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DK3687576T3 - Anvendelse af cannabidiol i kombination med norfenfluramin eller fenfluramin i behandling af epilepsi - Google Patents

Anvendelse af cannabidiol i kombination med norfenfluramin eller fenfluramin i behandling af epilepsi

Info

Publication number
DK3687576T3
DK3687576T3 DK18782178.0T DK18782178T DK3687576T3 DK 3687576 T3 DK3687576 T3 DK 3687576T3 DK 18782178 T DK18782178 T DK 18782178T DK 3687576 T3 DK3687576 T3 DK 3687576T3
Authority
DK
Denmark
Prior art keywords
norfenfluramine
cannabidiol
fenfluramine
epilepsy
treatment
Prior art date
Application number
DK18782178.0T
Other languages
English (en)
Inventor
Benjamin Whalley
Geoffrey Guy
Volker Knappertz
Royston Gray
Rohini Rana
Original Assignee
Jazz Pharmaceuticals Res Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jazz Pharmaceuticals Res Uk Limited filed Critical Jazz Pharmaceuticals Res Uk Limited
Application granted granted Critical
Publication of DK3687576T3 publication Critical patent/DK3687576T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/658Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK18782178.0T 2017-09-29 2018-10-01 Anvendelse af cannabidiol i kombination med norfenfluramin eller fenfluramin i behandling af epilepsi DK3687576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1715919.5A GB201715919D0 (en) 2017-09-29 2017-09-29 use of cannabinoids in the treatment of epilepsy
GBGB1806481.6A GB201806481D0 (en) 2017-09-29 2018-04-20 Use of cannabinoids in the treatment of epilepsy
PCT/GB2018/052805 WO2019064031A1 (en) 2017-09-29 2018-10-01 USE OF CANNABIDIOL IN COMBINATION WITH 5-HT2B RECEPTOR AGONISTS OR AMPHETAMINES IN THE TREATMENT OF EPILEPSY

Publications (1)

Publication Number Publication Date
DK3687576T3 true DK3687576T3 (da) 2025-09-29

Family

ID=60270232

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18782178.0T DK3687576T3 (da) 2017-09-29 2018-10-01 Anvendelse af cannabidiol i kombination med norfenfluramin eller fenfluramin i behandling af epilepsi

Country Status (16)

Country Link
US (1) US11419829B2 (da)
EP (1) EP3687576B1 (da)
JP (1) JP7359757B2 (da)
KR (1) KR102739080B1 (da)
CN (1) CN111201039B (da)
AU (1) AU2018341091B2 (da)
BR (1) BR112020006105A2 (da)
CA (1) CA3076995A1 (da)
DK (1) DK3687576T3 (da)
ES (1) ES3041966T3 (da)
FI (1) FI3687576T3 (da)
GB (3) GB201715919D0 (da)
IL (1) IL273583B2 (da)
MX (1) MX2020003934A (da)
RU (1) RU2020114753A (da)
WO (1) WO2019064031A1 (da)

