DK2678329T3 - Triazolopyridinforbindelser som pim-kinase-hæmmere - Google Patents

Triazolopyridinforbindelser som pim-kinase-hæmmere Download PDF

Info

Publication number: DK2678329T3
Authority: DK; Denmark
Prior art keywords: triazolopyride; pim; compounds; kinase inhibitors; kinase
Prior art date: 2011-02-25

Application number

DK12716770.8T

Other languages

English (en)

Inventor

James F Blake

Robert Kirk Delisle

Meese Lisa A De

James M Graham

Huerou Yvan Le

Michael Lyon

John E Robinson

Eli M Wallace

Bin Wang

Rui Xu

Original Assignee

Array Biopharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-02-25

Filing date

2012-02-24

Publication date

2016-02-22

2012-02-24 Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc

2016-02-22 Application granted granted Critical

2016-02-22 Publication of DK2678329T3 publication Critical patent/DK2678329T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

DK12716770.8T 2011-02-25 2012-02-24 Triazolopyridinforbindelser som pim-kinase-hæmmere DK2678329T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161446902P	2011-02-25	2011-02-25
PCT/US2012/026572 WO2012154274A1 (en)	2011-02-25	2012-02-24	Triazolopyridine compounds as pim kinase inhibitors

Publications (1)

Publication Number	Publication Date
DK2678329T3 true DK2678329T3 (da)	2016-02-22

Family

ID=46000320

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK12716770.8T DK2678329T3 (da)	2011-02-25	2012-02-24	Triazolopyridinforbindelser som pim-kinase-hæmmere

Country Status (32)

