DK3179991T3 - Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor - Google Patents
Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor Download PDFInfo
- Publication number
- DK3179991T3 DK3179991T3 DK15757002.9T DK15757002T DK3179991T3 DK 3179991 T3 DK3179991 T3 DK 3179991T3 DK 15757002 T DK15757002 T DK 15757002T DK 3179991 T3 DK3179991 T3 DK 3179991T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- bcl
- therapeutic combinations
- btk
- btk inhibitor
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035795P | 2014-08-11 | 2014-08-11 | |
| US201462088240P | 2014-12-05 | 2014-12-05 | |
| US201562115497P | 2015-02-12 | 2015-02-12 | |
| US201562181160P | 2015-06-17 | 2015-06-17 | |
| PCT/IB2015/056126 WO2016024230A1 (en) | 2014-08-11 | 2015-08-11 | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3179991T3 true DK3179991T3 (da) | 2021-12-06 |
Family
ID=54015145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15757002.9T DK3179991T3 (da) | 2014-08-11 | 2015-08-11 | Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20170231986A1 (da) |
| EP (1) | EP3179991B1 (da) |
| AR (1) | AR101505A1 (da) |
| CY (1) | CY1125588T1 (da) |
| DK (1) | DK3179991T3 (da) |
| ES (1) | ES2900184T3 (da) |
| HR (1) | HRP20211813T1 (da) |
| HU (1) | HUE056329T2 (da) |
| LT (1) | LT3179991T (da) |
| MA (1) | MA40596B1 (da) |
| PL (1) | PL3179991T3 (da) |
| PT (1) | PT3179991T (da) |
| RS (1) | RS62713B1 (da) |
| SI (1) | SI3179991T1 (da) |
| SM (1) | SMT202100674T1 (da) |
| TW (1) | TW201618772A (da) |
| WO (1) | WO2016024230A1 (da) |
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| KR101537148B1 (ko) | 2010-05-31 | 2015-07-15 | 오노 야꾸힝 고교 가부시키가이샤 | 푸리논 유도체 |
| US9199997B2 (en) | 2011-11-29 | 2015-12-01 | Ono Pharmaceutical Co., Ltd. | Purinone derivative hydrochloride |
| US9416131B2 (en) | 2014-03-25 | 2016-08-16 | Ono Pharmaceutical Co., Ltd. | Prophylactic agent and/or therapeutic agent for diffuse large B-cell lymphoma |
| HRP20211813T1 (hr) * | 2014-08-11 | 2022-03-04 | Acerta Pharma B.V. | Terapeutske kombinacije inhibitora btk i inhibitora bcl-2 |
| US10239879B2 (en) | 2015-04-09 | 2019-03-26 | Ono Pharmaceutical Co., Ltd. | Process for producing purinone derivative |
| JP6785804B2 (ja) * | 2015-06-23 | 2020-11-18 | ギリアド サイエンシズ， インコーポレイテッド | Ｂ細胞悪性腫瘍を治療するための組合せ療法 |
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| KR102494039B1 (ko) | 2016-03-28 | 2023-01-30 | 프레시지 바이오싸이언시스, 인크. | 암 치료를 위한 제약학적 조합물 |
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| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| US11351176B2 (en) | 2017-08-14 | 2022-06-07 | Mei Pharma, Inc. | Combination therapy |
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-
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- 2015-08-11 EP EP15757002.9A patent/EP3179991B1/en active Active
- 2015-08-11 SI SI201531754T patent/SI3179991T1/sl unknown
- 2015-08-11 US US15/503,217 patent/US20170231986A1/en not_active Abandoned
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- 2015-08-11 MA MA40596A patent/MA40596B1/fr unknown
- 2015-08-11 PT PT157570029T patent/PT3179991T/pt unknown
- 2015-08-11 RS RS20211442A patent/RS62713B1/sr unknown
- 2015-08-11 HU HUE15757002A patent/HUE056329T2/hu unknown
- 2015-08-11 WO PCT/IB2015/056126 patent/WO2016024230A1/en not_active Ceased
- 2015-08-11 PL PL15757002T patent/PL3179991T3/pl unknown
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| Publication number | Publication date |
|---|---|
| US11654143B2 (en) | 2023-05-23 |
| EP3179991A1 (en) | 2017-06-21 |
| SMT202100674T1 (it) | 2022-01-10 |
| EP3179991B1 (en) | 2021-10-06 |
| US20180250298A1 (en) | 2018-09-06 |
| HUE056329T2 (hu) | 2022-02-28 |
| MA40596B1 (fr) | 2021-12-31 |
| SI3179991T1 (sl) | 2022-04-29 |
| US20170231986A1 (en) | 2017-08-17 |
| LT3179991T (lt) | 2021-11-10 |
| PL3179991T3 (pl) | 2022-02-14 |
| ES2900184T3 (es) | 2022-03-16 |
| HRP20211813T1 (hr) | 2022-03-04 |
| WO2016024230A1 (en) | 2016-02-18 |
| PT3179991T (pt) | 2021-11-26 |
| RS62713B1 (sr) | 2022-01-31 |
| TW201618772A (zh) | 2016-06-01 |
| US20220088013A1 (en) | 2022-03-24 |
| AR101505A1 (es) | 2016-12-21 |
| CY1125588T1 (el) | 2024-02-16 |
| US11166951B2 (en) | 2021-11-09 |
| MA40596A (fr) | 2021-05-05 |
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