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GB2551987A (en) 2016-07-01 2018-01-10 Gw Res Ltd Oral cannabinoid formulations
GB2551986A (en) 2016-07-01 2018-01-10 Gw Res Ltd Parenteral formulations
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GB2564383B (en) 2017-06-23 2021-04-21 Gw Res Ltd Use of cannabidiol in the treatment of tumours assoicated with Tuberous Sclerosis Complex
GB201715919D0 (en) 2017-09-29 2017-11-15 Gw Res Ltd use of cannabinoids in the treatment of epilepsy
GB2568929A (en) 2017-12-01 2019-06-05 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
GB2569961B (en) 2018-01-03 2021-12-22 Gw Res Ltd Pharmaceutical
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US12083116B2 (en) * 2018-06-21 2024-09-10 Robert John Petcavich Method of inducing dendritic and synaptic genesis in neurodegenerative chronic diseases
JP2021530541A (ja) * 2018-07-27 2021-11-11 ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. てんかんの治療方法
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AU2019384963B2 (en) * 2018-11-19 2022-05-26 Zogenix International Limited Methods of treating Rett syndrome using fenfluramine
US12398093B2 (en) 2019-04-12 2025-08-26 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compounds and methods for treating inflammatory disorders
GB2584140A (en) * 2019-05-23 2020-11-25 Gw Res Ltd Use of cannabidiol in the treatment of epileptic spasms
GB201910389D0 (en) 2019-07-19 2019-09-04 Gw Pharma Ltd Novel compounds, methods for their manufacture, and uses thereof
GB2588576A (en) 2019-08-27 2021-05-05 Gw Res Ltd Use of cannabinoids in the treatment of dyskinesia associated with Parkinson's disease
US12409131B2 (en) 2019-10-03 2025-09-09 Pike Therapeutics Usa, Inc. Transdermal delivery of dronabinol
US20210100737A1 (en) 2019-10-03 2021-04-08 Starton Therapeutics, Inc. Transdermal delivery of dronabinol
US12016829B2 (en) 2019-10-11 2024-06-25 Pike Therapeutics Inc. Pharmaceutical composition and method for treating seizure disorders
WO2021070120A1 (en) 2019-10-11 2021-04-15 Pike Therapeutics, Inc., 1219014 B.C. Ltd. Transdermal compositions comprising cannabidiol (cbd) for use in the treatment of seizure disorders
US12268699B2 (en) 2019-10-14 2025-04-08 Pike Therapeutics Inc. Transdermal delivery of tetrahydrocannabinol
JP2022551730A (ja) 2019-10-14 2022-12-13 パイク セラピューティクス,インコーポレイテッド カンナビジオールの経皮送達
US12121617B2 (en) 2019-10-14 2024-10-22 Pike Therapeutics Inc. Transdermal delivery of cannabidiol
WO2021072530A1 (en) * 2019-10-15 2021-04-22 Tassili Life Sciences, Corp. Controlled release formulations of psilocybe-derived agents and method for their use, and methods and compositions for threating mild traumatic brain injury with post traumatic stress disorder.
GB201916846D0 (en) 2019-11-19 2020-01-01 Gw Res Ltd Cannabidiol-type cannabinoid compound
GB201916849D0 (en) 2019-11-19 2020-01-01 Gw Res Ltd Cannabidiol-type cannabinoid compound
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GB201916977D0 (en) 2019-11-21 2020-01-08 Gw Res Ltd Cannibidol-type cannabinoid compound
GB202002754D0 (en) 2020-02-27 2020-04-15 Gw Res Ltd Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
CA3182156A1 (en) 2020-05-08 2021-11-11 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
CN115667217A (zh) 2020-05-19 2023-01-31 赛本爱尔兰有限公司 氘化的色胺衍生物和使用方法
GB2597316A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
CN114196645B (zh) * 2021-09-10 2022-08-09 北京蓝晶微生物科技有限公司 一种橄榄醇合成酶变体l及其用途
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CN118873517A (zh) * 2024-07-05 2024-11-01 上海柯西医药科技发展有限公司 大麻二酚与5-ht2b受体激动剂的组合的用途

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Also Published As

Publication number Publication date
GB201806481D0 (en) 2018-06-06
AU2018341091B2 (en) 2024-09-26
IL273583A (en) 2020-05-31
IL273583B1 (en) 2025-01-01
US20200237683A1 (en) 2020-07-30
ES3041966T3 (en) 2025-11-17
JP2020535198A (ja) 2020-12-03
US11419829B2 (en) 2022-08-23
CA3076995A1 (en) 2019-04-04
CN111201039B (zh) 2022-11-22
EP3687576B1 (en) 2025-09-03
GB201715919D0 (en) 2017-11-15
JP7359757B2 (ja) 2023-10-11
RU2020114753A3 (da) 2021-10-29
GB2568809B (en) 2022-04-27
CN111201039A (zh) 2020-05-26
IL273583B2 (en) 2025-05-01
KR102739080B1 (ko) 2024-12-04
KR20200060422A (ko) 2020-05-29
MX2020003934A (es) 2020-10-12
FI3687576T3 (fi) 2025-10-12
EP3687576A1 (en) 2020-08-05
BR112020006105A2 (pt) 2020-09-29
GB2568809A (en) 2019-05-29
WO2019064031A1 (en) 2019-04-04
RU2020114753A (ru) 2021-10-29
AU2018341091A1 (en) 2020-04-23

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