Country	Link
US (1)	US8889704B2 (da)
EP (1)	EP2678329B1 (da)
JP (2)	JP6039585B2 (da)
KR (1)	KR101940338B1 (da)
CN (1)	CN103492377B (da)
AR (1)	AR085489A1 (da)
AU (1)	AU2012254082B2 (da)
BR (1)	BR112013021675A2 (da)
CA (1)	CA2828269C (da)
CL (1)	CL2013002446A1 (da)
CO (1)	CO6771441A2 (da)
CR (1)	CR20130460A (da)
CY (1)	CY1117197T1 (da)
DK (1)	DK2678329T3 (da)
ES (1)	ES2563152T3 (da)
HR (1)	HRP20160134T1 (da)
HU (1)	HUE027675T2 (da)
IL (1)	IL228108A (da)
ME (1)	ME02365B (da)
MX (1)	MX339899B (da)
PH (1)	PH12013501754A1 (da)
PL (1)	PL2678329T3 (da)
RS (1)	RS54586B1 (da)
RU (1)	RU2598846C2 (da)
SG (1)	SG192944A1 (da)
SI (1)	SI2678329T1 (da)
SM (1)	SMT201600052B (da)
TW (1)	TWI529170B (da)
UA (1)	UA111075C2 (da)
UY (1)	UY33924A (da)
WO (1)	WO2012154274A1 (da)
ZA (1)	ZA201306997B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2671748T3 (es)	2011-07-21	2018-06-08	Tolero Pharmaceuticals, Inc.	Inhibidores heterocíclicos de proteína quinasas
MX2014011419A (es) *	2012-04-25	2014-11-25	Hoffmann La Roche	Clorhidrato de (3,4-dicloro-fenil)-((s)-3-propil-pirrolidin-3-il)- metanona y procesos de manufacturacion.
ES2649156T3 (es)	2013-01-14	2018-01-10	Incyte Holdings Corporation	Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
CA2897333C (en)	2013-01-15	2021-07-06	Incyte Corporation	Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
CR20160135A (es)	2013-08-23	2016-08-05	Incyte Corp	Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de cinasas pim
US9580418B2 (en)	2014-07-14	2017-02-28	Incyte Corporation	Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en)	2014-07-14	2016-01-21	Incyte Corporation	Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
US9540347B2 (en)	2015-05-29	2017-01-10	Incyte Corporation	Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh)	2015-09-09	2021-08-01	美商英塞特公司	Ｐｉｍ激酶抑制劑之鹽
TW201718546A (zh)	2015-10-02	2017-06-01	英塞特公司	適用作pim激酶抑制劑之雜環化合物
WO2017205536A2 (en) *	2016-05-24	2017-11-30	Genentech, Inc.	Therapeutic compounds and uses thereof
WO2019113487A1 (en)	2017-12-08	2019-06-13	Incyte Corporation	Low dose combination therapy for treatment of myeloproliferative neoplasms
WO2019200254A1 (en)	2018-04-13	2019-10-17	Tolero Pharmaceuticals, Inc.	Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer
WO2020017569A1 (ja)	2018-07-17	2020-01-23	日本ケミファ株式会社	Ｔ型カルシウムチャネル阻害剤
CN108912032A (zh) *	2018-08-13	2018-11-30	南通大学	一种（3s，4r）-4-甲基吡咯烷-3-基氨基甲醇叔丁酯盐酸盐的化学合成方法
CN109053526A (zh) *	2018-08-13	2018-12-21	南通大学	一种（3r，4s）-4-甲基吡咯烷-3-基氨基甲酸叔丁酯盐酸盐的化学合成方法
WO2020157709A1 (en)	2019-02-01	2020-08-06	Pfizer Inc.	Combination of a cdk inhibitor and a pim inhibitor
CA3127502A1 (en)	2019-02-12	2020-08-20	Sumitomo Dainippon Pharma Oncology, Inc.	Formulations comprising heterocyclic protein kinase inhibitors
US20220056043A1 (en) *	2019-02-19	2022-02-24	Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.	Nitrogen-containing fused cyclic compound, preparation method therefor and use thereof
AU2020250468A1 (en)	2019-03-29	2021-11-04	Kinki University	Use of T-type calcium channel blocker for treating pruritus
CN111171023B (zh) *	2020-01-10	2021-12-21	中国药科大学	一种具有Pim1抑制活性的化合物及其制备方法与医药用途
CN120302975A (zh)	2022-10-31	2025-07-11	住友制药美国公司	治疗骨髓增生性肿瘤的pim1抑制剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02004735A (es)	1999-11-12	2003-01-28	Orive Javier Uhthoff	Compuestos heteroaromaticos, biciclicos y triciclicos.
UA75055C2 (uk) *	1999-11-30	2006-03-15	Пфайзер Продактс Інк.	Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
CN1173975C (zh)	2000-04-27	2004-11-03	山之内制药株式会社	咪唑并吡啶衍生物
DE10038019A1 (de)	2000-08-04	2002-02-14	Bayer Ag	Substituierte Triazolopyrid(az)ine
OA12552A (en)	2001-03-09	2006-06-06	Pfizer Prod Inc	Triazolopyridines as anti-inflammatory agents.
US7227006B2 (en)	2002-01-19	2007-06-05	Sanofi-Aventis Deutschland Gmbh	PIM-3 kinase as a target for type 2 diabetes mellitus
KR101075812B1 (ko)	2002-12-18	2011-10-25	버텍스 파마슈티칼스 인코포레이티드	단백질 키나제 억제제로서의 트리아졸로피리다진
DE60326646D1 (de)	2002-12-18	2009-04-23	Vertex Pharma	Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen
US20050164300A1 (en)	2003-09-15	2005-07-28	Plexxikon, Inc.	Molecular scaffolds for kinase ligand development
US20050256309A1 (en)	2004-05-12	2005-11-17	Altenbach Robert J	Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
EP1781655A2 (en)	2004-08-18	2007-05-09	Pharmacia & Upjohn Company LLC	Triazolopyridine compounds useful for the treatment of inflammation
ES2330872T3 (es)	2004-12-01	2009-12-16	Merck Serono Sa	Derivados de (1,2,4)triazolo(4,3-a)piridina para el tratamiento de enfermedades hiperproliferativas.
JP5238506B2 (ja)	2005-10-06	2013-07-17	エグゼリクシス，インコーポレイテッド	Ｐｉｍ−１および／またはｐｉｍ−３のピリドピリミジノンインヒビター
WO2007087250A2 (en)	2006-01-23	2007-08-02	Amira Pharmaceuticals, Inc.	Tricyclic inhibitors of 5-lipoxygenase
TW200808802A (en)	2006-06-06	2008-02-16	Schering Corp	Imidazopyrazines as protein kinase inhibitors
CN101600718B (zh)	2006-11-06	2013-07-03	特雷罗药物股份有限公司	咪唑并[1,2-b]哒嗪和吡唑并[1,5-a]嘧啶衍生物及其作为蛋白激酶抑制剂的用途
WO2008082839A2 (en)	2006-12-29	2008-07-10	Abbott Laboratories	Pim kinase inhibitors as cancer chemotherapeutics
RU2009136263A (ru) *	2007-03-02	2011-04-10	Шеринг Корпорейшн (US)	Производные бензимидазола и способы их применения
EP2139888A2 (en) *	2007-03-28	2010-01-06	Array Biopharma, Inc.	Imidazoý1,2-a¨pyridine compounds as receptor tyrosine kinase inhibitors
WO2008124323A1 (en) *	2007-04-03	2008-10-16	Array Biopharma Inc.	Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
AR071717A1 (es)	2008-05-13	2010-07-07	Array Biopharma Inc	Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
US8557809B2 (en)	2008-08-19	2013-10-15	Array Biopharma Inc.	Triazolopyridine compounds as PIM kinase inhibitors
TWI496779B (zh)	2008-08-19	2015-08-21	Array Biopharma Inc	作為ｐｉｍ激酶抑制劑之三唑吡啶化合物
US20110184013A1 (en) *	2008-10-01	2011-07-28	Shelley Allen	Imidazo[1,2-a]Pyridine Compounds As Receptor Tyrosine Kinase Inhibitors
JP2012521428A (ja) *	2009-03-23	2012-09-13	メルク・シャープ・エンド・ドーム・コーポレイション	疼痛治療用のｐ２ｘ３受容体アンタゴニスト

