DK3658684T3 - Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer - Google Patents
Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer Download PDFInfo
- Publication number
- DK3658684T3 DK3658684T3 DK18838558.7T DK18838558T DK3658684T3 DK 3658684 T3 DK3658684 T3 DK 3658684T3 DK 18838558 T DK18838558 T DK 18838558T DK 3658684 T3 DK3658684 T3 DK 3658684T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- nucleic acids
- viral nucleic
- cancer screening
- improving cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/708—Specific hybridization probes for papilloma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537328P | 2017-07-26 | 2017-07-26 | |
| PCT/CN2018/097072 WO2019020057A1 (en) | 2017-07-26 | 2018-07-25 | ENHANCING CANCER SCREENING WITH ACELLULAR VIRAL NUCLEIC ACIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3658684T3 true DK3658684T3 (da) | 2023-10-09 |
Family
ID=65039389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18838558.7T DK3658684T3 (da) | 2017-07-26 | 2018-07-25 | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10731224B2 (da) |
| EP (2) | EP3658684B1 (da) |
| JP (2) | JP7776099B2 (da) |
| KR (1) | KR102889224B1 (da) |
| CN (1) | CN111051536A (da) |
| AU (2) | AU2018305609B2 (da) |
| CA (1) | CA3070898A1 (da) |
| DK (1) | DK3658684T3 (da) |
| ES (1) | ES2959360T3 (da) |
| IL (2) | IL272030B2 (da) |
| PH (1) | PH12020500156A1 (da) |
| SG (1) | SG11202000609SA (da) |
| TW (1) | TWI860979B (da) |
| WO (1) | WO2019020057A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201903509QA (en) | 2016-10-24 | 2019-05-30 | Univ Hong Kong Chinese | Methods and systems for tumor detection |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| DK3658684T3 (da) * | 2017-07-26 | 2023-10-09 | Univ Hong Kong Chinese | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
| CA3128379A1 (en) * | 2019-04-02 | 2020-10-08 | Grail, Inc. | Stratification of risk of virus associated cancers |
| US12437839B2 (en) | 2019-05-03 | 2025-10-07 | Ultima Genomics, Inc. | Methods for detecting nucleic acid variants |
| WO2020227137A1 (en) | 2019-05-03 | 2020-11-12 | Ultima Genomics, Inc. | Methods for detecting nucleic acid variants |
| AU2021292311A1 (en) * | 2020-06-20 | 2023-02-16 | Grail, Llc | Detection and classification of human papillomavirus associated cancers |
| EP4247979A4 (en) * | 2020-11-18 | 2024-09-25 | Ultima Genomics, Inc. | METHODS AND SYSTEMS FOR DETECTION OF RESIDUAL DISEASE |
| CN114457192B (zh) * | 2021-07-07 | 2023-02-07 | 中山大学 | 对唾液中EB病毒CpG位点进行甲基化分型的试剂在制备鼻咽癌诊断试剂盒中的应用 |
| EP4530356A3 (en) * | 2022-02-07 | 2025-07-09 | Centre for Novostics | Fragmentation for measuring methylation and disease |
| CN116694762B (zh) * | 2023-05-06 | 2025-03-28 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 一种检测鼻咽癌的试剂盒 |
| CN120048351A (zh) * | 2025-04-22 | 2025-05-27 | 深圳市睿法生物科技有限公司 | 基于靶标区域甲基化分析的测序数据处理方法及系统 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0009505A (pt) | 1999-04-02 | 2002-06-11 | Corixa Corp | Compostos e processos para terapia e diagnóstico de câncer de pulmão |
| US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| JP2005514956A (ja) | 2002-01-18 | 2005-05-26 | ジェンザイム・コーポレーション | 胎児dnaの検出および対立遺伝子の定量化のための方法 |
| ATE312946T1 (de) | 2002-03-05 | 2005-12-15 | Epigenomics Ag | Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten |
| US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
| ATE435301T1 (de) | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
| EP1751306A1 (en) | 2004-04-30 | 2007-02-14 | Yale University | Methods and compositions for cancer diagnosis |
| CN1790021A (zh) | 2004-12-15 | 2006-06-21 | 杨华显 | 利用循环伊波病毒dna对前癌、原位癌和癌病灶的筛查 |
| US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
| TR201910868T4 (tr) | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| WO2007100911A2 (en) | 2006-02-28 | 2007-09-07 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2008024009A1 (en) | 2006-08-15 | 2008-02-28 | Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) | Transcriptional level of a timp3 gene in the form of a diagnosis marker of a non-small cell carcinoma of lung |
| US7842482B2 (en) | 2007-02-26 | 2010-11-30 | The Chinese University Of Hong Kong | Methods and kits for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer |
