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DK3060577T3 - Produktion af rekombinant lubricin - Google Patents

Produktion af rekombinant lubricin Download PDF

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Publication number
DK3060577T3
DK3060577T3 DK14856188.9T DK14856188T DK3060577T3 DK 3060577 T3 DK3060577 T3 DK 3060577T3 DK 14856188 T DK14856188 T DK 14856188T DK 3060577 T3 DK3060577 T3 DK 3060577T3
Authority
DK
Denmark
Prior art keywords
production
recombinant lubricin
lubricin
recombinant
Prior art date
Application number
DK14856188.9T
Other languages
English (en)
Inventor
Tannin Schmidt
Gregory D Jay
Original Assignee
Lubris Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubris Llc filed Critical Lubris Llc
Application granted granted Critical
Publication of DK3060577T3 publication Critical patent/DK3060577T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725Proteoglycans, e.g. aggreccan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK14856188.9T 2013-10-22 2014-10-22 Produktion af rekombinant lubricin DK3060577T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361894366P 2013-10-22 2013-10-22
PCT/US2014/061827 WO2015061488A1 (en) 2013-10-22 2014-10-22 Production of recombinant lubricin

Publications (1)

Publication Number Publication Date
DK3060577T3 true DK3060577T3 (da) 2021-10-04

Family

ID=52993344

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14856188.9T DK3060577T3 (da) 2013-10-22 2014-10-22 Produktion af rekombinant lubricin

Country Status (22)

Country Link
US (5) US9982027B2 (da)
EP (2) EP3060577B1 (da)
JP (2) JP6669649B2 (da)
KR (1) KR102488928B1 (da)
CN (1) CN105899527A (da)
AU (2) AU2014340080B2 (da)
BR (1) BR112016008923A2 (da)
CA (1) CA2927949A1 (da)
CY (1) CY1124861T1 (da)
DK (1) DK3060577T3 (da)
ES (1) ES2891331T3 (da)
HR (1) HRP20211497T1 (da)
HU (1) HUE056397T2 (da)
IL (2) IL245236B (da)
LT (1) LT3060577T (da)
MX (2) MX380735B (da)
PL (1) PL3060577T3 (da)
PT (1) PT3060577T (da)
RU (1) RU2758115C2 (da)
SG (2) SG11201603151VA (da)
SI (1) SI3060577T1 (da)
WO (2) WO2015060935A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2432492B1 (en) 2009-05-22 2014-12-24 Lubris, Llc Application and uses of prg4 and therapeutic modulation thereof
EP2948553B1 (en) * 2013-01-25 2020-04-01 Baylor College Of Medicine A helper-dependent adenoviral gene therapy delivery and expression system
WO2015060935A1 (en) 2013-10-22 2015-04-30 Lubris, Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
AU2014354859B2 (en) 2013-11-26 2020-04-09 Lubris Llc Compositions and methods for inhibiting intercellular interactions
RU2017129880A (ru) 2015-01-26 2019-03-04 ЛУБРИС ЭлЭлСи Применение prg4 в качестве противовоспалительного средства
PL3300482T3 (pl) * 2015-05-19 2022-01-03 Lubris Llc Zastosowanie prg4 do poprawy dynamicznej ostrości wzroku i aberracji wyższego rzędu
EP3563894B1 (en) 2018-05-04 2021-12-22 Boehringer Ingelheim International GmbH Nebulizer and container
CN109055426B (zh) * 2018-08-06 2021-06-25 智享生物(苏州)有限公司 一种在中华仓鼠卵巢细胞中表达生产类人润滑素的方法
JP7667569B2 (ja) 2019-01-15 2025-04-23 コーネル ユニバーシティー 組換えラブリシン、並びにそれを使用するための組成物及び方法
US20220332839A1 (en) * 2019-06-03 2022-10-20 Lubris Llc Use of prg4 to treat cancer
WO2021171165A1 (en) 2020-02-24 2021-09-02 Novartis Ag Purification of recombinantly produced polypeptides
US20250282981A1 (en) 2022-04-27 2025-09-11 Lubris Llc Methods of making polymer films
CN115154667A (zh) * 2022-06-27 2022-10-11 天津大学 一种基于重组润滑素蛋白修饰的胶原蛋白基质的制备方法
CN115177790A (zh) * 2022-06-27 2022-10-14 天津大学 透明质酸和润滑素蛋白协同修饰胶原蛋白基质的制备方法

Family Cites Families (35)

