DK3248967T3 - Krystallinsk form af et benzimidazolderivat og en fremstillingsfremgangsmåde herfor - Google Patents
Krystallinsk form af et benzimidazolderivat og en fremstillingsfremgangsmåde herfor Download PDFInfo
- Publication number
- DK3248967T3 DK3248967T3 DK15879068.3T DK15879068T DK3248967T3 DK 3248967 T3 DK3248967 T3 DK 3248967T3 DK 15879068 T DK15879068 T DK 15879068T DK 3248967 T3 DK3248967 T3 DK 3248967T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- crystalline form
- benzimidazole derivative
- benzimidazole
- derivative
- Prior art date
Links
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150009326A KR101684053B1 (ko) | 2015-01-20 | 2015-01-20 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| PCT/KR2015/012385 WO2016117814A2 (ko) | 2015-01-20 | 2015-11-18 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3248967T3 true DK3248967T3 (da) | 2020-09-07 |
Family
ID=56417901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15879068.3T DK3248967T3 (da) | 2015-01-20 | 2015-11-18 | Krystallinsk form af et benzimidazolderivat og en fremstillingsfremgangsmåde herfor |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9908870B2 (da) |
| EP (1) | EP3248967B1 (da) |
| JP (2) | JP6535748B2 (da) |
| KR (1) | KR101684053B1 (da) |
| CN (2) | CN107207478B (da) |
| AR (1) | AR103444A1 (da) |
| BR (1) | BR102016001167B1 (da) |
| CL (1) | CL2017001377A1 (da) |
| CO (1) | CO2017005396A2 (da) |
| CY (1) | CY1123423T1 (da) |
| DK (1) | DK3248967T3 (da) |
| EA (1) | EA030919B1 (da) |
| EC (1) | ECSP17035416A (da) |
| ES (1) | ES2816646T3 (da) |
| GE (1) | GEP20196974B (da) |
| HR (1) | HRP20201275T1 (da) |
| HU (1) | HUE050979T2 (da) |
| IL (1) | IL253186B (da) |
| JO (1) | JO3592B1 (da) |
| LT (1) | LT3248967T (da) |
| MX (1) | MX359916B (da) |
| MY (1) | MY186830A (da) |
| PH (2) | PH12016000029B1 (da) |
| PL (1) | PL3248967T3 (da) |
| PT (1) | PT3248967T (da) |
| RS (1) | RS60758B1 (da) |
| SA (1) | SA517381904B1 (da) |
| SG (1) | SG10201509488YA (da) |
| SI (1) | SI3248967T1 (da) |
| SM (1) | SMT202000688T1 (da) |
| TW (1) | TWI589575B (da) |
| UY (1) | UY36521A (da) |
| WO (1) | WO2016117814A2 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101829706B1 (ko) | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 산부가염 |
| KR20230114163A (ko) | 2022-01-24 | 2023-08-01 | 엠에프씨 주식회사 | 칼륨 경쟁적 위산분비억제제 계열 약물의 신규한 무정형 고체분산체 및 그의 제조방법 |
| KR20230114164A (ko) | 2022-01-24 | 2023-08-01 | 엠에프씨 주식회사 | 벤즈이미다졸 유도체의 공동 무정형 고형체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| KR20240028127A (ko) | 2022-08-24 | 2024-03-05 | 위더스제약주식회사 | 테고프라잔 고체분산체 조성물 |
| WO2024045255A1 (zh) * | 2022-08-30 | 2024-03-07 | 上海皓元医药股份有限公司 | 一种特戈拉赞晶型b及其制备方法 |
| KR20240109898A (ko) | 2023-01-05 | 2024-07-12 | 위더스제약주식회사 | 무정형 테고프라잔 고체분산체 |
