DK3030581T3 - Antistofbindingssteder, der er specifikke for egfrviii - Google Patents
Antistofbindingssteder, der er specifikke for egfrviii Download PDFInfo
- Publication number
- DK3030581T3 DK3030581T3 DK14758087.2T DK14758087T DK3030581T3 DK 3030581 T3 DK3030581 T3 DK 3030581T3 DK 14758087 T DK14758087 T DK 14758087T DK 3030581 T3 DK3030581 T3 DK 3030581T3
- Authority
- DK
- Denmark
- Prior art keywords
- egfrviii
- sites specific
- sites
- specific
- specification sites
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13179630 | 2013-08-07 | ||
| EP13189599 | 2013-10-21 | ||
| PCT/EP2014/002177 WO2015018527A1 (en) | 2013-08-07 | 2014-08-07 | ANTIBODY BINDING SITES SPECIFIC FOR EGFRvIII |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3030581T3 true DK3030581T3 (da) | 2021-04-12 |
Family
ID=51453717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14758087.2T DK3030581T3 (da) | 2013-08-07 | 2014-08-07 | Antistofbindingssteder, der er specifikke for egfrviii |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10273309B2 (da) |
| EP (1) | EP3030581B1 (da) |
| JP (1) | JP6529498B2 (da) |
| CN (1) | CN105555804B (da) |
| AU (1) | AU2014304930B2 (da) |
| CA (1) | CA2920173C (da) |
| DK (1) | DK3030581T3 (da) |
| HR (1) | HRP20210561T1 (da) |
| HU (1) | HUE054057T2 (da) |
| LT (1) | LT3030581T (da) |
| RU (1) | RU2696892C2 (da) |
| SI (1) | SI3030581T1 (da) |
| WO (1) | WO2015018527A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201900439T1 (it) * | 2014-03-11 | 2019-09-09 | Regeneron Pharma | Anticorpi anti-egfrviii e loro usi |
| US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| EP2982693A1 (en) | 2014-08-07 | 2016-02-10 | Affimed Therapeutics AG | CD3 binding domain |
| PT3239177T (pt) * | 2014-11-25 | 2021-05-14 | Pharmabcine Inc | Novo anticorpo egfrviii e composição compreendendo o mesmo |
| AU2016271113B2 (en) | 2015-05-29 | 2022-09-08 | Amphivena Therapeutics, Inc. | Methods of using bispecific CD33 and CD3 binding proteins |
| KR20180023949A (ko) | 2015-06-09 | 2018-03-07 | 메모리얼 슬로안-케터링 캔서 센터 | 인간 hla에 의해 제시된 ebv 잠복성 막 단백질 2a 펩티드에 특이적인 t 세포 수용체-유사 항체 작용제 |
| EP3916018A1 (en) * | 2015-06-16 | 2021-12-01 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| EA039859B1 (ru) * | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TW201936640A (zh) * | 2016-01-21 | 2019-09-16 | 美商輝瑞股份有限公司 | 對表皮生長因子受體變異體ｉｉｉ具特異性之抗體類及彼等之用途 |
| AU2017208834B2 (en) | 2016-01-21 | 2021-09-02 | Pfizer Inc. | Chimeric Antigen Receptors targeting Epidermal Growth Factor Receptor Variant III |
| SG11201806150RA (en) | 2016-02-03 | 2018-08-30 | Amgen Res Munich Gmbh | Psma and cd3 bispecific t cell engaging antibody constructs |
| CN107556386A (zh) * | 2016-06-30 | 2018-01-09 | 中国科学院深圳先进技术研究院 | 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用 |
| RU2721582C1 (ru) | 2016-08-05 | 2020-05-20 | И-Байолоджикс Инк. | Антитела против лиганда-1 запрограммированной смерти (PD-L1) и их применение |
| EP3495390A4 (en) * | 2016-08-05 | 2020-08-19 | Y-Biologics Inc. | NOVEL ANTIBODY AGAINST PROGRAMMED CELL DEATH PROTEIN (PD-1) AND USE OF IT |
| CN106501518A (zh) * | 2017-01-06 | 2017-03-15 | 北京弘润天源生物技术股份有限公司 | 一种检测EGFRvⅢ的免疫组化抗体试剂及检测方法 |
| AU2018228719B2 (en) * | 2017-02-28 | 2023-03-30 | Affimed Gmbh | Tandem diabody for CD16A-directed NK-cell engagement |