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EP2218775B1 (en) * 1996-08-30 2015-01-28 Life Technologies Corporation Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US6960562B2 (en) 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US7001881B1 (en) 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
ATE437233T1 (de) 2001-01-26 2009-08-15 Selexis Sa Matrix-anheftungsregionen und verfahren zu deren verwendung
TW200307011A (en) 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
US7415381B2 (en) 2003-01-09 2008-08-19 Rhode Island Hospital, A Lifespan Partner Joint friction sensing
US20060240037A1 (en) 2003-06-04 2006-10-26 Edward Fey Methods and compositions for the treatment and prevention of degenerative joint disorders
BRPI0413553A (pt) 2003-08-14 2006-10-17 Wyeth Corp moléculas de lubricina recombinante e usos das mesmas
EP2298898B1 (en) 2003-10-24 2012-12-26 Selexis S.A. High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences
WO2005102363A2 (en) * 2004-04-20 2005-11-03 Mucosal Therapeutics Llc Methods of promoting cartilage healing or cartilage integration
JP2008507553A (ja) 2004-07-23 2008-03-13 ミューコサル セラピューティクス リミテッド ライアビリディ カンパニー 粘性補給のための組成物および方法
EP1827478A4 (en) 2004-12-03 2009-08-05 Mucosal Therapeutics Llc METHODS OF TREATING JOINED OR SICK JOINTS
US20070111327A1 (en) 2005-05-05 2007-05-17 Jay Gregory D Methods of detecting lubricin
KR20080047538A (ko) 2005-09-09 2008-05-29 라보팜 인코포레이트 서방형 약제 조성물
KR20090053893A (ko) 2006-08-23 2009-05-28 셀렉시스 에스. 에이. 전사를 증가시키기 위한 기질부착부위(mars) 및 그의 용도
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SI2915529T1 (sl) 2008-05-07 2017-09-29 The Regents Of The University Of California Terapevtska regeneracija in obogatitev lubrikacije okularne površine
US8506944B2 (en) * 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
EP2381957B1 (en) 2009-01-13 2015-01-07 Lubris LLC Therapeutic modulation of vaginal epithelium boundary lubrication
EP2432492B1 (en) 2009-05-22 2014-12-24 Lubris, Llc Application and uses of prg4 and therapeutic modulation thereof
US9107885B2 (en) 2009-08-13 2015-08-18 Lubris Llc PRG4 treatment for interstitial cystitis
CN102575264A (zh) * 2009-09-18 2012-07-11 瑟莱克斯公司 增加的转基因表达和加工的产品和方法
EP2525805B1 (en) 2010-01-19 2017-03-15 Lubris LLC Oral care compositions and methods
US20130116186A1 (en) 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
WO2015060935A1 (en) 2013-10-22 2015-04-30 Lubris, Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
AU2014354859B2 (en) 2013-11-26 2020-04-09 Lubris Llc Compositions and methods for inhibiting intercellular interactions
US20180161393A1 (en) 2015-01-26 2018-06-14 Lubris Llc Prg4 for treating gout and its symptoms
RU2017129880A (ru) 2015-01-26 2019-03-04 ЛУБРИС ЭлЭлСи Применение prg4 в качестве противовоспалительного средства
PL3300482T3 (pl) 2015-05-19 2022-01-03 Lubris Llc Zastosowanie prg4 do poprawy dynamicznej ostrości wzroku i aberracji wyższego rzędu
US20170312335A1 (en) 2015-12-30 2017-11-02 Lubris Llc Topical use of prg4 for treatment of allergy and symptoms of inflammation

Also Published As

Publication number Publication date
JP6970164B2 (ja) 2021-11-24
WO2015060935A1 (en) 2015-04-30
IL283447A (en) 2021-07-29
AU2014340080B2 (en) 2018-12-06
JP2020039348A (ja) 2020-03-19
KR102488928B1 (ko) 2023-01-13
US20210130427A1 (en) 2021-05-06
PT3060577T (pt) 2021-10-01
US20190270783A1 (en) 2019-09-05
EP3060577A1 (en) 2016-08-31
SG11201603151VA (en) 2016-05-30
CY1124861T1 (el) 2022-11-25
CN105899527A (zh) 2016-08-24
AU2019201478B2 (en) 2021-07-08
RU2016119532A (ru) 2017-11-28
RU2016119532A3 (da) 2018-05-16
AU2014340080A1 (en) 2016-06-02
US10723773B2 (en) 2020-07-28
MX2016005302A (es) 2017-02-15
US11485764B2 (en) 2022-11-01
WO2015061488A1 (en) 2015-04-30
US10125180B2 (en) 2018-11-13
SG10201913598TA (en) 2020-02-27
MX2021003243A (es) 2021-05-12
IL245236B (en) 2021-12-01
BR112016008923A2 (pt) 2017-09-19
LT3060577T (lt) 2021-12-27
HUE056397T2 (hu) 2022-02-28
US12435115B2 (en) 2025-10-07
US20230234999A1 (en) 2023-07-27
ES2891331T3 (es) 2022-01-27
EP3060577B1 (en) 2021-07-07
PL3060577T3 (pl) 2022-01-24
AU2019201478A1 (en) 2019-03-28
CA2927949A1 (en) 2015-04-30
US9982027B2 (en) 2018-05-29
EP3971203A1 (en) 2022-03-23
EP3060577A4 (en) 2017-05-17
JP6669649B2 (ja) 2020-03-18
KR20160086843A (ko) 2016-07-20
MX380735B (es) 2025-03-12
US20160304572A1 (en) 2016-10-20
IL245236A0 (en) 2016-06-30
JP2016535590A (ja) 2016-11-17
HRP20211497T1 (hr) 2021-12-24
US20160250286A1 (en) 2016-09-01
SI3060577T1 (sl) 2021-12-31
RU2758115C2 (ru) 2021-10-26

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