| KR20240120271A (ko) | 2023-01-31 | 2024-08-07 | 주식회사 엔비피헬스케어 | 신규한 테고프라잔 말론산 공무정형 |
| WO2024171128A1 (en) * | 2023-02-18 | 2024-08-22 | Lee Pharma Limited | Stable amorphous form of potassium-competitive acid blocker and process for the preparation thereof |
| KR20240131641A (ko) | 2023-02-24 | 2024-09-02 | 엠에프씨 주식회사 | 신규 테고프라잔의 염 결정형 및 이의 용매화물 결정형, 및 이들의 제조방법 |
| CN116178352A (zh) * | 2023-03-16 | 2023-05-30 | 宙晟智维生命科学(上海)有限公司 | 一种氮稠杂环化合物的晶型及其制备方法 |
| KR102715562B1 (ko) | 2023-03-16 | 2024-10-11 | (주) 에프엔지리서치 | 테고프라잔의 신규 염 및 이의 제조 방법 |
| KR20240160980A (ko) | 2023-05-03 | 2024-11-12 | 구주제약주식회사 | 신규한 테고프라잔 공무정형 |
| CN116621821A (zh) * | 2023-05-29 | 2023-08-22 | 宙晟智维生命科学(上海)有限公司 | 一种无定形的苯并咪唑基化合物及固体分散体 |
| KR20240171624A (ko) | 2023-05-31 | 2024-12-09 | 권대길 | 치환된 벤즈이미다졸의 결정형 및 이의 제조방법 |
| KR20240171566A (ko) | 2023-05-31 | 2024-12-09 | 주식회사 셀트리온제약 | 테고프라잔의 신규한 공동무정형 및 이를 포함하는 약학 조성물 |
| KR20240174813A (ko) * | 2023-06-09 | 2024-12-17 | 이니스트에스티 주식회사 | 크로메인 치환 벤즈이미다졸 유도체 및 염화아연을포함하는 공결정 고체 및 그 제조방법 |
| CN116715660A (zh) * | 2023-06-14 | 2023-09-08 | 上海柏狮生物科技有限公司 | 一种特格拉赞的无定型物及其制备方法 |
| KR102866076B1 (ko) * | 2023-07-05 | 2025-09-29 | 주식회사 다산제약 | 고순도의 무정형 테고프라잔 제조방법 |
| KR20250041270A (ko) | 2023-09-18 | 2025-03-25 | (주)국전약품 | 벤즈이미다졸 유도체의 공결정화물, 및 이를 포함하는 약제학적 조성물 |
| KR20250066641A (ko) | 2023-11-07 | 2025-05-14 | 엠에프씨 주식회사 | 테고프라잔 말리에이트염 1수화물 결정형 및 이의 제조방법 |
| KR20250088407A (ko) * | 2023-12-08 | 2025-06-17 | 주식회사 종근당 | 테고프라잔 설폰산염의 신규 결정형 및 이를 포함하는 약제학적 조성물 |
| KR20250118583A (ko) | 2024-01-30 | 2025-08-06 | 진양제약주식회사 | 테고프라잔을 포함하는 제약 조성물 |
| KR20250140387A (ko) | 2024-03-18 | 2025-09-25 | 최광진 | 벤즈이미다졸 유도체 약물의 신규한 공결정 소재 및 그의 제조방법 |
| WO2025232904A1 (zh) * | 2024-05-10 | 2025-11-13 | 上海新礼泰药业有限公司 | 替戈拉生富马酸单乙酯、其制备方法、药物组合物及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| US7256294B2 (en) * | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
| WO2006134460A1 (en) * | 2005-06-14 | 2006-12-21 | Pfizer Japan Inc. | Chromane substituted benzimidazole derivatives as acid pump antagonists |
| BR122020004679B1 (pt) * | 2005-12-19 | 2021-09-21 | Raqualia Pharma Inc | Composição farmacêutica |
| EP2318411A2 (en) * | 2008-07-03 | 2011-05-11 | Ratiopharm GmbH | Crystalline salts of sitagliptin |
| MX2012000275A (es) * | 2009-07-09 | 2012-02-08 | Raqualia Pharma Inc | Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal. |
| JP2014047304A (ja) * | 2012-08-31 | 2014-03-17 | Sanyo Chem Ind Ltd | 樹脂粒子の製造方法 |
| GB2508352B (en) * | 2012-11-28 | 2017-08-16 | Douwe Egberts Bv | Treating soluble coffee |
| BR112015016370A2 (pt) * | 2013-01-11 | 2017-07-11 | Novartis Ag | formas de sais de meglumina de ácido 2-((1r,4r)-4-(-4-(5-(benzoxazol-2-ilamino)piridinila-2-il)fenil)ciclo-hexila) acético e seus usos como inibidores de dgat1 |
