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DK3573600T3 - Fremgangsmåde til fremstilling af en stabil emulsion til peptidlevering - Google Patents

Fremgangsmåde til fremstilling af en stabil emulsion til peptidlevering Download PDF

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Publication number
DK3573600T3
DK3573600T3 DK18710760.2T DK18710760T DK3573600T3 DK 3573600 T3 DK3573600 T3 DK 3573600T3 DK 18710760 T DK18710760 T DK 18710760T DK 3573600 T3 DK3573600 T3 DK 3573600T3
Authority
DK
Denmark
Prior art keywords
pepti
delivery
preparing
procedure
stable emulsion
Prior art date
Application number
DK18710760.2T
Other languages
English (en)
Inventor
Jean-Pascal Conduzorgues
Original Assignee
Ose Immunotherapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ose Immunotherapeutics filed Critical Ose Immunotherapeutics
Application granted granted Critical
Publication of DK3573600T3 publication Critical patent/DK3573600T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00118Cancer antigens from embryonic or fetal origin
    • A61K39/001182Carcinoembryonic antigen [CEA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001184Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203Receptors for growth factors
    • A61K40/4205Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4264Cancer antigens from embryonic or fetal origin
    • A61K40/4266Carcinoembryonic antigen [CEA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4267Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • General Preparation And Processing Of Foods (AREA)
DK18710760.2T 2017-01-25 2018-01-24 Fremgangsmåde til fremstilling af en stabil emulsion til peptidlevering DK3573600T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17305079 2017-01-25
PCT/EP2018/051647 WO2018138110A1 (en) 2017-01-25 2018-01-24 Method for manufacturing a stable emulsion for peptide delivery

Publications (1)

Publication Number Publication Date
DK3573600T3 true DK3573600T3 (da) 2022-05-09

Family

ID=57965869

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18710760.2T DK3573600T3 (da) 2017-01-25 2018-01-24 Fremgangsmåde til fremstilling af en stabil emulsion til peptidlevering

Country Status (25)

Country Link
US (2) US11325959B2 (da)
EP (3) EP4029494B1 (da)
JP (1) JP7140778B2 (da)
KR (1) KR102577036B1 (da)
CN (2) CN110191703B (da)
AR (1) AR113209A1 (da)
AU (1) AU2018213890B2 (da)
BR (1) BR112019014917A2 (da)
CA (1) CA3047492C (da)
CY (1) CY1125239T1 (da)
DK (1) DK3573600T3 (da)
ES (1) ES2913268T3 (da)
HR (1) HRP20220605T1 (da)
HU (1) HUE058717T2 (da)
IL (1) IL267237B2 (da)
LT (1) LT3573600T (da)
MX (1) MX2019008878A (da)
PL (1) PL3573600T3 (da)
PT (1) PT3573600T (da)
RS (1) RS63259B1 (da)
SI (1) SI3573600T1 (da)
SM (1) SMT202200189T1 (da)
TW (1) TWI793099B (da)
WO (1) WO2018138110A1 (da)
ZA (1) ZA201905487B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2913268T3 (es) 2017-01-25 2022-06-01 Ose Immunotherapeutics Método para fabricar una emulsión estable para la administración de péptidos
BR112021011982A2 (pt) 2018-12-21 2021-09-14 Ose Immunotherapeutics Anticorpo anti-humano-pd-1 humanizado

