DK3325488T3 - Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer - Google Patents
Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer Download PDFInfo
- Publication number
- DK3325488T3 DK3325488T3 DK16828471.9T DK16828471T DK3325488T3 DK 3325488 T3 DK3325488 T3 DK 3325488T3 DK 16828471 T DK16828471 T DK 16828471T DK 3325488 T3 DK3325488 T3 DK 3325488T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- treatment
- chiral diaryl
- macrocycle
- diaryl macrocycle
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- -1 diaryl macrocycle Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195081P | 2015-07-21 | 2015-07-21 | |
| US201662302231P | 2016-03-02 | 2016-03-02 | |
| PCT/US2016/043132 WO2017015367A1 (en) | 2015-07-21 | 2016-07-20 | Chiral diaryl macrocycles and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3325488T3 true DK3325488T3 (da) | 2020-09-14 |
Family
ID=57834656
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16828471.9T DK3325488T3 (da) | 2015-07-21 | 2016-07-20 | Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer |
| DK20181616.2T DK3733187T3 (da) | 2015-07-21 | 2016-07-20 | Chiral diarylmakrocyklus og anvendelse deraf i behandling af cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20181616.2T DK3733187T3 (da) | 2015-07-21 | 2016-07-20 | Chiral diarylmakrocyklus og anvendelse deraf i behandling af cancer |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20180325901A1 (da) |
| EP (3) | EP4480543A3 (da) |
| JP (1) | JP6817287B2 (da) |
| KR (1) | KR102772574B1 (da) |
| CN (1) | CN108026109B (da) |
| AU (1) | AU2016296878B2 (da) |
| BR (1) | BR112018001065A2 (da) |
| CA (1) | CA2992324A1 (da) |
| DK (2) | DK3325488T3 (da) |
| ES (2) | ES2818528T3 (da) |
| FI (1) | FI3733187T3 (da) |
| HR (1) | HRP20241615T1 (da) |
| HU (1) | HUE070316T2 (da) |
| IL (1) | IL256868B (da) |
| LT (1) | LT3733187T (da) |
| MX (1) | MX383823B (da) |
| PL (1) | PL3733187T3 (da) |
| PT (1) | PT3733187T (da) |
| RS (1) | RS66238B1 (da) |
| RU (2) | RU2728579C2 (da) |
| SI (1) | SI3733187T1 (da) |
| SM (1) | SMT202400496T1 (da) |
| WO (1) | WO2017015367A1 (da) |
| ZA (1) | ZA201800416B (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3636649B1 (en) | 2014-01-24 | 2024-02-14 | Turning Point Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| RU2732405C2 (ru) | 2015-07-02 | 2020-09-16 | Тёрнинг Поинт Терапьютикс, Инк. | Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ |
| WO2017007759A1 (en) * | 2015-07-06 | 2017-01-12 | Tp Therapeutics, Inc. | Diaryl macrocycle polymorph |
| US20180325901A1 (en) | 2015-07-21 | 2018-11-15 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles and uses thereof |
| JP2019527230A (ja) | 2016-07-28 | 2019-09-26 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 大環状キナーゼ阻害剤 |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN107267458B (zh) * | 2017-07-06 | 2019-10-29 | 中南大学湘雅二医院 | 一种耐克唑替尼人的非小细胞肺癌细胞株h3122-cr23及其应用 |
| LT3658148T (lt) | 2017-07-28 | 2024-09-10 | Turning Point Therapeutics, Inc. | Makrocikliniai junginiai ir jų panaudojimas |
| CN109516999B (zh) * | 2017-11-01 | 2021-08-17 | 郑州泰基鸿诺医药股份有限公司 | 用作蛋白质激酶调节剂的化合物及其应用 |
| KR102447084B1 (ko) * | 2017-11-10 | 2022-09-23 | 앤젝스 파마수티컬, 인크. | Trk 키나제 억제제로서의 거대 고리 화합물 및 그의 용도 |