| US11866498B2 (en) | 2018-02-08 | 2024-01-09 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| AU2019235433B2 (en) * | 2018-03-14 | 2025-11-20 | Affimed Gmbh | Bispecific EGFR/CD16 antigen-binding protein |
| CN118271445A (zh) * | 2018-12-21 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 与cd3结合的抗体 |
| SG11202106257WA (en) * | 2019-01-14 | 2021-07-29 | Nanjing Legend Biotech Co Ltd | Chimeric receptor polypeptides and uses thereof |
| CN114867494B9 (zh) | 2019-12-13 | 2024-01-12 | 基因泰克公司 | 抗ly6g6d抗体及使用方法 |
| KR20230015996A (ko) * | 2020-06-30 | 2023-01-31 | 하버 바이오메드 (상하이) 컴퍼니 리미티드 | H2l2 및 hcab 구조를 갖는 결합 단백질 |
| WO2022159685A2 (en) * | 2021-01-22 | 2022-07-28 | Vanderbilt University | Sars-cov-2 coronavirus antibodies and uses thereof |
| IL308417A (en) | 2021-05-14 | 2024-01-01 | Genentech Inc | Methods for the treatment of CD20-positive proliferative disorder with musuntozumab and folatuzumab and dotin |
| EP4370557A4 (en) * | 2021-07-16 | 2025-10-01 | Medical Guidance Systems Llc | TAX-INTERACTING PROTEIN-BINDING MOLECULES 1 (TIP1) |
| CN116375868A (zh) * | 2021-12-31 | 2023-07-04 | 康源博创生物科技(北京)有限公司 | 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用 |
| WO2024258870A2 (en) | 2023-06-12 | 2024-12-19 | Amgen Inc. | Lymphotoxin beta receptor agonist binding proteins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19819846B4 (de) * | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| WO2001062931A2 (en) * | 2000-02-25 | 2001-08-30 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | ANTI-EGFRvIII SCFVS WITH IMPROVED CYTOTOXICITY AND YIELD, IMMUNOTOXINS BASED THEREON, AND METHODS OF USE THEREOF |
| US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| IN2012DN00313A (da) * | 2003-06-27 | 2015-05-08 | Amgen Fremont Inc |
-
2014
- 2014-08-07 DK DK14758087.2T patent/DK3030581T3/da active
- 2014-08-07 HR HRP20210561TT patent/HRP20210561T1/hr unknown
- 2014-08-07 WO PCT/EP2014/002177 patent/WO2015018527A1/en not_active Ceased
- 2014-08-07 LT LTEP14758087.2T patent/LT3030581T/lt unknown
- 2014-08-07 CA CA2920173A patent/CA2920173C/en active Active
- 2014-08-07 HU HUE14758087A patent/HUE054057T2/hu unknown
- 2014-08-07 SI SI201431808T patent/SI3030581T1/sl unknown
- 2014-08-07 EP EP14758087.2A patent/EP3030581B1/en active Active
- 2014-08-07 JP JP2016532264A patent/JP6529498B2/ja active Active
- 2014-08-07 AU AU2014304930A patent/AU2014304930B2/en active Active
- 2014-08-07 RU RU2016106577A patent/RU2696892C2/ru active
- 2014-08-07 CN CN201480045405.5A patent/CN105555804B/zh active Active
-
2016
- 2016-02-04 US US15/015,261 patent/US10273309B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015018527A1 (en) | 2015-02-12 |
| HUE054057T2 (hu) | 2021-08-30 |
| CA2920173C (en) | 2021-08-10 |
| HRP20210561T1 (hr) | 2021-05-14 |
| CN105555804B (zh) | 2020-12-25 |
| BR112016002610A2 (pt) | 2017-09-12 |
| CN105555804A (zh) | 2016-05-04 |
| AU2014304930A1 (en) | 2016-02-25 |
| LT3030581T (lt) | 2021-05-25 |
| JP6529498B2 (ja) | 2019-06-12 |
| EP3030581A1 (en) | 2016-06-15 |
| SI3030581T1 (sl) | 2021-07-30 |
| RU2696892C2 (ru) | 2019-08-07 |
| JP2016536322A (ja) | 2016-11-24 |
| US10273309B2 (en) | 2019-04-30 |
| US20160152728A1 (en) | 2016-06-02 |
| EP3030581B1 (en) | 2021-01-20 |
| CA2920173A1 (en) | 2015-02-12 |
| BR112016002610A8 (pt) | 2018-01-23 |
| AU2014304930B2 (en) | 2019-11-21 |
| HK1218552A1 (zh) | 2017-02-24 |
| RU2016106577A (ru) | 2017-09-14 |
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