DK2791367T3 - Mutante mikroorganismer til syntetisering af colansyre, mannosylerede og/eller fucosylerede oligosaccharider - Google Patents
Mutante mikroorganismer til syntetisering af colansyre, mannosylerede og/eller fucosylerede oligosaccharider Download PDFInfo
- Publication number
- DK2791367T3 DK2791367T3 DK12812205.8T DK12812205T DK2791367T3 DK 2791367 T3 DK2791367 T3 DK 2791367T3 DK 12812205 T DK12812205 T DK 12812205T DK 2791367 T3 DK2791367 T3 DK 2791367T3
- Authority
- DK
- Denmark
- Prior art keywords
- oilosaccharides
- manosyled
- fucosyled
- synthetization
- organisms
- Prior art date
Links
- RPKLZQLYODPWTM-KBMWBBLPSA-N cholanoic acid Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(O)=O)C)[C@@]1(C)CC2 RPKLZQLYODPWTM-KBMWBBLPSA-N 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194103 | 2011-12-16 | ||
| PCT/EP2012/075639 WO2013087884A1 (en) | 2011-12-16 | 2012-12-14 | Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2791367T3 true DK2791367T3 (da) | 2019-07-01 |
Family
ID=47520039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12812205.8T DK2791367T3 (da) | 2011-12-16 | 2012-12-14 | Mutante mikroorganismer til syntetisering af colansyre, mannosylerede og/eller fucosylerede oligosaccharider |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9719119B2 (da) |
| EP (2) | EP3517631B9 (da) |
| JP (4) | JP6084985B2 (da) |
| CN (1) | CN103987841B (da) |
| AU (1) | AU2012351501B2 (da) |
| CA (1) | CA2859056C (da) |
| DK (1) | DK2791367T3 (da) |
| ES (1) | ES2733307T3 (da) |
| WO (1) | WO2013087884A1 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012351501B2 (en) * | 2011-12-16 | 2018-06-14 | Inbiose N.V. | Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides |
| WO2015021147A1 (en) * | 2013-08-06 | 2015-02-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Acid-resistant, attenuated microbial vector for improved oral delivery of multiple targeted antigens |
| US9902984B2 (en) | 2013-09-06 | 2018-02-27 | Glycom A/S | Fermentative production of oligosaccharides |
| BR112016018162B1 (pt) * | 2014-02-07 | 2023-04-11 | Basf Se | Micro-organismo modificado, método para produzir um composto orgânico e uso de um micro-organismo modificado |
| US10731193B2 (en) | 2014-06-27 | 2020-08-04 | Glycom A/S | Oligosaccharide production |
| US11926858B2 (en) | 2014-06-27 | 2024-03-12 | Glycom A/S | Oligosaccharide production |
| US11453900B2 (en) | 2014-09-09 | 2022-09-27 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| KR102579346B1 (ko) * | 2014-11-14 | 2023-09-15 | 인바이오스 엔.브이. | 락토스 사멸에 내성인 돌연변이 미생물 |
| KR101731263B1 (ko) * | 2016-04-25 | 2017-05-02 | 서울대학교 산학협력단 | 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법 |
| EP3315610B1 (en) * | 2016-10-29 | 2020-12-16 | Jennewein Biotechnologie GmbH | Process for the production of fucosylated oligosaccharides |
| WO2018198298A1 (ja) * | 2017-04-27 | 2018-11-01 | 日本電気株式会社 | パラメータ推定装置、パラメータ推定方法、及びコンピュータ読み取り可能な記録媒体 |
| BR112019000069A2 (pt) * | 2017-06-09 | 2019-12-17 | Asahi Kohsan Corp | bactérias de ácido lático e uso das mesmas |
| CN108013306A (zh) * | 2017-10-28 | 2018-05-11 | 中国科学院天津工业生物技术研究所 | 富含阿洛酮糖的果汁饮品的制备方法 |
| CN108018216B (zh) * | 2017-12-26 | 2021-06-18 | 天津科技大学 | 提高柠檬酸发酵中糖利用率和柠檬酸产量的方法及应用 |