| EP2164984A2 (en) | 2007-05-25 | 2010-03-24 | Decode Genetics EHF. | Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| US8835110B2 (en) | 2008-11-04 | 2014-09-16 | The Johns Hopkins University | DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy |
| US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
| WO2010112316A1 (en) | 2009-03-31 | 2010-10-07 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Method for diagnosis of cancer and monitoring of cancer treatments |
| WO2011038507A1 (en) | 2009-10-02 | 2011-04-07 | Centre For Addiction And Mental Health | Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids |
| AU2010311535B2 (en) | 2009-10-26 | 2015-05-21 | Lifecodexx Ag | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
| WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
| HUE061110T2 (hu) | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
| GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
| EP4074838A1 (en) | 2010-01-19 | 2022-10-19 | Verinata Health, Inc. | Novel protocol for preparing sequencing libraries |
| US10662474B2 (en) | 2010-01-19 | 2020-05-26 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
| EP2536854B1 (en) | 2010-02-18 | 2017-07-19 | The Johns Hopkins University | Personalized tumor biomarkers |
| PL2558854T3 (pl) | 2010-04-16 | 2019-04-30 | Chronix Biomedical | Biomarkery będące krążącymi kwasami nukleinowymi związanymi z rakiem piersi |
| EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| SG190344A1 (en) | 2010-11-30 | 2013-06-28 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US20140178348A1 (en) | 2011-05-25 | 2014-06-26 | The Regents Of The University Of California | Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| GB2485635B (en) | 2011-07-26 | 2012-11-28 | Verinata Health Inc | Method for determining the presence or absence of different aneuploidies in a sample |
| ES2693672T3 (es) | 2011-09-26 | 2018-12-13 | Qiagen Gmbh | Método rápido para aislar ácidos nucleicos extracelulares |
| JP6073902B2 (ja) | 2011-10-06 | 2017-02-01 | セクエノム, インコーポレイテッド | 遺伝的変異の非侵襲的評価のための方法およびプロセス |
| CA2852098C (en) | 2011-10-21 | 2023-05-02 | Chronix Biomedical | Colorectal cancer associated circulating nucleic acid biomarkers |
| WO2013060762A1 (en) | 2011-10-25 | 2013-05-02 | Roche Diagnostics Gmbh | Method for diagnosing a disease based on plasma-dna distribution |
| US10214775B2 (en) | 2011-12-07 | 2019-02-26 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013138510A1 (en) | 2012-03-13 | 2013-09-19 | Patel Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
| KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| FI4056712T3 (fi) * | 2012-09-20 | 2024-08-29 | Univ Hong Kong Chinese | Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta |
| US20160186267A1 (en) | 2013-02-21 | 2016-06-30 | Toma Biosciences, Inc. | Methods, compositions, and kits for nucleic acid analysis |
| EP3409791B1 (en) | 2013-03-15 | 2021-06-30 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| EP3495496B1 (en) | 2013-10-07 | 2020-11-25 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| US20150119260A1 (en) | 2013-10-18 | 2015-04-30 | National Taiwan University | Circulating cancer biomarker and its use |
| WO2015159293A2 (en) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| EP3521454A1 (en) | 2014-05-09 | 2019-08-07 | LifeCodexx AG | Detection of dna that originates from a specific cell-type and related methods |
| US9840742B2 (en) * | 2014-06-16 | 2017-12-12 | JBS Science Inc. | Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma |
| US20160002717A1 (en) | 2014-07-02 | 2016-01-07 | Boreal Genomics, Inc. | Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease |
| US11062789B2 (en) * | 2014-07-18 | 2021-07-13 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in a DNA mixture |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| WO2016011982A1 (zh) | 2014-07-25 | 2016-01-28 | 深圳华大基因股份有限公司 | 确定生物样本中游离核酸比例的方法、装置及其用途 |
| ES2791328T3 (es) | 2014-10-01 | 2020-11-03 | Chronix Biomedical | Métodos de cuantificación de ADN acelular |
| WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
| ES2989276T3 (es) | 2014-12-05 | 2024-11-25 | Found Medicine Inc | Análisis multigénico de muestras tumorales |
