[go: up one dir, main page]

DK3250554T3 - Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form - Google Patents

Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form Download PDF

Info

Publication number
DK3250554T3
DK3250554T3 DK16704029.4T DK16704029T DK3250554T3 DK 3250554 T3 DK3250554 T3 DK 3250554T3 DK 16704029 T DK16704029 T DK 16704029T DK 3250554 T3 DK3250554 T3 DK 3250554T3
Authority
DK
Denmark
Prior art keywords
diastereomers
crystalline form
stable crystalline
carboxamide derivative
carboxamide
Prior art date
Application number
DK16704029.4T
Other languages
English (en)
Inventor
Olli Törmäkangas
Terhi Heikkinen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55349869&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3250554(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Application granted granted Critical
Publication of DK3250554T3 publication Critical patent/DK3250554T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16704029.4T 2015-01-30 2016-01-28 Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form DK3250554T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20150033 2015-01-30
PCT/FI2016/050054 WO2016120530A1 (en) 2015-01-30 2016-01-28 A carboxamide derivative and its diastereomers in stable crystalline form

Publications (1)

Publication Number Publication Date
DK3250554T3 true DK3250554T3 (da) 2022-06-27

Family

ID=55349869

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16704029.4T DK3250554T3 (da) 2015-01-30 2016-01-28 Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form

Country Status (13)

Country Link
US (4) US10010530B2 (da)
EP (1) EP3250554B1 (da)
JP (2) JP7283861B2 (da)
DK (1) DK3250554T3 (da)
ES (1) ES2917549T3 (da)
HR (1) HRP20220998T1 (da)
HU (1) HUE058986T2 (da)
LT (1) LT3250554T (da)
PL (1) PL3250554T3 (da)
PT (1) PT3250554T (da)
RS (1) RS63477B1 (da)
SI (1) SI3250554T1 (da)
WO (1) WO2016120530A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3495352T3 (da) * 2016-08-26 2021-05-03 Crystal Pharmaceutical Suzhou Co Ltd Krystalformer af en androgenreceptorantagonist, fremgangsmåde til fremstilling og anvendelse deraf
CN108218908A (zh) * 2016-12-15 2018-06-29 连云港润众制药有限公司 一种新型雄激素受体拮抗剂的制备方法
RS66855B1 (sr) * 2017-03-07 2025-06-30 Orion Corp Proizvodnja kristalnog farmaceutskog proizvoda
CN110944979B (zh) * 2017-08-09 2023-05-12 杭州领业医药科技有限公司 Odm-201晶型及其制备方法和药物组合物
CN107602471B (zh) * 2017-09-22 2021-04-27 成都恒汇化成医药科技有限公司 一种达罗鲁胺的晶型制备方法
EP3759076A1 (en) 2018-02-27 2021-01-06 Sandoz AG Crystalline form ii of darolutamide
CA3145459A1 (en) 2019-07-02 2021-01-07 Orion Corporation Pharmaceutical composition of darolutamide
CN110590668A (zh) * 2019-07-17 2019-12-20 江苏君若医药有限公司 N-[(1s)-2-[3-(3-氯-4-氰基苯基)-1h-吡唑-1-基]-1-甲基乙基]-5-(1-羟基乙基)- 1h-吡唑-3-甲酰胺的制备方法
CN110452123B (zh) * 2019-08-30 2021-10-29 南京师范大学 一步构建c-c、c-n、c-s键的合成方法
CN111116476A (zh) * 2019-12-27 2020-05-08 武汉九州钰民医药科技有限公司 制备抗肿瘤药物多拉米胺的方法
WO2022036782A1 (zh) * 2020-08-18 2022-02-24 拜耳消费者护理股份有限公司 一种雄激素受体拮抗剂药物的晶型csvi及其制备方法和用途
WO2022049075A1 (en) 2020-09-02 2022-03-10 Bend Research, Inc. Amorphous solid dispersion of darolutamide
WO2022144926A1 (en) * 2020-12-31 2022-07-07 Msn Laboratories Private Limited, R&D Center Process for the preparation of amorphous n-{(2s)-1-[3-(3-chloro-4-cyanophenyl)-1h-pyrazol-1-yl]propan-2-yl}-5-(1-hydroxyethyl)-1h-pyrazole-3-carboxamide
MX2024009980A (es) 2022-02-28 2024-08-26 Quim Sintetica S A Forma cristalina de darolutamida.
WO2025229051A1 (en) 2024-05-03 2025-11-06 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with antiandrogen agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR078793A1 (es) * 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
JP5964407B2 (ja) 2011-04-21 2016-08-03 オリオン コーポレーション アンドロゲン受容体調節カルボキシアミド

