DK2793866T4 - Tolagstablet omfattende benazeprilhydrochlorid og pimobendan - Google Patents

Tolagstablet omfattende benazeprilhydrochlorid og pimobendan Download PDF

Info

Publication number: DK2793866T4
Authority: DK; Denmark
Prior art keywords: pimobendan; bilayer tablet; benazepril hydrochloride; benazepril; hydrochloride
Prior art date: 2011-12-21

Application number

DK12813324.6T

Other languages

English (en)

Other versions

DK2793866T3 (da

Inventor

Jernej Grmas

Zdenka Jerala-Strukelj

Sebastjan Reven

Original Assignee

Elanco Tiergesundheit Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-21

Filing date

2012-12-19

Publication date

2023-12-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47552987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2793866(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-12-19 Application filed by Elanco Tiergesundheit Ag filed Critical Elanco Tiergesundheit Ag

2016-02-15 Application granted granted Critical

2016-02-15 Publication of DK2793866T3 publication Critical patent/DK2793866T3/da

2023-12-04 Publication of DK2793866T4 publication Critical patent/DK2793866T4/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Edible Oils And Fats (AREA)

DK12813324.6T 2011-12-21 2012-12-19 Tolagstablet omfattende benazeprilhydrochlorid og pimobendan DK2793866T4 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP11195015		2011-12-21
EP12185714		2012-09-24
PCT/EP2012/076100 WO2013092673A2 (en)	2011-12-21	2012-12-19	New combination

Publications (2)

Publication Number	Publication Date
DK2793866T3 DK2793866T3 (da)	2016-02-15
DK2793866T4 true DK2793866T4 (da)	2023-12-04

Family

ID=47552987

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK12813324.6T DK2793866T4 (da)	2011-12-21	2012-12-19	Tolagstablet omfattende benazeprilhydrochlorid og pimobendan
DK15193269.6T DK3034071T3 (da)	2011-12-21	2012-12-19	Ny kombination

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK15193269.6T DK3034071T3 (da)	2011-12-21	2012-12-19	Ny kombination

Country Status (22)

Country	Link
US (1)	US10874618B2 (da)
EP (3)	EP3320894A1 (da)
JP (1)	JP6148252B2 (da)
CN (1)	CN104010632B (da)
AU (1)	AU2012357795B2 (da)
BR (1)	BR112014014896A2 (da)
CA (1)	CA2858941C (da)
CL (1)	CL2014001534A1 (da)
CO (1)	CO6970601A2 (da)
CY (1)	CY1117086T1 (da)
DK (2)	DK2793866T4 (da)
ES (2)	ES2560052T5 (da)
HR (1)	HRP20151347T1 (da)
HU (2)	HUE035830T2 (da)
MX (1)	MX365621B (da)
NO (1)	NO3034071T3 (da)
PL (2)	PL2793866T5 (da)
PT (1)	PT3034071T (da)
RS (1)	RS54475B1 (da)
RU (1)	RU2014129508A (da)
SI (1)	SI2793866T1 (da)
WO (1)	WO2013092673A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
EP1920785A1 (en)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Liquid preparation comprising a complex of pimobendan and cyclodextrin
PL2793866T5 (pl)	2011-12-21	2023-12-04	Elanco Tiergesundheit Ag	Tabletka dwuwarstwowa zawierająca chlorowodorek benazeprylu i pimobendan
ES2924478T3 (es) *	2012-03-15	2022-10-07	Boehringer Ingelheim Vetmedica Gmbh	Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
CN105377235A (zh)	2013-07-19	2016-03-02	勃林格殷格翰动物保健有限公司	含有防腐的醚化的环糊精衍生物的液体水性药物组合物
KR102308973B1 (ko)	2013-12-04	2021-10-08	베링거잉겔하임베트메디카게엠베하	개선된 피모벤단의 약제학적 조성물
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN112618505B (zh) *	2020-12-30	2022-11-15	南京朗博特动物药业有限公司	一种宠物用含有贝那普利和匹莫苯丹的复方药物组合物及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5364646A (en)	1990-01-10	1994-11-15	Dr. Karl Thomae Gmbh	Oral pharmaceutical forms of pimobendan
US6162802A (en)	1992-03-10	2000-12-19	Papa; Joseph	Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
MXPA03005462A (es)	2000-12-18	2003-09-25	Novartis Ag	Combinacion terapeutica de amlodipina y benazepril.
AU2003217916A1 (en)	2002-03-08	2003-09-22	Teva Pharmeceuticals Usa, Inc.	Stable formulations of angiotensin converting enzyme (ace) inhibitors
CO5400144A1 (es)	2002-03-11	2004-05-31	Novartis Ag	Compuestos organicos
SG147456A1 (en) *	2003-10-20	2008-11-28	Novartis Ag	Use of organic compounds
GB2394660A (en)	2003-12-17	2004-05-05	Niche Generics Ltd	Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
DE102004011512B4 (de) *	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) *	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
JP2005281283A (ja)	2004-03-31	2005-10-13	Akira Matsumori	ベンズイミダゾール系薬剤の併用医薬
US20080268049A1 (en) *	2005-02-11	2008-10-30	Dhaliwal Mona	Stable Solid Dosage Forms of Amlodipine and Benazepril
JP2010500374A (ja) *	2006-08-08	2010-01-07	エーシーシーユー−ブレイクテクノロジーズ，インク．	複数の活性セグメントを含む薬剤の錠剤
US9095519B2 (en)	2007-02-09	2015-08-04	Alphapharm Pty Ltd	Dosage form containing two or more active pharmaceutical ingredients in different physical forms
FR2917975B1 (fr) *	2007-06-26	2009-10-16	Ceva Sante Animale Sa	Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
WO2010055119A2 (en)	2008-11-17	2010-05-20	Novartis Ag	Pharmaceutical composition comprising pimobendan
WO2010097501A2 (en)	2009-02-26	2010-09-02	Orion Corporation	A combination treatment
WO2011111066A2 (en) *	2010-03-12	2011-09-15	Connexios Life Sciences Pvt. Ltd.	Composition and uses thereof
PL2793866T5 (pl)	2011-12-21	2023-12-04	Elanco Tiergesundheit Ag	Tabletka dwuwarstwowa zawierająca chlorowodorek benazeprylu i pimobendan

