DK3265564T3 - Fremgangsmåde til modulering af mecp2-ekspression - Google Patents
Fremgangsmåde til modulering af mecp2-ekspression Download PDFInfo
- Publication number
- DK3265564T3 DK3265564T3 DK16759471.2T DK16759471T DK3265564T3 DK 3265564 T3 DK3265564 T3 DK 3265564T3 DK 16759471 T DK16759471 T DK 16759471T DK 3265564 T3 DK3265564 T3 DK 3265564T3
- Authority
- DK
- Denmark
- Prior art keywords
- moduling
- mecp2 expression
- mecp2
- expression
- moduling mecp2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127693P | 2015-03-03 | 2015-03-03 | |
| PCT/US2016/020610 WO2016141145A1 (en) | 2015-03-03 | 2016-03-03 | Methods for modulating mecp2 expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3265564T3 true DK3265564T3 (da) | 2022-04-11 |
Family
ID=56848154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16759471.2T DK3265564T3 (da) | 2015-03-03 | 2016-03-03 | Fremgangsmåde til modulering af mecp2-ekspression |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180044673A1 (da) |
| EP (2) | EP4056703A1 (da) |
| DK (1) | DK3265564T3 (da) |
| ES (1) | ES2909308T3 (da) |
| WO (1) | WO2016141145A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11129844B2 (en) | 2015-03-03 | 2021-09-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating MECP2 expression |
| US10900036B2 (en) * | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
| IL252151A0 (en) | 2017-05-07 | 2017-07-31 | Fainzilber Michael | Treatment of stress disorders |
| KR20230035936A (ko) * | 2021-09-06 | 2023-03-14 | 한국과학기술연구원 | Mecp2의 발현 억제제를 포함하는 인지기능장애 예방 또는 치료용 조성물 |
| CN120239607A (zh) | 2022-09-23 | 2025-07-01 | Ionis制药公司 | 用于降低mecp2表达的化合物和方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0673559A1 (en) | 1992-12-14 | 1995-09-27 | Honeywell Inc. | Motor system with individually controlled redundant windings |
| US7875733B2 (en) | 2003-09-18 | 2011-01-25 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| WO1999014226A2 (en) | 1997-09-12 | 1999-03-25 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| HK1048322A1 (zh) | 1999-05-04 | 2003-03-28 | 埃克西库恩公司 | L-核糖-lna类似物 |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| JP2005504020A (ja) | 2001-07-03 | 2005-02-10 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヌクレアーゼ耐性キメラオリゴヌクレオチド |
| US7696345B2 (en) | 2002-11-05 | 2010-04-13 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| WO2004044139A2 (en) | 2002-11-05 | 2004-05-27 | Isis Parmaceuticals, Inc. | Modified oligonucleotides for use in rna interference |
| WO2004106356A1 (en) | 2003-05-27 | 2004-12-09 | Syddansk Universitet | Functionalized nucleotide derivatives |
| JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | Ｎ−ｏ結合性架橋構造型新規人工核酸 |
| DK2314594T3 (da) | 2006-01-27 | 2014-10-27 | Isis Pharmaceuticals Inc | 6-modificerede bicykliske nukleinsyreanaloger |
| DK2066684T3 (da) | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5´-Modificerede bicycliske nukleinsyreanaloge |
| EP2125852B1 (en) | 2007-02-15 | 2016-04-06 | Ionis Pharmaceuticals, Inc. | 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom |
| AU2008260277C1 (en) | 2007-05-30 | 2014-04-17 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| WO2008154401A2 (en) | 2007-06-08 | 2008-12-18 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| US20090082297A1 (en) * | 2007-06-25 | 2009-03-26 | Lioy Daniel T | Compositions and Methods for Regulating Gene Expression |
| ATE538127T1 (de) | 2007-07-05 | 2012-01-15 | Isis Pharmaceuticals Inc | 6-disubstituierte bicyclische nukleinsäureanaloga |
| EP2195029A2 (en) * | 2007-08-24 | 2010-06-16 | Oryzon Genomics SA | Treatment and prevention of neurodegenerative diseases |
| KR101198046B1 (ko) * | 2009-12-11 | 2012-11-07 | 한국생명공학연구원 | ＴＴＰ 프로모터 내 특정 단일 ＣｐＧ 부위의 후생유전학적 지표를 이용한 암 발병／예후 진단 및 이의 조절을 통한 암 치료기술 |
| EP2850190B1 (en) * | 2012-05-16 | 2020-07-08 | Translate Bio MA, Inc. | Compositions and methods for modulating mecp2 expression |
| US9833519B2 (en) * | 2012-09-25 | 2017-12-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for the diagnosis and treatment of sjögren's syndrome |
-
2016
- 2016-03-03 ES ES16759471T patent/ES2909308T3/es active Active
- 2016-03-03 EP EP22153020.7A patent/EP4056703A1/en not_active Withdrawn
- 2016-03-03 WO PCT/US2016/020610 patent/WO2016141145A1/en not_active Ceased
- 2016-03-03 US US15/554,407 patent/US20180044673A1/en not_active Abandoned
- 2016-03-03 DK DK16759471.2T patent/DK3265564T3/da active
- 2016-03-03 EP EP16759471.2A patent/EP3265564B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016141145A1 (en) | 2016-09-09 |
| EP4056703A1 (en) | 2022-09-14 |
| EP3265564A1 (en) | 2018-01-10 |
| US20180044673A1 (en) | 2018-02-15 |
| EP3265564B1 (en) | 2022-01-26 |
| EP3265564A4 (en) | 2018-08-29 |
| ES2909308T3 (es) | 2022-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3072835T3 (da) | Fremgangsmåde til fremføring | |
| EP3380140C0 (en) | Auto-injector | |
| IL249981A0 (en) | Method | |
| DK3286311T3 (da) | Fremgangsmåde til behandling af maligniteter | |
| DK3316703T3 (da) | Fremgangsmåde til forbedring af dyrs ydeevne | |
| HUE049175T2 (hu) | Eljárás anti-CD79b immunkonjugátumok alkalmazására | |
| DK3294700T3 (da) | Fremgangsmåde til fremstilling af limonen-4-ol | |
| DK3198035T3 (da) | Fremgangsmåder til forudsigelse af medicinrespons | |
| EP3331345A4 (en) | Hedge trimmer | |
| EP3313828A4 (en) | METALLO-BETA-Lactamase INHIBITORS | |
| DK3344805T3 (da) | Fremgangsmåde til udvælgelse af aptamerer til ubundne mål | |
| DK3314010T3 (da) | Fremgangsmåde til detektering af kromosomaberrationer | |
| DK3125898T3 (da) | Farmakofor til trail-induktion | |
| IL261341B (en) | Branch instruction | |
| DK3152332T3 (da) | Fremgangsmåde til at analysere methylering | |
| DK3393468T3 (da) | Fremgangsmåder til behandling af en immundefektsygdom | |
| DK3520591T3 (da) | Fremgangsmåde til spredning af gødningsmidler | |
| MA43367A (fr) | Inhibiteurs de métallo-bêta-lactamases | |
| DK3204492T3 (da) | Fremgangsmåde til generering af t-celleforløbere | |
| ITUB20152337A1 (it) | Metodo di dosaggio automatizzato | |
| DK3206586T3 (da) | Fremgangsmåde til detektion af dikrotisk hak | |
| DK3534709T3 (da) | Substituerede sulfonylamider til bekæmpelse af skadedyr | |
| DK4235628T3 (da) | System til frembringelse af en omgivelse | |
| DK3423714T3 (da) | Fremgangsmåde til generering af elektricitet | |
| DK3367910T3 (da) | Fremgangsmåde til anvendelse af en sondeafdækning |