| MY201861A (en) * | 2014-12-19 | 2024-03-20 | Univ Court Univ Of Edinburgh | 3-(6-alkoxy-5-chlorobenzo[d]isoxazol-3-yl)propanoic acid useful as kynurenine monooxygenase inhibitors |
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2015
- 2015-01-20 KR KR1020150009326A patent/KR101684053B1/ko active Active
- 2015-11-18 HU HUE15879068A patent/HUE050979T2/hu unknown
- 2015-11-18 ES ES15879068T patent/ES2816646T3/es active Active
- 2015-11-18 GE GEAP201514554A patent/GEP20196974B/en unknown
- 2015-11-18 SI SI201531354T patent/SI3248967T1/sl unknown
- 2015-11-18 SM SM20200688T patent/SMT202000688T1/it unknown
- 2015-11-18 PT PT158790683T patent/PT3248967T/pt unknown
- 2015-11-18 WO PCT/KR2015/012385 patent/WO2016117814A2/ko not_active Ceased
- 2015-11-18 HR HRP20201275TT patent/HRP20201275T1/hr unknown
- 2015-11-18 RS RS20201062A patent/RS60758B1/sr unknown
- 2015-11-18 CN CN201580073998.0A patent/CN107207478B/zh active Active
- 2015-11-18 CN CN202010070896.6A patent/CN111187259B/zh active Active
- 2015-11-18 PL PL15879068T patent/PL3248967T3/pl unknown
- 2015-11-18 US US15/543,941 patent/US9908870B2/en active Active
- 2015-11-18 EP EP15879068.3A patent/EP3248967B1/en active Active
- 2015-11-18 JP JP2017537963A patent/JP6535748B2/ja active Active
- 2015-11-18 LT LTEP15879068.3T patent/LT3248967T/lt unknown
- 2015-11-18 EA EA201791151A patent/EA030919B1/ru unknown
- 2015-11-18 SG SG10201509488YA patent/SG10201509488YA/en unknown
- 2015-11-18 DK DK15879068.3T patent/DK3248967T3/da active
-
2016
- 2016-01-19 MX MX2016000751A patent/MX359916B/es active IP Right Grant
- 2016-01-19 JO JOP/2016/0008A patent/JO3592B1/ar active
- 2016-01-19 PH PH12016000029A patent/PH12016000029B1/en unknown
- 2016-01-19 UY UY0001036521A patent/UY36521A/es active IP Right Grant
- 2016-01-19 TW TW105101516A patent/TWI589575B/zh active
- 2016-01-19 BR BR102016001167-1A patent/BR102016001167B1/pt active IP Right Grant
- 2016-01-19 AR ARP160100123A patent/AR103444A1/es unknown
- 2016-01-20 MY MYPI2016000101A patent/MY186830A/en unknown
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2017
- 2017-05-30 CL CL2017001377A patent/CL2017001377A1/es unknown
- 2017-05-30 CO CONC2017/0005396A patent/CO2017005396A2/es unknown
- 2017-06-07 EC ECIEPI201735416A patent/ECSP17035416A/es unknown
- 2017-06-26 IL IL253186A patent/IL253186B/en active IP Right Grant
- 2017-07-12 SA SA517381904A patent/SA517381904B1/ar unknown
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2019
- 2019-04-03 JP JP2019071121A patent/JP2019104760A/ja not_active Withdrawn
- 2019-12-05 PH PH12019000462A patent/PH12019000462A1/en unknown
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2020
- 2020-08-27 CY CY20201100808T patent/CY1123423T1/el unknown
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