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DK2591363T3 - Diagnose og behandling af brystcancer - Google Patents

Diagnose og behandling af brystcancer Download PDF

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Publication number
DK2591363T3
DK2591363T3 DK11804337.1T DK11804337T DK2591363T3 DK 2591363 T3 DK2591363 T3 DK 2591363T3 DK 11804337 T DK11804337 T DK 11804337T DK 2591363 T3 DK2591363 T3 DK 2591363T3
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ctc
expression
ctcs
positive
breast cancer
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DK11804337.1T
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English (en)
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Daniel Hayes
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Univ Michigan Regents
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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Claims (8)

1. fremgangsmåde til bestemmelse af et behandlingsforløb, omfattende a) at detektere niveauet af cirkulerende tumorceller (CTC) i en prøve fra et individ med metastatisk brystcancer; b) at bestemme antalllet af CTC, der er positive for ekspression af østrogenreceptor, HER-2, bcl-2 og ki67; c) at beregne et numerisk CTC-endokrin terapi-indeks (CTC-ETI) baseret på antallet af CTC, der er positive for ekspression af østrogenreceptoren (ER), HER-2, bcl-2, ki67, og det samlede antal af CTC ved at tildele point på basis af antallet af CTC, der er positive for ekspression of ER, HER-2, bcl-2 og ki67 på CTC'erne, hvor CTC-ETI'et beregnes ved i) at tildele nul point, når antallet af CTC er 0-4 pr. 7,5 ml, 1 point, når antallet af CTC er 5-10 pr. 7,5 ml, og 2 point, når antallet af CTC er større end 10 pr. 7,5 ml; ii) at tildele nul point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er større end 10 %, at tildele 2 point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er 1-10 %, og at tildele 6 point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er nul; iii) at tildele nul point, når antallet af CTC, der er positive for ekspression af HER-2, er 0 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af HER-2, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af HER-2, er større end 10 %; iv) at tildele nul point, når antallet af CTC, der er positive for ekspression af bcl-2, er større end 10 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af bcl-2, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af bcl-2, er 0 %; v) at tildele nul point, når antallet af CTC, der er positive for ekspression af ki67, er 0 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af ki-67, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af ki-67, er større end 10 %; og vi) at addere pointene til opnåelse af CTC-ETI'et; og d) at anbefale indgivelse af antiøstrogen-terapi til individet, når CTC-ETI'et er 0-3, og indgivelse af kemoterapi til individet, når CTC-ETI'et er 7-14, hvor et CTC-ETI på 0-3 indikerer et gunstigt respons på antiøstrogen-terapi, et CTC- ETI på 4-6 indikerer et moderat respons på antiøstrogen-terapi, og et CTC-ETI på 7-14 indikerer et dårligt respons på antiøstrogen-terapi.
2. Fremgangsmåde ifølge krav 1, hvor behandlingsforløbet omfatter antiøstrogen-terapi.
3. Fremgangsmåde ifølge krav 2, hvor antiøstrogen-terapien omfatter tamoxifen.
4. Fremgangsmåde ifølge krav 2, hvor antiøstrogen-terapien er udvalgt fra gruppen bestående af letrozol, anastrozol og exemestan.
5. Fremgangsmåde ifølge krav 1, hvor behandlingsforløbet omfatter kemoterapi.
6. Fremgangsmåde ifølge krav 1, hvor en eller flere af tumormarkørerne de-tekteres under anvendelse af en multiplex-PCR-fremgangsmåde.
7. Fremgangsmåde ifølge krav 1, hvor tumormarkørerne detekteres under anvendelse af et immunomagnetisk assay.
8. Fremgangsmåde ifølge krav 1, hvor brystcanceren er østrogenreceptor-positiv.
DK11804337.1T 2010-07-07 2011-07-07 Diagnose og behandling af brystcancer DK2591363T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36202110P 2010-07-07 2010-07-07
US201161469890P 2011-03-31 2011-03-31
PCT/US2011/043189 WO2012006421A2 (en) 2010-07-07 2011-07-07 Diagnosis and treatment of breast cancer

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DK2591363T3 true DK2591363T3 (da) 2017-12-11

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DK11804337.1T DK2591363T3 (da) 2010-07-07 2011-07-07 Diagnose og behandling af brystcancer

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US (3) US8790878B2 (da)
EP (2) EP2591363B1 (da)
JP (1) JP5951603B2 (da)
CN (1) CN103109187B (da)
AU (1) AU2011274789B2 (da)
BR (1) BR112013000433A2 (da)
CA (1) CA2804269A1 (da)
DK (1) DK2591363T3 (da)
ES (1) ES2652600T3 (da)
RU (1) RU2550925C2 (da)
WO (1) WO2012006421A2 (da)

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ES2652600T3 (es) 2010-07-07 2018-02-05 The Regents Of The University Of Michigan Diagnóstico y tratamiento de cáncer de mama
WO2012097820A1 (en) * 2011-01-20 2012-07-26 Syddansk Universitet Method and assay for predicting long-term efficacy of tamoxifen treatment in estrogen receptor-positive breast cancer patients
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ES2729638T3 (es) * 2013-10-11 2019-11-05 Ventana Med Syst Inc Ensayos múltiplex de tinción conjunta de receptores de HER2 y de estrógenos para detectar heterogeneidad tumoral
CN106456694B (zh) 2013-12-20 2020-06-30 通用医疗公司 与循环肿瘤细胞相关的方法和测定法
WO2015093670A1 (ko) * 2013-12-20 2015-06-25 (주)옵티팜 조직 및 혈액을 이용한 유방암의 치료제 선별 검사 및 조기진단을 위한 역전사 정량적 중합효소연쇄반응 키트
JP6582486B2 (ja) * 2015-03-27 2019-10-02 コニカミノルタ株式会社 血液中の稀少細胞検出方法
CN104892759B (zh) * 2015-06-18 2018-04-03 福州迈新生物技术开发有限公司 由杂交瘤细胞系分泌的抗Ki67单克隆抗体及其应用
CN104991010B (zh) * 2015-07-29 2017-10-13 中国药科大学 一种区分乳腺癌亚型生物标志物的组合物
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US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
RU2637859C1 (ru) * 2017-02-13 2017-12-07 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ дифференцированного лечения больных локализованным раком молочной железы
US11549139B2 (en) 2018-05-14 2023-01-10 Nanostring Technologies, Inc. Chemical compositions and methods of using same
RU2706029C1 (ru) * 2018-10-09 2019-11-13 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения люминального подтипа рака молочной железы
RU2760168C1 (ru) * 2021-02-05 2021-11-22 федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации Способ прогнозирования результатов лечения эмбриональных опухолей

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US20170242011A1 (en) 2017-08-24
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US20140295444A1 (en) 2014-10-02
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