DK3174976T3 - Fremgangsmåder og systemer til forarbejdning af partikler - Google Patents
Fremgangsmåder og systemer til forarbejdning af partikler Download PDFInfo
- Publication number
- DK3174976T3 DK3174976T3 DK15827324.3T DK15827324T DK3174976T3 DK 3174976 T3 DK3174976 T3 DK 3174976T3 DK 15827324 T DK15827324 T DK 15827324T DK 3174976 T3 DK3174976 T3 DK 3174976T3
- Authority
- DK
- Denmark
- Prior art keywords
- systems
- processing methods
- particle processing
- particle
- methods
- Prior art date
Links
- 239000002245 particle Substances 0.000 title 1
- 238000003672 processing method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462032520P | 2014-08-01 | 2014-08-01 | |
| PCT/US2015/043500 WO2016019393A1 (en) | 2014-08-01 | 2015-08-03 | Methods and systems for processing particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3174976T3 true DK3174976T3 (da) | 2020-11-23 |
Family
ID=55218409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15827324.3T DK3174976T3 (da) | 2014-08-01 | 2015-08-03 | Fremgangsmåder og systemer til forarbejdning af partikler |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3174976B1 (da) |
| DK (1) | DK3174976T3 (da) |
| ES (1) | ES2839998T3 (da) |
| WO (1) | WO2016019393A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3608022A1 (en) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| US11998594B2 (en) | 2014-04-02 | 2024-06-04 | Case Western Reserve University | Anti-cancer plant virus particles linked to HER2 antigens |
| US9925281B2 (en) | 2014-08-05 | 2018-03-27 | Case Western Reserve University | Coated plant virus imaging agents |
| JP6731405B2 (ja) | 2014-11-07 | 2020-07-29 | ケース ウエスタン リザーブ ユニバーシティ | ウイルス粒子を用いた癌免疫療法 |
| US11617787B2 (en) | 2014-11-07 | 2023-04-04 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| US12465624B2 (en) | 2018-05-08 | 2025-11-11 | Case Western Reserve University | Cancer immunotherapy using virus particles and immune checkpoint therapy |
| US10624975B2 (en) | 2015-06-29 | 2020-04-21 | Case Western Reserve University | Anticancer drug-containing plant virus particles |
| US10478510B2 (en) | 2015-07-16 | 2019-11-19 | Case Western Resrve University | Plant virus particles for delivery of antimitotic agents |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| WO2017197343A2 (en) * | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| US12433840B2 (en) | 2016-11-03 | 2025-10-07 | Case Western Reserve University | Melt processed viral nanoparticle constructs |
| AU2017354004C1 (en) * | 2016-11-03 | 2023-08-31 | Case Western Reserve University | Melt processed viral nanoparticle constructs |
| WO2018096005A1 (en) | 2016-11-24 | 2018-05-31 | Koninklijke Philips N.V. | Device, system method and kit for isolating an analyte from a body fluid sample |
| US11590183B2 (en) | 2017-03-10 | 2023-02-28 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| US11672840B2 (en) | 2017-05-17 | 2023-06-13 | Case Western Reserve University | Anticancer trail-targeted plant virus particles |
| CA3074495A1 (en) | 2017-09-01 | 2019-03-07 | Gpb Scientific, Llc | Methods for preparing therapeutically active cells using microfluidics |
| CN107603850A (zh) * | 2017-10-13 | 2018-01-19 | 深圳先进技术研究院 | 用于细胞分选的微流控装置及其制备方法 |
| WO2019084555A1 (en) | 2017-10-27 | 2019-05-02 | Case Western Reserve University | TYMOVIRUS VIRUSES AND VIRAL TYPE PARTICLES USEFUL AS NANOVECTORS FOR IMAGING AND THERAPEUTIC AGENTS |
| EP3647767B1 (de) * | 2018-10-30 | 2024-09-25 | Siemens Healthineers AG | Isovolumetrisches aufkugeln von roten blutzellen |
| US11896676B2 (en) | 2019-08-07 | 2024-02-13 | Case Western Reserve University | Targeting cancer cells and tissue using filamentous plant virus particles |
