active
- 2011-06-27 TW TW100122529A patent/TW201212936A/zh unknown
- 2011-06-27 AR ARP110102242A patent/AR081678A1/es not_active Application Discontinuation
- 2011-06-27 AR ARP110102244A patent/AR081680A1/es unknown
- 2011-06-27 AR ARP110102243A patent/AR081679A1/es unknown
- 2011-06-27 TW TW112102995A patent/TWI876260B/zh active
- 2011-06-27 TW TW106127273A patent/TWI698252B/zh active
- 2011-06-27 TW TW105115109A patent/TW201701899A/zh unknown
2012
- 2012-12-21 CL CL2012003655A patent/CL2012003655A1/es unknown
- 2012-12-21 CL CL2012003657A patent/CL2012003657A1/es unknown
- 2012-12-21 CL CL2012003656A patent/CL2012003656A1/es unknown
- 2012-12-21 CL CL2012003654A patent/CL2012003654A1/es unknown
2013
- 2013-05-10 US US13/892,076 patent/US9814764B2/en active Active
- 2013-08-23 US US13/974,457 patent/US9220677B2/en active Active
2015
- 2015-11-11 US US14/938,824 patent/US20160158324A1/en not_active Abandoned
- 2015-12-03 JP JP2015236539A patent/JP6250616B2/ja active Active
- 2015-12-17 JP JP2015246244A patent/JP6285409B2/ja active Active
- 2015-12-17 JP JP2015246589A patent/JP2016094451A/ja active Pending
- 2015-12-17 JP JP2015246258A patent/JP2016040335A/ja not_active Withdrawn
- 2015-12-18 JP JP2015246952A patent/JP6346162B2/ja active Active
2016
- 2016-02-04 US US15/016,141 patent/US10456454B2/en active Active
- 2016-02-25 HK HK16102145.2A patent/HK1214149A1/zh unknown
- 2016-03-22 US US15/077,046 patent/US20170042977A1/en not_active Abandoned
- 2016-10-27 SM SM201600385T patent/SMT201600385B/it unknown
- 2016-12-07 CL CL2016003159A patent/CL2016003159A1/es unknown
2017
- 2017-08-23 US US15/684,568 patent/US10646554B2/en active Active
- 2017-09-15 JP JP2017177784A patent/JP6466538B2/ja active Active
- 2017-09-26 US US15/715,748 patent/US11065307B2/en active Active
- 2017-10-03 CL CL2017002488A patent/CL2017002488A1/es unknown
- 2017-10-04 JP JP2017194508A patent/JP6522073B2/ja active Active
- 2017-10-04 JP JP2017194348A patent/JP6522072B2/ja active Active
2018
- 2018-07-16 US US16/036,584 patent/US11065308B2/en active Active
- 2018-10-11 JP JP2018192589A patent/JP6797876B2/ja active Active
- 2018-12-03 JP JP2018226358A patent/JP6898909B2/ja active Active
- 2018-12-04 JP JP2018227369A patent/JP6938456B2/ja active Active
2019
- 2019-07-18 US US16/515,568 patent/US11260112B2/en active Active
- 2019-09-17 US US16/573,557 patent/US11471516B2/en active Active
2020
- 2020-01-07 JP JP2020000930A patent/JP2020079244A/ja not_active Withdrawn
- 2020-02-14 JP JP2020023620A patent/JP2020079297A/ja active Pending
- 2020-02-17 JP JP2020024183A patent/JP2020079298A/ja active Pending
- 2020-02-26 CL CL2020000468A patent/CL2020000468A1/es unknown
- 2020-03-24 US US16/828,731 patent/US12168041B2/en active Active
2021
- 2021-02-23 HR HRP20210298TT patent/HRP20210298T1/hr unknown
- 2021-06-17 US US17/350,860 patent/US12161702B2/en active Active
- 2021-07-13 JP JP2021115560A patent/JP7448507B2/ja active Active
- 2021-07-13 JP JP2021115564A patent/JP7087175B2/ja active Active
- 2021-08-18 JP JP2021133184A patent/JP7591476B2/ja active Active
- 2021-12-03 JP JP2021196898A patent/JP7359827B2/ja active Active
2022
- 2022-01-18 US US17/578,119 patent/US12121569B2/en active Active
- 2022-08-16 US US17/820,155 patent/US12409210B2/en active Active
2023
- 2023-02-02 JP JP2023014814A patent/JP7543459B2/ja active Active
- 2023-02-20 JP JP2023024170A patent/JP2023062114A/ja active Pending
- 2023-05-11 JP JP2023078673A patent/JP2023099216A/ja active Pending
2024
- 2024-04-23 JP JP2024069806A patent/JP2024097029A/ja active Pending