Also Published As

Publication number Publication date
EP3250554B1 (en) 2022-05-18
SI3250554T1 (sl) 2022-09-30
JP2021020935A (ja) 2021-02-18
US20180280354A1 (en) 2018-10-04
US10010530B2 (en) 2018-07-03
LT3250554T (lt) 2022-06-10
US20180008577A1 (en) 2018-01-11
RS63477B1 (sr) 2022-08-31
US20180280355A1 (en) 2018-10-04
HRP20220998T1 (hr) 2022-11-11
US10383853B2 (en) 2019-08-20
WO2016120530A1 (en) 2016-08-04
JP2018503662A (ja) 2018-02-08
PL3250554T3 (pl) 2022-09-19
HUE058986T2 (hu) 2022-09-28
JP7283861B2 (ja) 2023-05-30
PT3250554T (pt) 2022-06-02
EP3250554A1 (en) 2017-12-06
ES2917549T3 (es) 2022-07-08
US10376494B2 (en) 2019-08-13
US20190321333A1 (en) 2019-10-24
US10835515B2 (en) 2020-11-17

Similar Documents

Publication Publication Date Title
DK3250554T3 (da) Carboxamidderivat og diastereomerer deraf i stabil, krystallinsk form
DK3580561T3 (da) Hla-baserede metoder, sammensætninger og anvendelse heraf
DK3307707T3 (da) Halogensubstituerede phenoxyphenylamidiner og anvendelsen deraf som fungicider
DK3319428T3 (da) Herbicid sammensætning omfattende cinmethylin og imazamox
DK3676297T3 (da) Forbindelser, sammensætninger og fremgangsmåder
DK3297637T3 (da) Benzen-1,3,5-tricarboxamidderivater og anvendelser deraf
DK3331894T3 (da) Nicotinamidmononukleotidderivater og anvendelser deraf
DK3328849T3 (da) 1,1,1-trifluor-3-hydroxypropan-2-yl-carbamat-derivater og 1,1,1-trifluor-4-hydroxybutan-2-yl-carbamat-derivater som magl-inhibitorer
DK3407888T3 (da) Pyridopyrroloquinoxalinforbindelser, deres sammensætninger og anvendelser
IL255028A0 (en) Hydroponics
HRP20181692T1 (hr) Liječenje fibroze
DK3360878T3 (da) Azetidinderivat, fremstillingsfremgangsmåde derfor og anvendelse deraf
DK3331877T3 (da) Pyrazolpyrimidinderivat og anvendelser deraf
DK3560924T3 (da) Imidazolonylquinoliner og deres anvendelse som atm-kinase-inhibitorer
DK3210977T3 (da) Hidtil ukendt aminoalkylbenzothiazepinderivat og anvendelse deraf
DK3143134T3 (da) Modificerede, naturlige dræberceller og anvendelser deraf
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3118096T3 (da) Cykelstel, energiforsyningsenhed hertil og elcykel hermed
DK3137168T3 (da) Substituerede 4-phenylpiperidiner, deres fremstilling og anvendelse
LT3347006T (lt) Deuterinti etifoksino analogai, jų dariniai ir panaudojimai
DK3390325T3 (da) Gødning omfattende bakterier og protozoer
DK3321279T3 (da) Exenatidmodificeringsmiddel og anvendelse deraf
DK3223796T3 (da) Farmaceutiske sammensætninger, fremstilling og anvendelser deraf
DK3337506T3 (da) Kombinationer og anvendelser deraf
DK3326971T3 (da) Antimikrobielt, insekticidt og akaricidt system