2012
- 2012-12-19 PL PL12813324.6T patent/PL2793866T5/pl unknown
- 2012-12-19 EP EP17199031.0A patent/EP3320894A1/en not_active Withdrawn
- 2012-12-19 EP EP12813324.6A patent/EP2793866B2/en active Active
- 2012-12-19 CA CA2858941A patent/CA2858941C/en active Active
- 2012-12-19 DK DK12813324.6T patent/DK2793866T4/da active
- 2012-12-19 CN CN201280062716.3A patent/CN104010632B/zh active Active
- 2012-12-19 EP EP15193269.6A patent/EP3034071B1/en active Active
- 2012-12-19 HR HRP20151347TT patent/HRP20151347T1/hr unknown
- 2012-12-19 RU RU2014129508A patent/RU2014129508A/ru unknown
- 2012-12-19 ES ES12813324T patent/ES2560052T5/es active Active
- 2012-12-19 PL PL15193269T patent/PL3034071T3/pl unknown
- 2012-12-19 RS RS20150850A patent/RS54475B1/sr unknown
- 2012-12-19 BR BR112014014896A patent/BR112014014896A2/pt active Search and Examination
- 2012-12-19 SI SI201230374T patent/SI2793866T1/sl unknown
- 2012-12-19 WO PCT/EP2012/076100 patent/WO2013092673A2/en not_active Ceased
- 2012-12-19 NO NO15193269A patent/NO3034071T3/no unknown
- 2012-12-19 HU HUE15193269A patent/HUE035830T2/en unknown
- 2012-12-19 DK DK15193269.6T patent/DK3034071T3/da active
- 2012-12-19 JP JP2014547959A patent/JP6148252B2/ja active Active
- 2012-12-19 ES ES15193269.6T patent/ES2656412T3/es active Active
- 2012-12-19 HU HUE12813324A patent/HUE028579T2/en unknown
- 2012-12-19 AU AU2012357795A patent/AU2012357795B2/en active Active
- 2012-12-19 MX MX2014007700A patent/MX365621B/es active IP Right Grant
- 2012-12-19 US US14/366,900 patent/US10874618B2/en active Active
- 2012-12-19 PT PT151932696T patent/PT3034071T/pt unknown
2014
- 2014-06-03 CO CO14118785A patent/CO6970601A2/es active IP Right Grant
- 2014-06-11 CL CL2014001534A patent/CL2014001534A1/es unknown
2015
- 2015-12-30 CY CY20151101200T patent/CY1117086T1/el unknown

