DK3377612T3 - Funktionel ekspression af monooxygenaser og fremgangsmåder til anvendelse - Google Patents
Funktionel ekspression af monooxygenaser og fremgangsmåder til anvendelse Download PDFInfo
- Publication number
- DK3377612T3 DK3377612T3 DK16867180.8T DK16867180T DK3377612T3 DK 3377612 T3 DK3377612 T3 DK 3377612T3 DK 16867180 T DK16867180 T DK 16867180T DK 3377612 T3 DK3377612 T3 DK 3377612T3
- Authority
- DK
- Denmark
- Prior art keywords
- monooxygenases
- methods
- functional expression
- expression
- functional
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/26—Processes using, or culture media containing, hydrocarbons
- C12N1/28—Processes using, or culture media containing, hydrocarbons aliphatic
- C12N1/30—Processes using, or culture media containing, hydrocarbons aliphatic having five or less carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13025—Methane monooxygenase (1.14.13.25)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257061P | 2015-11-18 | 2015-11-18 | |
| US201562270039P | 2015-12-21 | 2015-12-21 | |
| US201662320725P | 2016-04-11 | 2016-04-11 | |
| PCT/US2016/062623 WO2017087731A1 (en) | 2015-11-18 | 2016-11-17 | Functional expression of monooxygenases and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3377612T3 true DK3377612T3 (da) | 2021-12-13 |
Family
ID=58717965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16867180.8T DK3377612T3 (da) | 2015-11-18 | 2016-11-17 | Funktionel ekspression af monooxygenaser og fremgangsmåder til anvendelse |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10894951B2 (da) |
| EP (2) | EP3377612B1 (da) |
| CN (1) | CN108779429B (da) |
| AU (1) | AU2016358063B2 (da) |
| CA (1) | CA3005460A1 (da) |
| DK (1) | DK3377612T3 (da) |
| ES (1) | ES2905957T3 (da) |
| MY (1) | MY197415A (da) |
| WO (1) | WO2017087731A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3132022A4 (en) * | 2014-04-15 | 2017-12-13 | Industrial Microbes, Inc. | Synthetic methanotrophic and methylotrophic microorganisms |
| EP3093337A3 (en) * | 2015-05-13 | 2017-03-15 | Samsung Electronics Co., Ltd. | Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same |
| EP3377612B1 (en) * | 2015-11-18 | 2021-09-15 | Industrial Microbes, Inc. | Functional expression of monooxygenases and methods of use |
| US20200048639A1 (en) * | 2017-02-17 | 2020-02-13 | Industrial Microbes, Inc. | Culture modified to convert methane or methanol to 3-hydroxyproprionate |
| CA3069253A1 (en) * | 2017-07-07 | 2019-01-10 | Industrial Microbes, Inc. | Improved methane monooxygenase enzymes |
| US12084705B2 (en) | 2018-04-04 | 2024-09-10 | United States Of America As Represented By The Administrator Of Nasa | Methylotrophic microorganisms expressing soluble methane monooxygenase proteins |
| EP3613850A1 (en) * | 2018-08-22 | 2020-02-26 | Evonik Operations GmbH | Amino acid production |
| CA3103413C (en) | 2019-12-30 | 2023-04-25 | Marathon Petroleum Company Lp | Methods and systems for inline mixing of hydrocarbon liquids based on density or gravity |
| US11607654B2 (en) | 2019-12-30 | 2023-03-21 | Marathon Petroleum Company Lp | Methods and systems for in-line mixing of hydrocarbon liquids |
| US11559774B2 (en) | 2019-12-30 | 2023-01-24 | Marathon Petroleum Company Lp | Methods and systems for operating a pump at an efficiency point |
| US11247184B2 (en) | 2019-12-30 | 2022-02-15 | Marathon Petroleum Company Lp | Methods and systems for spillback control of in-line mixing of hydrocarbon liquids |
| WO2022103799A1 (en) | 2020-11-10 | 2022-05-19 | Industrial Microbes, Inc. | Microorganisms capable of producing poly(hiba) from feedstock |
| WO2022165158A1 (en) * | 2021-01-29 | 2022-08-04 | Industrial Microbes, Inc. | Ethane or ethanol into 3-hydroxypropionate using an engineered microorganism |
| US12012883B2 (en) | 2021-03-16 | 2024-06-18 | Marathon Petroleum Company Lp | Systems and methods for backhaul transportation of liquefied gas and CO2 using liquefied gas carriers |
| US11578638B2 (en) | 2021-03-16 | 2023-02-14 | Marathon Petroleum Company Lp | Scalable greenhouse gas capture systems and methods |
| US11578836B2 (en) | 2021-03-16 | 2023-02-14 | Marathon Petroleum Company Lp | Scalable greenhouse gas capture systems and methods |