2012
- 2012-02-24 HR HRP20160134TT patent/HRP20160134T1/hr unknown
- 2012-02-24 RU RU2013143292/04A patent/RU2598846C2/ru not_active IP Right Cessation
- 2012-02-24 AR ARP120100626A patent/AR085489A1/es active IP Right Grant
- 2012-02-24 UA UAA201311350A patent/UA111075C2/uk unknown
- 2012-02-24 WO PCT/US2012/026572 patent/WO2012154274A1/en not_active Ceased
- 2012-02-24 RS RS20160095A patent/RS54586B1/sr unknown
- 2012-02-24 CN CN201280020416.9A patent/CN103492377B/zh not_active Expired - Fee Related
- 2012-02-24 MX MX2013009820A patent/MX339899B/es active IP Right Grant
- 2012-02-24 PL PL12716770T patent/PL2678329T3/pl unknown
- 2012-02-24 DK DK12716770.8T patent/DK2678329T3/da active
- 2012-02-24 SG SG2013064324A patent/SG192944A1/en unknown
- 2012-02-24 UY UY0001033924A patent/UY33924A/es not_active Application Discontinuation
- 2012-02-24 SI SI201230453A patent/SI2678329T1/sl unknown
- 2012-02-24 PH PH1/2013/501754A patent/PH12013501754A1/en unknown
- 2012-02-24 ES ES12716770.8T patent/ES2563152T3/es active Active
- 2012-02-24 US US14/001,657 patent/US8889704B2/en not_active Expired - Fee Related
- 2012-02-24 EP EP12716770.8A patent/EP2678329B1/en active Active
- 2012-02-24 CA CA2828269A patent/CA2828269C/en not_active Expired - Fee Related
- 2012-02-24 ME MEP-2016-35A patent/ME02365B/me unknown
- 2012-02-24 AU AU2012254082A patent/AU2012254082B2/en not_active Ceased
- 2012-02-24 BR BR112013021675A patent/BR112013021675A2/pt not_active Application Discontinuation
- 2012-02-24 JP JP2013555610A patent/JP6039585B2/ja not_active Expired - Fee Related
- 2012-02-24 KR KR1020137025297A patent/KR101940338B1/ko not_active Expired - Fee Related
- 2012-02-24 HU HUE12716770A patent/HUE027675T2/en unknown
- 2012-02-29 TW TW101106629A patent/TWI529170B/zh not_active IP Right Cessation
2013
- 2013-08-23 CL CL2013002446A patent/CL2013002446A1/es unknown
- 2013-08-25 IL IL228108A patent/IL228108A/en active IP Right Grant
- 2013-09-11 CR CR20130460A patent/CR20130460A/es unknown
- 2013-09-17 ZA ZA2013/06997A patent/ZA201306997B/en unknown
- 2013-09-18 CO CO13222097A patent/CO6771441A2/es unknown
2016
- 2016-02-16 CY CY20161100127T patent/CY1117197T1/el unknown
- 2016-02-22 SM SM201600052T patent/SMT201600052B/xx unknown
- 2016-02-24 JP JP2016032675A patent/JP2016106118A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP2678329B1 (en)	2015-11-18
SI2678329T1 (sl)	2016-05-31
CA2828269C (en)	2019-01-15
UA111075C2 (uk)	2016-03-25
UY33924A (es)	2013-09-30
EP2678329A1 (en)	2014-01-01
JP2014509322A (ja)	2014-04-17
RU2013143292A (ru)	2015-04-10
RS54586B1 (sr)	2016-08-31
AU2012254082B2 (en)	2016-12-08
PL2678329T3 (pl)	2016-06-30
IL228108A (en)	2017-07-31
SMT201600052B (it)	2016-04-29
CO6771441A2 (es)	2013-10-15
JP2016106118A (ja)	2016-06-16
JP6039585B2 (ja)	2016-12-07
US8889704B2 (en)	2014-11-18
MX339899B (es)	2016-06-16
MX2013009820A (es)	2014-09-01
HUE027675T2 (en)	2016-11-28
PH12013501754A1 (en)	2013-10-14
CA2828269A1 (en)	2012-11-15
HK1190714A1 (zh)	2014-07-11
HRP20160134T1 (hr)	2016-04-08
TWI529170B (zh)	2016-04-11
WO2012154274A1 (en)	2012-11-15
CN103492377B (zh)	2016-04-20
ES2563152T3 (es)	2016-03-11
CL2013002446A1 (es)	2014-04-11
RU2598846C2 (ru)	2016-09-27
CN103492377A (zh)	2014-01-01
ZA201306997B (en)	2015-05-27
AR085489A1 (es)	2013-10-09
CY1117197T1 (el)	2017-04-05
KR101940338B1 (ko)	2019-01-18
SG192944A1 (en)	2013-09-30
TW201245193A (en)	2012-11-16
NZ615300A (en)	2014-12-24
IL228108A0 (en)	2013-09-30
BR112013021675A2 (pt)	2016-11-01
AU2012254082A1 (en)	2013-09-26
US20140005213A1 (en)	2014-01-02
KR20140021577A (ko)	2014-02-20
ME02365B (me)	2016-06-20
CR20130460A (es)	2013-10-16

