DK2704724T3 - Improved suspension formulation of beclomethasone dipropionate for administration by inhalation - Google Patents

Improved suspension formulation of beclomethasone dipropionate for administration by inhalation Download PDF

Info

Publication number: DK2704724T3
Authority: DK; Denmark
Prior art keywords: formulation; particles; volume diameter; comprised; range
Prior art date: 2011-05-03

Application number

DK12719304.3T

Other languages

Danish (da)

English (en)

Inventor

Anna Maria Cantarelli

Stefano Minari

Barbara Bassi

Original Assignee

Chiesi Farm Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-03

Filing date

2012-04-18

Publication date

2017-01-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44584766&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2704724(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-04-18 Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa

2017-01-09 Application granted granted Critical

2017-01-09 Publication of DK2704724T3 publication Critical patent/DK2704724T3/en

Links

239000000203 mixture Substances 0.000 title claims description 57
238000009472 formulation Methods 0.000 title claims description 55
239000000725 suspension Substances 0.000 title claims description 10
229950000210 beclometasone dipropionate Drugs 0.000 title description 11
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title description 10
239000002245 particle Substances 0.000 claims description 76
239000004480 active ingredient Substances 0.000 claims description 15
238000000034 method Methods 0.000 claims description 14
239000008346 aqueous phase Substances 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 5
239000007900 aqueous suspension Substances 0.000 claims description 5
208000006673 asthma Diseases 0.000 claims description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 5
230000002265 prevention Effects 0.000 claims description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
208000023504 respiratory system disease Diseases 0.000 claims description 4
238000004659 sterilization and disinfection Methods 0.000 claims description 4
239000000080 wetting agent Substances 0.000 claims description 4
210000004072 lung Anatomy 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
239000003381 stabilizer Substances 0.000 claims description 3
230000001954 sterilising effect Effects 0.000 claims description 3
XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 2
229920001213 Polysorbate 20 Polymers 0.000 claims description 2
QHQJZIXSVLFOHD-LYRZEVDOSA-N [2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate;hydrate Chemical compound O.C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O QHQJZIXSVLFOHD-LYRZEVDOSA-N 0.000 claims description 2
239000011521 glass Substances 0.000 claims description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 2
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
229940068977 polysorbate 20 Drugs 0.000 claims description 2
229920000053 polysorbate 80 Polymers 0.000 claims description 2
229940068968 polysorbate 80 Drugs 0.000 claims description 2
239000011780 sodium chloride Substances 0.000 claims description 2
229940035044 sorbitan monolaurate Drugs 0.000 claims description 2
238000003756 stirring Methods 0.000 claims description 2
229940038482 beclomethasone dipropionate monohydrate Drugs 0.000 claims 3
BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical group OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 claims 1
239000003995 emulsifying agent Substances 0.000 claims 1
238000007602 hot air drying Methods 0.000 claims 1
238000002663 nebulization Methods 0.000 claims 1
230000005855 radiation Effects 0.000 claims 1
238000009826 distribution Methods 0.000 description 12
239000003246 corticosteroid Substances 0.000 description 11
239000003814 drug Substances 0.000 description 11
229940079593 drug Drugs 0.000 description 9
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 6
201000010099 disease Diseases 0.000 description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
229960002052 salbutamol Drugs 0.000 description 6
230000008569 process Effects 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
239000010419 fine particle Substances 0.000 description 4
230000036512 infertility Effects 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000006199 nebulizer Substances 0.000 description 4
101150034459 Parpbp gene Proteins 0.000 description 3
230000009471 action Effects 0.000 description 3
229960001334 corticosteroids Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
208000007345 glycogen storage disease Diseases 0.000 description 3
230000000241 respiratory effect Effects 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
-1 BDP monohydrate Chemical class 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
208000027771 Obstructive airways disease Diseases 0.000 description 2
239000013543 active substance Substances 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
230000008021 deposition Effects 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
208000027866 inflammatory disease Diseases 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
239000000463 material Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000003380 propellant Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
206010006458 Bronchitis chronic Diseases 0.000 description 1
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
206010061818 Disease progression Diseases 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
239000000022 bacteriostatic agent Substances 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
210000005178 buccal mucosa Anatomy 0.000 description 1
229960004436 budesonide Drugs 0.000 description 1
230000008859 change Effects 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
208000007451 chronic bronchitis Diseases 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
230000005750 disease progression Effects 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
229960001022 fenoterol Drugs 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229960000676 flunisolide Drugs 0.000 description 1
229960000289 fluticasone propionate Drugs 0.000 description 1
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 1
229960002848 formoterol Drugs 0.000 description 1
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
239000007789 gas Substances 0.000 description 1
201000004541 glycogen storage disease I Diseases 0.000 description 1
238000000227 grinding Methods 0.000 description 1
229920001903 high density polyethylene Polymers 0.000 description 1
239000004700 high-density polyethylene Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
229960001361 ipratropium bromide Drugs 0.000 description 1
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
230000007794 irritation Effects 0.000 description 1
229940127212 long-acting beta 2 agonist Drugs 0.000 description 1
229920001684 low density polyethylene Polymers 0.000 description 1
239000004702 low-density polyethylene Substances 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
238000003801 milling Methods 0.000 description 1
229960002744 mometasone furoate Drugs 0.000 description 1
WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 1
238000003921 particle size analysis Methods 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000004044 response Effects 0.000 description 1
229960004017 salmeterol Drugs 0.000 description 1
239000013049 sediment Substances 0.000 description 1
229940127211 short-acting beta 2 agonist Drugs 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