- 2024-09-19 US US18/890,181 patent/US20250121040A1/en active Pending
- 2024-10-29 US US18/930,737 patent/US20250161417A1/en active Pending
2025
- 2025-08-15 US US19/301,198 patent/US20250375506A1/en active Pending

Also Published As

Publication number	Publication date
JP6466538B2 (ja)	2019-02-06
CL2012003656A1 (es)	2013-07-19
US10456454B2 (en)	2019-10-29
AR081681A1 (es)	2012-10-10
AR081680A1 (es)	2012-10-10
TW202506172A (zh)	2025-02-16
JP2016037504A (ja)	2016-03-22
JP2023062114A (ja)	2023-05-02
TW201206465A (en)	2012-02-16
PT2585104T (pt)	2019-10-30
JP2018002734A (ja)	2018-01-11
ES2895655T3 (es)	2022-02-22
US20180085438A1 (en)	2018-03-29
TW202337489A (zh)	2023-10-01
CL2016003159A1 (es)	2017-05-12
PT3103469T (pt)	2021-03-04
CN106139133A (zh)	2016-11-23
JP7591476B2 (ja)	2024-11-28
US20220133862A1 (en)	2022-05-05
US12161702B2 (en)	2024-12-10
CL2012003654A1 (es)	2013-06-14
MX354776B (es)	2018-03-20
JP2020079297A (ja)	2020-05-28
TWI698252B (zh)	2020-07-11
UA125060C2 (uk)	2022-01-05
ES2858726T3 (es)	2021-09-30
TWI876260B (zh)	2025-03-11
LT3626258T (lt)	2021-12-10
CL2012003657A1 (es)	2013-04-19
LT3626257T (lt)	2021-12-10
JP6797876B2 (ja)	2020-12-09
JP2016040335A (ja)	2016-03-24
US10646554B2 (en)	2020-05-12
US11471516B2 (en)	2022-10-18
JP6346162B2 (ja)	2018-06-20
JP2019038853A (ja)	2019-03-14
JP6285409B2 (ja)	2018-02-28
UA129740C2 (uk)	2025-07-23
SI3626257T1 (sl)	2021-12-31
US9220677B2 (en)	2015-12-29
TW201212936A (en)	2012-04-01
TWI609694B (zh)	2018-01-01
RU2018113327A3 (da)	2021-07-21
JP7087175B2 (ja)	2022-06-20
PE20130589A1 (es)	2013-05-19
US20140271598A1 (en)	2014-09-18
RS62620B1 (sr)	2021-12-31
DK3103469T3 (en)	2021-02-22
SMT201600385B (it)	2017-03-08
HRP20211660T1 (hr)	2022-02-04
RU2018113327A (ru)	2019-03-01
MX2013000321A (es)	2013-04-03
AR082025A1 (es)	2012-11-07
HK1218719A1 (zh)	2017-03-10
JP2016094451A (ja)	2016-05-26
US20170042977A1 (en)	2017-02-16
PE20180130A1 (es)	2018-01-18
JP2017214434A (ja)	2017-12-07
JP2021167341A (ja)	2021-10-21
TW201825111A (zh)	2018-07-16
US20250121040A1 (en)	2025-04-17
RU2018137304A3 (da)	2022-02-22
US11260112B2 (en)	2022-03-01
US20200113981A1 (en)	2020-04-16
US20250375506A1 (en)	2025-12-11
PT2588130T (pt)	2016-11-25
HUE056884T2 (hu)	2022-03-28
JP2019031575A (ja)	2019-02-28
JP2020079298A (ja)	2020-05-28
RS62520B1 (sr)	2021-11-30
CN106139133B (zh)	2020-12-04
JP2023099216A (ja)	2023-07-11
HUE052944T2 (hu)	2021-05-28
US20160158324A1 (en)	2016-06-09
JP2021181489A (ja)	2021-11-25
SI3103469T1 (sl)	2021-04-30
CL2017002488A1 (es)	2017-12-15
JP2021167340A (ja)	2021-10-21
US12409210B2 (en)	2025-09-09
TWI790444B (zh)	2023-01-21
RU2018137304A (ru)	2019-03-21
HK1214149A1 (zh)	2016-07-22
CL2012003655A1 (es)	2013-04-19
JP2019006826A (ja)	2019-01-17
RS61683B1 (sr)	2021-05-31
PE20130578A1 (es)	2013-05-19
LT3103469T (lt)	2021-03-25
US20230165942A1 (en)	2023-06-01
JP2016040337A (ja)	2016-03-24
PT3626257T (pt)	2021-11-12
HUE046409T2 (hu)	2020-02-28
US20190183984A1 (en)	2019-06-20
JP2020079244A (ja)	2020-05-28
UA125743C2 (uk)	2022-06-01
PL2588130T3 (pl)	2017-09-29
HRP20211520T1 (hr)	2021-12-24
TW201815411A (zh)	2018-05-01
CN105233277B (zh)	2019-01-01
US20170042978A1 (en)	2017-02-16
PE20130579A1 (es)	2013-05-19
JP2023052868A (ja)	2023-04-12
HUE031036T2 (en)	2017-06-28
BR112012033214A2 (pt)	2017-05-23
US11065308B2 (en)	2021-07-20
PT3626258T (pt)	2021-10-19
CL2020000468A1 (es)	2020-09-04
AR081678A1 (es)	2012-10-10
US9814764B2 (en)	2017-11-14
AR081677A1 (es)	2012-10-10
JP7448507B2 (ja)	2024-03-12
CN105664142A (zh)	2016-06-15
PE20130637A1 (es)	2013-06-13