Publication	Publication Date	Title
DK2678329T3 (da)	2016-02-22	Triazolopyridinforbindelser som pim-kinase-hæmmere
DK3196202T3 (da)	2019-05-13	Heterocyclylaminer som pi3k-inhibitorer
DK2710018T3 (da)	2022-03-21	Makrocykliske forbindelser som proteinkinasehæmmere
DK2693881T3 (da)	2019-12-09	Substituerede n-phenylpyrimidin-2-amin-analoger som inhibitorer af axl-kinase
SMT201600308B (it)	2016-11-10	Composti di benzene arile-o eteroarile-sostituiti
DK3181567T3 (da)	2019-06-11	Pyrazolopyrimidinforbindelser som kinasehæmmere
CO6930358A2 (es)	2014-04-28	Compuestos inhibidores de metaloenzimas
LT2751083T (lt)	2018-03-26	Kvinolono junginys
HRP20181786T1 (hr)	2019-02-08	Inhibitori aktivacije t-stanica
BR112014012159A2 (pt)	2017-05-30	tetra-hidrocanabivarina fitocanabinóide
CO6900145A2 (es)	2014-03-20	Compuesto de ciclopropanoamina
HUE036259T2 (hu)	2018-06-28	Inhibitor vegyületek
IL229513A0 (en)	2014-01-30	Imidazopyridine compounds
DK3673906T3 (da)	2025-08-18	Glycosylceramidsyntase-hæmmere
DK2710007T3 (da)	2020-01-27	Kinasehæmmere
CO6890099A2 (es)	2014-03-10	Nuevos derivados dihidroquinolina-2-ona
BR112014012016A2 (pt)	2017-05-16	compostos
LT2742151T (lt)	2018-02-12	Polimerazės kompozicija
BR112013022112A2 (pt)	2018-06-26	composição
SMT201600328B (it)	2016-11-10	Nuovi composti come inibitori di diacilglicerolo aciltransferasi
BR112013022102A2 (pt)	2018-06-26	composição
DK2686017T3 (da)	2019-10-07	Oftalmisk sammensætning
BR112014004395A2 (pt)	2017-03-28	composição
CO6910197A2 (es)	2014-03-31	Compuestos novedosos
CU24164B1 (es)	2016-03-31	Inhibidores sustituidos de acetil-coa carboxilasa