| US11655940B2 (en) | 2021-03-16 | 2023-05-23 | Marathon Petroleum Company Lp | Systems and methods for transporting fuel and carbon dioxide in a dual fluid vessel |
| CN113249238B (zh) * | 2021-05-07 | 2022-08-23 | 江南大学 | 一株耐酸酿酒酵母及其在有机酸制备中的应用 |
| US12129559B2 (en) | 2021-08-26 | 2024-10-29 | Marathon Petroleum Company Lp | Test station assemblies for monitoring cathodic protection of structures and related methods |
| US12180597B2 (en) | 2021-08-26 | 2024-12-31 | Marathon Petroleum Company Lp | Test station assemblies for monitoring cathodic protection of structures and related methods |
| US11447877B1 (en) | 2021-08-26 | 2022-09-20 | Marathon Petroleum Company Lp | Assemblies and methods for monitoring cathodic protection of structures |
| US12043905B2 (en) | 2021-08-26 | 2024-07-23 | Marathon Petroleum Company Lp | Electrode watering assemblies and methods for maintaining cathodic monitoring of structures |
| US11686070B1 (en) | 2022-05-04 | 2023-06-27 | Marathon Petroleum Company Lp | Systems, methods, and controllers to enhance heavy equipment warning |
| CN117050981A (zh) * | 2022-05-07 | 2023-11-14 | 中国科学院深圳先进技术研究院 | 一种微生物菌微胶囊的制备方法、微生物菌群的合成方法 |
| CN114807182B (zh) * | 2022-06-07 | 2023-07-25 | 天津大学 | 降解长链烷烃的酵母菌株及其应用 |
| US12012082B1 (en) | 2022-12-30 | 2024-06-18 | Marathon Petroleum Company Lp | Systems and methods for a hydraulic vent interlock |
| US12043361B1 (en) | 2023-02-18 | 2024-07-23 | Marathon Petroleum Company Lp | Exhaust handling systems for marine vessels and related methods |
| US12006014B1 (en) | 2023-02-18 | 2024-06-11 | Marathon Petroleum Company Lp | Exhaust vent hoods for marine vessels and related methods |
| WO2024243248A2 (en) * | 2023-05-22 | 2024-11-28 | Dmc Biotechnologies, Inc. | Methods and microorganisms for production of a product using ethanol as a carbon source |
| US12297965B2 (en) | 2023-08-09 | 2025-05-13 | Marathon Petroleum Company Lp | Systems and methods for mixing hydrogen with natural gas |
| US12087002B1 (en) | 2023-09-18 | 2024-09-10 | Marathon Petroleum Company Lp | Systems and methods to determine depth of soil coverage along a right-of-way |
| CN117126875B (zh) * | 2023-10-20 | 2024-02-06 | 中国农业科学院生物技术研究所 | 一种适用于毕赤酵母的4-异丙基苯甲酸诱导表达系统及诱导表达方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050176121A1 (en) * | 2001-09-06 | 2005-08-11 | Ryo Takeshita | Method for producing alcohol by using microorganism |
| RU2294370C2 (ru) * | 2001-09-06 | 2007-02-27 | Адзиномото Ко., Инк. | Способ получения спирта с использованием микроорганизма |
| US7723498B2 (en) | 2004-06-04 | 2010-05-25 | University Of Connecticut | Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use |
| US8535916B2 (en) | 2006-02-13 | 2013-09-17 | Ls9, Inc. | Modified microorganisms and uses therefor |
| WO2010118409A1 (en) | 2009-04-10 | 2010-10-14 | Ls9, Inc. | Production of commercial biodiesel from genetically modified microorganisms |
| WO2011066076A1 (en) * | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone |
| US9663791B2 (en) * | 2011-04-29 | 2017-05-30 | Cj Research Center Llc | Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock |
| GB201201178D0 (en) | 2012-01-25 | 2012-03-07 | Sinvent As | Novel enzymes |
| US9081378B2 (en) | 2012-02-10 | 2015-07-14 | General Electric Company | Methods and apparatuses for advanced multiple variable control with high dimension multiple constraints |
| BR112015000671A2 (pt) | 2012-07-13 | 2017-06-27 | Calysta Inc | sistema de biorrefinaria, métodos e composições dos mesmos. |
| US9816111B2 (en) | 2012-09-18 | 2017-11-14 | Calysta, Inc. | Propylene synthesis using engineered enzymes |
| US9267158B2 (en) | 2013-03-14 | 2016-02-23 | Intrexon Corporation | Biological production of multi-carbon compounds from methane |
| BR112016001026A2 (pt) * | 2013-07-19 | 2017-10-24 | Cargill Inc | organismo geneticamente modificado |
| WO2015013295A1 (en) * | 2013-07-22 | 2015-01-29 | Lygos, Inc. | Recombinant production of chemicals from methane or methanol |
| US10323232B2 (en) | 2013-10-15 | 2019-06-18 | Mogene Lc | Metabolically engineered methanotrophic, phototrophic microorganisms |
| EP3132022A4 (en) * | 2014-04-15 | 2017-12-13 | Industrial Microbes, Inc. | Synthetic methanotrophic and methylotrophic microorganisms |