| EP3620510B1 (en) | 2018-09-06 | 2023-11-01 | Chr. Hansen HMO GmbH | Fermentative production of oligosaccharides by total fermentation utilizing a mixed feedstock |
| CN109468244B (zh) * | 2018-11-15 | 2021-10-22 | 中国科学院上海高等研究院 | 一种抗酸型高密度生长的大肠杆菌及其应用 |
| CN109439708B (zh) * | 2018-11-15 | 2021-11-30 | 中国科学院上海高等研究院 | 一种抗酸型高密度生长的大肠杆菌生产可拉酸的方法 |
| CN109852648B (zh) * | 2019-04-11 | 2022-08-09 | 广西大学 | 酶法制备右旋糖酐硒聚物的方法 |
| KR102254548B1 (ko) * | 2019-04-26 | 2021-05-24 | 고려대학교 산학협력단 | 돌연변이 대장균을 이용한 콜라닉 산 생산 |
| BR112022007151A2 (pt) * | 2019-10-14 | 2022-08-23 | Inbiose Nv | Produção de bioproduto em uma célula hospedeira |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| JP7697887B2 (ja) * | 2019-12-16 | 2025-06-24 | 協和発酵バイオ株式会社 | 改変されたラクトースパーミアーゼを有する微生物及びラクトース含有オリゴ糖の製造法 |
| CN114901825A (zh) | 2019-12-18 | 2022-08-12 | 因比奥斯公司 | 在宿主细胞中产生唾液酸化寡糖 |
| WO2021160830A1 (en) | 2020-02-14 | 2021-08-19 | Inbiose N.V. | Glycominimized bacterial host cells |
| CN115087740A (zh) | 2020-02-14 | 2022-09-20 | 因比奥斯公司 | 在宿主细胞中产生糖基化产物 |
| CN111304228B (zh) * | 2020-03-18 | 2022-02-22 | 中国热带农业科学院橡胶研究所 | 一种橡胶树线粒体型己糖激酶基因及其编码蛋白和应用 |
| CN116171329A (zh) | 2020-08-10 | 2023-05-26 | 因比奥斯公司 | 通过细胞培养或微生物发酵产生的寡糖溶液的纯化方法 |
| CN111893150A (zh) * | 2020-09-16 | 2020-11-06 | 南开大学 | 一种蔗糖诱导细菌固态发酵生产可拉酸及纯化方法 |
| CN112574936A (zh) * | 2020-12-21 | 2021-03-30 | 中国科学院合肥物质科学研究院 | 一种重组大肠杆菌及其构建方法与应用 |
| WO2022155554A1 (en) * | 2021-01-17 | 2022-07-21 | Genomatica, Inc. | Methods and compositions for making amide compounds |
| KR102568773B1 (ko) * | 2021-02-16 | 2023-08-23 | 고려대학교 산학협력단 | 재조합 대장균을 이용한 콜라닉 산 생산 방법 |
| CN113637620B (zh) * | 2021-07-27 | 2023-07-18 | 西宝生物科技（上海）股份有限公司 | 一种克拉酸高产菌株构建方法和应用 |
| KR102477273B1 (ko) * | 2021-11-24 | 2022-12-16 | (주)에이피테크놀로지 | 효소 처리를 통한 2'-푸코실락토오스의 생산성 증대 방법 |
| CN118574859A (zh) | 2021-12-15 | 2024-08-30 | 因比奥斯公司 | 新型的用于寡糖的干燥方法 |
| WO2023122641A1 (en) * | 2021-12-22 | 2023-06-29 | Zymergen Inc. | Compositions and methods for producing acetic acid and polysaccharides |
| CN115960933A (zh) * | 2022-07-27 | 2023-04-14 | 苏州一兮生物技术有限公司 | 一种gdp-l-岩藻糖高产菌株的构建方法和应用 |
| CN116024246B (zh) * | 2022-07-27 | 2025-04-25 | 苏州一兮生物技术有限公司 | 一种高效表达gmd、wcaG的重组大肠杆菌及构建方法 |
| CN120018780A (zh) | 2022-08-25 | 2025-05-16 | 帝斯曼知识产权资产管理有限公司 | 生产复杂hmo的混合方法 |
| EP4623089A1 (en) | 2022-11-25 | 2025-10-01 | DSM IP Assets B.V. | Two-strain system for producing oligosaccharides |
| EP4644533A1 (en) * | 2022-12-30 | 2025-11-05 | Shenzhen Pam2L Biotechnologies Co., Ltd. | Construction and use of engineering bacterium that produces colanic acid with high yield |
| CN117646048A (zh) * | 2023-12-08 | 2024-03-05 | 重庆智合生物医药有限公司 | 一种缩短岩藻多糖发酵时间的生产方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858752A (en) | 1995-06-07 | 1999-01-12 | The General Hospital Corporation | Fucosyltransferase genes and uses thereof |
| US5939279A (en) | 1997-09-18 | 1999-08-17 | The Board Of Trustees Of The University Of Arkansas | Inhibition of bacterial binding by high-mannose oligosaccharides |
| WO2000029603A2 (en) * | 1998-11-18 | 2000-05-25 | Neose Technologies, Inc. | Low cost manufacture of oligosaccharides |