TWI602573B (zh)	2017-10-21
US12168041B2 (en)	2024-12-17
US20200046810A1 (en)	2020-02-13
BR112012033214B1 (pt)	2020-11-03
CA3171308A1 (en)	2011-12-29
PE20130648A1 (es)	2013-07-03
US11065307B2 (en)	2021-07-20
JP7543459B2 (ja)	2024-09-02
US20250161417A1 (en)	2025-05-22
RU2017125281A (ru)	2019-01-31
JP6898909B2 (ja)	2021-07-07
DK3626258T3 (da)	2021-09-20
SI3626258T1 (sl)	2021-11-30
US12121569B2 (en)	2024-10-22
TWI669128B (zh)	2019-08-21
US20230026836A1 (en)	2023-01-26
HRP20210298T1 (hr)	2021-04-16
JP7359827B2 (ja)	2023-10-11
JP6522073B2 (ja)	2019-05-29
JP2016041755A (ja)	2016-03-31
TW201701899A (zh)	2017-01-16
TW202112391A (zh)	2021-04-01
JP2018002735A (ja)	2018-01-11
US20130295077A1 (en)	2013-11-07
ES2896060T3 (es)	2022-02-23
PE20180801A1 (es)	2018-05-09
TW201726161A (zh)	2017-08-01
JP6250616B2 (ja)	2017-12-20
NZ702800A (en)	2017-03-31
RU2017125281A3 (da)	2020-11-09
CN105233277A (zh)	2016-01-13
PE20170938A1 (es)	2017-07-13
RU2761342C2 (ru)	2021-12-07
US20180071212A1 (en)	2018-03-15
HUE055963T2 (hu)	2022-01-28
JP2022024176A (ja)	2022-02-08
JP6938456B2 (ja)	2021-09-22
AR081679A1 (es)	2012-10-10
HUE046856T2 (hu)	2020-03-30
CN104857504A (zh)	2015-08-26
PT2593131T (pt)	2019-10-30
NZ702803A (en)	2017-05-26
US20200405825A1 (en)	2020-12-31
JP2024097029A (ja)	2024-07-17
JP6522072B2 (ja)	2019-05-29

Publication	Publication Date	Title
DK3626257T3 (da)	2021-11-08	Fremgangsmåder og sammensætninger til levering af arylsulfatase a i centralnervesystemet
DK2585104T3 (da)	2019-10-14	Fremgangsmåder og sammensætninger tilcns-levering af arylsulfatase a
DK2890780T3 (da)	2020-09-21	Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
DK2788958T3 (da)	2019-12-16	Fremgangsmåde og system til at karakterisere plantefænotype
DK2506896T3 (da)	2025-07-21	Anordning og fremgangsmåde til afgivelse af to eller flere lægemidler
DK2485761T3 (da)	2019-05-06	Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS
EP2561074A4 (en)	2013-10-23	IMPROVED METHODS OF GENE REGULATION IN PLANTS
DK3121280T3 (da)	2025-06-30	Antisense-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf
DK2625253T3 (da)	2021-02-15	System og fremgangsmåde til ristning af biomasse
DK2602898T4 (da)	2023-12-18	System og fremgangsmåde til reaktiv effekt-kompensation i ledningsnet
DK2085611T3 (da)	2019-07-15	Stabilitetsstyringssystemer og metoder til strømgenerering
DK2576477T3 (da)	2014-08-18	Granulær pimpsten samt fremgangsmåde til fremstilling af granulær pimpsten
DK3578201T3 (da)	2023-05-08	Fremgangsmåder og sammensætninger til naturlige dræberceller
DK2240155T3 (da)	2012-09-17	Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
EP2483791A4 (en)	2016-11-09	Modular device authentication framework
DK3868881T3 (da)	2025-09-29	Sammensætninger og fremgangsmåder, der omfatter subtilisin-varianter
DK3421051T3 (da)	2020-06-22	Fremgangsmåder til glycokonjugering og sammensætninger
HUE033056T2 (hu)	2017-11-28	Polinukleotid molekulák génszabályozáshoz növényekben
DK2475880T3 (da)	2020-02-10	Vindmøllehåndteringssystem og fremgangsmåde til anvendelse deraf
DK2337568T3 (da)	2020-05-11	Fremgangsmåder og midler til blødvævsteknologi
DK2624567T3 (da)	2020-04-14	Blokinddelingsfremgangsmåde og afkodningsindretning
PL2729627T3 (pl)	2016-08-31	System fundamentowy dla mostów i innych konstrukcji
DK2292928T3 (da)	2020-11-16	Fremgangsmåder og systemer til vindmøllestyring
DK3211082T3 (da)	2021-05-10	Mikrorna-forbindelser og fremgangsmåder til modulering af mir-21-aktivitet
DK2758655T3 (da)	2020-02-10	Systemer og fremgangsmåder til forbedrede vandrotorer