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DK3383436T3 - Forbedret fremgangsmåde til fremstilling af indocyaningrønt - Google Patents

Forbedret fremgangsmåde til fremstilling af indocyaningrønt Download PDF

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Publication number
DK3383436T3
DK3383436T3 DK16870081.3T DK16870081T DK3383436T3 DK 3383436 T3 DK3383436 T3 DK 3383436T3 DK 16870081 T DK16870081 T DK 16870081T DK 3383436 T3 DK3383436 T3 DK 3383436T3
Authority
DK
Denmark
Prior art keywords
preparation
improved process
indocyanine green
indocyanine
green
Prior art date
Application number
DK16870081.3T
Other languages
English (en)
Inventor
Janmejay Rajnikant Vyas
Himani DHOTRE
Narasimha Sarma
Babulal R Patel
Dinesh Kumar Sharma
Dilip N Patel
Ashish A Soni
Original Assignee
Dishman Carbogen Amcis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dishman Carbogen Amcis Ltd filed Critical Dishman Carbogen Amcis Ltd
Application granted granted Critical
Publication of DK3383436T3 publication Critical patent/DK3383436T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/60Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • A61K49/0034Indocyanine green, i.e. ICG, cardiogreen
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0071Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
    • C09B67/0092Dyes in solid form
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0096Purification; Precipitation; Filtration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16870081.3T 2015-12-01 2016-11-29 Forbedret fremgangsmåde til fremstilling af indocyaningrønt DK3383436T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4536MU2015 2015-12-01
PCT/IB2016/057178 WO2017093889A1 (en) 2015-12-01 2016-11-29 An improved process for the preparation of indocyanine green

Publications (1)

Publication Number Publication Date
DK3383436T3 true DK3383436T3 (da) 2023-11-20

Family

ID=58796411

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16870081.3T DK3383436T3 (da) 2015-12-01 2016-11-29 Forbedret fremgangsmåde til fremstilling af indocyaningrønt

Country Status (8)

Country Link
US (1) US10287436B2 (da)
EP (1) EP3383436B1 (da)
JP (1) JP2018538428A (da)
KR (1) KR102786409B1 (da)
AU (1) AU2016362673A1 (da)
CA (1) CA3007062A1 (da)
DK (1) DK3383436T3 (da)
WO (1) WO2017093889A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102794967B1 (ko) * 2015-12-01 2025-04-10 디쉬맨 카보젠 아믹스 리미티드 개선된 인디고 카르민의 제조방법
US20190337896A1 (en) * 2018-05-02 2019-11-07 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
CN110885570B (zh) * 2019-12-16 2021-05-25 常州工程职业技术学院 一种近红外染料的制备方法
CN112469698B (zh) * 2020-07-28 2023-05-02 北京数字精准医疗科技有限公司 吲哚菁绿酸三乙胺盐的制备方法
CN112638873B (zh) * 2020-12-01 2023-07-14 珠海市迪谱医疗科技有限公司 吲哚菁绿的精制方法
US20240299549A1 (en) 2021-03-17 2024-09-12 Provepharm Life Solutions Stable formulations of indocyanine green
EP4308081A2 (en) 2021-03-17 2024-01-24 Provepharm Life Solutions Stable formulations of indocyanine green
WO2022194734A1 (en) 2021-03-17 2022-09-22 Provepharm Life Solutions Stable formulations of indocyanine green
IT202100006794A1 (it) 2021-03-22 2022-09-22 Icrom Srl Processo per preparare il verde indocianina
CN113332428B (zh) * 2021-05-31 2022-08-30 南京诺源医疗器械有限公司 一种基于吲哚三碳菁结构的小分子在制备肿瘤光热治疗药物中的应用
KR102635160B1 (ko) 2021-06-14 2024-02-13 농심태경 주식회사 아몬드 단백질 발효물 및 콩 단백의 효소 반응물을 주 단백질원으로 함유하는 식물성 치즈 및 그의 제조방법
EP4519360A1 (en) 2022-05-06 2025-03-12 Provepharm Life Solutions Crystalline indocyanine green and method for the production thereof
WO2023250116A1 (en) * 2022-06-23 2023-12-28 The Children's Medical Center Corporation Indocyanine green (icg) modification for treatment of liver cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580869A (da) 1957-06-05
FR2710060B1 (fr) * 1993-09-17 1995-11-17 Rech Biolog Et Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins.
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
EP1065250B1 (en) * 1999-07-02 2004-12-08 Visen Medical, Inc. New fluorescent cyanine labels containing a sulfamido linker arm
DE102005025560A1 (de) 2005-06-01 2006-12-07 Pulsion Medical Systems Ag Verfahren zur Aufreinigung von Betainen
FR2889700B1 (fr) * 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
US20080181965A1 (en) 2006-04-10 2008-07-31 Leon Jeffrey W Loaded latex optical molecular imaging probes
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
US9329185B2 (en) * 2013-03-15 2016-05-03 University Of Massachusetts Sulfonate compounds
WO2014192972A1 (en) 2013-05-30 2014-12-04 Canon Kabushiki Kaisha Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent
CN104130178A (zh) * 2014-06-30 2014-11-05 辽宁天医生物制药股份有限公司 一种药用吲哚菁绿的工业化合成方法

Also Published As

Publication number Publication date
KR102786409B1 (ko) 2025-03-24
EP3383436A4 (en) 2019-07-03
KR20180087413A (ko) 2018-08-01
AU2016362673A1 (en) 2018-06-28
JP2018538428A (ja) 2018-12-27
US10287436B2 (en) 2019-05-14
WO2017093889A1 (en) 2017-06-08
US20180346728A1 (en) 2018-12-06
EP3383436A1 (en) 2018-10-10
CA3007062A1 (en) 2017-06-08
EP3383436B1 (en) 2023-08-30

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