Also Published As

Publication number	Publication date
EP3034071A1 (en)	2016-06-22
US20140363505A1 (en)	2014-12-11
US10874618B2 (en)	2020-12-29
ES2560052T3 (es)	2016-02-17
CA2858941A1 (en)	2013-06-27
CN104010632A (zh)	2014-08-27
NZ625506A (en)	2016-10-28
CY1117086T1 (el)	2017-04-05
ES2656412T3 (es)	2018-02-27
JP6148252B2 (ja)	2017-06-14
HUE028579T2 (en)	2016-12-28
ES2560052T5 (es)	2024-06-07
CO6970601A2 (es)	2014-06-13
EP3320894A1 (en)	2018-05-16
CN104010632B (zh)	2016-08-24
PL2793866T3 (pl)	2016-05-31
EP2793866A2 (en)	2014-10-29
JP2015506337A (ja)	2015-03-02
DK3034071T3 (da)	2018-01-22
HRP20151347T1 (hr)	2016-01-01
BR112014014896A2 (pt)	2017-06-13
SI2793866T1 (sl)	2016-01-29
AU2012357795B2 (en)	2017-04-06
AU2012357795A1 (en)	2014-06-19
WO2013092673A2 (en)	2013-06-27
CL2014001534A1 (es)	2014-09-05
EP3034071B1 (en)	2017-12-06
EP2793866B1 (en)	2015-11-25
RU2014129508A (ru)	2016-02-10
PL2793866T5 (pl)	2023-12-04
MX365621B (es)	2019-06-07
PT3034071T (pt)	2018-01-19
CA2858941C (en)	2020-11-10
DK2793866T3 (da)	2016-02-15
RS54475B1 (sr)	2016-06-30
WO2013092673A3 (en)	2013-09-12
PL3034071T3 (pl)	2018-05-30
MX2014007700A (es)	2014-08-21
HUE035830T2 (en)	2018-05-28
EP2793866B2 (en)	2023-10-25
NO3034071T3 (da)	2018-05-05

Publication	Publication Date	Title
LTPA2020003I1 (lt)	2020-05-11	Dvisluoksnės tabletės formuluotės
DK2793866T4 (da)	2023-12-04	Tolagstablet omfattende benazeprilhydrochlorid og pimobendan
DK3597644T3 (da)	2021-11-08	Kationiske aminlipider og anvendelser deraf
CO6910189A2 (es)	2014-03-31	Derivado heterociclico y farmacéutico
ATE526024T1 (de)	2011-10-15	Fluvoxamin vermeidende pirfenidontheraphy
DK3415157T3 (da)	2020-10-19	N-acyldipeptidderivater og anvendelser deraf
DK3608325T3 (da)	2022-08-22	Polycykliske-carbamoylpyridonforbindelser og deres farmaceutiske anvendelse
DK3202760T3 (da)	2019-11-25	Pegylerede lipider og deres anvendelse til lægemiddelfremføring
BR112013014875A2 (pt)	2016-10-18	tablete oralmente desintegrável
EP2641510A4 (en)	2014-04-09	Mattress
DK2670587T3 (da)	2019-09-30	Tabletpresse
DK3199533T3 (da)	2019-05-20	Pyrazolforbindelse og farmaceutisk anvendelse deraf
BR112013009579A2 (pt)	2016-07-12	método e comprimido
DK3392252T3 (da)	2024-01-08	Pyrimido-pyridazinonforbindelser og deres anvendelse
DK2921493T3 (da)	2017-11-27	Heteroarylpiperidin og ¿piperazinderivater
DK2704744T3 (da)	2019-07-15	Komplementfaktor-b-analoger og anvendelser deraf
EP2702995A4 (en)	2014-11-26	FAST RESOLVING ORAL TABLET
DK2488043T4 (da)	2021-03-15	Forbedret ernæringstablet
BRPI1009367A2 (pt)	2016-03-08	tablete de camada múltipla
DK2753346T3 (da)	2020-05-25	Ceramidase og celledifferentiering
IT1399219B1 (it)	2013-04-11	Divano componibile
EP2757881A4 (en)	2014-11-12	KAPPA OPIATE RECEPTOR EFFECTORS AND USES THEREOF
BR112013000298A2 (pt)	2016-05-31	tablete
FR2971529B1 (fr)	2014-03-28	Garde-corps
UA19818S (uk)	2009-12-25	Молочний продукт у таблетованій формі