DK12719304.3T 2011-05-03 2012-04-18 Improved suspension formulation of beclomethasone dipropionate for administration by inhalation DK2704724T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP11164575		2011-05-03
PCT/EP2012/057068 WO2012150131A1 (en)	2011-05-03	2012-04-18	Improved suspension formulation of a corticosteroid for administration by inhalation

Publications (1)

Publication Number	Publication Date
DK2704724T3 true DK2704724T3 (en)	2017-01-09

Family

ID=44584766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK12719304.3T DK2704724T3 (en)	2011-05-03	2012-04-18	Improved suspension formulation of beclomethasone dipropionate for administration by inhalation

Country Status (18)

Country	Link
EP (2)	EP2704724B1 (ru)
CN (1)	CN103501791B (ru)
AR (1)	AR086248A1 (ru)
BR (1)	BR112013027391A2 (ru)
CY (1)	CY1118315T1 (ru)
DK (1)	DK2704724T3 (ru)
ES (2)	ES2612257T3 (ru)
HR (1)	HRP20161757T1 (ru)
HU (1)	HUE030016T2 (ru)
LT (1)	LT2704724T (ru)
ME (1)	ME02586B (ru)
PL (2)	PL2704724T3 (ru)
PT (1)	PT2704724T (ru)
RS (1)	RS55477B1 (ru)
RU (1)	RU2611665C2 (ru)
SI (1)	SI2704724T1 (ru)
WO (1)	WO2012150131A1 (ru)
ZA (1)	ZA201308158B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2704724B1 (en)	2011-05-03	2016-10-26	Chiesi Farmaceutici S.p.A.	Improved suspension formulation of beclometasone dipropionate for administration by inhalation
CN107260665B (zh) *	2016-04-08	2021-03-30	天津金耀集团有限公司	一种吸入用糠酸莫米松混悬液组合物
CN107510687B (zh) *	2017-08-18	2020-07-03	南京海纳医药科技股份有限公司	一种供雾化用含有福莫特罗和布地奈德的吸入混悬液及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19653969A1 (de) *	1996-12-20	1998-06-25	Boehringer Ingelheim Kg	Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
SE9704186D0 (sv)	1997-11-14	1997-11-14	Astra Ab	New composition of matter
IT1303692B1 (it)	1998-11-03	2001-02-23	Chiesi Farma Spa	Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
WO2003086374A1 (en)	2002-04-05	2003-10-23	University Of Utah Research Foundation	Regulation of a novel colon specific retinol dehydrogenase by apc and cdx2
ITMI20020808A1 (it)	2002-04-17	2003-10-17	Chiesi Farma Spa	Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
ITMI20022674A1 (it)	2002-12-18	2004-06-19	Chiesi Farma Spa	Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
EP1454636A1 (en)	2003-03-04	2004-09-08	Dompé S.P.A.	Sterilization of glucocorticoid drug particles for pulmonary delivery
US8912174B2 (en) *	2003-04-16	2014-12-16	Mylan Pharmaceuticals Inc.	Formulations and methods for treating rhinosinusitis
US7811606B2 (en) *	2003-04-16	2010-10-12	Dey, L.P.	Nasal pharmaceutical formulations and methods of using the same
GB0410995D0 (en) *	2004-05-17	2004-06-23	Norton Healthcare Ltd	Heat sterilization of glucocorticosteroids
ITMI20051999A1 (it) *	2005-10-21	2007-04-22	Eratech S R L	Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
EP1968547A1 (en)	2005-11-29	2008-09-17	Farmabios S.p.A.	Process for the preparation of micronised sterile steroids
KR20100095587A (ko) *	2007-12-13	2010-08-31	노파르티스 아게	유기 화합물
EP2704724B1 (en)	2011-05-03	2016-10-26	Chiesi Farmaceutici S.p.A.	Improved suspension formulation of beclometasone dipropionate for administration by inhalation

