DK3433273T3 - Binding af molekyler til cd38 og pd-l1 - Google Patents
Binding af molekyler til cd38 og pd-l1 Download PDFInfo
- Publication number
- DK3433273T3 DK3433273T3 DK17713672.8T DK17713672T DK3433273T3 DK 3433273 T3 DK3433273 T3 DK 3433273T3 DK 17713672 T DK17713672 T DK 17713672T DK 3433273 T3 DK3433273 T3 DK 3433273T3
- Authority
- DK
- Denmark
- Prior art keywords
- molecules
- binding
- Prior art date
Links
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 title 1
- 102000008096 B7-H1 Antigen Human genes 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 title 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305350 | 2016-03-25 | ||
| PCT/EP2017/057220 WO2017162890A1 (en) | 2016-03-25 | 2017-03-27 | Binding molecules to cd38 and pd-l1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3433273T3 true DK3433273T3 (da) | 2022-02-14 |
Family
ID=55646510
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21214273.1T DK3998285T3 (da) | 2016-03-25 | 2017-03-27 | Bindingsmolekyler til cd38 og pd-l1 |
| DK17713672.8T DK3433273T3 (da) | 2016-03-25 | 2017-03-27 | Binding af molekyler til cd38 og pd-l1 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21214273.1T DK3998285T3 (da) | 2016-03-25 | 2017-03-27 | Bindingsmolekyler til cd38 og pd-l1 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11505616B2 (da) |
| EP (2) | EP3998285B1 (da) |
| JP (2) | JP7529401B2 (da) |
| KR (1) | KR102361412B1 (da) |
| CN (2) | CN109476741B (da) |
| AU (1) | AU2017236183B2 (da) |
| CA (1) | CA3022143A1 (da) |
| DK (2) | DK3998285T3 (da) |
| ES (2) | ES3023551T3 (da) |
| FI (1) | FI3998285T3 (da) |
| HU (2) | HUE070697T2 (da) |
| PL (2) | PL3433273T3 (da) |
| PT (2) | PT3998285T (da) |
| RU (1) | RU2764201C2 (da) |
| SG (1) | SG11201808289SA (da) |
| WO (1) | WO2017162890A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2764201C2 (ru) * | 2016-03-25 | 2022-01-14 | Биомюнё Фармасьютикалз | Связывающиеся с cd38 и pd-l1 молекулы |
| SG11201809316XA (en) * | 2016-04-28 | 2018-11-29 | Biomunex Pharmaceuticals | Bispecific antibodies targeting egfr and her2 |
| KR102589422B1 (ko) * | 2017-01-09 | 2023-10-13 | 바이오뮤넥스 파마슈티컬스 | 다중특이적 항체를 제조하기 위한 폴리펩티드 링커 |
| SG11201908825TA (en) | 2017-03-27 | 2019-10-30 | Biomunex Pharmaceuticals | Stable multispecific antibodies |
| CN118852460A (zh) * | 2017-12-28 | 2024-10-29 | 尤利乌斯·马克西米利安维尔茨堡大学 | 具有非FcγR依赖性激动活性的肿瘤坏死因子(TNF)受体超家族(TNFRSF)受体-激活抗体融合蛋白(具有非FcγR依赖性激动活性的TNFRSF受体-激活抗体融合蛋白；TRAAFFIAA) |
| EA202091053A1 (ru) * | 2018-01-15 | 2020-12-03 | Ай-Маб Биофарма Юэс Лимитед | Модифицированные c- и ch1-домены |
| MX2020010267A (es) | 2018-03-30 | 2020-11-06 | Merus Nv | Anticuerpo multivalente. |
| EP3866851A4 (en) * | 2018-10-17 | 2022-11-02 | Immunome, Inc. | Exosome-targeting bispecific antibodies |
| WO2020127618A1 (en) * | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
| MX2021007672A (es) | 2018-12-24 | 2021-09-30 | Sanofi Sa | Proteinas de union multiespecificas con dominios fab mutantes. |
| EP4132582A4 (en) * | 2020-04-10 | 2024-07-24 | The Board of Trustees of the Leland Stanford Junior University | TARGETED REDUCTION OF ACTIVATED IMMUNE CELLS |
