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DK2500360T3 - Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer - Google Patents

Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer Download PDF

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Publication number
DK2500360T3
DK2500360T3 DK12156146.8T DK12156146T DK2500360T3 DK 2500360 T3 DK2500360 T3 DK 2500360T3 DK 12156146 T DK12156146 T DK 12156146T DK 2500360 T3 DK2500360 T3 DK 2500360T3
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DK
Denmark
Prior art keywords
cancer
tumor
pro
leu
cells
Prior art date
Application number
DK12156146.8T
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English (en)
Inventor
Austin Gurney
John Lewicki
Sanjeev Satyal
Timothy Hoey
Original Assignee
Oncomed Pharm Inc
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Publication of DK2500360T3 publication Critical patent/DK2500360T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (7)

1. Farmaceutisk sammensætning omfattende en opløselig FZD8-receptor og et farmaceutisk acceptabelt bærestof, hjælpestof og/eller en farmaceutisk acceptabel stabilisator, hvor aminosyresekvensen af den opløselige FZD8-receptor består af rest 28 til 158 af SEQ ID NO: 7, bundet til en non-FZD-receptorsekvens, hvor non-FZD-receptorsekvensen omfatter et humant Fc.
2. Farmaceutisk sammensætning ifølge krav 1, hvor det humane Fc er humant lgG1 Fc.
3. Farmaceutisk sammensætning ifølge krav 1, hvor aminosyresekvensen af den opløselige receptor består af rest 28 til 158 af SEQ ID NO: 7, bundet til SEQ ID NO: 4.
4. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3 til anvendelse i en fremgangsmåde til behandling af menneskekroppen ved terapi.
5. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3 til anvendelse i en fremgangsmåde til behandling af cancer.
6. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3 til anvendelse ifølge krav 5, hvor canceren er brystcancer, kolorektal cancer, pancreascancer, prostatacancer, hoved- og halscancer, en lungetumor, ovariecancer, melanom, basalcellecarcinom, sarkom eller hepatocellulær cancer.
7. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3 til anvendelse ifølge krav 5 eller krav 6, hvor fremgangsmåden omfatter indgivelse af den opløselige receptor til en patient, der er et menneske, med strålebehandling, kemoterapi eller eller et antistof mod et antigen associeret med en yderligere tumor.
DK12156146.8T 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer DK2500360T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73146805P 2005-10-31 2005-10-31
US81296606P 2006-06-13 2006-06-13
EP07752161.5A EP1978993B1 (en) 2005-10-31 2006-10-31 Compositions and methods for treating cancer based on human fzd receptors

Publications (1)

Publication Number Publication Date
DK2500360T3 true DK2500360T3 (da) 2015-10-26

Family

ID=38006447

Family Applications (3)

Application Number Title Priority Date Filing Date
DK12156146.8T DK2500360T3 (da) 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer
DK12154780.6T DK2481756T3 (da) 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer
DK07752161.5T DK1978993T3 (da) 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til behandling af cancer baseret på humane FZD-receptorer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK12154780.6T DK2481756T3 (da) 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til diagnosticering og behandling af cancer
DK07752161.5T DK1978993T3 (da) 2005-10-31 2006-10-31 Sammensætninger og fremgangsmåder til behandling af cancer baseret på humane FZD-receptorer

Country Status (16)

Country Link
US (2) US9850311B2 (da)
EP (6) EP2511298B1 (da)
JP (4) JP2009513708A (da)
CN (1) CN102827287B (da)
AU (2) AU2006344359B2 (da)
CA (2) CA2628116A1 (da)
DK (3) DK2500360T3 (da)
ES (3) ES2547421T3 (da)
HR (1) HRP20151172T1 (da)
HU (2) HUE025908T2 (da)
ME (1) ME02226B (da)
PL (3) PL2481756T3 (da)
PT (2) PT2500360E (da)
RS (1) RS54215B1 (da)
SI (1) SI2500360T1 (da)
WO (3) WO2007133250A2 (da)

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PT2500360E (pt) 2005-10-31 2015-10-15 Oncomed Pharm Inc Composições e métodos para diagnóstico e tratamento do cancro
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TWI762516B (zh) * 2016-10-06 2022-05-01 日商腫瘤療法 科學股份有限公司 針對ｆｚｄ１０之單株抗體及其用途
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WO2007053577A2 (en) 2007-05-10
EP1961065A2 (en) 2008-08-27
EP1978993A2 (en) 2008-10-15
EP2500360B1 (en) 2015-08-05
JP2009515513A (ja) 2009-04-16

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