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DK3253755T3 - Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner - Google Patents

Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner Download PDF

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Publication number
DK3253755T3
DK3253755T3 DK16702810.9T DK16702810T DK3253755T3 DK 3253755 T3 DK3253755 T3 DK 3253755T3 DK 16702810 T DK16702810 T DK 16702810T DK 3253755 T3 DK3253755 T3 DK 3253755T3
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DK
Denmark
Prior art keywords
cyclopropabenzofuranyl
pyridopyrazine
diones
novel
pyridopyrazine diones
Prior art date
Application number
DK16702810.9T
Other languages
English (en)
Inventor
Martin Youngjin Pettersson
Ende Christopher William Am
Douglas Scott Johnson
Gregory Wayne Kauffman
Antonia Friederike Stepan
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of DK3253755T3 publication Critical patent/DK3253755T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16702810.9T 2015-02-03 2016-01-26 Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner DK3253755T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562111222P 2015-02-03 2015-02-03
PCT/IB2016/050384 WO2016125048A1 (en) 2015-02-03 2016-01-26 Novel cyclopropabenzofuranyl pyridopyrazinediones

Publications (1)

Publication Number Publication Date
DK3253755T3 true DK3253755T3 (da) 2020-09-28

Family

ID=55299692

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16702810.9T DK3253755T3 (da) 2015-02-03 2016-01-26 Hidtil ukendte cyclopropabenzofuranyl-pyridopyrazindioner

Country Status (22)

Country Link
US (2) US20160222007A1 (da)
EP (1) EP3253755B1 (da)
JP (1) JP6628805B2 (da)
KR (1) KR102000382B1 (da)
CN (1) CN107406445B (da)
AR (1) AR103582A1 (da)
AU (1) AU2016214102B2 (da)
BR (1) BR112017015693A2 (da)
CA (1) CA2919338A1 (da)
DK (1) DK3253755T3 (da)
EA (1) EA033423B1 (da)
EC (1) ECSP17050310A (da)
ES (1) ES2818806T3 (da)
IL (1) IL253635A0 (da)
MX (1) MX368391B (da)
PE (1) PE20171318A1 (da)
PH (1) PH12017501369A1 (da)
SG (1) SG11201705780PA (da)
TN (1) TN2017000342A1 (da)
TW (1) TWI616445B (da)
UY (1) UY36546A (da)
WO (1) WO2016125048A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
KR102271305B1 (ko) 2020-05-21 2021-06-30 주식회사 아리바이오 치매 예방 및 치료용 조성물
CN111978324A (zh) * 2020-08-28 2020-11-24 开封康诺药业有限公司 一种多索茶碱的晶型及其制备方法
KR102272907B1 (ko) 2020-11-05 2021-07-05 주식회사 아리바이오 치매 예방 및 치료용 조성물
KR102272910B1 (ko) 2021-01-28 2021-07-06 주식회사 아리바이오 당뇨병을 동반한 치매 예방 및 치료용 조성물
KR102311224B1 (ko) 2021-04-23 2021-10-13 주식회사 아리바이오 Pde5 억제제와 글루코코르티코이드 수용체 길항제 병용투여를 통한 치매 예방 및 치료용 조성물

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EA201700356A1 (ru) 2018-01-31
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US20170096428A1 (en) 2017-04-06
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MX368391B (es) 2019-09-30
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US20160222007A1 (en) 2016-08-04
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