| JP2022045530A (ja) * | 2020-09-09 | 2022-03-22 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｐｄ－１標的化ｉｌ－２変異体免疫サイトカインとヒトｐｄ－ｌ１に対する抗体との併用療法 |
| CN117203228A (zh) * | 2021-01-11 | 2023-12-08 | 阿迪马布有限责任公司 | 被工程化为优先进行链配对的变体ch1结构域和变体cl结构域以及包括所述变体ch1结构域和所述变体cl结构域的多特异性抗体 |
| WO2023238949A1 (ja) | 2022-06-10 | 2023-12-14 | 富士フイルム株式会社 | 細胞の作出方法、ヘテロ多量体タンパク質の製造方法、バイスペシフィック抗体の製造方法、ベクターセット、哺乳動物細胞、ｃｈｏ細胞、及び細胞プールの作出方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DK1272647T3 (da) * | 2000-04-11 | 2014-12-15 | Genentech Inc | Multivalente antistoffer og anvendelser deraf |
| CA2555185C (en) * | 2004-02-06 | 2020-03-24 | Morphosys Ag | Anti-cd38 human antibodies and uses therefor |
| EA015584B1 (ru) * | 2005-03-23 | 2011-10-31 | Генмаб А/С | Антитело к cd38 человека и его применение |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| TW201138821A (en) * | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| US9409950B2 (en) | 2010-12-23 | 2016-08-09 | Biogen Ma Inc. | Linker peptides and polypeptides comprising same |
| SG10201602371VA (en) | 2011-03-25 | 2016-04-28 | Glenmark Pharmaceuticals Sa | Hetero-dimeric immunoglobulins |
| EP2543680A1 (en) | 2011-07-07 | 2013-01-09 | Centre National de la Recherche Scientifique | Multispecific mutated antibody Fab fragments |
| US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| WO2014028776A1 (en) | 2012-08-15 | 2014-02-20 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
| US10047163B2 (en) | 2013-02-08 | 2018-08-14 | Abbvie Stemcentrx Llc | Multispecific constructs |
| BR112016009919A2 (pt) | 2013-11-04 | 2017-12-05 | Glenmark Pharmaceuticals Sa | imunoglobulina hetero-dimérica ou fragmento da mesma e método para produzir in vitro uma imunoglobulina hetero-dimérica ou fragmento da mesma |
| EP3954713A3 (en) | 2014-03-28 | 2022-03-30 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
| EP3143043B1 (en) | 2014-05-16 | 2022-12-14 | Pfizer Inc. | Bispecific antibodies with engineered ch1-cl interfaces |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| JP6952605B2 (ja) | 2015-04-24 | 2021-10-20 | ジェネンテック， インコーポレイテッド | 多特異性抗原結合タンパク質 |
| RU2764201C2 (ru) * | 2016-03-25 | 2022-01-14 | Биомюнё Фармасьютикалз | Связывающиеся с cd38 и pd-l1 молекулы |
| SG11201809316XA (en) | 2016-04-28 | 2018-11-29 | Biomunex Pharmaceuticals | Bispecific antibodies targeting egfr and her2 |
| WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
| KR102589422B1 (ko) | 2017-01-09 | 2023-10-13 | 바이오뮤넥스 파마슈티컬스 | 다중특이적 항체를 제조하기 위한 폴리펩티드 링커 |
| SG11201908825TA (en) | 2017-03-27 | 2019-10-30 | Biomunex Pharmaceuticals | Stable multispecific antibodies |
| MY202919A (en) | 2017-09-22 | 2024-05-29 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
| GB201814562D0 (en) | 2018-09-07 | 2018-10-24 | Hummingbird Bioscience Pte Ltd | Vista antigen-binding molecules |
| US20190300610A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
| WO2019185164A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Holdings Pte. Ltd. | Her3 antigen-binding molecules |