2012
- 2012-04-18 EP EP12719304.3A patent/EP2704724B1/en not_active Revoked
- 2012-04-18 SI SI201230800A patent/SI2704724T1/sl unknown
- 2012-04-18 LT LTEP12719304.3T patent/LT2704724T/lt unknown
- 2012-04-18 RS RS20161116A patent/RS55477B1/sr unknown
- 2012-04-18 EP EP16178624.9A patent/EP3097915B1/en active Active
- 2012-04-18 PL PL12719304T patent/PL2704724T3/pl unknown
- 2012-04-18 HU HUE12719304A patent/HUE030016T2/en unknown
- 2012-04-18 ES ES12719304.3T patent/ES2612257T3/es active Active
- 2012-04-18 RU RU2013148786A patent/RU2611665C2/ru active
- 2012-04-18 WO PCT/EP2012/057068 patent/WO2012150131A1/en not_active Ceased
- 2012-04-18 BR BR112013027391A patent/BR112013027391A2/pt not_active Application Discontinuation
- 2012-04-18 HR HRP20161757TT patent/HRP20161757T1/hr unknown
- 2012-04-18 ES ES16178624T patent/ES2974900T3/es active Active
- 2012-04-18 CN CN201280021420.7A patent/CN103501791B/zh active Active
- 2012-04-18 PT PT127193043T patent/PT2704724T/pt unknown
- 2012-04-18 ME MEP-2016-285A patent/ME02586B/me unknown
- 2012-04-18 PL PL16178624.9T patent/PL3097915T3/pl unknown
- 2012-04-18 DK DK12719304.3T patent/DK2704724T3/en active
- 2012-05-02 AR ARP120101550A patent/AR086248A1/es not_active Application Discontinuation
2013
- 2013-10-31 ZA ZA2013/08158A patent/ZA201308158B/en unknown
2016
- 2016-12-08 CY CY20161101267T patent/CY1118315T1/el unknown

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Publication number	Publication date
EP3097915A1 (en)	2016-11-30
HUE030016T2 (en)	2017-04-28
LT2704724T (lt)	2017-01-10
PL2704724T3 (pl)	2017-03-31
WO2012150131A1 (en)	2012-11-08
CN103501791B (zh)	2016-05-18
SI2704724T1 (sl)	2017-01-31
ES2612257T3 (es)	2017-05-16
PL3097915T3 (pl)	2024-05-20
CN103501791A (zh)	2014-01-08
AR086248A1 (es)	2013-11-27
ES2974900T3 (es)	2024-07-02
CY1118315T1 (el)	2017-06-28
RU2013148786A (ru)	2015-05-10
HRP20161757T1 (hr)	2017-02-10
RU2611665C2 (ru)	2017-02-28
ME02586B (me)	2017-06-20
BR112013027391A2 (pt)	2017-01-17
EP2704724A1 (en)	2014-03-12
PT2704724T (pt)	2017-02-02
EP3097915B1 (en)	2024-01-24
ZA201308158B (en)	2014-09-25
RS55477B1 (sr)	2017-04-28
EP2704724B1 (en)	2016-10-26

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