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DK3515924T3 - Krystallinske former - Google Patents

Krystallinske former Download PDF

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Publication number
DK3515924T3
DK3515924T3 DK17771436.7T DK17771436T DK3515924T3 DK 3515924 T3 DK3515924 T3 DK 3515924T3 DK 17771436 T DK17771436 T DK 17771436T DK 3515924 T3 DK3515924 T3 DK 3515924T3
Authority
DK
Denmark
Prior art keywords
crystallic
forms
crystallic forms
Prior art date
Application number
DK17771436.7T
Other languages
English (en)
Inventor
Daniel Leuenberger
Stefan Reber
Raumer Markus Von
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK3515924T3 publication Critical patent/DK3515924T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK17771436.7T 2016-09-22 2017-09-21 Krystallinske former DK3515924T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016072562 2016-09-22
PCT/EP2017/073858 WO2018055016A1 (en) 2016-09-22 2017-09-21 Crystalline forms

Publications (1)

Publication Number Publication Date
DK3515924T3 true DK3515924T3 (da) 2022-03-21

Family

ID=59923448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17771436.7T DK3515924T3 (da) 2016-09-22 2017-09-21 Krystallinske former

Country Status (27)

Country Link
US (4) US10730896B2 (da)
EP (2) EP3515924B1 (da)
JP (1) JP7097369B2 (da)
KR (1) KR102552795B1 (da)
CN (1) CN109715639B (da)
AU (1) AU2017331930B2 (da)
CA (1) CA3037794A1 (da)
CL (1) CL2019000728A1 (da)
CY (1) CY1125052T1 (da)
DK (1) DK3515924T3 (da)
EA (1) EA201990723A1 (da)
ES (1) ES2908572T3 (da)
HR (1) HRP20220234T1 (da)
HU (1) HUE057772T2 (da)
IL (1) IL265445B2 (da)
LT (1) LT3515924T (da)
MA (1) MA46266B1 (da)
MX (1) MX381590B (da)
MY (1) MY193080A (da)
PH (1) PH12019500567B1 (da)
PL (1) PL3515924T3 (da)
PT (1) PT3515924T (da)
RS (1) RS62946B1 (da)
SI (1) SI3515924T1 (da)
TW (1) TWI752086B (da)
UA (1) UA124073C2 (da)
WO (1) WO2018055016A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI752086B (zh) 2016-09-22 2022-01-11 瑞士商愛杜西亞製藥有限公司 結晶型式
KR102510832B1 (ko) 2017-03-15 2023-03-15 이도르시아 파마슈티컬스 리미티드 P2y12 수용체 안타고니스트의 피하 투여
CA3185564A1 (en) 2020-07-15 2022-01-20 Stephan Buchmann Aqueous pharmaceutical composition comprising a p2y12 receptor antagonist
JP2024524658A (ja) 2021-07-13 2024-07-05 イドルシア・ファーマシューティカルズ・リミテッド 4-((r)-2-{[6-((s)-3-メトキシ-ピロリジン-1-イル)-2-フェニル-ピリミジン-4-カルボニル]-アミノ}-3-ホスホノ-プロピオニル)-ピペラジン-1-カルボン酸ブチルエステルの合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373586A (en) 1976-12-09 1978-06-30 Mitsubishi Chem Ind Ltd New penicillin derivatives
CA2020437A1 (en) 1989-07-05 1991-01-06 Yoshihide Fuse Cinnamamide derivative
EP1192132B1 (en) 1999-06-14 2005-09-07 Eli Lilly And Company Serine protease inhibitors
US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
US7056923B2 (en) 2002-12-11 2006-06-06 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
DK1611144T3 (da) 2003-04-09 2010-11-22 Wyeth Llc Derivater af 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl-phosphonsyre og deres avendelse som n-methyl-D-aspartat (NMDA)-receptor-antagonister
TW200640877A (en) 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
MY147373A (en) 2005-10-21 2012-11-30 Actelion Pharmaceuticals Ltd Piperazine derivatives as antimalarial agents
CL2007002920A1 (es) 2006-10-13 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
CL2007003038A1 (es) 2006-10-25 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos.
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
WO2008128647A1 (en) 2007-04-23 2008-10-30 Sanofi-Aventis Quinoline-carboxamide derivatives as p2y12 antagonists
HRP20120735T1 (hr) * 2007-11-29 2012-10-31 Actelion Pharmaceuticals Ltd. Derivati fosfonske kiseline i njihova uporaba kao antagonista p2y12 receptora
EP2238128B1 (en) 2007-12-26 2012-08-22 Sanofi Heterocyclic pyrazole-carboxamides as p2y12 antagonists
WO2009080227A2 (en) 2007-12-26 2009-07-02 Sanofi-Aventis Pyrazole-carboxamide derivatives as p2y12 antagonists
AR071652A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2- fenil-piridina substituidos
AR071653A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
NZ596213A (en) 2009-04-08 2013-05-31 Actelion Pharmaceuticals Ltd 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as adenosine 5'-diphosphate (ADP) receptor antagonists
CA2756654C (en) 2009-04-22 2017-08-22 Actelion Pharmaceuticals Ltd Thiazole derivatives and their use as p2y12 receptor antagonists
TWI752086B (zh) 2016-09-22 2022-01-11 瑞士商愛杜西亞製藥有限公司 結晶型式
KR102510832B1 (ko) 2017-03-15 2023-03-15 이도르시아 파마슈티컬스 리미티드 P2y12 수용체 안타고니스트의 피하 투여
CA3185564A1 (en) 2020-07-15 2022-01-20 Stephan Buchmann Aqueous pharmaceutical composition comprising a p2y12 receptor antagonist