| JP2001546898A (en) * | 1999-12-21 | 2003-06-10 | Kyowa Hakko Kogyo Kk | MODIFIED alpha -1,2-FUCOSYLTRANSFERASE GENE AND PROCESS FOR PRODUCING alpha -1,2-FUCOSYLTRANSFERASE AND FUCOSE-CONTAINING SUGAR CHAIN |
| AU2003280305B2 (en) | 2002-07-01 | 2008-05-01 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and N-acetylglucosamine |
| JP4771437B2 (ja) * | 2004-08-27 | 2011-09-14 | ライス ユニバーシティー | 増加したコハク酸産生を有する変異Ｅ．ｃｏｌｉ株 |
| KR20070065870A (ko) * | 2004-09-17 | 2007-06-25 | 라이스 유니버시티 | 다량의 숙신산염을 생산하는 세균 |
| WO2010070104A1 (en) * | 2008-12-19 | 2010-06-24 | Jennewein Biotechnologie Gmbh | Synthesis of fucosylated compounds |
| EP2233562A1 (en) * | 2009-03-24 | 2010-09-29 | Metabolic Explorer | Method for producing high amount of glycolic acid by fermentation |
| WO2011083059A1 (en) | 2010-01-06 | 2011-07-14 | Universiteit Gent | Bacterial mutants and uses thereof in protein production |
| AU2012351501B2 (en) * | 2011-12-16 | 2018-06-14 | Inbiose N.V. | Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides |
-
2012
- 2012-12-14 AU AU2012351501A patent/AU2012351501B2/en active Active
- 2012-12-14 CA CA2859056A patent/CA2859056C/en active Active
- 2012-12-14 EP EP19163081.3A patent/EP3517631B9/en active Active
- 2012-12-14 JP JP2014546548A patent/JP6084985B2/ja active Active
- 2012-12-14 DK DK12812205.8T patent/DK2791367T3/da active
- 2012-12-14 WO PCT/EP2012/075639 patent/WO2013087884A1/en not_active Ceased
- 2012-12-14 US US14/365,063 patent/US9719119B2/en active Active
- 2012-12-14 EP EP12812205.8A patent/EP2791367B1/en active Active
- 2012-12-14 CN CN201280061882.1A patent/CN103987841B/zh active Active
- 2012-12-14 ES ES12812205T patent/ES2733307T3/es active Active
-
2016
- 2016-12-15 JP JP2016243506A patent/JP6530365B2/ja active Active
-
2017
- 2017-06-09 US US15/619,377 patent/US9951362B2/en active Active
- 2017-12-12 US US15/839,264 patent/US10738336B2/en active Active
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2019
- 2019-05-16 JP JP2019092948A patent/JP6889205B2/ja active Active
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2021
- 2021-05-20 JP JP2021085417A patent/JP2021121215A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10738336B2 (en) | 2020-08-11 |
| WO2013087884A1 (en) | 2013-06-20 |
| JP2019150051A (ja) | 2019-09-12 |
| EP3517631C0 (en) | 2023-06-07 |
| JP2017079767A (ja) | 2017-05-18 |
| AU2012351501B2 (en) | 2018-06-14 |
| US20180216147A1 (en) | 2018-08-02 |
| HK1203208A1 (en) | 2015-10-23 |
| EP3517631B9 (en) | 2023-10-04 |
| JP6889205B2 (ja) | 2021-06-18 |
| CN103987841B (zh) | 2016-09-28 |
| EP3517631A1 (en) | 2019-07-31 |
| CA2859056C (en) | 2022-12-13 |
| JP2021121215A (ja) | 2021-08-26 |
| EP2791367B1 (en) | 2019-04-24 |
| EP3517631B1 (en) | 2023-06-07 |
| ES2733307T3 (es) | 2019-11-28 |
| CA2859056A1 (en) | 2013-06-20 |
| AU2012351501A1 (en) | 2014-07-03 |
| JP6530365B2 (ja) | 2019-06-12 |
| US9719119B2 (en) | 2017-08-01 |
| US20170342452A1 (en) | 2017-11-30 |
| EP2791367A1 (en) | 2014-10-22 |
| NZ625199A (en) | 2015-07-31 |
| JP6084985B2 (ja) | 2017-02-22 |
| JP2015504654A (ja) | 2015-02-16 |
| US9951362B2 (en) | 2018-04-24 |
| CN103987841A (zh) | 2014-08-13 |
| US20140349348A1 (en) | 2014-11-27 |
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