DK3268013T3 - Il-10-producerende cd4+-t-celler til anvendelse ved behandling af en cancer - Google Patents
Il-10-producerende cd4+-t-celler til anvendelse ved behandling af en cancer Download PDFInfo
- Publication number
- DK3268013T3 DK3268013T3 DK16710702.8T DK16710702T DK3268013T3 DK 3268013 T3 DK3268013 T3 DK 3268013T3 DK 16710702 T DK16710702 T DK 16710702T DK 3268013 T3 DK3268013 T3 DK 3268013T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- cells
- producing
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15159075 | 2015-03-13 | ||
| PCT/EP2016/055353 WO2016146542A1 (en) | 2015-03-13 | 2016-03-11 | Il-10-producing cd4+ t cells and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3268013T3 true DK3268013T3 (da) | 2021-12-20 |
Family
ID=52669533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16710702.8T DK3268013T3 (da) | 2015-03-13 | 2016-03-11 | Il-10-producerende cd4+-t-celler til anvendelse ved behandling af en cancer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180050092A1 (da) |
| EP (2) | EP3268013B1 (da) |
| CA (1) | CA2978655A1 (da) |
| DK (1) | DK3268013T3 (da) |
| ES (1) | ES2900632T3 (da) |
| WO (1) | WO2016146542A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3384027A1 (en) | 2015-12-04 | 2018-10-10 | Novartis AG | Compositions and methods for immunooncology |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| EA201992232A1 (ru) | 2017-03-22 | 2020-05-14 | Новартис Аг | Композиции и способы для иммуноонкологии |
| WO2020214849A1 (en) * | 2019-04-16 | 2020-10-22 | Regents Of The University Of Minnesota | Biomarker for transplantation tolerance induced by apoptotic donor leukocytes |
| WO2022005462A1 (en) | 2020-06-30 | 2022-01-06 | Tr1X, Inc. | Poly-donor cd4+ t cells expressing il-10 and uses thereof |
| EP4196229A4 (en) * | 2020-08-14 | 2024-10-23 | The Board of Trustees of the Leland Stanford Junior University | CD200 BLOCKADE TO INCREASE THE ANTITUMOR ACTIVITY OF CYTOTOXIC T CELLS |
| EP4457238A1 (en) | 2021-12-30 | 2024-11-06 | TR1X, Inc. | Polydonor cd4t cells expressing il-10 and uses thereof |
| KR20250005566A (ko) * | 2021-12-30 | 2025-01-09 | 티알1엑스, 인크. | Il-10 및 키메라 항원 수용체를 발현하는 cd4+ t 세포 및 이의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003004625A1 (en) * | 2001-07-02 | 2003-01-16 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Methods of generating human cd4+ th2 cells and uses thereof |
| WO2013192215A1 (en) | 2012-06-18 | 2013-12-27 | Yale University | Compositions and methods for diminishing an immune response |
-
2016
- 2016-03-11 DK DK16710702.8T patent/DK3268013T3/da active
- 2016-03-11 WO PCT/EP2016/055353 patent/WO2016146542A1/en not_active Ceased
- 2016-03-11 CA CA2978655A patent/CA2978655A1/en active Pending
- 2016-03-11 EP EP16710702.8A patent/EP3268013B1/en active Active
- 2016-03-11 EP EP21196509.0A patent/EP3988106A1/en not_active Withdrawn
- 2016-03-11 ES ES16710702T patent/ES2900632T3/es active Active
- 2016-03-11 US US15/557,263 patent/US20180050092A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3268013A1 (en) | 2018-01-17 |
| US20180050092A1 (en) | 2018-02-22 |
| CA2978655A1 (en) | 2016-09-22 |
| ES2900632T3 (es) | 2022-03-17 |
| EP3268013B1 (en) | 2021-10-13 |
| WO2016146542A1 (en) | 2016-09-22 |
| EP3988106A1 (en) | 2022-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3288581T3 (da) | Fremgangsmåde til behandling af cancer | |
| DK3193929T3 (da) | Behandlingsregimer ved anvendelse af anti-nkg2a-antistoffer | |
| DK3268013T3 (da) | Il-10-producerende cd4+-t-celler til anvendelse ved behandling af en cancer | |
| IL249313A0 (en) | Improved t cell compositions | |
| DK3185957T3 (da) | Patisiran til anvendelse ved behandlingen af transthyretin-medieret amyloidosis | |
| DK3492632T3 (da) | Metoder til behandling af lithiumholdige materialer | |
| DK3456330T3 (da) | Cortexolon-17alpha-valerat til anvendelse ved behandling af tumorer | |
| DK3483593T3 (da) | Luminescent-oxygen-channeling-immunoassay ved anvendelse af tre antistoffer og fremgangsmåder til fremstilling og anvendelse deraf | |
| DK3186244T3 (da) | Dioxolananaloger af uridin til behandling af cancer | |
| DK3380086T3 (da) | Cyp26-resistente rar-alpha-selektive agonister i behandling af cancer | |
| IL251905A0 (en) | Epilimod for use in the treatment of kidney cancer | |
| DK3391902T3 (da) | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati | |
| DK3374497T3 (da) | Modificerede makrofager til anvendelse i behandlingen af kræft | |
| DK3164123T3 (da) | Hidtil ukendte anvendelser af benzylidenguanidinderivater til behandling af proteopatier | |
| DK3089749T3 (da) | Kombinerede præparater til behandling af cancer | |
| DK3149049T3 (da) | Il-22 til anvendelse til behandling af stofskiftesygdomme | |
| DK3213752T3 (da) | Sammensætning til behandling af cancerstamceller | |
| DK3236960T3 (da) | Fluralaner til anvendelse i behandling af demodicose | |
| DK3253208T3 (da) | Kombinationsterapier til anvendelse i behandlingen af brystcancer | |
| DK3556383T3 (da) | Plasminogen til anvendelse ved behandling af diabetes | |
| IL251903A0 (en) | Apilimod for use in the treatment of colorectal cancer | |
| DK3468604T3 (da) | Farmaceutiske kombinationer til behandling af cancer | |
| DK3125874T3 (da) | Et terapeutisk middel til anvendelse i behandlingen af infektioner | |
| DK3442558T3 (da) | Bmp-7-afledte peptider til anvendelse i behandlingen af osteoartritis | |
| DK3217980T3 (da) | Ciclopirox, ciclopirox-olamin, eller et ciclopirox-prodrug til anvendelse i behandlingen af blærekræft |