| KR102814342B1 (ko) | 2017-12-19 | 2025-05-29 | 터닝 포인트 테라퓨틱스, 인크. | 질병 치료용 대환식 화합물 |
| WO2019184955A1 (en) * | 2018-03-28 | 2019-10-03 | Fochon Pharmaceuticals, Ltd. | Macrocyclic compounds as trk kinases inhibitors |
| EP3770161B1 (en) * | 2018-04-16 | 2022-08-24 | Shenzhen TargetRx, Inc. | Di(hetero)aryl macrocyclic compound for inhibiting protein kinase activity |
| PL3786167T3 (pl) * | 2018-04-25 | 2024-11-25 | Primegene (Beijing) Co., Ltd. | Diarylowy związek makrocykliczny i kompozycja farmaceutyczna oraz ich zastosowanie |
| CN111918868B (zh) * | 2018-05-04 | 2022-12-30 | 正大天晴药业集团股份有限公司 | 作为蛋白激酶调节剂的二芳基大环化合物 |
| AU2019364336B2 (en) | 2018-10-22 | 2023-11-16 | Alumis Inc. | TYK2 inhibitors and uses thereof |
| CN111171049B (zh) * | 2018-11-09 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂及其用途 |
| PE20220135A1 (es) * | 2019-06-19 | 2022-01-27 | Turning Point Therapeutics Inc | Polimorfos de un inhibidor de cinasas macrociclicas |
| IL293208A (en) * | 2019-11-27 | 2022-07-01 | Turning Point Therapeutics Inc | Combination therapy involving diaryl macrocyclic compounds |
| CN111689883B (zh) * | 2020-05-22 | 2022-02-11 | 上海应用技术大学 | 一种二芳基砜类化合物的合成方法 |
| WO2021244609A1 (zh) * | 2020-06-04 | 2021-12-09 | 成都倍特药业股份有限公司 | 具有大环结构的化合物及其用途 |
| WO2025217347A2 (en) * | 2024-04-11 | 2025-10-16 | Bristol-Myers Squibb Company | Process of preparing repotrectinib |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0690843T3 (da) | 1993-03-25 | 2000-11-13 | Upjohn Co | Fornyl- eller cyanosubstituerede indolderivater med dopaninerg aktivitet |
| NO308798B1 (no) * | 1993-12-07 | 2000-10-30 | Lilly Co Eli | Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| AU2002227371B2 (en) * | 2000-12-08 | 2007-05-10 | Ortho-Mcneil Pharmaceutical, Inc. | Macroheterocylic compounds useful as kinase inhibitors |
| EP2065380A1 (en) * | 2007-08-22 | 2009-06-03 | F.Hoffmann-La Roche Ag | Pyridoneamide derivatives as focal adhesion kinase (FAK) inhibitors and their use for the treatment of cancer |
| CA2735420C (en) | 2008-09-08 | 2016-06-28 | Merck Patent Gmbh | Macrocyclic pyrimidines as protein kinase inhibitors |
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| SG10201914059WA (en) | 2008-10-22 | 2020-03-30 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| CA2740792C (en) | 2008-10-31 | 2016-06-21 | Genentech, Inc. | Pyrazolopyrimidine jak inhibitor compounds and methods |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| EA019558B1 (ru) | 2009-10-13 | 2014-04-30 | Эланко Энимал Хэлс Аиэлэнд Лимитед | Макроциклические ингибиторы интегразы |
| SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| EP2918588B1 (en) | 2010-05-20 | 2017-05-03 | Array Biopharma, Inc. | Macrocyclic compounds as TRK kinase inhibitors |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| EP2508607A1 (en) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| MX2014001944A (es) * | 2011-08-19 | 2014-03-27 | Merck Sharp & Dohme | Formas cristalinas de un inhibidor de la proteasa del virus de la hepatitis c. |
| EA025881B1 (ru) | 2011-09-30 | 2017-02-28 | Онкодизайн С.А. | Макроциклические ингибиторы flt3-киназы |
| EP2822953B9 (en) | 2012-03-06 | 2017-06-21 | Pfizer Inc | Macrocyclic derivatives for the treatment of proliferative diseases |