| WO2016094853A1 (en) | 2014-12-12 | 2016-06-16 | Verinata Health, Inc. | Using cell-free dna fragment size to determine copy number variations |
| WO2016109604A2 (en) | 2014-12-29 | 2016-07-07 | InnoGenomics Technologies, LLC | Multiplexed assay for quantitating and assessing integrity of cell-free dna in biological fluids for cancer diagnosis, prognosis, and surveillance |
| ES2923602T3 (es) | 2014-12-31 | 2022-09-28 | Guardant Health Inc | Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas |
| US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US10319463B2 (en) | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
| EP4012715B1 (en) | 2015-02-10 | 2025-09-24 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| CA2980078C (en) | 2015-03-16 | 2024-03-12 | Personal Genome Diagnostics Inc. | Systems and methods for analyzing nucleic acid |
| EP3739061B1 (en) * | 2015-07-20 | 2022-03-23 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| CN108026572B (zh) * | 2015-07-23 | 2022-07-01 | 香港中文大学 | 游离dna的片段化模式的分析 |
| US10428391B2 (en) * | 2015-07-27 | 2019-10-01 | The Johns Hopkins University | Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: PCR and sequencing based process methods |
| EP3798321B1 (en) * | 2015-12-17 | 2025-08-27 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| US20190085417A1 (en) * | 2015-12-18 | 2019-03-21 | Lucence Diagnostics Pte Ltd | Detection and Quantification of Target Nucleic Acid Sequence of a Microorganism |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| US10781490B2 (en) | 2016-05-30 | 2020-09-22 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free DNA in blood |
| SG11201903509QA (en) * | 2016-10-24 | 2019-05-30 | Univ Hong Kong Chinese | Methods and systems for tumor detection |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| DK3658684T3 (da) * | 2017-07-26 | 2023-10-09 | Univ Hong Kong Chinese | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
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2018
- 2018-07-25 DK DK18838558.7T patent/DK3658684T3/da active
- 2018-07-25 IL IL272030A patent/IL272030B2/en unknown
- 2018-07-25 EP EP18838558.7A patent/EP3658684B1/en active Active
- 2018-07-25 CA CA3070898A patent/CA3070898A1/en active Pending
- 2018-07-25 SG SG11202000609SA patent/SG11202000609SA/en unknown
- 2018-07-25 ES ES18838558T patent/ES2959360T3/es active Active
- 2018-07-25 AU AU2018305609A patent/AU2018305609B2/en active Active
- 2018-07-25 KR KR1020207005415A patent/KR102889224B1/ko active Active
- 2018-07-25 CN CN201880055081.1A patent/CN111051536A/zh active Pending
- 2018-07-25 EP EP23171661.4A patent/EP4234723A3/en active Pending
- 2018-07-25 IL IL316163A patent/IL316163A/en unknown
- 2018-07-25 WO PCT/CN2018/097072 patent/WO2019020057A1/en not_active Ceased
- 2018-07-25 JP JP2020503956A patent/JP7776099B2/ja active Active
- 2018-07-26 US US16/046,795 patent/US10731224B2/en active Active
- 2018-07-26 TW TW107125941A patent/TWI860979B/zh active
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2020
- 2020-01-21 PH PH12020500156A patent/PH12020500156A1/en unknown
- 2020-06-25 US US16/912,410 patent/US12234515B2/en active Active
-
2023
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| EP3658684A4 (en) | 2021-04-14 |
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| CA3070898A1 (en) | 2019-01-31 |
| US20200325546A1 (en) | 2020-10-15 |
| US20190032145A1 (en) | 2019-01-31 |
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| EP4234723A2 (en) | 2023-08-30 |
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| JP2020527958A (ja) | 2020-09-17 |
| US12234515B2 (en) | 2025-02-25 |
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| SG11202000609SA (en) | 2020-02-27 |
| AU2018305609B2 (en) | 2023-01-19 |
| US10731224B2 (en) | 2020-08-04 |
| TWI860979B (zh) | 2024-11-11 |
| AU2018305609A1 (en) | 2020-02-06 |
| KR20200035427A (ko) | 2020-04-03 |
| JP7781441B2 (ja) | 2025-12-08 |
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| ES2959360T3 (es) | 2024-02-23 |
| WO2019020057A1 (en) | 2019-01-31 |
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| PH12020500156A1 (en) | 2020-09-14 |
| IL272030A (en) | 2020-03-31 |
| AU2023202318A1 (en) | 2023-05-11 |
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