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2456666T3 (es) * 2003-04-18 2014-04-23 Biotech Synergy, Inc. Péptidos antígenos HLA-A2 asociados a un tumor y composiciones
ES2545457T3 (es) 2006-10-17 2015-09-11 Oncotherapy Science, Inc. Vacunas de péptidos para cánceres que expresan los polipéptidos DEPDC1
TWI494319B (zh) 2007-02-21 2015-08-01 Oncotherapy Science Inc 表現腫瘤相關抗原之癌症的胜肽疫苗
MX2010002001A (es) 2007-08-20 2010-03-11 Oncotherapy Science Inc Peptido cdca1 y agente farmaceutico que comprende elmismo.
US20110104101A1 (en) 2008-03-06 2011-05-05 University Of Medicine And Dentistry Of New Jersey Immunotherapy for Unresectable Pancreatic Cancer
CN104086625B (zh) 2008-10-22 2016-08-31 肿瘤疗法科学股份有限公司 Rab6kifl/kif20a表位肽及包含它的疫苗
TWI507204B (zh) 2009-05-26 2015-11-11 Oncotherapy Science Inc Cdc45l胜肽與含此胜肽之疫苗
EP2292258A1 (en) 2009-08-18 2011-03-09 Pevion Biotech Ltd. Multiepitope vaccine for Her2/neu-associated cancers
TW201124530A (en) 2009-12-01 2011-07-16 Oncotherapy Science Inc IMP-3 oligopeptides and vaccines including the same
AU2011225577B2 (en) 2010-03-11 2017-01-19 Oncotherapy Science, Inc. HJURP peptides and vaccines including the same
TW201216982A (en) 2010-10-21 2012-05-01 Oncotherapy Science Inc WDHD1 peptides and vaccines including the same
JP2014500001A (ja) 2010-10-21 2014-01-09 オンコセラピー・サイエンス株式会社 C18orf54ペプチドおよびそれを含むワクチン
MY166516A (en) 2010-12-02 2018-07-05 Oncotherapy Science Inc Tomm34 peptides and vaccines including the same
TW201302800A (zh) 2011-06-10 2013-01-16 Oncotherapy Science Inc Sema5b胜肽及含其之疫苗
CA2842887C (en) 2011-08-12 2021-01-19 Oncotherapy Science, Inc. Mphosph1 peptides and vaccines including the same
RU2633503C2 (ru) 2011-10-28 2017-10-12 Онкотерапи Сайенс, Инк. Пептиды торк и содержащие их вакцины
EP2785375B1 (en) 2011-11-28 2020-07-22 Merck Patent GmbH Anti-pd-l1 antibodies and uses thereof
RU2663350C2 (ru) 2012-09-11 2018-08-03 Онкотерапи Сайенс, Инк. Пептиды ube2t и содержащие их вакцины
CN105163754B (zh) 2012-09-20 2018-01-05 王荣福 前列腺特异性肿瘤抗原及其用途
CA2898457A1 (en) 2013-02-14 2014-08-21 Immunocellular Therapeutics, Ltd. Ovarian cancer vaccines and vaccination methods
WO2014136453A1 (en) 2013-03-08 2014-09-12 Oncotherapy Science, Inc. C12orf48 PEPTIDES AND VACCINES CONTAINING THE SAME
WO2014141652A1 (en) 2013-03-11 2014-09-18 Oncotherapy Science, Inc. Smyd3 peptides and vaccines containing the same
TWI658049B (zh) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Kntc2胜肽及含此胜肽之疫苗
JP6419693B2 (ja) 2013-04-01 2018-11-07 学校法人 久留米大学 腫瘍抗原ペプチド
GB2530236A (en) 2014-04-11 2016-03-23 Univ Nottingham Trent PAP Peptide analogues
EP3137100B1 (en) 2014-04-15 2023-12-20 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
EP2944652A1 (en) 2014-05-13 2015-11-18 Technische Universität München Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma
EP3215184B1 (en) * 2014-11-06 2021-03-03 OSE Immunotherapeutics Therapeutic multi-peptides t specific immune therapy for treatment of brain metastasis
EP3313431B1 (en) 2015-06-29 2023-11-15 OSE Immunotherapeutics Method for inducing early t memory response with short peptides anti-tumor vaccine
ES2913268T3 (es) 2017-01-25 2022-06-01 Ose Immunotherapeutics Método para fabricar una emulsión estable para la administración de péptidos
CA3081774A1 (en) 2017-11-27 2019-05-31 Ose Immunotherapeutics Improved treatment of cancer
BR112021011982A2 (pt) 2018-12-21 2021-09-14 Ose Immunotherapeutics Anticorpo anti-humano-pd-1 humanizado
KR20210107062A (ko) 2018-12-21 2021-08-31 오제 이뮈노테라프틱스 이작용성 항-PD-1/SIRPα 분자
CA3123338A1 (en) 2018-12-21 2020-06-25 Ose Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
CA3122899A1 (en) 2018-12-21 2020-06-25 Ose Immunotherapeutics Bifunctional molecule directed against human pd-1

Also Published As

Publication number Publication date
AU2018213890A1 (en) 2019-07-04
AU2018213890B2 (en) 2023-07-20
KR20190107113A (ko) 2019-09-18
US11325959B2 (en) 2022-05-10
HUE058717T2 (hu) 2022-09-28
EP3573600A1 (en) 2019-12-04
EP3573600B1 (en) 2022-03-02
TW201840331A (zh) 2018-11-16
US20220259277A1 (en) 2022-08-18
CN110191703B (zh) 2022-04-08
US11981713B2 (en) 2024-05-14
AR113209A1 (es) 2020-02-19
LT3573600T (lt) 2022-06-27
CN114917189B (zh) 2024-05-14
PT3573600T (pt) 2022-05-11
MX2019008878A (es) 2020-02-13
JP7140778B2 (ja) 2022-09-21
IL267237B1 (en) 2024-06-01
ES2913268T3 (es) 2022-06-01
EP4029494A1 (en) 2022-07-20
KR102577036B1 (ko) 2023-09-08
ZA201905487B (en) 2020-05-27
EP4029494B1 (en) 2025-09-24
US20190345213A1 (en) 2019-11-14
RS63259B1 (sr) 2022-06-30
JP2020505464A (ja) 2020-02-20
IL267237A (en) 2019-08-29
CA3047492A1 (en) 2018-08-02
NZ754471A (en) 2023-12-22
SI3573600T1 (sl) 2022-07-29
IL267237B2 (en) 2024-10-01
PL3573600T3 (pl) 2022-07-11
BR112019014917A2 (pt) 2020-03-31
EP4649954A3 (en) 2025-12-17
WO2018138110A1 (en) 2018-08-02
HRP20220605T1 (hr) 2022-07-08
EP4649954A2 (en) 2025-11-19
TWI793099B (zh) 2023-02-21
SMT202200189T1 (it) 2022-07-21
CN110191703A (zh) 2019-08-30
CA3047492C (en) 2024-01-02
CN114917189A (zh) 2022-08-19
CY1125239T1 (el) 2024-12-13

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