| WO2013134219A1 (en) * | 2012-03-09 | 2013-09-12 | Lexicon Pharmaceuticals, Inc. | Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof |
| PL2834243T3 (pl) | 2012-03-09 | 2018-09-28 | Lexicon Pharmaceuticals, Inc. | Związki na bazie pirazolo[1,5-a]pirymidyny, zawierające je kompozycje i sposoby ich zastosowania |
| GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| EP3636649B1 (en) | 2014-01-24 | 2024-02-14 | Turning Point Therapeutics, Inc. | Diaryl macrocycles as modulators of protein kinases |
| RU2732405C2 (ru) * | 2015-07-02 | 2020-09-16 | Тёрнинг Поинт Терапьютикс, Инк. | Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ |
| WO2017007759A1 (en) * | 2015-07-06 | 2017-01-12 | Tp Therapeutics, Inc. | Diaryl macrocycle polymorph |
| US20180325901A1 (en) | 2015-07-21 | 2018-11-15 | Tp Therapeutics, Inc. | Chiral diaryl macrocycles and uses thereof |
| JP2019527230A (ja) | 2016-07-28 | 2019-09-26 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 大環状キナーゼ阻害剤 |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| LT3658148T (lt) | 2017-07-28 | 2024-09-10 | Turning Point Therapeutics, Inc. | Makrocikliniai junginiai ir jų panaudojimas |
-
2016
- 2016-07-20 US US15/745,915 patent/US20180325901A1/en not_active Abandoned
- 2016-07-20 AU AU2016296878A patent/AU2016296878B2/en active Active
- 2016-07-20 ES ES16828471T patent/ES2818528T3/es active Active
- 2016-07-20 FI FIEP20181616.2T patent/FI3733187T3/fi active
- 2016-07-20 ES ES20181616T patent/ES2993492T3/es active Active
- 2016-07-20 PL PL20181616.2T patent/PL3733187T3/pl unknown
- 2016-07-20 RU RU2018106245A patent/RU2728579C2/ru active
- 2016-07-20 SM SM20240496T patent/SMT202400496T1/it unknown
- 2016-07-20 HR HRP20241615TT patent/HRP20241615T1/hr unknown
- 2016-07-20 JP JP2018502668A patent/JP6817287B2/ja active Active
- 2016-07-20 DK DK16828471.9T patent/DK3325488T3/da active
- 2016-07-20 RU RU2020123800A patent/RU2020123800A/ru unknown
- 2016-07-20 LT LTEP20181616.2T patent/LT3733187T/lt unknown
- 2016-07-20 CN CN201680052319.6A patent/CN108026109B/zh active Active
- 2016-07-20 EP EP24198628.0A patent/EP4480543A3/en active Pending
- 2016-07-20 KR KR1020187002289A patent/KR102772574B1/ko active Active
- 2016-07-20 PT PT201816162T patent/PT3733187T/pt unknown
- 2016-07-20 EP EP16828471.9A patent/EP3325488B1/en active Active
- 2016-07-20 EP EP20181616.2A patent/EP3733187B1/en active Active
- 2016-07-20 SI SI201631859T patent/SI3733187T1/sl unknown
- 2016-07-20 CA CA2992324A patent/CA2992324A1/en active Pending
- 2016-07-20 HU HUE20181616A patent/HUE070316T2/hu unknown
- 2016-07-20 MX MX2018000718A patent/MX383823B/es unknown
- 2016-07-20 DK DK20181616.2T patent/DK3733187T3/da active
- 2016-07-20 BR BR112018001065-0A patent/BR112018001065A2/pt not_active Application Discontinuation
- 2016-07-20 WO PCT/US2016/043132 patent/WO2017015367A1/en not_active Ceased
- 2016-07-20 RS RS20241314A patent/RS66238B1/sr unknown
-
2018
- 2018-01-11 IL IL256868A patent/IL256868B/en active IP Right Grant
- 2018-01-19 ZA ZA2018/00416A patent/ZA201800416B/en unknown
-
2020
- 2020-08-20 US US16/998,763 patent/US11452725B2/en active Active
-
2022
- 2022-08-15 US US17/819,858 patent/US12310968B2/en active Active
-
2025
- 2025-04-25 US US19/190,116 patent/US20250375451A1/en active Pending
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