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DK3366688T3 - Substituerede pyrazolpyrimidiner som glucocerebrosidaseaktivatorer - Google Patents

Substituerede pyrazolpyrimidiner som glucocerebrosidaseaktivatorer Download PDF

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Publication number
DK3366688T3
DK3366688T3 DK18165005.2T DK18165005T DK3366688T3 DK 3366688 T3 DK3366688 T3 DK 3366688T3 DK 18165005 T DK18165005 T DK 18165005T DK 3366688 T3 DK3366688 T3 DK 3366688T3
Authority
DK
Denmark
Prior art keywords
substituted pyrazole
pyrimidines
glucocerebrosidase
activators
glucocerebrosidase activators
Prior art date
Application number
DK18165005.2T
Other languages
English (en)
Inventor
Juan Jose Marugan
Noel Southall
Samarjit Patnaik
Ellen Sidransky
Omid Motabar
Wendy Westbrook
Wei Zheng
M Ehud Goldin
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of DK3366688T3 publication Critical patent/DK3366688T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK18165005.2T 2010-12-08 2011-12-08 Substituerede pyrazolpyrimidiner som glucocerebrosidaseaktivatorer DK3366688T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
EP11810714.3A EP2649075B1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (1)

Publication Number Publication Date
DK3366688T3 true DK3366688T3 (da) 2022-05-02

Family

ID=45498099

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18165005.2T DK3366688T3 (da) 2010-12-08 2011-12-08 Substituerede pyrazolpyrimidiner som glucocerebrosidaseaktivatorer
DK11810714.3T DK2649075T3 (da) 2010-12-08 2011-12-08 Substituerede pyrazolopyrimidiner som glucocerebrosidase-aktivatorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11810714.3T DK2649075T3 (da) 2010-12-08 2011-12-08 Substituerede pyrazolopyrimidiner som glucocerebrosidase-aktivatorer

Country Status (24)

Country Link
US (3) US9353117B2 (da)
EP (2) EP2649075B1 (da)
JP (1) JP6154746B2 (da)
KR (1) KR101931224B1 (da)
CN (1) CN103534255B (da)
AU (1) AU2011338377B2 (da)
BR (1) BR112013014242B1 (da)
CA (1) CA2820362C (da)
CY (1) CY1125186T1 (da)
DK (2) DK3366688T3 (da)
ES (2) ES2681218T3 (da)
HR (1) HRP20220512T1 (da)
HU (1) HUE038635T2 (da)
IL (2) IL226767B (da)
LT (1) LT3366688T (da)
MX (2) MX385600B (da)
PL (2) PL3366688T3 (da)
PT (2) PT2649075T (da)
RS (1) RS63320B1 (da)
RU (1) RU2603637C2 (da)
SI (2) SI2649075T1 (da)
TR (1) TR201810523T4 (da)
WO (1) WO2012078855A1 (da)
ZA (1) ZA201304215B (da)

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Also Published As

Publication number Publication date
SI3366688T1 (sl) 2022-07-29
WO2012078855A1 (en) 2012-06-14
US20180263988A1 (en) 2018-09-20
PT3366688T (pt) 2022-05-11
RS63320B1 (sr) 2022-07-29
EP2649075A1 (en) 2013-10-16
PT2649075T (pt) 2018-07-30
EP3366688A1 (en) 2018-08-29
AU2011338377B2 (en) 2016-08-04
EP2649075B1 (en) 2018-04-25
LT3366688T (lt) 2022-05-25
KR20140010012A (ko) 2014-01-23
MX385600B (es) 2025-03-18
BR112013014242B1 (pt) 2022-02-22
BR112013014242A2 (pt) 2018-06-26
US20160346284A1 (en) 2016-12-01
SI2649075T1 (sl) 2018-10-30
PL3366688T3 (pl) 2022-05-23
US9974789B2 (en) 2018-05-22
IL226767B (en) 2018-06-28
JP6154746B2 (ja) 2017-06-28
HRP20220512T1 (hr) 2022-05-27
CA2820362A1 (en) 2012-06-14
US9353117B2 (en) 2016-05-31
TR201810523T4 (tr) 2018-08-27
RU2013126094A (ru) 2015-01-20
US20140249145A1 (en) 2014-09-04
CN103534255B (zh) 2016-12-21
ZA201304215B (en) 2014-03-26
ES2912284T3 (es) 2022-05-25
CN103534255A (zh) 2014-01-22
MX2013006462A (es) 2013-10-01
ES2681218T3 (es) 2018-09-12
MX354506B (es) 2018-01-16
PL2649075T3 (pl) 2018-09-28
US10925874B2 (en) 2021-02-23
CA2820362C (en) 2020-03-24
AU2011338377A8 (en) 2015-10-29
DK2649075T3 (da) 2018-07-30
IL259648A (en) 2018-07-31
KR101931224B1 (ko) 2018-12-20
IL259648B (en) 2021-03-25
AU2011338377A1 (en) 2013-07-04
RU2603637C2 (ru) 2016-11-27
HUE038635T2 (hu) 2018-11-28
CY1125186T1 (el) 2024-12-13
JP2013544893A (ja) 2013-12-19
EP3366688B1 (en) 2022-02-09

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