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DK2766364T3 - Folatkonjugater af albumin-bindende enheder - Google Patents

Folatkonjugater af albumin-bindende enheder Download PDF

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Publication number
DK2766364T3
DK2766364T3 DK12746091.3T DK12746091T DK2766364T3 DK 2766364 T3 DK2766364 T3 DK 2766364T3 DK 12746091 T DK12746091 T DK 12746091T DK 2766364 T3 DK2766364 T3 DK 2766364T3
Authority
DK
Denmark
Prior art keywords
albumin
binding units
folate conjugates
folate
conjugates
Prior art date
Application number
DK12746091.3T
Other languages
English (en)
Inventor
Roger Schibli
Rudolf Moser
Cristina Magdalena Müller
Harriet Struthers
Viola Groehn
Simon Mensah Ametamey
Cindy Ramona Fischer
Original Assignee
Merck & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Cie filed Critical Merck & Cie
Application granted granted Critical
Publication of DK2766364T3 publication Critical patent/DK2766364T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/551Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0472Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0491Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/02Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK12746091.3T 2011-08-17 2012-08-10 Folatkonjugater af albumin-bindende enheder DK2766364T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11177732 2011-08-17
PCT/EP2012/065702 WO2013024035A1 (en) 2011-08-17 2012-08-10 Folate conjugates of albumin-binding entities

Publications (1)

Publication Number Publication Date
DK2766364T3 true DK2766364T3 (da) 2024-09-30

Family

ID=46650547

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12746091.3T DK2766364T3 (da) 2011-08-17 2012-08-10 Folatkonjugater af albumin-bindende enheder

Country Status (17)

Country Link
US (1) US9295739B2 (da)
EP (1) EP2766364B1 (da)
JP (1) JP6152104B2 (da)
KR (1) KR102036199B1 (da)
CN (1) CN103732595B (da)
AU (1) AU2012296937B2 (da)
CA (1) CA2839647C (da)
DK (1) DK2766364T3 (da)
EA (1) EA201400237A1 (da)
ES (1) ES2990974T3 (da)
FI (1) FI2766364T3 (da)
HU (1) HUE068833T2 (da)
IL (1) IL230758B (da)
PL (1) PL2766364T3 (da)
PT (1) PT2766364T (da)
WO (1) WO2013024035A1 (da)
ZA (1) ZA201400174B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201819447T4 (tr) * 2011-08-22 2019-01-21 Merck & Cie 18F-sakkarid-folatlar.
GB201417067D0 (en) * 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
CN104897627B (zh) * 2015-02-04 2017-07-11 浙江工商大学 一种基于分子识别的荧光检测叶酸的方法
WO2016168471A1 (en) * 2015-04-17 2016-10-20 Endocyte, Inc. Dual disulfide drug conjugates
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
CA3017211A1 (en) 2016-03-16 2017-09-21 Endocyte, Inc. Carbonic anhydrase ix inhibitor conjugates and uses thereof
AU2017234676A1 (en) 2016-03-16 2018-09-20 Purdue Research Foundation Carbonic anhydrase IX targeting agents and methods
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
WO2017223357A1 (en) 2016-06-23 2017-12-28 Cornell University Double targeted constructs to affect tumor kill
CA3030907A1 (en) * 2016-08-10 2018-02-15 Cancer Targeted Technology Llc Chelated psma inhibitors
CN117563022A (zh) * 2017-04-05 2024-02-20 康奈尔大学 可用于成像和抗肿瘤治疗的具有可调的药代动力学的三功能构建体
KR102843240B1 (ko) 2017-05-24 2025-08-05 이테엠 이소토페 테크놀로기에스 뮈니치 에스이 신규 psma-결합제 및 이의 용도
WO2018233798A1 (en) 2017-06-20 2018-12-27 ITM Isotopen Technologien München AG Novel psma-binding agents and uses thereof
WO2019056098A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER
CN112409436B (zh) * 2020-11-06 2022-02-18 厦门大学 一种放射性核素标记的雌激素受体分子靶向化合物及其应用
WO2024025845A1 (en) * 2022-07-25 2024-02-01 Sorrento Therapeutics, Inc. Folate-conjugated drugs and uses thereof
WO2024051794A1 (zh) * 2022-09-09 2024-03-14 同宜医药(苏州)有限公司 放射性核素偶联药物及其药物组合物和应用
WO2025171887A1 (en) 2024-02-16 2025-08-21 Paul Scherrer Institut Radiolabeled complexes and pharmaceutical compositions including the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136159A (en) 1977-02-28 1979-01-23 New England Nuclear Corporation Radioassay of folates
US5688488A (en) 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5919934A (en) 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US7067111B1 (en) 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
ES2472423T3 (es) 2002-05-06 2014-07-01 Endocyte, Inc. Agentes de formación de imágenes dirigidos al receptor de folato
KR101138643B1 (ko) 2002-05-30 2012-04-26 더 스크립스 리서치 인스티튜트 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션
WO2006116629A2 (en) 2005-04-27 2006-11-02 Siemens Medical Solutions Usa, Inc. The preparation of molecular imaging probes using click chemistry
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
JP5368099B2 (ja) * 2005-10-07 2013-12-18 ゲルベ ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物
EA200901345A1 (ru) * 2007-04-11 2010-04-30 Мерк Эпрова Аг F-меченые фолаты
EP2146995A1 (en) * 2007-04-11 2010-01-27 Merck Eprova AG Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy
CA2708171C (en) 2007-12-04 2018-02-27 Alnylam Pharmaceuticals, Inc. Folate conjugates

Also Published As

Publication number Publication date
PL2766364T3 (pl) 2024-12-16
AU2012296937B2 (en) 2017-10-12
EA201400237A1 (ru) 2014-08-29
IL230758B (en) 2020-11-30
JP2014531407A (ja) 2014-11-27
CN103732595A (zh) 2014-04-16
KR20140052027A (ko) 2014-05-02
ES2990974T3 (es) 2024-12-02
US20140234216A1 (en) 2014-08-21
ZA201400174B (en) 2015-09-30
CA2839647C (en) 2022-08-16
EP2766364A1 (en) 2014-08-20
JP6152104B2 (ja) 2017-06-21
HUE068833T2 (hu) 2025-01-28
CA2839647A1 (en) 2013-02-21
KR102036199B1 (ko) 2019-10-24
IL230758A0 (en) 2014-03-31
AU2012296937A1 (en) 2014-02-20
CN103732595B (zh) 2017-02-08
PT2766364T (pt) 2024-09-24
US9295739B2 (en) 2016-03-29
EP2766364B1 (en) 2024-07-31
WO2013024035A1 (en) 2013-02-21
FI2766364T3 (fi) 2024-10-23

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