| GB201913079D0 (en) | 2019-09-11 | 2019-10-23 | Hummingbird Bioscience Holdings Pte Ltd | Treatment and prevention of cancer using her3 antigen-binding molecules |
-
2017
- 2017-03-27 RU RU2018137419A patent/RU2764201C2/ru active
- 2017-03-27 HU HUE21214273A patent/HUE070697T2/hu unknown
- 2017-03-27 PT PT212142731T patent/PT3998285T/pt unknown
- 2017-03-27 AU AU2017236183A patent/AU2017236183B2/en active Active
- 2017-03-27 PL PL17713672T patent/PL3433273T3/pl unknown
- 2017-03-27 KR KR1020187030790A patent/KR102361412B1/ko active Active
- 2017-03-27 DK DK21214273.1T patent/DK3998285T3/da active
- 2017-03-27 PT PT177136728T patent/PT3433273T/pt unknown
- 2017-03-27 PL PL21214273.1T patent/PL3998285T3/pl unknown
- 2017-03-27 DK DK17713672.8T patent/DK3433273T3/da active
- 2017-03-27 HU HUE17713672A patent/HUE057657T2/hu unknown
- 2017-03-27 WO PCT/EP2017/057220 patent/WO2017162890A1/en not_active Ceased
- 2017-03-27 EP EP21214273.1A patent/EP3998285B1/en active Active
- 2017-03-27 CN CN201780028279.6A patent/CN109476741B/zh active Active
- 2017-03-27 ES ES21214273T patent/ES3023551T3/es active Active
- 2017-03-27 CA CA3022143A patent/CA3022143A1/en active Pending
- 2017-03-27 EP EP17713672.8A patent/EP3433273B1/en active Active
- 2017-03-27 JP JP2019501761A patent/JP7529401B2/ja active Active
- 2017-03-27 ES ES17713672T patent/ES2906639T3/es active Active
- 2017-03-27 FI FIEP21214273.1T patent/FI3998285T3/fi active
- 2017-03-27 CN CN202310140318.9A patent/CN116284428A/zh active Pending
- 2017-03-27 US US16/088,181 patent/US11505616B2/en active Active
- 2017-03-27 SG SG11201808289SA patent/SG11201808289SA/en unknown
-
2022
- 2022-05-25 JP JP2022085095A patent/JP2022116166A/ja active Pending
- 2022-11-17 US US18/056,279 patent/US20230146591A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2764201C2 (ru) | 2022-01-14 |
| JP7529401B2 (ja) | 2024-08-06 |
| CN116284428A (zh) | 2023-06-23 |
| JP2022116166A (ja) | 2022-08-09 |
| PT3433273T (pt) | 2022-02-21 |
| HUE070697T2 (hu) | 2025-06-28 |
| PT3998285T (pt) | 2025-04-14 |
| AU2017236183A1 (en) | 2018-11-15 |
| US20230146591A1 (en) | 2023-05-11 |
| RU2018137419A (ru) | 2020-04-27 |
| PL3998285T3 (pl) | 2025-06-09 |
| EP3998285A1 (en) | 2022-05-18 |
| HUE057657T2 (hu) | 2022-06-28 |
| DK3998285T3 (da) | 2025-04-14 |
| EP3433273B1 (en) | 2021-12-29 |
| FI3998285T3 (fi) | 2025-04-08 |
| ES3023551T3 (en) | 2025-06-02 |
| CA3022143A1 (en) | 2017-09-28 |
| AU2017236183B2 (en) | 2024-03-07 |
| CN109476741A (zh) | 2019-03-15 |
| KR102361412B1 (ko) | 2022-02-09 |
| US11505616B2 (en) | 2022-11-22 |
| CN109476741B (zh) | 2023-02-24 |
| ES2906639T3 (es) | 2022-04-19 |
| JP2019516396A (ja) | 2019-06-20 |
| EP3433273A1 (en) | 2019-01-30 |
| EP3998285B1 (en) | 2025-01-22 |
| RU2018137419A3 (da) | 2020-08-17 |
| WO2017162890A1 (en) | 2017-09-28 |
| KR20190016942A (ko) | 2019-02-19 |
| PL3433273T3 (pl) | 2022-04-04 |
| SG11201808289SA (en) | 2018-10-30 |
| US20200010559A1 (en) | 2020-01-09 |
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