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DK3335140T3 - Systemer, apparater og fremgangsmåder til analyse og prognose af cellulære veje - Google Patents

Systemer, apparater og fremgangsmåder til analyse og prognose af cellulære veje Download PDF

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Publication number
DK3335140T3
DK3335140T3 DK16835817.4T DK16835817T DK3335140T3 DK 3335140 T3 DK3335140 T3 DK 3335140T3 DK 16835817 T DK16835817 T DK 16835817T DK 3335140 T3 DK3335140 T3 DK 3335140T3
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DK
Denmark
Prior art keywords
prognosis
analysis
systems
methods
cellular pathways
Prior art date
Application number
DK16835817.4T
Other languages
English (en)
Inventor
Leila Pirhaji
Ernest Fraenkel
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK3335140T3 publication Critical patent/DK3335140T3/da

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DK16835817.4T 2015-08-10 2016-08-10 Systemer, apparater og fremgangsmåder til analyse og prognose af cellulære veje DK3335140T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562203292P 2015-08-10 2015-08-10
US201662368715P 2016-07-29 2016-07-29
PCT/US2016/046289 WO2017027559A1 (en) 2015-08-10 2016-08-10 Systems, apparatus, and methods for analyzing and predicting cellular pathways

Publications (1)

Publication Number Publication Date
DK3335140T3 true DK3335140T3 (da) 2025-04-22

Family

ID=57984512

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16835817.4T DK3335140T3 (da) 2015-08-10 2016-08-10 Systemer, apparater og fremgangsmåder til analyse og prognose af cellulære veje

Country Status (4)

Country Link
US (1) US10446259B2 (da)
EP (1) EP3335140B1 (da)
DK (1) DK3335140T3 (da)
WO (1) WO2017027559A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11024403B2 (en) * 2018-01-22 2021-06-01 X Development Llc Method for analyzing and optimizing metabolic networks
CN108647490B (zh) * 2018-05-04 2022-06-17 安徽大学 基于多目标进化算法的大规模蛋白质功能模块识别方法和系统
CN110806456B (zh) * 2019-11-12 2022-03-15 浙江工业大学 一种UPLC-HRMS Profile模式非靶向代谢轮廓数据自动解析的方法
CN112986411B (zh) * 2019-12-17 2022-08-09 中国科学院地理科学与资源研究所 一种生物代谢物筛查方法
CN112305119B (zh) * 2020-10-30 2021-08-17 河北医科大学第二医院 动脉粥样硬化性脑梗死的生物标志物及其应用
CN115112778B (zh) * 2021-03-19 2023-08-04 复旦大学 一种疾病蛋白质生物标志物鉴定方法
CN114923992B (zh) * 2022-03-29 2023-05-26 中国科学院上海有机化学研究所 鉴定已知和未知代谢物的分析方法、装置和设备
CN119007827B (zh) * 2024-10-24 2025-05-23 焕一生物科技(杭州)有限公司 通路数据库拓展方法、系统、存储介质及电子设备
CN120125779B (zh) * 2025-05-13 2025-07-25 上海交通大学医学院附属仁济医院 基于人工智能的肿瘤细胞代谢物分布三维重建方法及系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7444308B2 (en) * 2001-06-15 2008-10-28 Health Discovery Corporation Data mining platform for bioinformatics and other knowledge discovery
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US8396884B2 (en) 2006-02-27 2013-03-12 The Regents Of The University Of California Graph querying, graph motif mining and the discovery of clusters
US8612160B2 (en) 2008-11-14 2013-12-17 Massachusetts Institute Of Technology Identifying biological response pathways
EP2577535A4 (en) 2010-06-02 2014-10-22 Univ Texas METHOD AND SYSTEMS FOR SIMULATING COMPLEX BIOLOGICAL NETWORKS WITH GENE EXPRESSION INDICATION IN CALCULATION MODELS

Also Published As

Publication number Publication date
US20170046476A1 (en) 2017-02-16
US10446259B2 (en) 2019-10-15
EP3335140A4 (en) 2019-05-22
EP3335140B1 (en) 2025-02-19
EP3335140A1 (en) 2018-06-20
WO2017027559A1 (en) 2017-02-16

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