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DK3362453T3 - Cykliske etherderivater af pyrazolo[1,5-a]pyrimidin-3-carboxyamid - Google Patents

Cykliske etherderivater af pyrazolo[1,5-a]pyrimidin-3-carboxyamid Download PDF

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Publication number
DK3362453T3
DK3362453T3 DK16788047.5T DK16788047T DK3362453T3 DK 3362453 T3 DK3362453 T3 DK 3362453T3 DK 16788047 T DK16788047 T DK 16788047T DK 3362453 T3 DK3362453 T3 DK 3362453T3
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Prior art keywords
ethererivatives
carboxyamide
pyrazolo
pyrimidine
cyclic
Prior art date
Application number
DK16788047.5T
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English (en)
Inventor
Christoph Hoenke
Barbara Bertani
Marco Ferrara
Giacomo Fossati
Sara Frattini
Riccardo Giovannini
Scott Hobson
Original Assignee
Boehringer Ingelheim Int
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Publication of DK3362453T3 publication Critical patent/DK3362453T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
DK16788047.5T 2015-10-13 2016-10-12 Cykliske etherderivater af pyrazolo[1,5-a]pyrimidin-3-carboxyamid DK3362453T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
PCT/EP2016/074380 WO2017064082A1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide

Publications (1)

Publication Number Publication Date
DK3362453T3 true DK3362453T3 (da) 2022-06-07

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ID=54293164

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DK16788047.5T DK3362453T3 (da) 2015-10-13 2016-10-12 Cykliske etherderivater af pyrazolo[1,5-a]pyrimidin-3-carboxyamid

Country Status (30)

Country Link
US (5) US10023575B2 (da)
EP (2) EP3156405A1 (da)
JP (1) JP6626965B2 (da)
KR (1) KR102611558B1 (da)
CN (2) CN108137602B (da)
AU (1) AU2016338602B2 (da)
BR (1) BR112018004347B1 (da)
CA (1) CA3001929C (da)
CL (1) CL2018000856A1 (da)
CO (1) CO2018003756A2 (da)
CY (1) CY1125323T1 (da)
DK (1) DK3362453T3 (da)
EA (1) EA035350B1 (da)
ES (1) ES2912223T3 (da)
HR (1) HRP20220595T1 (da)
IL (1) IL258070B (da)
LT (1) LT3362453T (da)
MA (1) MA42988B1 (da)
MX (1) MX376458B (da)
MY (1) MY195169A (da)
NZ (1) NZ740119A (da)
PE (2) PE20181447A1 (da)
PH (1) PH12018500796B1 (da)
PL (1) PL3362453T3 (da)
PT (1) PT3362453T (da)
RS (1) RS63218B1 (da)
SA (1) SA518391334B1 (da)
SI (1) SI3362453T1 (da)
UA (1) UA124576C2 (da)
WO (1) WO2017064082A1 (da)

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EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
RU2671964C1 (ru) * 2017-08-30 2018-11-08 Сиа Эволед Пиразоло[1,5-а]пиримидинкарбоксилаты гадолиния и органические светодиоды на их основе
US11498928B2 (en) 2019-01-18 2022-11-15 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic spiroethers as Mcl-1 inhibitors
CN110339197A (zh) * 2019-06-24 2019-10-18 中山大学 一种防治血管性痴呆的磷酸二酯酶9a抑制剂的用途
EP4045037A4 (en) * 2019-10-16 2023-11-15 ChemoCentryx, Inc. HETEROARYL-BIPHENYL AMINE FOR THE TREATMENT OF PD-L1 DISEASE

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NZ740119A (en) 2022-02-25
US10479794B2 (en) 2019-11-19
AU2016338602B2 (en) 2020-07-16
US11691977B2 (en) 2023-07-04
HK1254651A1 (en) 2019-07-26
CA3001929C (en) 2023-11-28
CO2018003756A2 (es) 2018-07-10
MA42988A (fr) 2021-04-07
AU2016338602A1 (en) 2018-03-15
PH12018500796B1 (en) 2022-10-26
PE20190778A1 (es) 2019-06-06
EP3362453B1 (en) 2022-03-30
JP2018534279A (ja) 2018-11-22
US20210032259A1 (en) 2021-02-04
IL258070B (en) 2020-06-30
US20200039991A1 (en) 2020-02-06
RS63218B1 (sr) 2022-06-30
HRP20220595T1 (hr) 2022-06-10
SA518391334B1 (ar) 2021-03-29
LT3362453T (lt) 2022-05-25
SI3362453T1 (sl) 2022-06-30
EA035350B1 (ru) 2020-05-29
US10023575B2 (en) 2018-07-17
US20230286993A1 (en) 2023-09-14
WO2017064082A1 (en) 2017-04-20
CY1125323T1 (el) 2024-12-13
PE20181447A1 (es) 2018-09-12
PL3362453T3 (pl) 2022-07-25
UA124576C2 (uk) 2021-10-13
PT3362453T (pt) 2022-05-04
BR112018004347B1 (pt) 2023-12-05
KR102611558B1 (ko) 2023-12-11
CL2018000856A1 (es) 2018-07-27
EA201890922A1 (ru) 2018-11-30
CA3001929A1 (en) 2017-04-20
IL258070A (en) 2018-05-31
US12351584B2 (en) 2025-07-08
CN114181213A (zh) 2022-03-15
EP3156405A1 (en) 2017-04-19
MX376458B (es) 2025-03-07
MX2018004524A (es) 2018-06-27
JP6626965B2 (ja) 2019-12-25
KR20180063316A (ko) 2018-06-11
CN108137602A (zh) 2018-06-08
CN108137602B (zh) 2021-09-28
MY195169A (en) 2023-01-11
US10875867B2 (en) 2020-12-29
ES2912223T3 (es) 2022-05-25
US20180134720A1 (en) 2018-05-17
BR112018004347A2 (pt) 2018-10-09
PH12018500796A1 (en) 2018-10-29
EP3362453A1 (en) 2018-08-22
MA42988B1 (fr) 2022-04-29
US20170101411A1 (en) 2017-04-13
CN114181213B (zh) 2024-08-30

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