DK2847204T3 - Sterolderivater og anvendelse deraf til behandling af sygdomme, der involverer transformerede astrocytceller, eller til behandling af maligne hæmopatier - Google Patents
Sterolderivater og anvendelse deraf til behandling af sygdomme, der involverer transformerede astrocytceller, eller til behandling af maligne hæmopatier Download PDFInfo
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- DK2847204T3 DK2847204T3 DK13729470.8T DK13729470T DK2847204T3 DK 2847204 T3 DK2847204 T3 DK 2847204T3 DK 13729470 T DK13729470 T DK 13729470T DK 2847204 T3 DK2847204 T3 DK 2847204T3
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- methylheptan
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Classifications
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- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Forbindelse med formlen (I) med en beta-hydroxycholesterol-grundstruktur
kendetegnet ved, at den er udvalgt fra følgende forbindelser: - 7-((fer£-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1 H-cyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1 .a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1.b); - 7-((tert-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1 H-cyclopenta[a]phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta[a]-phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.b), til anvendelse i behandlingen af maligne hæmopatier.
2. Forbindelse til anvendelse ifølge krav 1, hvor de maligne hæmopatier er af myeloidtypen.
3. Forbindelse til anvendelse ifølge krav 1, hvor de maligne hæmopatier er lymfomer.
4. Forbindelse med formlen (I) med en beta-hydroxycholesterol-grundstruktur
kendetegnet ved, at den er udvalgt fra følgende forbindelser: - 7-((te/t-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1 H-cyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1 .a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1Hcyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1.b); - 7-((tert-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1 H-cyclopenta[a]phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1 Hcyclopenta[a]-phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.b), til anvendelse i behandlingen af neuroblastomer.
5. Forbindelse med formlen (I) med en beta-hydroxycholesterol-grundstruktur
kendetegnet ved, at den er udvalgt fra følgende forbindelser: - 7-((terf-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1 H-cyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1 .a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2-(2-(((benzyloxy)carbonyl)amino)-acetamido)propanoat (molekyle 1.b); - 7-((tert-butoxycarbonyl)oxy)-10,13-dimethyl-17-(6-methylheptan-2-yl)- 2.3.4.7.8.9.10.11.12.13.14.15.16.17- tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.a); - 7-acetoxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1 Hcyclopenta[a]-phenanthren-3-yl 2,2-dimethyl-1,3-dioxolan-4-carboxylat (molekyle 2.b), til anvendelse i behandlingen af melanomer.
6. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form af en farmaceutisk sammensætning, der omfatter mindst én forbindelse som defineret i krav 1,4 og 5 og en farmaceutisk acceptabel vehikel.
7. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form af en farmaceutisk sammensætning, der består af et liposom, der omfatter mindst én forbindelse som defineret i krav 1,4 og 5 alene eller i kombination med en anden aktiv ingrediens.
8. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form af en farmaceutisk sammensætning, der består afen alkoholopløsning, der omfatter mindst én forbindelse som defineret i krav 1,4 og 5 alene i kombination med en anden aktiv ingrediens.
9. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form af en farmaceutisk sammensætning, der er egnet til administration ad oral vej.
10. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form afen farmaceutisk sammensætning til administration ad oral vej, udvalgt fra tabletter, kapsler, pulvere, granuler, opløsninger, emulsioner, orale suspensioner, drop, sirupper, komplekser af forbindelser som defineret i krav 1,4 og 5 med galdesalte og kombinationer af forbindelser med formlen (I) med phospholipider, i liposomal eller ikke-liposomal form.
11. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, der er i form af en farmaceutisk sammensætning, hvori forbindelsen som defineret i krav 1, 4 og 5 anvendes som den eneste aktive ingrediens, eller i kombination med et anticancermiddel.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305518.8A EP2662382B1 (fr) | 2012-05-10 | 2012-05-10 | Dérivés de stérol, leur procédé de préparation, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement du glioblastome multiple |
| US201261656151P | 2012-06-06 | 2012-06-06 | |
| PCT/IB2013/053669 WO2013168096A1 (en) | 2012-05-10 | 2013-05-07 | Sterol derivatives and use thereof for treating diseases involving transformed astrocyte cells or for treating malignant haemopathies |
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| DK2847204T3 true DK2847204T3 (da) | 2018-03-12 |
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| DK13729470.8T DK2847204T3 (da) | 2012-05-10 | 2013-05-07 | Sterolderivater og anvendelse deraf til behandling af sygdomme, der involverer transformerede astrocytceller, eller til behandling af maligne hæmopatier |
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| US (1) | US10800806B2 (da) |
| EP (2) | EP2662382B1 (da) |
| JP (1) | JP6270823B2 (da) |
| KR (1) | KR102160316B1 (da) |
| CN (1) | CN104302655B (da) |
| BR (1) | BR112014026948B1 (da) |
| CA (1) | CA2871714C (da) |
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| SI (2) | SI2662382T1 (da) |
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| FR3013048A1 (fr) * | 2013-11-12 | 2015-05-15 | Beta Innov | Derive de sterol, son procede de preparation, composition pharmaceutique le contenant et son utilisation pour le traitement du glioblastome multiforme |
| EP3593789A1 (fr) * | 2018-07-11 | 2020-01-15 | Beta Innov | Composition contenant un dérivé de 7beta-hydroxycholestérol et un véhicule lipidique, et son utilisation dans le traitement de pathologies néoplasiques |
| KR102748745B1 (ko) * | 2021-05-18 | 2025-01-03 | 연세대학교 산학협력단 | 암의 예방, 개선 또는 치료용 조성물 |
| KR102689231B1 (ko) * | 2021-05-18 | 2024-07-30 | 연세대학교 산학협력단 | 암의 예방, 개선 또는 치료용 조성물 |
| WO2024030660A2 (en) * | 2022-08-04 | 2024-02-08 | University Of Massachusetts | Cholesterol-modified hyaluronic acids |
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| SE9602100D0 (sv) | 1996-05-30 | 1996-05-30 | Magnus Axelson | New pharmaceuticals |
| WO2004029068A1 (en) * | 2002-09-25 | 2004-04-08 | Forbes Medi-Tech Inc. | Derivatives comprising sterols and/or stanols and specific classes of anti-inflammatory agents and use thereof in treating or preventing cardiovascular disease |
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