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DK3062824T3 - Telomerase-kodende dna-vaccine - Google Patents

Telomerase-kodende dna-vaccine Download PDF

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Publication number
DK3062824T3
DK3062824T3 DK14790592.1T DK14790592T DK3062824T3 DK 3062824 T3 DK3062824 T3 DK 3062824T3 DK 14790592 T DK14790592 T DK 14790592T DK 3062824 T3 DK3062824 T3 DK 3062824T3
Authority
DK
Denmark
Prior art keywords
telomerase
dna vaccine
coding dna
coding
vaccine
Prior art date
Application number
DK14790592.1T
Other languages
English (en)
Inventor
Demoyen Pierre Langlade
Simon Wain-Hobson
Thierry Huet
Christelle Liard
Elodie Pliquet
Original Assignee
Invectys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invectys filed Critical Invectys
Application granted granted Critical
Publication of DK3062824T3 publication Critical patent/DK3062824T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001157Telomerase or TERT [telomerase reverse transcriptase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1276RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07049RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK14790592.1T 2013-10-28 2014-10-28 Telomerase-kodende dna-vaccine DK3062824T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13190547 2013-10-28
PCT/EP2014/073164 WO2015063117A1 (en) 2013-10-28 2014-10-28 A telomerase encoding dna vaccine

Publications (1)

Publication Number Publication Date
DK3062824T3 true DK3062824T3 (da) 2020-02-17

Family

ID=49515221

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14790592.1T DK3062824T3 (da) 2013-10-28 2014-10-28 Telomerase-kodende dna-vaccine

Country Status (25)

Country Link
US (2) US10183065B2 (da)
EP (2) EP3666290A1 (da)
JP (1) JP6545162B2 (da)
KR (1) KR102252756B1 (da)
CN (1) CN106061509B (da)
AU (1) AU2014343813B2 (da)
BR (1) BR112016009002B1 (da)
CA (1) CA2927702C (da)
CY (1) CY1122839T1 (da)
DK (1) DK3062824T3 (da)
EA (1) EA034928B1 (da)
ES (1) ES2771862T3 (da)
HR (1) HRP20200211T1 (da)
HU (1) HUE047898T2 (da)
IL (1) IL245186B (da)
LT (1) LT3062824T (da)
MX (1) MX372778B (da)
NZ (1) NZ719098A (da)
PL (1) PL3062824T3 (da)
PT (1) PT3062824T (da)
RS (1) RS60232B1 (da)
SG (1) SG11201603118TA (da)
SI (1) SI3062824T1 (da)
WO (1) WO2015063117A1 (da)
ZA (1) ZA201603452B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3062824T (pt) 2013-10-28 2020-02-21 Invectys Vacina de adn de codificação da telomerase
ES2809508T3 (es) * 2015-10-06 2021-03-04 Invectys Estructuras artificiales de poliepítopos para uso en inmunoterapia
WO2018206512A1 (en) 2017-05-09 2018-11-15 Invectys Recombinant measles vaccine expressing htert
KR20220035937A (ko) * 2019-07-25 2022-03-22 노파르티스 아게 조절 가능한 발현 시스템
JP7728772B2 (ja) * 2020-02-12 2025-08-25 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 遺伝子発現の誘導性選択的スプライシング調節のための組成物および方法
AU2021294322A1 (en) * 2020-06-26 2023-02-02 National Breast Cancer Coalition Breast cancer vaccine
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
WO2022236301A1 (en) * 2021-05-05 2022-11-10 Inovio Pharmaceuticals Inc. Vaccines against coronavirus and methods of use
WO2024126758A2 (en) * 2022-12-14 2024-06-20 Ultimovacs Ab A nucleic acid molecule and a chimeric polypeptide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0458841T3 (da) 1989-02-17 1995-11-20 Chiron Mimotopes Pty Ltd Fremgangsmåde til anvendelse og fremstilling af peptider
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
IL129222A0 (en) 1996-10-01 2000-02-17 Geron Corp Telomerase reverse transcriptase
WO2003038047A2 (en) 2001-10-29 2003-05-08 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-ii restricted tumor-associated antigen
AU2003249357A1 (en) 2002-06-27 2004-01-19 Geron Corporation Cancer vaccine containing cross-species epitopes of telomerase reverse transcriptase
EP1748067A1 (en) 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
US20090162405A1 (en) 2006-12-14 2009-06-25 Yong Qian Proteinase-engineered cancer vaccine induces immune responses to prevent cancer and to systemically kill cancer cells
AU2007306368B2 (en) 2006-10-12 2012-05-03 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
JP5630769B2 (ja) * 2008-04-11 2014-11-26 井戸川 雅史 アポトーシス誘導剤
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
JP2012039877A (ja) 2009-04-10 2012-03-01 Fukuoka Univ ユビキチン融合遺伝子およびそれを用いたdnaワクチン
WO2011073796A2 (en) 2009-12-16 2011-06-23 Chrontech Pharma Ab Injection needle and device
AU2014242915B2 (en) 2013-03-28 2018-08-09 Invectys A cancer vaccine for cats
US10138488B2 (en) 2013-03-28 2018-11-27 Invectys Cancer vaccine for dogs
PT3062824T (pt) 2013-10-28 2020-02-21 Invectys Vacina de adn de codificação da telomerase
JP6655017B2 (ja) * 2014-01-27 2020-02-26 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. Mhcクラスiエピトープ送達ポリペプチド

Also Published As

Publication number Publication date
CA2927702A1 (en) 2015-05-07
US10183065B2 (en) 2019-01-22
CA2927702C (en) 2022-06-07
NZ719098A (en) 2022-08-26
IL245186B (en) 2021-02-28
CN106061509A (zh) 2016-10-26
EP3666290A1 (en) 2020-06-17
EP3062824A1 (en) 2016-09-07
JP2017502649A (ja) 2017-01-26
BR112016009002B1 (pt) 2023-05-02
MX2016005389A (es) 2016-08-03
SI3062824T1 (sl) 2020-04-30
EP3062824B1 (en) 2019-11-27
WO2015063117A1 (en) 2015-05-07
PT3062824T (pt) 2020-02-21
EA034928B1 (ru) 2020-04-08
PL3062824T3 (pl) 2020-06-15
AU2014343813A1 (en) 2016-05-19
EA201690884A1 (ru) 2016-11-30
US20160263204A1 (en) 2016-09-15
IL245186A0 (en) 2016-06-30
HK1225986A1 (en) 2017-09-22
LT3062824T (lt) 2020-05-25
HUE047898T2 (hu) 2020-05-28
KR102252756B1 (ko) 2021-05-17
HRP20200211T1 (hr) 2020-05-15
BR112016009002A2 (pt) 2017-10-03
AU2014343813B2 (en) 2020-02-27
ZA201603452B (en) 2020-08-26
MX372778B (es) 2020-06-29
US12064474B2 (en) 2024-08-20
SG11201603118TA (en) 2016-05-30
CN106061509B (zh) 2022-04-08
ES2771862T3 (es) 2020-07-07
RS60232B1 (sr) 2020-06-30
JP6545162B2 (ja) 2019-07-17
US20190000946A1 (en) 2019-01-03
CY1122839T1 (el) 2021-10-29
KR20160111362A (ko) 2016-09-26

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