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DK3240895T3 - Sammensætninger og fremgangsmåder til proteinglykosylering - Google Patents

Sammensætninger og fremgangsmåder til proteinglykosylering Download PDF

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Publication number
DK3240895T3
DK3240895T3 DK15822948.4T DK15822948T DK3240895T3 DK 3240895 T3 DK3240895 T3 DK 3240895T3 DK 15822948 T DK15822948 T DK 15822948T DK 3240895 T3 DK3240895 T3 DK 3240895T3
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DK
Denmark
Prior art keywords
compositions
methods
protein glycosylation
glycosylation
protein
Prior art date
Application number
DK15822948.4T
Other languages
English (en)
Inventor
Jurgen Haas
Julian Ihssen
Michael Thomas Kowarik
Torsten Franz Schwede
Linda Christiane Thöny-Meyer
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Application granted granted Critical
Publication of DK3240895T3 publication Critical patent/DK3240895T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK15822948.4T 2014-12-30 2015-12-24 Sammensætninger og fremgangsmåder til proteinglykosylering DK3240895T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462097975P 2014-12-30 2014-12-30
US201462098071P 2014-12-30 2014-12-30
PCT/EP2015/081229 WO2016107818A1 (en) 2014-12-30 2015-12-24 Compositions and methods for protein glycosylation

Publications (1)

Publication Number Publication Date
DK3240895T3 true DK3240895T3 (da) 2022-04-11

Family

ID=55080101

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15822948.4T DK3240895T3 (da) 2014-12-30 2015-12-24 Sammensætninger og fremgangsmåder til proteinglykosylering

Country Status (18)

Country Link
US (3) US10150952B2 (da)
EP (2) EP4043561A1 (da)
JP (1) JP6850724B2 (da)
CN (1) CN107614679A (da)
BE (1) BE1022998B1 (da)
BR (1) BR112017014031B1 (da)
CA (1) CA2971653C (da)
CY (1) CY1125392T1 (da)
DK (1) DK3240895T3 (da)
ES (1) ES2907211T3 (da)
HR (1) HRP20220500T1 (da)
HU (1) HUE057726T2 (da)
LT (1) LT3240895T (da)
MX (1) MX389093B (da)
PL (1) PL3240895T3 (da)
PT (1) PT3240895T (da)
SI (1) SI3240895T1 (da)
WO (2) WO2016107819A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201807924T4 (tr) 2013-01-17 2018-06-21 Arsanis Biosciences Gmbh MDR e. koli spesifik antikor.
PL3110441T3 (pl) 2014-02-24 2024-08-05 Glaxosmithkline Biologicals S.A. Nowatorski polisacharyd i jego zastosowania
EP4043561A1 (en) 2014-12-30 2022-08-17 GlaxoSmithKline Biologicals SA Compositions and methods for protein glycosylation
ES3039659T3 (en) 2015-02-26 2025-10-23 Vaxnewmo Llc Acinetobacter o-oligosaccharyltransferases and uses thereof
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
GB201704117D0 (en) * 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
WO2019241672A2 (en) 2018-06-16 2019-12-19 Vaxnewmo Llc Glycosylated comp pilin variants, methods of making and uses thereof
WO2020131236A1 (en) * 2018-12-21 2020-06-25 Vaxnewmo Llc O-linked glycosylation recognition motifs
IL286467B1 (en) * 2019-03-18 2025-10-01 Janssen Pharmaceuticals Inc Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them
TWI751513B (zh) * 2019-03-18 2022-01-01 美商詹森藥物公司 E. coli O-抗原多醣生物結合物、其製備方法及其使用方法
EP3770269A1 (en) * 2019-07-23 2021-01-27 GlaxoSmithKline Biologicals S.A. Quantification of bioconjugate glycosylation
US20220403347A1 (en) * 2019-08-09 2022-12-22 Glaxosmithkline Biologicals S.A. Mutated pglb oligosaccharyltransferase enzymes
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
CN110910960B (zh) * 2019-11-30 2022-07-08 浙江天科高新技术发展有限公司 一种鲍曼不动杆菌分子血清型快速分析方法
PE20231385A1 (es) 2020-09-17 2023-09-12 Janssen Pharmaceuticals Inc Composiciones de vacunas multivalentes y usos de las mismas
EP4291673A2 (en) * 2021-02-11 2023-12-20 GlaxoSmithKline Biologicals SA Mutated pglb oligosaccharyltransferase enzymes
IL307247A (en) 2021-04-01 2023-11-01 Janssen Pharmaceuticals Inc Production of E. Coli O18 bioconjugates
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101524636B1 (ko) * 2005-05-11 2015-06-03 에테하 취리히 원핵 세포로부터의 재조합 n-글리코실화 단백질
KR101589554B1 (ko) * 2008-01-03 2016-02-01 코넬 리서치 파운데이션 인코포레이티드 원핵생물에서의 글리코실화 단백질 발현
US8895014B2 (en) * 2008-02-20 2014-11-25 Glycovaxyn Ag Bioconjugates made from recombinant N-glycosylated proteins from procaryotic cells
ES2660227T3 (es) * 2009-11-19 2018-03-21 Glaxosmithkline Biologicals S.A. Sistema biosintético que produce polisacáridos inmunogénicos en células procariotas
PL2566507T3 (pl) 2010-05-06 2018-05-30 Glaxosmithkline Biologicals Sa Szczepionki na bazie biokoniugatu przeciw otoczkowym bakteriom gram-dodatnim
WO2013067523A1 (en) * 2011-11-04 2013-05-10 Cornell University A prokaryote-based cell-free system for the synthesis of glycoproteins
WO2014111724A1 (en) * 2013-01-18 2014-07-24 London School Of Hygiene And Tropical Medicine Glycosylation method
EP4043561A1 (en) 2014-12-30 2022-08-17 GlaxoSmithKline Biologicals SA Compositions and methods for protein glycosylation
GB201704117D0 (en) * 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide

Also Published As

Publication number Publication date
EP4043561A1 (en) 2022-08-17
US20200181586A1 (en) 2020-06-11
WO2016107818A1 (en) 2016-07-07
LT3240895T (lt) 2022-04-11
PT3240895T (pt) 2022-03-02
HRP20220500T1 (hr) 2022-06-10
US10150952B2 (en) 2018-12-11
JP6850724B2 (ja) 2021-03-31
CA2971653C (en) 2024-06-11
MX2017008817A (es) 2017-10-24
CN107614679A (zh) 2018-01-19
CA2971653A1 (en) 2016-07-07
PL3240895T3 (pl) 2022-05-02
EP3240895B1 (en) 2022-01-26
US10577592B2 (en) 2020-03-03
BE1022998A1 (fr) 2016-10-28
EP3240895A1 (en) 2017-11-08
WO2016107819A1 (en) 2016-07-07
MX389093B (es) 2025-03-20
US20190078064A1 (en) 2019-03-14
SI3240895T1 (sl) 2022-04-29
HUE057726T2 (hu) 2022-06-28
BE1022998B1 (fr) 2016-10-28
US11015177B2 (en) 2021-05-25
BR112017014031A2 (pt) 2018-01-16
US20180002679A1 (en) 2018-01-04
WO2016107818A8 (en) 2017-08-31
CY1125392T1 (el) 2024-02-16
ES2907211T3 (es) 2022-04-22
BR112017014031B1 (pt) 2023-11-07
JP2018500912A (ja) 2018-01-18

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