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DK2990798T3 - Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet for et specifikt mål - Google Patents

Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet for et specifikt mål Download PDF

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Publication number
DK2990798T3
DK2990798T3 DK15186647T DK15186647T DK2990798T3 DK 2990798 T3 DK2990798 T3 DK 2990798T3 DK 15186647 T DK15186647 T DK 15186647T DK 15186647 T DK15186647 T DK 15186647T DK 2990798 T3 DK2990798 T3 DK 2990798T3
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Denmark
Prior art keywords
hngal
lcn2
muteins
affinity
specific target
Prior art date
Application number
DK15186647T
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English (en)
Inventor
Arne Skerra
Michaela Gebauer
Dominik Hinz
Martin Huelsmeyer
Sabine Rauth
Gabriele Matschiner
Original Assignee
Pieris Pharmaceuticals Gmbh
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Filing date
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Application filed by Pieris Pharmaceuticals Gmbh filed Critical Pieris Pharmaceuticals Gmbh
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Publication of DK2990798T3 publication Critical patent/DK2990798T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/00041Use of virus, viral particle or viral elements as a vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
DK15186647T 2009-12-07 2010-12-07 Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet for et specifikt mål DK2990798T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26709809P 2009-12-07 2009-12-07
EP10784824.4A EP2510357B1 (en) 2009-12-07 2010-12-07 Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target

Publications (1)

Publication Number Publication Date
DK2990798T3 true DK2990798T3 (da) 2019-12-02

Family

ID=43597993

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15186647T DK2990798T3 (da) 2009-12-07 2010-12-07 Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet for et specifikt mål
DK10784824.4T DK2510357T3 (da) 2009-12-07 2010-12-07 Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet til et specifikt mål

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10784824.4T DK2510357T3 (da) 2009-12-07 2010-12-07 Muteiner af human lipocalin 2 (lcn2, hngal) med affinitet til et specifikt mål

Country Status (12)

Country Link
US (3) US9549968B2 (da)
EP (3) EP3660510A3 (da)
JP (5) JP5913120B2 (da)
KR (2) KR101842076B1 (da)
CN (1) CN102770764B (da)
AU (1) AU2010329995B2 (da)
BR (1) BR112012013662B1 (da)
CA (1) CA2779562C (da)
DK (2) DK2990798T3 (da)
RU (2) RU2564125C2 (da)
SG (1) SG10201408073XA (da)
WO (1) WO2011069992A2 (da)

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CN107403074B (zh) * 2017-06-09 2018-05-29 天津市湖滨盘古基因科学发展有限公司 一种突变蛋白的检测方法及装置
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TW201725212A (zh) 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白

Also Published As

Publication number Publication date
JP2021006024A (ja) 2021-01-21
WO2011069992A2 (en) 2011-06-16
RU2012128586A (ru) 2014-01-20
JP2016105709A (ja) 2016-06-16
KR20180031081A (ko) 2018-03-27
KR20120117815A (ko) 2012-10-24
EP2990798A1 (en) 2016-03-02
CA2779562C (en) 2019-12-31
RU2707126C2 (ru) 2019-11-22
JP2018148914A (ja) 2018-09-27
RU2015137158A (ru) 2018-12-25
AU2010329995B2 (en) 2015-09-17
US20170114109A1 (en) 2017-04-27
BR112012013662B1 (pt) 2022-08-02
SG10201408073XA (en) 2015-01-29
WO2011069992A3 (en) 2011-08-11
CN102770764B (zh) 2016-04-20
US9549968B2 (en) 2017-01-24
BR112012013662A2 (pt) 2020-11-03
JP6346159B2 (ja) 2018-06-20
EP2510357B1 (en) 2016-03-30
CA2779562A1 (en) 2011-06-16
US20130079286A1 (en) 2013-03-28
RU2564125C2 (ru) 2015-09-27
RU2015137158A3 (da) 2018-12-25
CN102770764A (zh) 2012-11-07
KR101842076B1 (ko) 2018-03-27
KR101974044B1 (ko) 2019-04-30
US10618941B2 (en) 2020-04-14
US20200308237A1 (en) 2020-10-01
EP2510357A2 (en) 2012-10-17
JP2022160410A (ja) 2022-10-19
EP3660510A2 (en) 2020-06-03
US11827681B2 (en) 2023-11-28
EP2990798B1 (en) 2019-09-25
JP5913120B2 (ja) 2016-05-11
DK2510357T3 (da) 2016-07-18
JP7482544B2 (ja) 2024-05-14
EP3660510A3 (en) 2020-07-08
AU2010329995A1 (en) 2012-05-10
JP2013512683A (ja) 2013-04-18

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