| US11529430B2 (en) | 2019-12-20 | 2022-12-20 | Case Western Reserve University | Polydopamine decorated tobacco mosaic theranostic virus nanoparticles |
| US12203073B2 (en) | 2019-12-20 | 2025-01-21 | Case Western Reserve University | Plant viral RNA delivery nanoparticles and uses thereof |
| CN115209996B (zh) * | 2019-12-28 | 2025-09-05 | 日本瑞翁株式会社 | 用于处理颗粒和细胞的微流体盒 |
| WO2021142309A1 (en) * | 2020-01-08 | 2021-07-15 | The General Hospital Corporation | Microfluidic systems and methods for low-shear isolation of rare cells from large sample volumes |
| CN114594170B (zh) * | 2020-12-03 | 2024-05-17 | 复旦大学 | 一种磁固相萃取结合快速原位衍生化的体内药物分析方法 |
| CN113695748B (zh) * | 2021-08-23 | 2022-10-25 | 西安交通大学 | 一种基于空间光调制器的鲨鱼皮表面结构快速制备方法 |
| US12252678B2 (en) | 2021-12-01 | 2025-03-18 | Microfluidx Ltd | Systems and methods for bioprocessing |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5427663A (en) | 1993-06-08 | 1995-06-27 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| AU2002230979A1 (en) | 2000-12-18 | 2002-07-01 | Trustees Of Princeton University | Fractionation of macro-molecules using asymmetric pulsed field electrophoresis |
| US7704728B2 (en) * | 2001-07-18 | 2010-04-27 | The University Of Michigan | Microfluidic gravity pump with constant flow rate |
| WO2003066191A1 (en) | 2002-02-04 | 2003-08-14 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| EP1585583B1 (en) | 2002-10-23 | 2010-04-07 | The Trustees of Princeton University | Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US7735652B2 (en) | 2006-06-01 | 2010-06-15 | The Trustees Of Princeton University | Apparatus and method for continuous particle separation |
| US8579117B2 (en) | 2008-07-24 | 2013-11-12 | The Trustees Of Princeton University | Bump array device having asymmetric gaps for segregation of particles |
| US9090663B2 (en) * | 2009-04-21 | 2015-07-28 | The Trustees Of Columbia University In The City Of New York | Systems and methods for the capture and separation of microparticles |
| EP2421628A4 (en) * | 2009-04-23 | 2012-10-10 | Logos Energy Inc | LATERAL DISPLACEMENT ARRANGEMENT FOR MICROFILTRATION |
| US8801922B2 (en) * | 2009-06-24 | 2014-08-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Dialysis system |
| US8830451B1 (en) | 2010-05-07 | 2014-09-09 | Stc.Unm | Multinode acoustic focusing for parallel flow cytometry analysis applications |
| US20130143197A1 (en) | 2010-08-15 | 2013-06-06 | Gpb Scientific, Llc | Microfluidic Cell Separation in the Assay of Blood |
| CN103889556A (zh) | 2011-01-06 | 2014-06-25 | Gpb科学有限责任公司 | 在引入亲和性和大小两者的微流体芯片上的循环肿瘤细胞捕获 |
| WO2012149472A2 (en) | 2011-04-27 | 2012-11-01 | Ignite Institute For Individualized Health | Methods, compositions, and kits for treating and preventing neurological conditions |
| CA2844056A1 (en) | 2011-08-04 | 2013-02-07 | Sage Science, Inc. | Systems and methods for processing fluids |
| CN104797340A (zh) * | 2012-09-21 | 2015-07-22 | 麻省理工学院 | 微流体装置及其用途 |
| WO2014052968A1 (en) * | 2012-09-28 | 2014-04-03 | Canon U.S. Life Sciences, Inc. | Particle separation and concentration using spiral inertial filtration |
-
2015
- 2015-08-03 EP EP15827324.3A patent/EP3174976B1/en active Active
- 2015-08-03 DK DK15827324.3T patent/DK3174976T3/da active
- 2015-08-03 WO PCT/US2015/043500 patent/WO2016019393A1/en not_active Ceased
- 2015-08-03 ES ES15827324T patent/ES2839998T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3174976B1 (en) | 2020-10-28 |
| ES2839998T3 (es) | 2021-07-06 |
| EP3174976A1 (en) | 2017-06-07 |
| EP3174976A4 (en) | 2018-01-17 |
| WO2016019393A1 (en) | 2016-02-04 |
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