Also Published As

Publication number Publication date
TW201813965A (zh) 2018-04-16
WO2018055016A1 (en) 2018-03-29
JP7097369B2 (ja) 2022-07-07
PH12019500567A1 (en) 2019-11-18
EA201990723A1 (ru) 2019-10-31
PT3515924T (pt) 2022-03-11
UA124073C2 (uk) 2021-07-14
BR112019004845A2 (pt) 2019-06-04
IL265445B1 (en) 2024-01-01
CA3037794A1 (en) 2018-03-29
MA46266A (fr) 2019-07-31
KR102552795B1 (ko) 2023-07-06
JP2019529553A (ja) 2019-10-17
HRP20220234T1 (hr) 2022-05-13
MX381590B (es) 2025-03-12
PH12019500567B1 (en) 2024-01-31
EP3981774A1 (en) 2022-04-13
AU2017331930A1 (en) 2019-03-07
TWI752086B (zh) 2022-01-11
CL2019000728A1 (es) 2019-07-05
MA46266B1 (fr) 2022-02-28
ES2908572T3 (es) 2022-05-03
PL3515924T3 (pl) 2022-04-11
US20250163086A1 (en) 2025-05-22
NZ750772A (en) 2023-10-27
US20200017534A1 (en) 2020-01-16
CY1125052T1 (el) 2024-02-16
RS62946B1 (sr) 2022-03-31
IL265445A (en) 2019-05-30
US10730896B2 (en) 2020-08-04
US20220275011A1 (en) 2022-09-01
SI3515924T1 (sl) 2022-04-29
MY193080A (en) 2022-09-26
US20210009614A1 (en) 2021-01-14
HUE057772T2 (hu) 2022-06-28
CN109715639A (zh) 2019-05-03
CN109715639B (zh) 2022-04-19
LT3515924T (lt) 2022-03-10
KR20190052704A (ko) 2019-05-16
US11365209B2 (en) 2022-06-21
AU2017331930B2 (en) 2021-07-15
US12227532B2 (en) 2025-02-18
IL265445B2 (en) 2024-05-01
MX2019003093A (es) 2019-07-18
EP3515924A1 (en) 2019-07-31
EP3515924B1 (en) 2021-12-15

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