DK3377049T3 - Crystalline forms of tapentadol salts and process for preparation thereof - Google Patents
Crystalline forms of tapentadol salts and process for preparation thereof Download PDFInfo
- Publication number
- DK3377049T3 DK3377049T3 DK16865892.0T DK16865892T DK3377049T3 DK 3377049 T3 DK3377049 T3 DK 3377049T3 DK 16865892 T DK16865892 T DK 16865892T DK 3377049 T3 DK3377049 T3 DK 3377049T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- crystalline forms
- tapentadol salts
- tapentadol
- salts
- Prior art date
Links
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical class CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN6191CH2015 | 2015-11-17 | ||
| PCT/IN2016/000270 WO2017085734A1 (en) | 2015-11-17 | 2016-11-16 | Crystalline forms of tapentadol salts and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3377049T3 true DK3377049T3 (en) | 2021-04-12 |
Family
ID=58718521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16865892.0T DK3377049T3 (en) | 2015-11-17 | 2016-11-16 | Crystalline forms of tapentadol salts and process for preparation thereof |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3377049B1 (da) |
| DK (1) | DK3377049T3 (da) |
| ES (1) | ES2860907T3 (da) |
| HR (1) | HRP20210503T1 (da) |
| HU (1) | HUE054338T2 (da) |
| PL (1) | PL3377049T3 (da) |
| WO (1) | WO2017085734A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX341072B (es) | 2010-07-23 | 2016-08-05 | Grünenthal Gmbh * | Sales o co-cristales de 3-(3-dimetilamino-1-etil-2-metil-propil)-f enol. |
| DE202020005470U1 (de) | 2020-11-10 | 2022-01-25 | Grünenthal GmbH | Darreichungsformen mit verlängerter Freisetzung eines Salzes von Tapentadol mit L-(+)-Weinsäure |
| WO2022101247A1 (de) | 2020-11-10 | 2022-05-19 | Grünenthal GmbH | Darreichungsformen mit verlängerter freisetzung eines salzes von tapentadol mit l-(+)-weinsäure |
| HUE059465T2 (hu) | 2020-11-10 | 2022-11-28 | Gruenenthal Gmbh | A tapentadol L-(+)- borkõsav-só késleltetett felszabadulású adagolási formája |
| EP4011369A1 (en) | 2020-12-14 | 2022-06-15 | G.L. Pharma GmbH | Aqueous pharmaceutical composition comprising tapentadol tartrate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| JP5700904B2 (ja) | 2004-07-01 | 2015-04-15 | グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | （１ｒ，２ｒ）−３−（３−ジメチルアミノ−１−エチル−２−メチル−プロピル）フェノールを含有する乱用防止経口投与形態物 |
| TWI448447B (zh) | 2006-07-24 | 2014-08-11 | Gruenenthal Chemie | 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法 |
| DE102007019417A1 (de) | 2007-04-23 | 2008-11-13 | Grünenthal GmbH | Tapentadol zur Schmerzbehandlung bei Arthrose |
| US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| MX341072B (es) | 2010-07-23 | 2016-08-05 | Grünenthal Gmbh * | Sales o co-cristales de 3-(3-dimetilamino-1-etil-2-metil-propil)-f enol. |
| WO2012051246A1 (en) * | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| SI2943454T1 (sl) | 2013-01-10 | 2022-01-31 | Krka, Tovarna Zdravil, D.D. | Tapentadolijev maleat in njegove kristalne oblike |
| CN103553940A (zh) * | 2013-11-07 | 2014-02-05 | 南京艾德凯腾生物医药有限责任公司 | 一种新晶型盐酸他喷他多的制备方法 |
-
2016
- 2016-11-16 WO PCT/IN2016/000270 patent/WO2017085734A1/en not_active Ceased
- 2016-11-16 HU HUE16865892A patent/HUE054338T2/hu unknown
- 2016-11-16 DK DK16865892.0T patent/DK3377049T3/da active
- 2016-11-16 PL PL16865892T patent/PL3377049T3/pl unknown
- 2016-11-16 HR HRP20210503TT patent/HRP20210503T1/hr unknown
- 2016-11-16 EP EP16865892.0A patent/EP3377049B1/en not_active Revoked
- 2016-11-16 ES ES16865892T patent/ES2860907T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3377049T3 (pl) | 2021-06-28 |
| HUE054338T2 (hu) | 2021-08-30 |
| HRP20210503T1 (hr) | 2021-10-15 |
| WO2017085734A1 (en) | 2017-05-26 |
| EP3377049B1 (en) | 2021-01-06 |
| EP3377049A1 (en) | 2018-09-26 |
| EP3377049A4 (en) | 2019-06-12 |
| ES2860907T3 (es) | 2021-10-05 |
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