| EP3093337A3 (en) | 2015-05-13 | 2017-03-15 | Samsung Electronics Co., Ltd. | Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same |
| EP3377612B1 (en) * | 2015-11-18 | 2021-09-15 | Industrial Microbes, Inc. | Functional expression of monooxygenases and methods of use |
| US20170183638A1 (en) | 2015-12-23 | 2017-06-29 | Samsung Electronics Co., Ltd. | Soluble methane monooxygenase protein variant and method of reducing concentration of fluorinated methane in sample using the same |
-
2016
- 2016-11-17 EP EP16867180.8A patent/EP3377612B1/en active Active
- 2016-11-17 US US15/777,158 patent/US10894951B2/en active Active
- 2016-11-17 EP EP21163129.6A patent/EP3926038A3/en active Pending
- 2016-11-17 DK DK16867180.8T patent/DK3377612T3/da active
- 2016-11-17 AU AU2016358063A patent/AU2016358063B2/en active Active
- 2016-11-17 CN CN201680079252.5A patent/CN108779429B/zh active Active
- 2016-11-17 WO PCT/US2016/062623 patent/WO2017087731A1/en not_active Ceased
- 2016-11-17 ES ES16867180T patent/ES2905957T3/es active Active
- 2016-11-17 CA CA3005460A patent/CA3005460A1/en active Pending
- 2016-11-17 MY MYPI2018000776A patent/MY197415A/en unknown
-
2021
- 2021-01-14 US US17/149,394 patent/US11692177B2/en active Active
-
2023
- 2023-06-30 US US18/217,021 patent/US12448609B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3005460A1 (en) | 2017-05-26 |
| EP3377612A4 (en) | 2019-07-24 |
| US12448609B2 (en) | 2025-10-21 |
| EP3377612A1 (en) | 2018-09-26 |
| AU2016358063A1 (en) | 2018-05-31 |
| US10894951B2 (en) | 2021-01-19 |
| CN108779429B (zh) | 2022-12-23 |
| US11692177B2 (en) | 2023-07-04 |
| US20210254026A1 (en) | 2021-08-19 |
| CN108779429A (zh) | 2018-11-09 |
| EP3926038A2 (en) | 2021-12-22 |
| ES2905957T3 (es) | 2022-04-12 |
| MY197415A (en) | 2023-06-16 |
| US20240043816A1 (en) | 2024-02-08 |
| EP3926038A3 (en) | 2022-03-16 |
| WO2017087731A1 (en) | 2017-05-26 |
| AU2016358063B2 (en) | 2022-08-11 |
| EP3377612B1 (en) | 2021-09-15 |
| US20190032028A1 (en) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3377612T3 (da) | Funktionel ekspression af monooxygenaser og fremgangsmåder til anvendelse | |
| IL271025A (en) | Multibiotic agents and methods of using the same | |
| DK3317284T3 (da) | Benzoxazepin-oxazolidinonforbindelser og fremgangsmåder til anvendelse | |
| DK3234133T3 (da) | Crispr-baserede sammensætninger og fremgangsmåder til anvendelse | |
| DK3436048T3 (da) | Neoantigener og fremgangsmåder til anvendelse deraf | |
| DK3394065T3 (da) | Tetrahydropyranyl-amino-pyrrolopyrimidinon og fremgangsmåder til anvendelse deraf | |
| DK3429596T3 (da) | Cykliske dinukleotide forbindelser og brugs metoder | |
| DK3353210T3 (da) | Anti-TIGIT-antistoffer og fremgangsmåder til anvendelse | |
| DK3386484T3 (da) | Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler | |
| DK3828194T3 (da) | Oxysteroler og fremgangsmåder til anvendelse deraf | |
| DK3368069T3 (da) | Anvendelse af myostatininhibitorer og kombinationsterapier | |
| DK3529257T3 (da) | Oxysteroler og fremgangsmåder til anvendelse deraf | |
| DK3653221T3 (da) | Anti-pvrig-antistoffer og anvendelsesfremgangsmåder | |
| DK4105223T3 (da) | Oxysteroler og fremgangsmåder til anvendelse deraf | |
| DK3144001T3 (da) | Sammensætninger af selenoorganiske forbindelser og fremgangsmåder til anvendelse deraf | |
| DK3215532T3 (da) | Anti-TIM3-antistoffer og fremgangsmåder til anvendelse | |
| DK3102673T3 (da) | Fremgangsmåder og sammensætninger til behandling af beta-talassæmi | |
| DK3212226T3 (da) | Sammensætninger og anvendelsesfremgangsmåder til behandling af metaboliske lidelser | |
| DK3557998T3 (da) | Sammensætninger, kompositioner og anvendelsesmetoder | |
| DK3548033T3 (da) | Forbindelser og deres fremgangsmåde til anvendelse | |
| DK3259597T3 (da) | Pvrig-polypeptider og fremgangsmåder til behandling | |
| DK3426781T3 (da) | Mikro-rna'er og fremgangsmåder til anvendelse deraf | |
| DK3089971T3 (da) | Forbindelser og fremgangsmåder til anvendelse | |
| DK3288553T3 (da) | Kombinationer af cannabinoider og n-acylethanolaminer | |
| DK3484469T3 (da) | Sammensætninger og fremgangsmåder til potentiering af antimikrober |